最近到休斯顿开一个系统生物学方面的会，M. D. Anderson 的Gordon Mills 做了一个充满曙光的关于个人化癌症治疗的报告。最近 M. D. Anderson从阿联酋国王那里拉到了1.5亿美金的赞助，将用于建立首家个人化癌症治疗研究所。 Gordon Mills的方案是对癌症病人的癌症组织深度测序，确定个人化的cancer driver genes。然后通过高通量的化疗筛选方案得到针对这些 driver genes的特别药物。如何抗药性发生，则继续由高通量的化疗筛选方案 筛选新药。这种治疗方案的好处是针对性强，副作用小。但是最大的问题在于初发癌症克隆未见得是 抗药性最强的克隆，花费了大量精力的第一步往往很快失败。真正好的方案可能应该从 克隆入手。今年的Nature有相关讨论的文章： Title: The genetic basis of early T-cell precursor acute lymphoblastic leukaemia http://www.nature.com/nature/journal/v481/n7380/full/nature10725.html M. D. Anderson 的Gordon Mills关于个人化癌症治疗 http://www.youtube.com/watch?v=FXkcSry6EtQ 研究所的网址： http://www.mdanderson.org/education-and-research/research-at-md-anderson/personalized-advanced-therapy/institute-for-personalized-cancer-therapy/index.html The University of Texas M.D. Anderson Cancer Center will receive $150 million from Sheikh Khalifa bin Zayed Al Nahyan , the ruler of UAE,the largest donation ever given to an institution in the Texas Medical Center. The gift, announced Tuesday by the Khalifa Bin Zayed Al Nahyan Foundation , will fund M.D. Anderson’s Institute for Personalized Cancer Therapy, both research and a building.The 600,000 square-foot facility will house the Khalifa bin Zayed Al Nahyan Institute for Personalized Cancer Therapy and the Ahmed bin Zayed Al Nahyan Center for Pancreatic Cancer Research. The University of Texas MD Anderson Cancer Center in Houston ranks as one of the world’s most respected centers focused on cancer patient care, research, education and prevention. MD Anderson is one of only 40 comprehensive cancer centers designated by the National Cancer Institute. The grant also will fund three distinguished university chairs named after Sheikh Zayed bin Sultan Al Nahyan for oncology, the Sheikh Khalifa bin Zayed Al Nahyan for medical or scientific discipline dedicated to cancer research and the Mohammed bin Zayed Al Nahyan for scientific and medical knowledge in cancer research. This is the third gift in the past four years from the UAE. It also gave $150 million to the Children’s National Medical Center in Washington, one of the largest to a pediatric hospital, to establish the Sheikh Zayed Institute for Pediatric Surgical Innovation in 2009.In 2007, Sheikh Khalifa gave an undisclosed major sum to Johns Hopkins Medicine to help construct The Johns Hopkins Hospital new cardiovascular and critical care tower. Also named after Sheikh Khalifa’s father, it is one of two towers scheduled to open in early 2012, at a cost of $994 million.
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