IVF Successful in Endometriosis-Related Infertility As long as they're ovulating normally and their partner's sperm is normal, women with endometriosis have the same odds of successful in vitro fertilization (IVF) as women with tubal factor infertility, a new study shows. While the same finding has been seen in registry data, it contradicts a recent meta-analysis - and it also goes against advice from the European Society of Human Reproduction and Embryology, which says endometriosis can cut IVF success rates almost in half. Dr. Hans Kristian Opien, lead author of the new study, told Reuters Health by email, "In previous studies, lower success rates with IVF have been shown in women with endometriosis, but these studies have been flawed by different hormone stimulation protocols and not taken into consideration the extent of endometriosis." "In our study," he continued, "which is the largest single center study performed, all patients had their endometriosis surgically classified according to a recognized classification system and treated with a similar treatment protocol -- gonadotrophin-releasing hormone agonist that temporarily causes regression of the endometric lesions and possibly the degree of inflammation." In a paper online February 15 in Fertility and Sterility, Dr. Opien of Oslo University Hospital and colleagues compare IVF and intracytoplasmic sperm injection outcomes in 1,074 infertile women with endometriosis (American Society for Reproductive Medicine stages I-IV) and 1,171 women with tubal factor infertility. Over the first five embryo transfers, pregnancy and live birth/ongoing pregnancy rates, respectively, were similar in the ASRM I-II group (87% and 73%) and the tubal factor group (84% and 66%). Pregnancy and live birth/ongoing pregnancy rates were lower in the ASRM III-IV group (72% and 58%), however. Further analysis of this group showed that women with endometrioma received significantly higher cumulative doses of FSH and had significantly lower success rates. With the exception of those with endometrioma, Dr. Opien said, "We found similar success rates in women with all stages of endometriosis compared with a group of women who were treated with IVF because of blocked Fallopian tubes." The study was funded by the Norwegian Resource Center for Women's Health at Oslo University Hospital. 来源： http://www.medscape.com/viewarticle/759832
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