Dear Prof. Peiyang: New articles: colleagues in your discipline have identified the following article(s) as being of interest: Article Title Discipline Rele- vance News- worthiness Azithromycin for prevention of exacerbations in non-cystic fibrosis bronchiectasis (EMBRACE): a randomised, double-blind, placebo-controlled trial. Lancet Respirology/Pulmonology 6 5 Vandetanib in locally advanced or metastatic differentiated thyroid cancer: a randomised, double-blind, phase 2 trial. Lancet Oncol Oncology - General 6 6 Randomized controlled trial comparing treatment outcome of two compression bandaging systems and standard care without compression in patients with venous leg ulcers. J Vasc Surg Surgery - Vascular 4 4 A randomized placebo-controlled trial of oxybutynin for the initial treatment of palmar and axillary hyperhidrosis. J Vasc Surg General Practice(GP)/Family Practice(FP) 5 5 General Internal Medicine-Primary Care(US) 5 5 A prospective randomized study comparing fibrin sealant to manual compression for the treatment of anastomotic suture-hole bleeding in expanded polytetrafluoroethylene grafts. J Vasc Surg Hematology/Thrombosis 6 6 Neonatal respiratory morbidity in the early term delivery. Am J Obstet Gynecol Pediatric Neonatology 7 4 Lipid-modifying therapies and risk of pancreatitis: a meta-analysis. JAMA Endocrine 6 5 Gastroenterology 5 6 Cardiology 5 5 Antiplatelet and anticoagulant drugs for prevention of restenosis/reocclusion following peripheral endovascular treatment. Cochrane Database Syst Rev General Practice(GP)/Family Practice(FP) 5 5 General Internal Medicine-Primary Care(US) 5 5 Hospital Doctor/Hospitalists 5 5 Internal Medicine 5 5 Blood pressure lowering efficacy of loop diuretics for primary hypertension. Cochrane Database Syst Rev General Practice(GP)/Family Practice(FP) 6 5 General Internal Medicine-Primary Care(US) 6 5 Internal Medicine 5 5 Costs and Cost-Effectiveness of Carotid Stenting Versus Endarterectomy for Patients at Standard Surgical Risk: Results From the Carotid Revascularization Endarterectomy Versus Stenting Trial (CREST). Stroke Cardiology 6 6 Fractional Flow Reserve-Guided PCI versus Medical Therapy in Stable Coronary Disease. N Engl J Med Cardiology 6 6 Diagnostic Accuracy of Fractional Flow Reserve From Anatomic CT Angiography. JAMA Cardiology 5 6
Dear Prof. Peiyang: New articles: colleagues in your discipline have identified the following article(s) as being of interest: Article Title Discipline Rele- vance News- worthiness Treatment with aliskiren/amlodipine combination in patients with moderate-to-severe hypertension: a randomised, double-blind, active comparator trial. Int J Clin Pract Cardiology 5 4 General Practice(GP)/Family Practice(FP) 4 3 General Internal Medicine-Primary Care(US) 4 3 Phlebotonics for haemorrhoids. Cochrane Database Syst Rev General Practice(GP)/Family Practice(FP) 6 5 General Internal Medicine-Primary Care(US) 6 5 A meta-analysis of anticoagulation for calf deep venous thrombosis. J Vasc Surg Hematology/Thrombosis 6 4 Questions remain about quality of life after abdominal aortic aneurysm repair. J Vasc Surg Surgery - Vascular 6 5 Image-guided versus blind glucocorticoid injection for shoulder pain. Cochrane Database Syst Rev General Practice(GP)/Family Practice(FP) 6 6 General Internal Medicine-Primary Care(US) 6 6 Comparison of novel risk markers for improvement in cardiovascular risk assessment in intermediate-risk individuals. JAMA Internal Medicine 6 6 General Practice(GP)/Family Practice(FP) 6 5 General Internal Medicine-Primary Care(US) 6 5 Effect of biolimus-eluting stents with biodegradable polymer vs bare-metal stents on cardiovascular events among patients with acute myocardial infarction: the COMFORTABLE AMI randomized trial. JAMA Hospital Doctor/Hospitalists 5 5 Internal Medicine 5 5 Intraaortic Balloon Support for Myocardial Infarction with Cardiogenic Shock. N Engl J Med Hospital Doctor/Hospitalists 6 5 Internal Medicine 6 5 Emergency Medicine 5 6 Cardiology 5 5
Dear Prof. Peiyang: New articles: colleagues in your discipline have identified the following article(s) as being of interest: Article Title Discipline Rele- vance News- worthiness Pregabalin for chronic prostatitis. Cochrane Database Syst Rev Surgery - Urology 5 4 Antivirals for idiopathic sudden sensorineural hearing loss. Cochrane Database Syst Rev Surgery - Ear Nose Throat 6 5 Task shifting of antiretroviral treatment from doctors to primary-care nurses in South Africa (STRETCH): a pragmatic, parallel, cluster-randomised trial. Lancet Infectious Disease 5 5 Effect of screening for partner violence on women`s quality of life: a randomized controlled trial. JAMA General Practice(GP)/Family Practice(FP) 5 5 General Internal Medicine-Primary Care(US) 5 5 Management of late-preterm premature rupture of membranes: the PPROMEXIL-2 trial. Am J Obstet Gynecol Obstetrics 5 5
Dear Prof. Peiyang: New articles: colleagues in your discipline have identified the following article(s) as being of interest: Article Title Discipline Rele- vance News- worthiness Temozolomide versus standard 6-week radiotherapy versus hypofractionated radiotherapy in patients older than 60 years with glioblastoma: the Nordic randomised, phase 3 trial. Lancet Oncol Oncology - Palliative and Supportive Care 6 6 ``Early`` versus ``late`` 23-week infant outcomes. Am J Obstet Gynecol Pediatric Neonatology 5 5 Human papillomavirus vaccination in Tanzanian schoolgirls: cluster-randomized trial comparing 2 vaccine-delivery strategies. J Infect Dis Infectious Disease 5 5 Public Health 4 4 Randomized trial of transversus abdominis plane block at total laparoscopic hysterectomy: effect of regional analgesia on quality of recovery. Am J Obstet Gynecol Anesthesiology 7 6 Patient-controlled versus scheduled, nurse-administered analgesia following vaginal reconstructive surgery: a randomized trial. Am J Obstet Gynecol Gynecology 7 5 Anesthesiology 5 3 Tofacitinib, an oral Janus kinase inhibitor, in active ulcerative colitis. N Engl J Med Gastroenterology 6 7 Benefits and Harms of Statin Therapy for Persons With Chronic Kidney Disease: A Systematic Review and Meta-analysis. Ann Intern Med Nephrology 7 6 General Practice(GP)/Family Practice(FP) 6 6 General Internal Medicine-Primary Care(US) 6 6 Lipid-Lowering Therapy in Persons With Chronic Kidney Disease: A Systematic Review and Meta-analysis. Ann Intern Med Nephrology 7 5
Dear Prof. Peiyang: New articles: colleagues in your discipline have identified the following article(s) as being of interest: Article Title Discipline Rele- vance News- worthiness Clinicopathologic Characteristics of Angioimmunoblastic T-Cell Lymphoma: Analysis of the International Peripheral T-Cell Lymphoma Project. J Clin Oncol Oncology - Hematology 6 6 The relative clinical effectiveness of ranibizumab and bevacizumab in diabetic macular oedema: an indirect comparison in a systematic review. BMJ Endocrine 6 5 Surgery - Ophthalmology 6 4 Internal Medicine 5 4 Intra-pleural Fibrinolytic Therapy for Treatment of Adult Parapneumonic Effusions and Empyemas: A Systematic Review and Meta-analysis. Chest Internal Medicine 6 4 Imatinib after induction for treatment of children and adolescents with Philadelphia-chromosome-positive acute lymphoblastic leukaemia (EsPhALL): a randomised, open-label, intergroup study. Lancet Oncol Pediatrics (General) 5 4 A randomized, placebo-controlled trial of acupuncture in patients with chronic obstructive pulmonary disease (COPD): the COPD-acupuncture trial (CAT). Arch Intern Med General Practice(GP)/Family Practice(FP) 6 7 General Internal Medicine-Primary Care(US) 6 7 Respirology/Pulmonology 5 6
Fornew readers and those who request to be “ 好友 good friends” please read my 公告 栏 first. Dear colleagues, It gives me great pleasure to announce the appointment ofXiao-Li Meng, Whipple V.N. Jones Professor of Statistics in the FAS'sDepartment of Statistics, as the next Dean of the Graduate School of Arts andSciences, effective August 15, 2012. Xiao-Li is a remarkable scholar, teacher, and citizen ofthe University. With Harvard roots dating back to his days as a student atGSAS, Xiao-Li has deep institutional understanding, coupled with remarkableopen-mindedness and a drive to move Harvard forward. His knowledge of the FASstems not only from his role as an engaged and accomplished teacher and mentor,but also from his years of departmental service as a head tutor, director ofgraduate studies, and three-term department chair. He has also been an active memberof the FAS Faculty Council, the Committee on Undergraduate Education, and theGraduate Policy Committee. In addition to his strong ties to undergraduate andgraduate education, Xiao-Li has worked effectively with colleagues acrossdisciplinary and school boundaries. He has served with distinction as a memberof the School of Engineering and Applied Sciences’ Computational Science andEngineering Program, the University’s Institute for Quantitative SocialScience, the Committee on Higher Degrees in the Public Health Sciences, and thesubcommittee on the Biostatistics Ph.D. degree, a collaborative effort withHarvard Medical School and the Harvard School of Public Health. Xiao-Li joined the FAS faculty in 2001 as Professor ofStatistics, assuming his present title in 2007. As chair of the StatisticsDepartment (2004-2010 and 2011 to the present), Xiao-Li has revitalized teachertraining and professional development for the department’s graduate studentsand fostered an energizing and welcoming departmental culture for its students. Xiao-Li has long been a creative advocate for advancingexcellence in teaching at Harvard. He served on the FAS Committee onPedagogical Improvement (2004-2010) and the FAS Task Force on Teaching andCareer Development (2006-2007). His own teaching is exceptional, and he is awarm and inspiring mentor to students. Xiao-Li’s work spans a broad spectrum, from theoreticalfoundations of statistical inferences, to statistical methods and computation,and to a wide range of applications in natural, social, and medical sciencesand engineering. Examples of the applications of his work include complexstatistical modeling in astronomy and astrophysics, quantifying statisticalinformation in genetic studies, detecting and estimating trends inenvironmental and geophysical measurements, measuring disparities in Latino andAsian mental health services, assessing reporting delay in AIDS surveillancesystems, and de-noising and de-mosaicing in digital cameras. For his research contributions, Xiao-Li has received the2001 COPSS (Committee of Presidents of Statistical Societies) Award, the mostprestigious award by five statistical societies to a single statisticianannually for being the outstanding statistician under the age of forty.He also received the 2003 Distinguished Achievement Award from theInternational Chinese Statistics Association (ICSA), and was elected fellow bythe Institute of Mathematical Statistics (IMS) in 1997 and by the AmericanStatistical Association (ASA) in 2004. Most recently, he was the 2010 MedallionLecturer of IMS, 2011 Mosteller Statistician of the Year by the ASA BostonChapter, the recipient of a 2011 Distinguished Alumni Award by FudanUniversity, and a recipient of the inaugural (2012) PL Hsu Award for distinguishedachievements in research and education by a statistician under the age offifty. Receiving his B.S. in mathematics from Fudan University(Shanghai, China) in 1982, Xiao-Li earned a graduate diploma in 1986 fromFudan’s Research Institute of Mathematics. He then pursued master’s anddoctoral work in statistics at Harvard, receiving the M.A. and Ph.D. degrees in1987 and 1990. Before joining Harvard as a faculty member, Xiao-Li movedthrough the ranks at the University of Chicago, as an assistant professor(1991-1997), associate professor (1997-2000, winning the 1997-1998 FacultyAward for Excellence in Graduate Teaching), and professor (2000-2001). I want to take this opportunity to express my sincerethanks to Richard J. Tarrant, Pope Professor of the Latin Language andLiterature, who so ably served as interim dean of GSAS while the search wasunderway. Please join me in congratulating Xiao-Li as he takes onthis important new role. I look forward to working with him in the years tocome. Sincerely yours, Michael D. Smith Dean of the Faculty of Arts and Sciences Harvard University
Dear Prof. Peiyang: New articles: colleagues in your discipline have identified the following article(s) as being of interest: Article Title Discipline Rele- vance News- worthiness Fluticasone/Salmeterol combination confers benefits in people with asthma who smoke. Chest Respirology/Pulmonology 6 5 The effect of clinical covariates on the diagnostic and prognostic value of soluble mesothelin and megakaryocyte potentiating factor. Chest Occupational and Environmental Health 5 5 Predicting cardiac arrest on the wards: a nested case-control study. Chest Cardiology 5 4 A Randomized Trial of Two Weight-Based Doses of Insulin Glargine and Glulisine in Hospitalized Subjects With Type 2 Diabetes and Renal Insufficiency. Diabetes Care Hospital Doctor/Hospitalists 6 6 Internal Medicine 6 6 Thrombotic stroke and myocardial infarction with hormonal contraception. N Engl J Med Hospital Doctor/Hospitalists 6 6 Internal Medicine 6 6 Gynecology 6 5 Progression of early structural lung disease in young children with cystic fibrosis assessed using CT. Thorax Respirology/Pulmonology 6 5 Rivaroxaban compared with warfarin in patients with atrial fibrillation and previous stroke or transient ischaemic attack: a subgroup analysis of ROCKET AF. Lancet Neurol Hematology/Thrombosis 6 6 Applicability of stroke-unit care to low-income and middle-income countries. Lancet Neurol Neurology 5 4 Adjuvant platinum-based chemotherapy for early stage cervical cancer. Cochrane Database Syst Rev Gynecology 5 4 Anticoagulation versus placebo for heart failure in sinus rhythm. Cochrane Database Syst Rev Hematology/Thrombosis 6 6
Dear Prof. Peiyang: New articles: colleagues in your discipline have identified the following article(s) as being of interest: Article Title Discipline Rele- vance News- worthiness Carnitine for fatigue in multiple sclerosis. Cochrane Database Syst Rev Neurology 5 4 Uterine artery embolization for symptomatic uterine fibroids. Cochrane Database Syst Rev Gynecology 6 6 Scalpel versus electrosurgery for abdominal incisions. Cochrane Database Syst Rev Surgery - Gastrointestinal 6 4 Validation of the pulmonary hypertension connection equation for survival prediction in pulmonary arterial hypertension. Chest Respirology/Pulmonology 5 4
Prenatal exposure to currently approved pesticides in greenhouse workers appears to be linked to earlier breast development in their daughters as measured 10 years later, according to a new report by Christine Wohlfahrt-Veje, MD, from the University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark, and colleagues. The authors report their findings in an article March 9 in the . 根据哥本哈一所综合大学生长与发育系的研究人员报告，在温室花房的工作者中，其出生胎儿暴露到目前常用的经过批准的杀虫剂下，对她们的女儿们的乳房发育有影响。作者的研究结果报告已发表在２０１２年３月的《 International Journal of Andrology 》 published online 上。 欲知更多：请链接： http://www.medscape.com/viewarticle/760307
Dear Prof. Peiyang: New articles: colleagues in your discipline have identified the following article(s) as being of interest: Article Title Discipline Rele- vance News- worthiness Clinical and cost effectiveness of booklet based vestibular rehabilitation for chronic dizziness in primary care: single blind, parallel group, pragmatic, randomised controlled trial. BMJ General Practice(GP)/Family Practice(FP) 6 6 General Internal Medicine-Primary Care(US) 6 6 Just click on the title to review the abstract and/or PubMed record. Best wishes from Evidence Updates
National Writing Project teachers understand the value of critical thinking and collaboration with their colleagues . Writing Project teachers understand the value of critical thinking and collaboration with their colleagues . 附录 ：2010 Annual Report Download 2010 Annual Report (PDF) Past annual reports: NWP 2009 Annual Report (PDF) NWP 2008 Annual Report (PDF) NWP 2007 Annual Report (PDF) NWP 2006 Annual Report (PDF) NWP 2005 Annual Report (PDF) NWP 2004 Annual Report (PDF) NWP 2003 Annual Report (PDF) NWP 2002 Annual Report (PDF) NWP 2001 Annual Report (PDF) NWP 2000 Annual Report (PDF) NWP 1999 Annual Report (PDF) NWP 1998 Annual Report (PDF) About NWP Our Mission The National Writing Project focuses the knowledge, expertise, and leadership of our nation's educators on sustained efforts to improve writing and learning for all learners . Our Vision Writing in its many forms is the signature means of communication in the 21st century. The NWP envisions a future where every person is an accomplished writer, engaged learner, and active participant in a digital, interconnected world . Who We Are Unique in breadth and scale, the NWP is a network of sites anchored at colleges and universities and serving teachers across disciplines and at all levels , early childhood through university . We provide professional development , develop resources, generate research, and act on knowledge to improve the teaching of writing and learning in schools and communities. The National Writing Project believes that access to high-quality educational experiences is a basic right of all learners and a cornerstone of equity. We work in partnership with institutions, organizations, and communities to develop and sustain leadership for educational improvement. Throughout our work, we value and seek diversity—our own as well as that of our students and their communities—and recognize that practice is strengthened when we incorporate multiple ways of knowing that are informed by culture and experience. A Network of University-Based Sites Co-directed by faculty from the local university and from K–12 schools, nearly 200 local sites serve all 50 states, the District of Columbia, Puerto Rico, and the U.S. Virgin Islands. Sites work in partnership with area school districts to offer high-quality professional development programs for educators. NWP continues to add new sites each year, with the goal of placing a writing project site within reach of every teacher in America. The network now includes two associated international sites . A Successful Model Customized for Local Needs NWP sites share a national program model , adhering to a set of shared principles and practices for teachers’ professional development, and offering programs that are common across the network. In addition to developing a leadership cadre of local teachers (called “teacher-consultants”) through invitational summer institutes , NWP sites design and deliver customized inservice programs for local schools, districts, and higher education institutions, and they provide a diverse array of continuing education and research opportunities for teachers at all levels. National research studies have confirmed significant gains in writing performance among students of teachers who have participated in NWP programs. The NWP is the only federally funded program that focuses on the teaching of writing. Support for the NWP is provided by the U.S. Department of Education, foundations, individuals, corporations, universities, and K-12 schools. NWP Core Principles The core principles at the foundation of NWP’s national program model are: Teachers at every level—from kindergarten through college—are the agents of reform; universities and schools are ideal partners for investing in that reform through professional development. Writing can and should be taught, not just assigned, at every grade level. Professional development programs should provide opportunities for teachers to work together to understand the full spectrum of writing development across grades and across subject areas. Knowledge about the teaching of writing comes from many sources: theory and research, the analysis of practice, and the experience of writing. Effective professional development programs provide frequent and ongoing opportunities for teachers to write and to examine theory, research, and practice together systematically. There is no single right approach to teaching writing; however, some practices prove to be more effective than others. A reflective and informed community of practice is in the best position to design and develop comprehensive writing programs. Teachers who are well informed and effective in their practice can be successful teachers of other teachers as well as partners in educational research, development, and implementation. Collectively, teacher-leaders are our greatest resource for educational reform. http://www.nwp.org/cs/public/print/doc/about. csp
这两个网站的服务真好，每天给我发送大量的科学信息和文献，很受感动，应该去信感谢他们。相比国内这样的网站信息服务，还没有碰到呢。 我在英国医学会BMJ集团网站上定制了医学临床证据每日推送，这个网站的服务真好，每天及时将全世界的临床证据，循证医学文献推送到我的信箱，我每天及时转载到我的博客循证医学栏目，这个栏目的用户访问量很大，说明国内临床医生很需要最新的医学研究文献和信息。 Dear Prof. Peiyang: New articles: colleagues in your discipline have identified the following article(s) as being of interest: 他们的网址是 http://plus.mcmaster.ca/EvidenceUpdates/Default.aspx 每日临床证据 Evidence Updates is a service made available by the BMJ Group that incorporates the McMaster PLUS email alerting system and searchable database of best evidence from the medical literature as a new feature to the BMJ electronic product suite. Users of Evidence Updates with interests in a specific clinical problem or treatment are invited to use the openly accessible search engine to look up topics covered in the McMaster PLUS database published as far back as 2002. Physicians who are in general practice or primary care, internal medicine or its subspecialties are invited to register their interests so that they can receive email alerts and searching access for literature that is matched to their personal clinical interests. 另一个是科学博客网站，我定制了他们的每日推送服务，他们将当天的精选科学博文发送到我的信箱，我及时转载到科学网，读者十分喜欢。 他们的网址是 http://scienceblog.com/ Implantable Medical Device is Designed to Warn Patients of Impending Heart Attack Could ‘advanced’ dinosaurs rule other planets? Climate Change Boosts Then Quickly Stunts Plants Bats save energy by drawing in wings on upstroke Ocean Acidification Linked With Larval Oyster Failure in Hatcheries Decoding worm lingo
A recent study found that combined oral contraceptives (COCs) and, to a lesser extent, increasing age reduced the severity of dysmenorrhea in women aged 19 to 24 years. Ingela Lindh, PhD, and colleagues Agneta Andersson Ellstrm, MD, PhD, and Ian Milsom, MD, PhD, all from the Institute of Clinical Sciences, Sahlgrenska Academy, Gothenburg University, Sweden, reported their findings in an article published online January 17 in Human Reproduction . They used 2 tools, a verbal multidimensional scoring system (VMS) and a visual analogue scale (VAS), to evaluate dysmenorrhea in 3 groups of women at 19 and 24 years of age. The researchers used the population registers from the city of Gothenburg to identify women who were 19 years old in 1981, 1991, and 2001. They picked every fourth woman from the register in 1981, and every third woman from the registers in 1991 and 2001. The women all resided in Gothenburg at the time of birth and at the times of assessment. They were born in 1962 (62 cohort), 1972 (72 cohort), and 1982 (82 cohort) and were first evaluated at age 19 years in 1981 (n = 489), 1991 (n = 523), and 2001 (n = 392), respectively. They were evaluated again 5 years later, at age 24 years. The team sent postal questionnaires with about 40 questions regarding contraception, reproductive history, menstrual pattern, duration and intensity of menstrual pain, need for medical care, ability to work during menses, and information including height, weight, and smoking status. The VMS instructs the individual to rate their pain as none, mild, moderate, or severe. The VAS has the person rate their pain along a straight line representing a continuum of 1 to 10, with "no pain at all" at one end and "unbearable" pain at the other. The researchers performed a correlation analysis to compare the VMS and VAS in all women who completed them at both ages. They found a significant correlation ( r = 0.83; P .0001) between reports of dysmenorrhea by both tools; therefore, they report the VMS results as mean values. The researchers compared menstrual bleeding pattern and dysmenorrhea severity both within and between the 3 cohorts at 19 and 24 years of age. Fewer women in the 82 cohort reported no dysmenorrhea on the VMS than in the other 2 cohorts. Participants in the 82 cohort had a higher VMS score at 19 and 24 years of age ( P .05 and P .001) compared with the 62 cohort, and a higher VMS score at age 24 than the 72 cohort ( P .01). The 82 cohort reported more severe dysmenorrhea on the VAS compared with the 62 cohort ( P .001) and the 72 cohort ( P .01) at ages 19 and 24 years, respectively. Dysmenorrhea-related absenteeism was 31% to 33% at 19 years of age and decreased in all 3 groups at age 24 years to 20% to 23%. The researchers placed the women in 1 of 2 groups: those who used COCs at age 19 years, but not at age 24 years, and those who did not use COCs at age 19 years, but did at age 24 years, and compared these groups with each other. Women were excluded from these analyses if they had given birth, used an intrauterine device, or used progestogen-only contraception methods. When all 3 cohorts were analyzed together, women who used COCs at age 19 years, but not at age 24 years, had increased severity of dysmenorrhea, and women who did not use COCs at age 19 years, but did at age 24 years, had decreased dysmenorrhea severity. The decrease in dysmenorrhea between the cohorts was demonstrated equally by the VMS tool (0.58, confidence interval, 0.35 - 0.81; P .0001) and the VAS tool (18.8, confidence interval, 11.6 - 26.0; P .0001). One study limitation is that few women included in the trial gave birth, which reduced the ability to assess the effect of childbirth on dysmenorrhea. "The study was a large longitudinal cohort study that used patients as their own controls, as it was done over time. The age-related findings may have had a decrease in smoking and increase in weight as confounders, but showed a statistically significant decrease in dysmenorrhea with the use of COCs," Leah Kaufman, MD, residency program director, North Shore Long Island Jewish/Hofstra School of Medicine, New York City, told Medscape Medical News in an interview. "When analysing the cohorts separately, a corresponding decreased severity of dysmenorrhoea was noted for the 62 and 72 cohorts according to both measurement systems, but in the 82 cohort only when using the VAS," write the Dr. Lindh and colleagues. COCs and increasing age reduced severity of dysmenorrhea independent of each other, according to the authors, and COCs reduced dysmenorrhea more than increasing age or childbirth. "The decrease in the severity of dysmenorrhoea achieved by COCs was equivalent to the transfer of every third woman one step down on the VMS scale, which — in clinical terms — will result in less pain, improved working ability and a decrease in the need for analgesics," the authors write. "Effective management of dysmenorrhoea is beneficial for both the afflicted individual and society and thus the possibility of a beneficial influence of COCs on dysmenorrhea should be included in contraceptive counselling," write the authors. Dr. Kaufman agrees. "As a practicing generalist I regularly prescribe COC's for the treatment of dysmenorrhea, with marked improvement in their functionality and a decrease in their absenteeism from work and school," she said. "The potential issue of difference in pain perception and a decrease in pain, particularly with respect to dysmenorrhea associated with age, was suggested in the article, but not proven. Differential pain perception by age and the need for physicians to tailor treatment and counseling based on this concept would be interesting, if proven with the elimination of other confounding factors," she explained. " t is desirable that the findings from this study providing evidence for a beneficial effect of COCs in dysmenorrhea be confirmed by a placebo-controlled, randomized trial where the efficacy of COCs in dysmenorrhea are assessed as a primary outcome measure," the authors conclude. 来源： http://www.medscape.com/viewarticle/757285
Dear media colleagues, Welcome to the Olympic city of Innsbruck for the 1st Winter Youth Olympic Games. From 13 to 22 January 2012, you will not only see the next generation of international winter sports stars, but you will also experience some great innovations and new formats that have never before featured in an Olympic sports programme. The world’s most talented young athletes will compete in the same disciplines as at the 2014 Olympic Winter Games in Sochi, with the addition of exciting new sports such as Women’s Ski Jumping, Ski Halfpipe and Snowboard Slopestyle. In addition to these ten days of intense competition, the athletes will also participate in an interactive Culture Education Programme. We are confident that Innsbruck 2012 will, just as Singapore 2010, prove to be truly inspirational.The Innsbruck Youth Olympic Games Organising Committee (IYOGOC) has done an incredible job in providing the best possible working conditions for you at the Games. I would like to congratulate the Innsbruck 2012 team for this comprehensive Media Guide, which contains useful information on the competitions, the athletes and the Culture Education Programme, as well as specific city information relating to the Games. I am sure this guide will serve as an invaluable tool during your stay. The media are key to communicating the passion and sporting endeavours that participants experience at the Games. I wish you every success in your work and, above all, enjoy the Games! Jacques Rogge President International Olympic Committee 原文见 http://www.innsbruck2012.com/uploads/cd_page_element/1207997961/037_17_Media_Guide_EN_A5_RZ.pdf
CERN的内部邮件： Dear colleagues, I would like to invite you to a seminar in the main auditorium on 13 December at 14:00, at which the ATLAS and CMS experiments will present the status of their searches for the Standard Model Higgs boson. These results will be based on the analysis of considerably more data than those presented at the Summer conferences, sufficient to make significant progress in the search for the Higgs boson, but not enough to make any conclusive statement on the existence or non-existence of the Higgs. The seminar will also be webcast.
Among patients with chronic kidney disease (CKD) and hypertension, taking at least 1 antihypertensive medication at bedtime significantly improves blood pressure (BP) control, with an associated decrease in risk for cardiovascular events, according to new research. Ramón C. Hermida, PhD, and colleagues from the Bioengineering and Chronobiology Laboratories at the University of Vigo, Campus Universitario, Spain, published their findings online October 24 in the Journal of the American Society of Nephrology . According to the researchers, the beneficial effect of taking BP medication at night has been previously documented, but "the potential reduction in risk associated with specifically reducing sleep-time BP is still a matter of debate." The current prospective study sought to investigate in hypertensive patients with CKD whether bedtime treatment with hypertension medications better controls BP and reduces CVD risk compared with treatment on waking. The study included 661 patients with CKD who were randomly assigned either to take all prescribed hypertension medications on awakening or to take at least 1 of them at bedtime. Ambulatory BP at 48 hours was measured at least once a year and/or at 3 months after any adjustment in treatment. The composite measure of cardiovascular events used included death, myocardial infarction, angina pectoris, revascularization, heart failure, arterial occlusion of lower extremities, occlusion of the retinal artery, and stroke. The investigators controlled their results for sex, age, and diabetes. Patients were followed for a median of 5.4 years; during that time, patients who took at least 1 BP-lowering medication at bedtime had approximately one third of the CVD risk compared with those who took all medications on awakening (adjusted hazard ratio , 0.31; 95% confidence interval , 0.21 - 0.46; P .001). A similar significant reduction in risk with bedtime dosing was noted when the composite CVD outcome included only cardiovascular death, myocardial infarction, and stroke (adjusted HR, 0.28; 95% CI, 0.13 - 0.61; P .001). Patients taking their medications at bedtime also had a significantly lower mean BP while sleeping, and a greater proportion of these patients had ambulatory BP control (56% vs 45%; P = .003). The researchers estimate that for each 5-mm-Hg decrease in mean sleep-time systolic BP, there was a 14% reduction in the risk for cardiovascular events during follow-up ( P .001). According to Dr. Hermida and colleagues, "treatment at bedtime is the most cost-effective and simplest strategy of successfully achieving the therapeutic goals of adequate asleep BP reduction and preserving or re-establishing the normal 24-hour BP dipping pattern." The authors suggest that a potential explanation for the benefit of nighttime treatment may be associated with the effect of nighttime treatment on urinary albumin excretion levels. "We previously demonstrated that urinary albumin excretion was significantly reduced after bedtime, but not morning, treatment with valsartan," they note. In addition, this reduction was independent of 24-hour changes of BP, but correlated with a decline in BP during sleep. 来源： http://www.medscape.com/viewarticle/752348
Agricultural ecology Organic farms flourish in the rain Japan produce the highest quality organic food in the world,the use less pesticide and following more pest-eat to control pest. Scientist from university of Cambridge study their efforts on organic farms and across a large scale,and find where (climate areas) will benefit most from organic farms. we might spent some funds to see what happens when increasing more nematode pesticide used in china, such as Shouguang vegetation greenhouse. this is not a difficult work, but might have good results. Organic farming is touted as a way to conserve wildlife while still producing food, but some organic farms are more biodiverse than others. This may be because of regional climatic differences. Tatsuya Amano, now at the University of Cambridge, UK, and his colleagues examined the influence of topography and climate on the diversity of 230 rice fields in Japan with varying levels of pesticide use. The researchers measured the abundance of pest-eating Tetragnatha spiders as a proxy for biodiversity. They modelled the data and found that fields with reduced pesticide use had more spiders, with the greatest abundance in cold or wet areas. The authors also used their model to predict which regions of Japan might benefit most from organic farming through increasing Tetragnatha numbers. Ecol. Lett. 10.1111/j.1461-0248.2011.01699.x ( 2011 )
Traffic-related air pollution may increase the risk for preterm births, according to the findings of a new study conducted in southern California. Polycyclic aromatic hydrocarbons (PAHs) were especially strongly associated with increased risk, with up to a 30% increase in premature births. Michelle Wilhelm, PhD, from the Department of Epidemiology, School of Public Health, University of California, Los Angeles, and colleagues reported their findings in an article published online October 7 in Environmental Health . According to the researchers, several studies have reported an association between levels of pollutants, including carbon monoxide and particulate matter exposure, and preterm birth; however, only 2 studies have reported a positive association when factoring in traffic levels near homes. The current study sought to examine risk for preterm birth in women from Los Angeles who were exposed to high levels of traffic-related air pollutants prenatally, using "more spatially-resolved exposure models...as well as available data on specific toxics of biologic interest for this outcome." The researchers analyzed data on 241,415 births occurring from June 2004 to March 2006 among women residing within 5 miles of a monitoring station. Of these births, 10,265 preterm births (infants born at 37 completed weeks of gestation) were reported. The number of preterm births was correlated with pregnancy period exposure averages for several pollutants, including PAHs, nitric oxide, nitrogen dioxide, and nitrogen oxides. Each preterm birth was matched with 10 normal-gestation healthy control patients. Three different information sources were used: government "criteria pollutant" monitoring stations (including carbon monoxide, nitrogen dioxide, ozone, and fine particulate matter), a traffic pollution model (Land Use Regression), and data about toxic chemicals collected by the South Coast Air Quality Management District. The risk for preterm birth increased from 6% to 21% for each quartile increase in exposures to organic carbon, elemental carbon, benzene and diesel, biomass burning, and ammonium nitrate (with aerodynamic diameter 2.5 μm; ie, PM 2.5 ), and a 30% per interquartile increase in PAHs. The short time period (ie, 22 months) was one study limitation. According to the researchers, oxidative stress may be "one potential biological pathway of interest" for the influence of air pollution on preterm birth. " potential biologic mechanism through which and PAHs could exhibit their influence on adverse birth outcomes is through acting on oxidative stress and inflammatory pathways during pregnancy," Dr. Wilhelm and colleagues add. "Our results point to PAHs as pollutants of special concern that should be a focus of future studies," they write. "PAH sources other than traffic also contributed to higher odds of preterm birth, as did ammonium nitrate PM 2.5 , the latter suggesting a role for secondary pollutants." The study was supported by the National Institute of Environmental Health Sciences and the California Air Resources Board. The authors have disclosed no relevant financial relationships. Environ Health . Published online October 7, 2011. 来源： http://www.medscape.com/viewarticle/751227
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