AAAS/Science 征集 神经生物学奖 昨天收到一封关于 AAAS/Science 征集2013年 神经生物学奖的 电子邮件。 The Eppendorf Science Prize for Neurobiology ： Prize money: US$25,000 Next application deadline: June 15, 2013 http://www.sciencemag.org/site/feature/data/prizes/eppendorf/howto.xhtml The Eppendorf Science Prize for Neurobiology acknowledges the increasingly active and important role of neurobiology in advancing our understanding of the functioning of the brain and the nervous system -- a quest that seems destined for dramatic expansion in the coming decades. This international prize, established in 2002, encourages the work of promising young neurobiologists by providing support in the early stages of their careers. It is awarded annually for the most outstanding neurobiological research by a young scientist of 35 years of age or younger, as described in a 1,000-word essay based on research performed during the past three years. The winner of the Eppendorf and Science Prize for Neurobiology is awarded US$25,000 and publication of his or her essay in Science . The essay and those of up to three finalists are also published on Science Online. The award is announced and presented at a ceremony concurrent with the annual meeting of the Society for Neuroscience in the USA. Eppendorf provides financial support to help enable the grand prize winner and finalists to attend the event. The 2012 winner of the Eppendorf and Science Prize for Neurobiology and their research http://www.sciencemag.org/site/feature/data/prizes/eppendorf/winning.xhtml
利用汤森路透科技集团的基本科学指标库（Essential Science Indicators）2004－2010间的高被引论文及其同被引聚类分析，通过同被引而密切关联的相关论文聚类形成若干个科学研究领域，由此绘制科学文献所反映的科学研究结构地图， 讨论科学发展的基本格局。通过研究和揭示科学结构及其演化，为各领域研究提供一种思考问题、发现潜在交叉学科、 “热点”领域。 /******************************************************************/ 第一部分： RA 4 的基本信息 /******************************************************************/ RA ID: 4 RA 的名称 成人神经干细胞对于成年神经再生的重要意义 RA 的关键词 neural stem cells; in the; in the adult; adult neurogenesis; stem cells; hippocampal neurogenesis; neural stem; adult hippocampal neurogenesis; adult hippocampal; the adult 包含 RF 数 (Hot RF 数 ) 核心论文数 被引用篇数 总被引次数 平均出版年 7(5) 60 2702 5495 2006.9 该 RA 中包含 RF 的图谱 成年神经再生的调控机制、功能性意义以及对病理学的贡献 RA 概述 神经干细胞 (neural stem cell ， NSC) 是近期神经生物科学领域和脑科学领域的热点，目前主要分为胚胎神经干细胞和成人神经干细胞两大领域。其中成人神经干细胞代表了最近十年最惊人的发现之一。它为神经干细胞的应用提供了更为广阔的前景。相当长时间以来，人们认为成年大脑的再生能力非常有限。现在研究发现神经再生是成年哺乳动物中枢神经系统中普遍存在的现象，妊娠也可以影响成年神经细胞再生。在成年大脑中存在着神经干细胞聚焦区，这些成人神经干细胞对于成年神经再生具有重要意义。由成人神经干细胞生成的新生神经元具有电生理功能，不仅能够对损伤的大脑进行修复，而且可能参与记忆和学习等高级神经功能。目前已有成人神经干细胞自体移植治疗脑损伤的初步临床研究。 /******************************************************************/ 第二部分： RA 4 包含的 7 个 RF 的基本信息 /******************************************************************/ RF ID: 7550 核心论文数 被引用篇数 总被引次数 平均出版年 是否为热点 40 1391 3544 2007.2 No RF 的关键词 spatial relational memory; hippocampal adult neurogenesis; adult hippocampal neurogenesis; failing adult hippocampal neurogenesis; adult neurogenesis; adult dentate gyrus form functional synapses RF ID: 9825 核心论文数 被引用篇数 总被引次数 平均出版年 是否为热点 6 121 287 2008.3 Yes RF 的关键词 periventricular neural stem cells; adult neural stem cells; neural stem cells confer unique pinwheel architecture; adult svz stem cells lie; cd133(+) neural stem cells RF ID: 12449 核心论文数 被引用篇数 总被引次数 平均出版年 是否为热点 4 628 866 2004.2 No RF 的关键词 radial glia serve; adult neural stem cells; adult dentate gyrus; adult mouse forebrain; germinal zone RF ID: 6811 核心论文数 被引用篇数 总被引次数 平均出版年 是否为热点 4 381 527 2006.0 Yes RF 的关键词 adult olfactory bulb neurogenesis neuronal fate determinants; neural stem cells; adult brain; adult svz; pdgfr alpha-positive b cells RF ID: 13516 核心论文数 被引用篇数 总被引次数 平均出版年 是否为热点 2 490 623 2005.5 Yes RF 的关键词 adult neurogenesis; mammalian central nervous system; functional plasticity; neuronal circuits RF ID: 15285 核心论文数 被引用篇数 总被引次数 平均出版年 是否为热点 2 204 251 2006.0 Yes RF 的关键词 hippocampal neurogenesis stress-antidepressant treatment opposing effects; regulation RF ID: 11796 核心论文数 被引用篇数 总被引次数 平均出版年 是否为热点 2 327 393 2005.0 Yes RF 的关键词 wnt signalling regulates adult hippocampal neurogenesis; quiescent adult neural stem cell sonic hedgehog response invivo analysis /******************************************************************/ 第三部分： 7 个 RF 的核心论文详细列表 /******************************************************************/ RF ID 核心论文数 被引用篇数 总被引次数 平均出版年 是否为热点 7550 40 1391 3544 2007.2 No RF 的关键词 spatial relational memory; hippocampal adult neurogenesis; adult hippocampal neurogenesis; failing adult hippocampal neurogenesis; adult neurogenesis; adult dentate gyrus form functional synapses 论文题目 被引 年份 刊名 第一作者 第一机构、国家 mechanisms and functional implications of adult neurogenesis 253 2008 CELL ZHAO CM Salk Inst Biol Studies, USA enhanced synaptic plasticity in newly generated granule cells of the adult hippocampus 250 2004 NATURE SCHMIDT-HIEBER C Univ Freiburg, Germany gaba regulates synaptic integration of newly generated neurons in the adult brain 217 2006 NATURE GE SY Johns Hopkins Univ, USA a role for adult neurogenesis in spatial long-term memory 181 2005 NEUROSCIENCE SNYDER JS Univ Toronto, Canada excitation-neurogenesis coupling in adult neural stem/progenitor cells 181 2004 NEURON DEISSEROTH K Stanford Univ, USA gabaergic excitation promotes neuronal differentiation in adult hippocampal progenitor cells 172 2005 NEURON TOZUKA Y Univ Tokyo, Japan distinct morphological stages of dentate granule neuron maturation in the adult mouse hippocampus 168 2006 J NEUROSCI ZHAO CM Salk Inst Biol Studies, USA brain-derived neurotrophic factor and antidepressant drugs have different but coordinated effects on neuronal turnover, proliferation, and survival in the adult dentate gyrus 167 2005 J NEUROSCI SAIRANEN M Univ Helsinki, Finland potential role for adult neurogenesis in the encoding of time in new memories 162 2006 NAT NEUROSCI AIMONE JB Salk Inst Biol Studies, USA is there a link between adult neurogenesis and learning? 147 2006 HIPPOCAMPUS LEUNER B Rutgers State Univ, USA ablation of hippocampal neurogenesis impairs contextual fear conditioning and synaptic plasticity in the dentate gyrus 128 2006 PROC NAT ACAD SCI USA SAXE MD Columbia Univ, USA preferential incorporation of adult-generated granule cells into spatial memory networks in the dentate gyrus 120 2007 NAT NEUROSCI KEE N Hosp Sick Children, Canada inhibition of neurogenesis interferes with hippocampus-dependent memory function 116 2006 HIPPOCAMPUS WINOCUR G Baycrest Ctr Geriatr Care, Canada hippocampal neurogenesis is not required for behavioral effects of environmental enrichment 116 2006 NAT NEUROSCI MESHI D Columbia Univ, USA nmda-receptor-mediated, cell-specific integration of new neurons in adult dentate gyrus 108 2006 NATURE TASHIRO A Salk Inst Biol Studies, USA adult hippocampal neurogenesis in depression 100 2007 NAT NEUROSCI SAHAY A Columbia Univ, USA a critical period for enhanced synaptic plasticity in newly generated neurons of the adult brain 86 2007 NEURON GE SY Johns Hopkins Univ, USA synapse formation on neurons born in the adult hippocampus 79 2007 NAT NEUROSCI TONI N Salk Inst Biol Studies, USA gaba sets the tempo for activity-dependent adult neurogenesis 69 2007 TRENDS NEUROSCI GE SY Johns Hopkins Univ, USA a role for adult tlx-positive neural stem cells in learning and behaviour 69 2008 NATURE ZHANG CL Salk Inst Biol Studies, USA experience-specific functional modification of the dentate gyrus through adult neurogenesis: a critical period during an immature stage 64 2007 J NEUROSCI TASHIRO A 10010 N Torrey Pines Rd, USA neurons born in the adult dentate gyrus form functional synapses with target cells 60 2008 NAT NEUROSCI TONI N Salk Inst Biol Studies, USA roles of continuous neurogenesis in the structural and functional integrity of the adult forebrain 60 2008 NAT NEUROSCI IMAYOSHI I Kyoto Univ, Japan in vivo fate analysis reveals the multipotent and self-renewal capacities of sox2(+) neural stem cells in the adult hippocampus 59 2007 CELL STEM CELL SUH H Salk Inst Biol Studies, USA behavioral effects of chronic fluoxetine in balb/cj mice do not require adult hippocampal neurogenesis or the serotonin 1a receptor 58 2008 NEUROPSYCHOPHARMACOLOGY HOLICK KA Columbia Univ, USA ketamine-induced neuronal cell death in the perinatal rhesus monkey 49 2007 TOXICOL SCI SLIKKER W US FDA, USA chronic fluoxetine stimulates maturation and synaptic plasticity of adult-born hippocampal granule cells 41 2008 J NEUROSCI WANG JW Columbia Univ, USA early exposure to anesthesia and learning disabilities in a population-based birth cohort 37 2009 ANESTHESIOLOGY WILDER RT Mayo Clin, USA isoflurane-induced neuroapoptosis in the developing brain of nonhypoglycemic mice 32 2008 J NEUROSURG ANESTHESIOL JOHNSON SA Washington Univ, USA the contribution of failing adult hippocampal neurogenesis to psychiatric disorders 27 2008 CURR OPIN PSYCHIATRY KEMPERMANN G Tech Univ Dresden, Germany dentate gyrus-specific knockdown of adult neurogenesis impairs spatial and object recognition memory in adult rats 21 2009 LEARN MEMORY JESSBERGER S Salk Inst Biol Studies, USA spatial relational memory requires hippocampal adult neurogenesis 20 2008 PLOS ONE DUPRET D Inst F Magendie, France a functional role for adult hippocampal neurogenesis in spatial pattern separation 20 2009 SCIENCE CLELLAND CD Salk Inst Biol Studies, USA computational influence of adult neurogenesis on memory encoding 19 2009 NEURON AIMONE JB Salk Inst Biol Studies, USA neurogenesis-dependent and -independent effects of fluoxetine in an animal model of anxiety/depression 19 2009 NEURON DAVID DJ Univ Paris Sud, France behavior and development in children and age at the time of first anesthetic exposure 16 2009 ANESTHESIOLOGY KALKMAN CJ Univ Med Ctr Utrecht, Netherlands inhibition of p75 neurotrophin receptor attenuates isoflurane-mediated neuronal apoptosis in the neonatal central nervous system 15 2009 ANESTHESIOLOGY HEAD BP Univ Calif San Diego, USA adult hippocampal neurogenesis: regulation, functional implications, and contribution to disease pathology 14 2009 NEUROSCI BIOBEHAV REV BALU DT Univ Penn, USA effect of hypercarbia and isoflurane on brain cell death and neurocognitive dysfunction in 7-day-old rats 12 2009 ANESTHESIOLOGY STRATMANN G Univ Calif San Francisco, USA isoflurane differentially affects neurogenesis and long-term neurocognitive function in 60-day-old and 7-day-old rats 12 2009 ANESTHESIOLOGY STRATMANN G Univ Calif San Francisco, USA RF ID 核心论文数 被引用篇数 总被引次数 平均出版年 是否为热点 9825 6 121 287 2008.3 Yes RF 的关键词 periventricular neural stem cells; adult neural stem cells; neural stem cells confer unique pinwheel architecture; adult svz stem cells lie; cd133(+) neural stem cells 论文题目 被引 年份 刊名 第一作者 第一机构、国家 a specialized vascular niche for adult neural stem cells 74 2008 CELL STEM CELL TAVAZOIE M Columbia Univ, USA adult svz stem cells lie in a vascular niche: a quantitative analysis of niche cell-cell interactions 65 2008 CELL STEM CELL SHEN Q New York Neural Stem Cell Inst, USA neural stem cells confer unique pinwheel architecture to the ventricular surface in neurogenic regions of the adult brain 51 2008 CELL STEM CELL MIRZADEH Z Univ Calif San Francisco, USA cd133(+) neural stem cells in the ependyma of mammalian postnatal forebrain 46 2008 PROC NAT ACAD SCI USA COSKUN V Univ Calif Los Angeles, USA forebrain ependymal cells are notch-dependent and generate neuroblasts and astrocytes after stroke 31 2009 NAT NEUROSCI CARLEN M Karolinska Inst, Sweden identity crisis for adult periventricular neural stem cells: subventricular zone astrocytes, ependymal cells or both? 20 2009 NAT REV NEUROSCI CHOJNACKI AK Univ Calgary, Canada RF ID 核心论文数 被引用篇数 总被引次数 平均出版年 是否为热点 12449 4 628 866 2004.2 No RF 的关键词 radial glia serve; adult neural stem cells; adult dentate gyrus; adult mouse forebrain; germinal zone 论文题目 被引 年份 刊名 第一作者 第一机构、国家 gfap-expressing progenitors are the principal source of constitutive neurogenesis in adult mouse forebrain 238 2004 NAT NEUROSCI DENISE A Univ Calif Los Angeles, USA radial glia serve as neuronal progenitors in all regions of the central nervous system 233 2004 NEURON ANTHONY TE Rockefeller Univ, USA radial glia give rise to adult neural stem cells in the subventricular zone 219 2004 PROC NAT ACAD SCI USA MERKLE FT Univ Calif San Francisco, USA cell types, lineage, and architecture of the germinal zone in the adult dentate gyrus 176 2004 J COMP NEUROL SERI B Univ Calif San Francisco, USA RF ID 核心论文数 被引用篇数 总被引次数 平均出版年 是否为热点 6811 4 381 527 2006.0 Yes RF 的关键词 adult olfactory bulb neurogenesis neuronal fate determinants; neural stem cells; adult brain; adult svz; pdgfr alpha-positive b cells 论文题目 被引 年份 刊名 第一作者 第一机构、国家 neuronal fate determinants of adult olfactory bulb neurogenesis 181 2005 NAT NEUROSCI HACK MA GSF, Germany origin of oligodendrocytes in the subventricular zone of the adult brain 121 2006 J NEUROSCI MENN B Univ Calif San Francisco, USA mosaic organization of neural stem cells in the adult brain 115 2007 SCIENCE MERKLE FT Univ Calif San Francisco, USA pdgfr alpha-positive b cells are neural stem cells in the adult svz that form glioma-like growths in response to increased pdgf signaling 110 2006 NEURON JACKSON EL Univ Calif San Francisco, USA RF ID 核心论文数 被引用篇数 总被引次数 平均出版年 是否为热点 13516 2 490 623 2005.5 Yes RF 的关键词 adult neurogenesis; mammalian central nervous system; functional plasticity; neuronal circuits 论文题目 被引 年份 刊名 第一作者 第一机构、国家 adult neurogenesis in the mammalian central nervous system 359 2005 ANNU REV NEUROSCI MING GL Johns Hopkins Univ, USA adult neurogenesis and functional plasticity in neuronal circuits 264 2006 NAT REV NEUROSCI LLEDO PM Inst Pasteur, France RF ID 核心论文数 被引用篇数 总被引次数 平均出版年 是否为热点 15285 2 204 251 2006.0 Yes RF 的关键词 hippocampal neurogenesis stress-antidepressant treatment opposing effects; regulation 论文题目 被引 年份 刊名 第一作者 第一机构、国家 hippocampal neurogenesis: opposing effects of stress and antidepressant treatment 130 2006 HIPPOCAMPUS WARNER-SCHMIDT JL 34 Pk St, USA hippocampal neurogenesis: regulation by stress and antidepressants 121 2006 BIOL PSYCHIAT DRANOVSKY A Columbia Univ, USA RF ID 核心论文数 被引用篇数 总被引次数 平均出版年 是否为热点 11796 2 327 393 2005.0 Yes RF 的关键词 wnt signalling regulates adult hippocampal neurogenesis; quiescent adult neural stem cell sonic hedgehog response invivo analysis 论文题目 被引 年份 刊名 第一作者 第一机构、国家 wnt signalling regulates adult hippocampal neurogenesis 242 2005 NATURE LIE DC Salk Inst Biol Studies, USA in vivo analysis of quiescent adult neural stem cells responding to sonic hedgehog 151 2005 NATURE AHN S NICHHD, USA
标签: 神经
