免费期刊：《今日药物发现》（DDT）2014第一期 诸平 马年初一，看到2014年第一期《今日药物发现》（ Drug Discovery Today ）的电子版，摘录其目录如下，作为一种马年初一的文化大餐，奉献给关心药学研究的朋友。 FOUNDATION 8 Tailoring chronic pain treatments for the elderly: are we prepared for the challenge? Stephen P. Arneric, Jennifer M.A. Laird, Amy S. Chappell and Jeffrey D. Kennedy 18 Thymoquinone: fi fty years of success in the battle against cancer models Regine Schneider-Stock, Isabelle H. Fakhoury, Angela M. Zaki, Chirine O. El-Baba and Hala U. Gali-Muhtasib KEYNOTE 31 Toward the practical implementation of eye-related bioavailability prediction models Ivan Pepi′c, Jasmina Lovri′c, Biserka Cetina-Cˇižmek, Stephan Reichl and Jelena Filipovi′c-Grcˇi′c INFORMATICS 45 Fragment-based error estimation in biomolecular modeling John C. Faver and Kenneth M. Merz Jr. POST SCREEN 51 Current strategies for inhibiting FGFR activities in clinical applications: opportunities, challenges and toxicological considerations Han Kiat Ho, Angie Hui Ling Yeo, Tse Siang Kang and Boon Tin Chua 63 Human pregnane X receptor: a novel target for anticancer drug development Vijay Rathod, Sumit Jain, Prajwal Nandekar and Abhay T. Sangamwar 71 Strategies and validation for siRNA-based therapeutics for the reversal of multi-drug resistance in cancer Tahereh Fatemian, Iekhsan Othman and Ezharul Hoque Chowdhury 79 Chemistry-enabled drug delivery (prodrugs): recent progress and challenges Sophie-Dorothee Clas, Rosa I. Sanchez and Rebecca Nofsinger 88 Biofunctionalisation of electrically conducting polymers Catalina Vallejo-Giraldo, Adriona Kelly and Manus J.P. Biggs 95 Hydrogen/deuterium exchange mass spectrometry for probing higher order structure of protein therapeutics: methodology and applications Hui Wei, Jingjie Mo, Li Tao, Reb J. Russell, Adrienne A. Tymiak, Guodong Chen, Roxana E. Iacob and John R. Engen EDITORIAL 1 Making drug development visible – and viable Roger Gunn and Ilan Rabiner PERSPECTIVE FEATURE 4 Traditional use of medicinal agents: a valid source of evidence Axel Helmstädter and Christiane Staiger 103 DIARY 信息内容请浏览： Read your January issue now The latest issue of Drug Discovery Today is packed full of industry focused research articles, new developments in drug discovery, and expert comment and opinion. View Drug Discovery Today now »» The latest issue highlights includes: Tailoring chronic pain treatments for the elderly Inhibiting FGFR activities for clinical applications Fragment-based error estimation in bimolecular modeling Human pregnane X receptor Remember - reading Drug Discovery Today is easy and free - you can access the issue at: http://e-ditionsbyfry.com/olive/ODE/DDT/Default.aspx?href=DDT/2014/01/01 Enjoy your digital edition! Drug Discovery Today www.drugdiscoverytoday.com P.S. If you are using Internet Explorer 6 to view the issue, you will be required to install a patch to fix your browser. If you have any problems viewing your digital edition, please email, Drug Discovery Today 's Marketing Manager, Jason Awerdick at j.awerdick@elsevier.com with any questions.
Read the August issue now The latest issue of Drug Discovery Today is packed full of industry focused research articles, new developments in drug discovery, and expert comment and opinion. View Drug Discovery Today now »» Our August issue review highlights includes: Pharmacokinetics and the drug-target residence time concept Tox21 robotic platform for assessment of environmental chemicals Matched molecular pair analysis in drug discovery Cover Story The leading story of this issue of Drug Discovery Today considers the combined effect of pharmacokinetics (PK) and binding kinetics (BK) on the duration of effect of a drug. Using a simple model that takes both PK and BK into account, Göran Dahl and Tomas Åkerud discuss how prolongation of binding owing to a long drug–target residence time can only occur when the binding dissociation is slower than the PK elimination. In addition, they discuss how data for a number of drugs and/or drug candidates in the literature indicate that the opposite is observed, that is, they have a slower elimination compared with dissociation. These observations greatly reduce the usability of drug–target residence times for estimating the duration of effect of a drug in vivo . Remember - reading and downloading Drug Discovery Today is easy and free - you can access the issue at: http://e-ditionsbyfry.com/olive/ODE/DDT/Default.aspx?href=DDT/2013/08/01 Enjoy your digital edition! Best Regards, Steve Carney Editor Drug Discovery Today www.drugdiscoverytoday.com
刚才转发了 Read Drug Discovery Today's April 2013 Issue Now，结果发现缺少3月份的《 Drug Discovery Today 》，重新下载补上，供大家参考。 Welcome to the latest issue of Drug Discovery Today , packed full of industry focused research articles, new developments in drug discovery, with expert comment and opinion. View the March issue of Drug Discovery Today now Our March issue highlights include: Social networks, web-based tools and diseases 3D cell culture: the missing link in drug discovery Biological network inference for drug discovery Expanding medicinal chemistry space Cover story: The leading story of this issue of Drug Discovery Today discusses how the emergence of different types of social networks has fostered connections between individuals, thus facilitating data exchange in a variety of fields. Therefore, the question posed now is: could these same tools be applied to life sciences to improve scientific and medical research? Fabricio F. Costa answers this question by reviewing how social networks and other web-based tools are changing the way we approach and track diseases in biomedical research. Remember - reading and downloading Drug Discovery Today is easy and free - you can access the issue here . Enjoy your digital edition!
Welcome to the latest issue of Drug Discovery Today , packed full of industry focused research articles, new developments in drug discovery, with expert comment and opinion. View the April issue of Drug Discovery Today now Our April issue highlights include: Injectable implants for release of protein and peptide drugs Genome-based drug repositioning: DNA microarrays Virtual screening towards its holistic integration Novel antitussive strategies Cover story: The leading story of this issue of Drug Discovery Today discusses the various mechanisms by which polymer systems assemble in situ to form implant devices for sustained release of therapeutic macromolecules, and highlights recent advances in polymer systems that gel in response to a combination of these mechanisms. Finally, the article explores release mechanisms, marketed products and limitations of injectable implants. Remember - reading and downloading Drug Discovery Today is easy and free - you can access the issue here . OR View the April issue of Drug Discovery Today now (2013-4-21 20:48:26) Enjoy your digital edition!
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Read your January digital edition now Cover story: The leading story of this issue of Drug Discovery Today aims to discuss general considerations related to oral chemotherapy, focusing on its potential benefits and limitations. The authors explore the availability problems of the long-used cytotoxic drugs, patient adherence and toxicity of new oral formulations. Welcome to the latest issue of Drug Discovery Today , packed full of industry focused research articles, new developments in drug discovery, with expert comment and opinion. View the January issue of Drug Discovery Today now Our January issue highlights include: Oral delivery of anticancer drugs I: general considerations Use of hydrogels in the treatment of limbal stem cell deficiency Graph mining: procedure and application to drug discovery Interactions of tumor cells with the immune system Remember - reading and downloading Drug Discovery Today is easy and free - you can access the January 2013 issue here . Enjoy your digital edition! Best Regards, Steve Carney Editor Drug Discovery Today www.drugdiscoverytoday.com
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