2015年2月出版的最新一期“ Drug Discovery Today ”（Feb. 2015）电子版，特在此转载其相关信息，希望能够为关心药物研究人士提供一些有用的信息。更多信息请浏览： http://www.sciencedirect.com/science/journal/13596446/20/1 Read your latest issue now The latest issue of Drug Discovery Today is packed full of industry focused research articles, new developments in drug discovery, and expert comment and opinion. View Drug Discovery Today now »» Highlights include: Expression of microRNA in ischemic heart disease Fiber-based bottom-up tissue engineering Angiotension receptor blockers for Marfan’s syndrome Small molecule inhibitors of Ebola virus infection You can access the issue at: http://e-ditionsbyfry.com/olive/ODE/DDT/Default.aspx?href=DDT/2015/02/01 Enjoy your digital edition! EDITORIAL 167 How many times should we screen a chemical library to discover an anticancer drug? Miguel López-Lázaro PERSPECTIVE FEATURE 170 Post-approval fate of pharmaceutical companies Michael S. Kinch 175 The Pistoia Alliance Controlled Substance Compliance Service Project: from start to fi nish Daniel Taylor, Stuart G. Bowden, Reinhard Knorr, Derek R. Wilson, John Proudfoot and Anne E. Dunlop 181 The Joint European Compound Library: boosting precompetitive research Jérémy Besnard, Philip S. Jones, Andrew L. Hopkins and Andrew D. Pannifer REVIEWS FOUNDATION 187 Computational systems biology approaches to anti-angiogenic cancer therapeutics Stacey D. Finley, Liang-Hui Chu and Aleksander S. Popel 198 Radionuclides in drug development Philipp Uhl, Gert Fricker, Uwe Haberkorn and Walter Mier KEYNOTE 209 Molecular perspectives on solid-state phase transformation and chemical reactivity of drugs: metoclopramide as an example Shan-Yang Lin 223 Differential expression of microRNAs in ischemic heart disease Minwoo A. Song, Alexandra N. Paradis, Maresha S. Gay, John Shin and Lubo Zhang GENE-TO-SCREEN 236 Cell-laden microfi bers for bottom-up tissue engineering Hiroaki Onoe and Shoji Takeuchi INFORMATICS 247 Databases and collaboration require standards for human stem cell research Nadia K. Litterman and Sean Ekins REVIEWS (continued) POST SCREEN 255 Discoidin domain receptor 1 (DDR1) kinase as target for structure-based drug discovery Sandeepkumar Kothiwale, Corina M. Borza, Edward W. Lowe Jr., Ambra Pozzi and Jens Meiler 262 Angiotensin receptor blockers: a panacea for Marfan syndrome and related disorders? Bart L. Loeys 267 Farnesyltransferase and geranylgeranyltransferase I: structures, mechanism, inhibitors and molecular modeling Mingyun Shen, Peichen Pan, Youyong Li, Dan Li, Huidong Yu and Tingjun Hou 277 Small molecule inhibitors of ebola virus infection Edwige Picazo and Fabrizio Giordanetto 287 DIARY 信息内容参见附件（附件太大，多次上传失败，在尝试其他方法，请等待）或者登录相关网页进行浏览。
Drug Discovery Today ： 最新一期电子版 诸平 2014年7月2日刚刚收到“Drug Discovery Today”2014年6月出版的第19卷，第6期（ Drug Discovery Today， June 2014， Volume 19，Number 6， pp. 711–810） 的电子版文件，转载如下，可以免费浏览，供大家参考。 Read your new issue now The latest issue of Drug Discovery Today is packed full of industry focused research articles, new developments in drug discovery, and expert comment and opinion. View Drug Discovery Today now »» SPECIAL ISSUE: Tissue Engineering and Regeneration Guest Editor: Dr Suwan Jayasinghe Drug-eluting scaffolds for bone and cartilage regeneration In vitro models for cancer cell extravasation Small molecule drugs in regenerative medicine Remember - reading Drug Discovery Today is easy and free - you can access the issue at: http://e-ditionsbyfry.com/olive/ODE/DDT/Default.aspx?href=DDT/2014/06/01 Enjoy your digital edition!
免费期刊：《今日药物发现》（DDT）2014第一期 诸平 马年初一，看到2014年第一期《今日药物发现》（ Drug Discovery Today ）的电子版，摘录其目录如下，作为一种马年初一的文化大餐，奉献给关心药学研究的朋友。 FOUNDATION 8 Tailoring chronic pain treatments for the elderly: are we prepared for the challenge? Stephen P. Arneric, Jennifer M.A. Laird, Amy S. Chappell and Jeffrey D. Kennedy 18 Thymoquinone: fi fty years of success in the battle against cancer models Regine Schneider-Stock, Isabelle H. Fakhoury, Angela M. Zaki, Chirine O. El-Baba and Hala U. Gali-Muhtasib KEYNOTE 31 Toward the practical implementation of eye-related bioavailability prediction models Ivan Pepi′c, Jasmina Lovri′c, Biserka Cetina-Cˇižmek, Stephan Reichl and Jelena Filipovi′c-Grcˇi′c INFORMATICS 45 Fragment-based error estimation in biomolecular modeling John C. Faver and Kenneth M. Merz Jr. POST SCREEN 51 Current strategies for inhibiting FGFR activities in clinical applications: opportunities, challenges and toxicological considerations Han Kiat Ho, Angie Hui Ling Yeo, Tse Siang Kang and Boon Tin Chua 63 Human pregnane X receptor: a novel target for anticancer drug development Vijay Rathod, Sumit Jain, Prajwal Nandekar and Abhay T. Sangamwar 71 Strategies and validation for siRNA-based therapeutics for the reversal of multi-drug resistance in cancer Tahereh Fatemian, Iekhsan Othman and Ezharul Hoque Chowdhury 79 Chemistry-enabled drug delivery (prodrugs): recent progress and challenges Sophie-Dorothee Clas, Rosa I. Sanchez and Rebecca Nofsinger 88 Biofunctionalisation of electrically conducting polymers Catalina Vallejo-Giraldo, Adriona Kelly and Manus J.P. Biggs 95 Hydrogen/deuterium exchange mass spectrometry for probing higher order structure of protein therapeutics: methodology and applications Hui Wei, Jingjie Mo, Li Tao, Reb J. Russell, Adrienne A. Tymiak, Guodong Chen, Roxana E. Iacob and John R. Engen EDITORIAL 1 Making drug development visible – and viable Roger Gunn and Ilan Rabiner PERSPECTIVE FEATURE 4 Traditional use of medicinal agents: a valid source of evidence Axel Helmstädter and Christiane Staiger 103 DIARY 信息内容请浏览： Read your January issue now The latest issue of Drug Discovery Today is packed full of industry focused research articles, new developments in drug discovery, and expert comment and opinion. View Drug Discovery Today now »» The latest issue highlights includes: Tailoring chronic pain treatments for the elderly Inhibiting FGFR activities for clinical applications Fragment-based error estimation in bimolecular modeling Human pregnane X receptor Remember - reading Drug Discovery Today is easy and free - you can access the issue at: http://e-ditionsbyfry.com/olive/ODE/DDT/Default.aspx?href=DDT/2014/01/01 Enjoy your digital edition! Drug Discovery Today www.drugdiscoverytoday.com P.S. If you are using Internet Explorer 6 to view the issue, you will be required to install a patch to fix your browser. If you have any problems viewing your digital edition, please email, Drug Discovery Today 's Marketing Manager, Jason Awerdick at j.awerdick@elsevier.com with any questions.
Read the August issue now The latest issue of Drug Discovery Today is packed full of industry focused research articles, new developments in drug discovery, and expert comment and opinion. View Drug Discovery Today now »» Our August issue review highlights includes: Pharmacokinetics and the drug-target residence time concept Tox21 robotic platform for assessment of environmental chemicals Matched molecular pair analysis in drug discovery Cover Story The leading story of this issue of Drug Discovery Today considers the combined effect of pharmacokinetics (PK) and binding kinetics (BK) on the duration of effect of a drug. Using a simple model that takes both PK and BK into account, Göran Dahl and Tomas Åkerud discuss how prolongation of binding owing to a long drug–target residence time can only occur when the binding dissociation is slower than the PK elimination. In addition, they discuss how data for a number of drugs and/or drug candidates in the literature indicate that the opposite is observed, that is, they have a slower elimination compared with dissociation. These observations greatly reduce the usability of drug–target residence times for estimating the duration of effect of a drug in vivo . Remember - reading and downloading Drug Discovery Today is easy and free - you can access the issue at: http://e-ditionsbyfry.com/olive/ODE/DDT/Default.aspx?href=DDT/2013/08/01 Enjoy your digital edition! Best Regards, Steve Carney Editor Drug Discovery Today www.drugdiscoverytoday.com
标签: 药物研究
