NATURE REVIEWS DRUG DISCOVERY November 2010 Volume 9 Number 11 Visit Nature Reviews Drug Discovery online to browse the journal. Now available at http://links.ealert.nature.com/ctt?kn=19m=35933506r=NDU1MzI2NDExMwS2b=2j=ODUzNDU0OTQS1mt=1rt=0 Please note that you need to be a subscriber to enjoy full text access to Nature Reviews Drug Discovery online. To purchase a subscription, please visit: http://links.ealert.nature.com/ctt?kn=82m=35933506r=NDU1MzI2NDExMwS2b=2j=ODUzNDU0OTQS1mt=1rt=0 Alternatively, to recommend a subscription to your library, please visit http://links.ealert.nature.com/ctt?kn=44m=35933506r=NDU1MzI2NDExMwS2b=2j=ODUzNDU0OTQS1mt=1rt=0 ********************************************************************* Nature Reviews Drug Discovery Impact Factor: 29.059* (*Journal Citation Reports, Thomson, 2009) ********************************************************************* =========================== ADVERTISEMENT =========================== ACQUITY UPLC H-Class Bio System: Ready for your biomolecular analysis Engineered with a bio-inert flow path made of non-stainless-steel materials, the ACQUITY UPLC H-Class Bio System keeps large molecules intact and on the move, for better sample recovery and no carryover, whether the chromatographic mode you're using is reversed phase (RP), ion exchange (IEX), size exclusion (SEC), or hydrophilic interaction (HILIC). Learn more http://links.ealert.nature.com/ctt?kn=79m=35933506r=NDU1MzI2NDExMwS2b=2j=ODUzNDU0OTQS1mt=1rt=0 =========================== ADVERTISEMENT =========================== Find over 5,000 vacancies across scientific disciplines as well as the latest job market news, career advice and more, only at... naturejobs.com http://links.ealert.nature.com/ctt?kn=42m=35933506r=NDU1MzI2NDExMwS2b=2j=ODUzNDU0OTQS1mt=1rt=0 ATTENTION EMPLOYERS! Stay up to date with Naturejobs advertising deadlines and upcoming features: http://links.ealert.nature.com/ctt?kn=122m=35933506r=NDU1MzI2NDExMwS2b=2j=ODUzNDU0OTQS1mt=1rt=0 or telephone: US: + 1 800 989 7718 EUR: +44 (0) 20 7843 4961 =========================== ADVERTISEMENT =========================== BioPharma Dealmakers Science, strategy innovation Recent content exclusively made freely available to you from Nature Biotechnology, Nature Reviews Drug Discovery and Nature Medicine Produced with support from TVG Sign up to receive this new bi-weekly newsletter today: http://links.ealert.nature.com/ctt?kn=84m=35933506r=NDU1MzI2NDExMwS2b=2j=ODUzNDU0OTQS1mt=1rt=0 =========================== ADVERTISEMENT =========================== BIOPARTNERING Visit our Biopartnering site to view Company Profiles and Partnership Opportunities: http://links.ealert.nature.com/ctt?kn=120m=35933506r=NDU1MzI2NDExMwS2b=2j=ODUzNDU0OTQS1mt=1rt=0 =========================== ADVERTISEMENT =========================== Personalized Medicine: Principles to Practice March 1, 2011 Dallas, TX, USA This symposium brings together leaders in the field to address key aspects of the science of therapeutic individualization, the enabling technologies underpinning this biomedical revolution, and the evolution in policies that will advance personalized medicine principles into healthcare management tools for individuals and populations. http://links.ealert.nature.com/ctt?kn=60m=35933506r=NDU1MzI2NDExMwS2b=2j=ODUzNDU0OTQS1mt=1rt=0 ===================================================================== This month's FEATURED article: The importance of new companies for drug discovery: origins of a decade of new drugs Robert Kneller p867 | doi:10.1038/nrd3251 http://links.ealert.nature.com/ctt?kn=91m=35933506r=NDU1MzI2NDExMwS2b=2j=ODUzNDU0OTQS1mt=1rt=0 ===================================================================== In this issue p821 | doi:10.1038/nrd3314 http://links.ealert.nature.com/ctt?kn=10m=35933506r=NDU1MzI2NDExMwS2b=2j=ODUzNDU0OTQS1mt=1rt=0 Comment: Accelerating the pulse of cardiovascular RD Andrew Plump p823 | doi:10.1038/nrd3315 Abstract: http://links.ealert.nature.com/ctt?kn=46m=35933506r=NDU1MzI2NDExMwS2b=2j=ODUzNDU0OTQS1mt=1rt=0 Article: http://links.ealert.nature.com/ctt?kn=13m=35933506r=NDU1MzI2NDExMwS2b=2j=ODUzNDU0OTQS1mt=1rt=0 ---------------------- NEWS AND ANALYSIS ---------------------- Modifying protein misfolding Dan Jones p825 | doi:10.1038/nrd3316 Two recent deals highlight growing interest in therapeutically targeting protein misfolding to treat both rare and common diseases. http://links.ealert.nature.com/ctt?kn=22m=35933506r=NDU1MzI2NDExMwS2b=2j=ODUzNDU0OTQS1mt=1rt=0 NEWS IN BRIEF Regulators restrict Avandia in the US and suspend it in the EU | First oral drug approved for multiple sclerosis in the US | Antibody-drug conjugates hit the headlines | Lasker awards go to obesity and VEGF researchers | Johnson Johnson bids to acquire vaccine firm Crucell | Embryonic stem cell trial begins p828 | doi:10.1038/nrd3317 http://links.ealert.nature.com/ctt?kn=47m=35933506r=NDU1MzI2NDExMwS2b=2j=ODUzNDU0OTQS1mt=1rt=0 BIOBUSINESS BRIEFS Deal watch: Acceleron and Shire to target the activin receptor pathway for muscular disorders p830 | doi:10.1038/nrd3308 http://links.ealert.nature.com/ctt?kn=113m=35933506r=NDU1MzI2NDExMwS2b=2j=ODUzNDU0OTQS1mt=1rt=0 Trial watch: Somatostatin analogue shows promise in Cushing's disease p830 | doi:10.1038/nrd3309 http://links.ealert.nature.com/ctt?kn=116m=35933506r=NDU1MzI2NDExMwS2b=2j=ODUzNDU0OTQS1mt=1rt=0 Deal watch: Co-promotion deals: panacea or poison pill? Nigel Borshell and Tibor Papp p831 | doi:10.1038/nrd3310 http://links.ealert.nature.com/ctt?kn=118m=35933506r=NDU1MzI2NDExMwS2b=2j=ODUzNDU0OTQS1mt=1rt=0 PATENT WATCH Triggering generics market exclusivity | Lead compounds not based on structure alone | Sphingosine 1-phosphate Charlotte Harrison p832 | doi:10.1038/nrd3312 http://links.ealert.nature.com/ctt?kn=50m=35933506r=NDU1MzI2NDExMwS2b=2j=ODUzNDU0OTQS1mt=1rt=0 AN AUDIENCE WITH Patrick Vallance p834 | doi:10.1038/nrd3307 The Senior Vice President of Medicines Discovery and Development at GlaxoSmithKline discusses the rationale for the recent evolution of the company's research and development strategy. http://links.ealert.nature.com/ctt?kn=111m=35933506r=NDU1MzI2NDExMwS2b=2j=ODUzNDU0OTQS1mt=1rt=0 FROM THE ANALYST'S COUCH Location of pharmaceutical innovation: 2000-2009 Yali Friedman p835 | doi:10.1038/nrd3298 http://links.ealert.nature.com/ctt?kn=102m=35933506r=NDU1MzI2NDExMwS2b=2j=ODUzNDU0OTQS1mt=1rt=0 FRESH FROM THE PIPELINE Velaglucerase alfa Johannes M. F. G. Aerts, Uma Yasothan and Peter Kirkpatrick p837 | doi:10.1038/nrd3311 http://links.ealert.nature.com/ctt?kn=100m=35933506r=NDU1MzI2NDExMwS2b=2j=ODUzNDU0OTQS1mt=1rt=0 ---------------------- RESEARCH HIGHLIGHTS ---------------------- Analgesics: Pain control at the periphery p839 | doi:10.1038/nrd3300 http://links.ealert.nature.com/ctt?kn=93m=35933506r=NDU1MzI2NDExMwS2b=2j=ODUzNDU0OTQS1mt=1rt=0 Inflammatory disorders: Constraining the complement cascade p840 | doi:10.1038/nrd3302 http://links.ealert.nature.com/ctt?kn=97m=35933506r=NDU1MzI2NDExMwS2b=2j=ODUzNDU0OTQS1mt=1rt=0 Fibrotic disease: Targeting the microenvironment p840 | doi:10.1038/nrd3303 http://links.ealert.nature.com/ctt?kn=95m=35933506r=NDU1MzI2NDExMwS2b=2j=ODUzNDU0OTQS1mt=1rt=0 Cancer: Targeting mutant BRAF in metastatic melanoma p841 | doi:10.1038/nrd3304 http://links.ealert.nature.com/ctt?kn=39m=35933506r=NDU1MzI2NDExMwS2b=2j=ODUzNDU0OTQS1mt=1rt=0 Antimalarial drugs: Speeding to a new lead p842 | doi:10.1038/nrd3301 http://links.ealert.nature.com/ctt?kn=41m=35933506r=NDU1MzI2NDExMwS2b=2j=ODUzNDU0OTQS1mt=1rt=0 IN BRIEF Pulmonary disorders | Anticancer drugs | Biotechnology | Neuordegenerative disease p842 | doi:10.1038/nrd3305 http://links.ealert.nature.com/ctt?kn=51m=35933506r=NDU1MzI2NDExMwS2b=2j=ODUzNDU0OTQS1mt=1rt=0 ---------------------- PERSPECTIVES ---------------------- OPINION Utilizing targeted cancer therapeutic agents in combination: novel approaches and urgent requirements Shivanni Kummar, Helen X. Chen, John Wright, Susan Holbeck, Myrtle Davis Millin, Joseph Tomaszewski, James Zweibel, Jerry Collins and James H. Doroshow p843 | doi:10.1038/nrd3216 Developing optimal combination strategies for molecularly targeted anticancer drugs is substantially more complex than for traditional chemotherapies. Here, Doroshow and colleagues discuss the lessons learned from the evaluation of combinations of molecularly targeted anticancer agents by the US National Cancer Institute (NCI), and highlight several new approaches that the NCI has initiated to improve the effectiveness of such combinations. Abstract: http://links.ealert.nature.com/ctt?kn=52m=35933506r=NDU1MzI2NDExMwS2b=2j=ODUzNDU0OTQS1mt=1rt=0 Article: http://links.ealert.nature.com/ctt?kn=32m=35933506r=NDU1MzI2NDExMwS2b=2j=ODUzNDU0OTQS1mt=1rt=0 OPINION Developing drug prototypes: pharmacology replaces safety and tolerability? Adam F. Cohen p856 | doi:10.1038/nrd3227 Currently, drug development is based on a consecutive phase model and Phase I clinical trials often have tolerability as their primary objective. Here, Cohen advocates new concepts for drug development that are based on pharmacological knowledge about the effects of the drug and an adaptive, cyclical development process. Abstract: http://links.ealert.nature.com/ctt?kn=53m=35933506r=NDU1MzI2NDExMwS2b=2j=ODUzNDU0OTQS1mt=1rt=0 Article: http://links.ealert.nature.com/ctt?kn=23m=35933506r=NDU1MzI2NDExMwS2b=2j=ODUzNDU0OTQS1mt=1rt=0 ---------------------- ANALYSIS ---------------------- The importance of new companies for drug discovery: origins of a decade of new drugs Robert Kneller p867 | doi:10.1038/nrd3251 Understanding the factors that promote drug innovation is important both for improvements in health care and the future of organizations engaged in the field. To investigate these factors, Kneller identifies the inventors of 252 new drugs approved by the US Food and Drug Administration from 1998 to 2007 and their places of work, and classifies these drugs according to innovativeness. This article presents a comprehensive analysis of these data, which highlight the strong contribution of biotechnology companies, particularly in the United States, to innovative drug discovery, and discusses potential contributing factors to the trends observed. Abstract: http://links.ealert.nature.com/ctt?kn=91m=35933506r=NDU1MzI2NDExMwS2b=2j=ODUzNDU0OTQS1mt=1rt=0 Article: http://links.ealert.nature.com/ctt?kn=5m=35933506r=NDU1MzI2NDExMwS2b=2j=ODUzNDU0OTQS1mt=1rt=0 ---------------------- REVIEW ---------------------- Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis Volker Brinkmann, Andreas Billich, Thomas Baumruker, Peter Heining, Robert Schmouder, Gordon Francis, Shreeram Aradhye and Pascale Burtin p883 | doi:10.1038/nrd3248 In September 2010, fingolimod (FTY720/Gilenya; Novartis) became the first oral disease-modifying therapy to be approved by the US Food and Drug Administration for relapsing-emitting multiple sclerosis. Brinkmann and colleagues describe its discovery and development, and how elucidation of its effects on sphingosine 1-phosphate receptors has improved the understanding of the biology of these receptors. Abstract: http://links.ealert.nature.com/ctt?kn=54m=35933506r=NDU1MzI2NDExMwS2b=2j=ODUzNDU0OTQS1mt=1rt=0 Article: http://links.ealert.nature.com/ctt?kn=1m=35933506r=NDU1MzI2NDExMwS2b=2j=ODUzNDU0OTQS1mt=1rt=0 ---------------------- CORRESPONDENCE ---------------------- Correspondence: Understanding transport through pharmacological barriers - are we there yet? Balazs Sarkadi and Gergely Szakacs p897 | doi:10.1038/nrd3187-c1 http://links.ealert.nature.com/ctt?kn=63m=35933506r=NDU1MzI2NDExMwS2b=2j=ODUzNDU0OTQS1mt=1rt=0 Corrigendum: Microtubule-binding agents: a dynamic field of cancer therapeutics Charles Dumontet and Mary Ann Jordan p897 | doi:10.1038/nrd3313 http://links.ealert.nature.com/ctt?kn=57m=35933506r=NDU1MzI2NDExMwS2b=2j=ODUzNDU0OTQS1mt=1rt=0 =========================== ADVERTISEMENT =========================== The Natureevents Directory 2011 http://links.ealert.nature.com/ctt?kn=81m=35933506r=NDU1MzI2NDExMwS2b=2j=ODUzNDU0OTQS1mt=1rt=0 Inform a potential 1 million scientists about your scientific events. Contact us now to be included in the 12th edition of the Natureevents directory: mailto:c.paulsen@us.nature.com T: +1 202 626 2522 ===================================================================== You have been sent this Table of Contents Alert because you have opted in to receive it. 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NATURE REVIEWS IMMUNOLOGY November 2010 Volume 10 Number 11 Visit Nature Reviews Immunology online to browse the journal. Now available at http://links.ealert.nature.com/ctt?kn=80m=35916564r=NDU1MzI2NDExMQS2b=2j=ODQ5OTk1NTIS1mt=1rt=0 Please note that you need to be a subscriber to enjoy full text access to Nature Reviews Immunology online. To purchase a subscription, please visit: http://links.ealert.nature.com/ctt?kn=31m=35916564r=NDU1MzI2NDExMQS2b=2j=ODQ5OTk1NTIS1mt=1rt=0 Alternatively, to recommend a subscription to your library, please visit http://links.ealert.nature.com/ctt?kn=58m=35916564r=NDU1MzI2NDExMQS2b=2j=ODQ5OTk1NTIS1mt=1rt=0 ********************************************************************* Nature Reviews Immunology Impact Factor: 30.01* (*2008 Journal Citation Report (Thomson Reuters, 2009)) ********************************************************************* =========================== ADVERTISEMENT =========================== Explore the T cell from any perspective. BD Biosciences offers a full range of flow cytometric tools to simplify studies of cytokines and phosphorylated proteins and give you more information and insight. Register today for free webinars and learn about our advanced tools for T-cell research. http://links.ealert.nature.com/ctt?kn=78m=35916564r=NDU1MzI2NDExMQS2b=2j=ODQ5OTk1NTIS1mt=1rt=0 http://links.ealert.nature.com/ctt?kn=56m=35916564r=NDU1MzI2NDExMQS2b=2j=ODQ5OTk1NTIS1mt=1rt=0 ===================================================================== =========================== ADVERTISEMENT =========================== Th1, Th2, Th17 or Treg? Cytokine expression patterns revealed by RayBiotech's Th1/Th2/Th17 Antibody Arrays can help you identify T helper profiles quickly and easily. 1-day processing time. No specialized equipment needed. Buy 4 Get 1 Free until December 31st! http://links.ealert.nature.com/ctt?kn=18m=35916564r=NDU1MzI2NDExMQS2b=2j=ODQ5OTk1NTIS1mt=1rt=0 http://links.ealert.nature.com/ctt?kn=35m=35916564r=NDU1MzI2NDExMQS2b=2j=ODQ5OTk1NTIS1mt=1rt=0 ===================================================================== =========================== ADVERTISEMENT =========================== The Natureevents Directory 2011 Inform a potential 1 million scientists about your scientific events. Contact us now to be included in the 12th edition of the Natureevents directory: mailto:c.paulsen@us.nature.com T: +1 202 626 2522 http://links.ealert.nature.com/ctt?kn=84m=35916564r=NDU1MzI2NDExMQS2b=2j=ODQ5OTk1NTIS1mt=1rt=0 ===================================================================== =========================== ADVERTISEMENT =========================== Nature Immunology Collection on CD4+ T cell Diversity Traditionally, CD4+ T helper cells were classified as either TH1 or TH2 cells based on cytokine secretion, signaling pathways and lineage-specific transcription factors. More recently, more CD4+ T cell subsets have been identified, including TH9, TH17 and Treg cells. Rather than being terminally differentiated, these heterogenous T cell subsets seem highly plastic. This collection of articles highlights seminal research in the area of CD4+ T cell diversity and plasticity. FREE access to the Collection is available for a limited time. http://links.ealert.nature.com/ctt?kn=25m=35916564r=NDU1MzI2NDExMQS2b=2j=ODQ5OTk1NTIS1mt=1rt=0 Produced with support from BD Biosciences http://links.ealert.nature.com/ctt?kn=48m=35916564r=NDU1MzI2NDExMQS2b=2j=ODQ5OTk1NTIS1mt=1rt=0 ===================================================================== =========================== ADVERTISEMENT =========================== The Natureevents Directory 2011 http://links.ealert.nature.com/ctt?kn=84m=35916564r=NDU1MzI2NDExMQS2b=2j=ODQ5OTk1NTIS1mt=1rt=0 Inform a potential 1 million scientists about your scientific events. Contact us now to be included in the 12th edition of the Natureevents directory: mailto:c.paulsen@us.nature.com T: +1 202 626 2522 ===================================================================== This month's FEATURED article: Antigen-presenting cell function in the tolerogenic liver environment Angus W. Thomson and Percy A. Knolle p753 | doi:10.1038/nri2858 http://links.ealert.nature.com/ctt?kn=34m=35916564r=NDU1MzI2NDExMQS2b=2j=ODQ5OTk1NTIS1mt=1rt=0 ===================================================================== From the editors p745 | doi:10.1038/nri2885 http://links.ealert.nature.com/ctt?kn=69m=35916564r=NDU1MzI2NDExMQS2b=2j=ODQ5OTk1NTIS1mt=1rt=0 ---------------------- RESEARCH HIGHLIGHTS ---------------------- Toll-like receptors: Two for the price of one p746 | doi:10.1038/nri2872 Spatial and temporal regulation of TLR9 signalling determines response pathway. http://links.ealert.nature.com/ctt?kn=70m=35916564r=NDU1MzI2NDExMQS2b=2j=ODQ5OTk1NTIS1mt=1rt=0 B cells: Survival centre p747 | doi:10.1038/nri2879 The anti-apoptotic protein MCL1 is crucial for germinal centre B cell responses. http://links.ealert.nature.com/ctt?kn=74m=35916564r=NDU1MzI2NDExMQS2b=2j=ODQ5OTk1NTIS1mt=1rt=0 T cell responses: Exhaustion through BATF p747 | doi:10.1038/nri2881 Activation of BATF by PD1 contributes to T cell exhaustion in HIV infection. http://links.ealert.nature.com/ctt?kn=77m=35916564r=NDU1MzI2NDExMQS2b=2j=ODQ5OTk1NTIS1mt=1rt=0 Inflammation: IAPP stokes the pancreatic fire p748 | doi:10.1038/nri2874 Islet amyloid polypeptide (IAPP) activates the NLRP3 inflammasome for IL-1 production. http://links.ealert.nature.com/ctt?kn=82m=35916564r=NDU1MzI2NDExMQS2b=2j=ODQ5OTk1NTIS1mt=1rt=0 Innate immunity: A new vein of TLR biology p748 | doi:10.1038/nri2875 Inflammatory responses generate endogenous TLR2 ligands that promote angiogenesis. http://links.ealert.nature.com/ctt?kn=61m=35916564r=NDU1MzI2NDExMQS2b=2j=ODQ5OTk1NTIS1mt=1rt=0 STRUCTURE WATCH How the pre-TCR self-associates | Immunoreceptor complex assembly p749 | doi:10.1038/nri2883 http://links.ealert.nature.com/ctt?kn=41m=35916564r=NDU1MzI2NDExMQS2b=2j=ODQ5OTk1NTIS1mt=1rt=0 Neuroimmunology: The TH17 kiss of death for neurons p750 | doi:10.1038/nri2876 TH17 cells form contacts with neurons in EAE, resulting in neuronal dysfunction. http://links.ealert.nature.com/ctt?kn=54m=35916564r=NDU1MzI2NDExMQS2b=2j=ODQ5OTk1NTIS1mt=1rt=0 Metabolism and immunology: Macrophages yo-yo during weight loss p750 | doi:10.1038/nri2880 Adipose tissue macrophages contribute to mopping up excess lipids during weight loss. http://links.ealert.nature.com/ctt?kn=51m=35916564r=NDU1MzI2NDExMQS2b=2j=ODQ5OTk1NTIS1mt=1rt=0 IN BRIEF T cell memory | Inflammation | Transplantation p751 | doi:10.1038/nri2884 http://links.ealert.nature.com/ctt?kn=40m=35916564r=NDU1MzI2NDExMQS2b=2j=ODQ5OTk1NTIS1mt=1rt=0 Immune regulation: Controlling neutrophil plasticity p752 | doi:10.1038/nri2877 A systemic acute-phase protein and crosstalk with NKT cells modulate neutrophil activity. http://links.ealert.nature.com/ctt?kn=86m=35916564r=NDU1MzI2NDExMQS2b=2j=ODQ5OTk1NTIS1mt=1rt=0 Innate immunity: One-two blow alerts immune system p752 | doi:10.1038/nri2882 Biphasic MAPK signalling discriminates between safe and dangerous forms of fungi. http://links.ealert.nature.com/ctt?kn=88m=35916564r=NDU1MzI2NDExMQS2b=2j=ODQ5OTk1NTIS1mt=1rt=0 ---------------------- REVIEWS ---------------------- Antigen-presenting cell function in the tolerogenic liver environment Angus W. Thomson and Percy A. Knolle p753 | doi:10.1038/nri2858 The mechanisms by which local antigen-presenting cells, such as myeloid and plasmacytoid dendritic cells, liver sinusoidal endothelial cells, Kupffer cells and hepatocytes, mediate tolerance to antigens metabolized in the liver are described here. These insights into hepatic tolerance may be harnessed in the clinic for the treatment of various diseases. Abstract: http://links.ealert.nature.com/ctt?kn=34m=35916564r=NDU1MzI2NDExMQS2b=2j=ODQ5OTk1NTIS1mt=1rt=0 Article: http://links.ealert.nature.com/ctt?kn=76m=35916564r=NDU1MzI2NDExMQS2b=2j=ODQ5OTk1NTIS1mt=1rt=0 The tipping points in the initiation of B cell signalling: how small changes make big differences Susan K. Pierce and Wanli Liu p767 | doi:10.1038/nri2853 Binding of antigen to the B cell receptor (BCR) on the cell surface results in B cell activation. But how is the information that antigen binding by a BCR has occurred translated across the cell membrane to trigger signalling cascades? And what are the implications for B cell tumorigenesis and autoimmunity? Abstract: http://links.ealert.nature.com/ctt?kn=44m=35916564r=NDU1MzI2NDExMQS2b=2j=ODQ5OTk1NTIS1mt=1rt=0 Article: http://links.ealert.nature.com/ctt?kn=22m=35916564r=NDU1MzI2NDExMQS2b=2j=ODQ5OTk1NTIS1mt=1rt=0 The importance of natural IgM: scavenger, protector and regulator Michael R. Ehrenstein and Clare A. Notley p778 | doi:10.1038/nri2849 Natural IgM has many roles in the immune system, from protection against infection to regulating autoimmunity. The authors discuss the pleiotropic properties of natural IgM, and the implications for B cell-targeted therapy. Abstract: http://links.ealert.nature.com/ctt?kn=42m=35916564r=NDU1MzI2NDExMQS2b=2j=ODQ5OTk1NTIS1mt=1rt=0 Article: http://links.ealert.nature.com/ctt?kn=27m=35916564r=NDU1MzI2NDExMQS2b=2j=ODQ5OTk1NTIS1mt=1rt=0 Vaccine delivery: a matter of size, geometry, kinetics and molecular patterns Martin F. Bachmann and Gary T. Jennings p787 | doi:10.1038/nri2868 When designing the best delivery system for a vaccine, a lot can be learnt from viruses. Here the authors propose that vaccines that mimic key properties of viruses induce optimal immune responses with minimal harmful side effects. Abstract: http://links.ealert.nature.com/ctt?kn=46m=35916564r=NDU1MzI2NDExMQS2b=2j=ODQ5OTk1NTIS1mt=1rt=0 Article: http://links.ealert.nature.com/ctt?kn=11m=35916564r=NDU1MzI2NDExMQS2b=2j=ODQ5OTk1NTIS1mt=1rt=0 ---------------------- PERSPECTIVES ---------------------- TIMELINE The Immune Tolerance Network at 10 years: tolerance research at the bedside Jeffrey A. Bluestone, Hugh Auchincloss, Gerald T. Nepom, Daniel Rotrosen, E. William St. Clair and Laurence A. Turka p797 | doi:10.1038/nri2869 The ITN was founded in 1999 with the goal of achieving ... a robust state of immune tolerance in the absence of ongoing immunotherapy while maintaining a competent immune system. What are the challenges that have been met along the way and the lessons learnt for future translational research? Abstract: http://links.ealert.nature.com/ctt?kn=45m=35916564r=NDU1MzI2NDExMQS2b=2j=ODQ5OTk1NTIS1mt=1rt=0 Article: http://links.ealert.nature.com/ctt?kn=39m=35916564r=NDU1MzI2NDExMQS2b=2j=ODQ5OTk1NTIS1mt=1rt=0 =========================== ADVERTISEMENT =========================== Nature Immunology Poster on therapeutic effects of interferon-beta for multiple sclerosis Recent data have shown that IFN-beta works on several levels to inhibit the MS disease process; proposed mechanisms include inhibiting cell trafficking to the inflamed CNS, inhibiting antigen presentation and modulating the TH17 response. This poster provides an overview of these recent developments in understanding IFN-beta treatment of MS. Download this poster for FREE! http://links.ealert.nature.com/ctt?kn=6m=35916564r=NDU1MzI2NDExMQS2b=2j=ODQ5OTk1NTIS1mt=1rt=0 Produced with support from PBL InterferonSource http://links.ealert.nature.com/ctt?kn=71m=35916564r=NDU1MzI2NDExMQS2b=2j=ODQ5OTk1NTIS1mt=1rt=0 ===================================================================== You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: http://links.ealert.nature.com/ctt?kn=53m=35916564r=NDU1MzI2NDExMQS2b=2j=ODQ5OTk1NTIS1mt=1rt=0 (You will need to log in to be recognised as a nature.com registrant). 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NATURE REVIEWS MOLECULAR CELL BIOLOGY November 2010 Volume 11 Number 11 Visit Nature Reviews Molecular Cell Biology online to browse the journal. Now available at http://links.ealert.nature.com/ctt?kn=10m=35910783r=NDU1MzI2NDEwOAS2b=2j=ODQ3OTUyMjkS1mt=1rt=0 Please note that you need to be a subscriber to enjoy full text access to Nature Reviews Molecular Cell Biology online. To purchase a subscription, please visit: http://links.ealert.nature.com/ctt?kn=33m=35910783r=NDU1MzI2NDEwOAS2b=2j=ODQ3OTUyMjkS1mt=1rt=0 Alternatively, to recommend a subscription to your library, please visit http://links.ealert.nature.com/ctt?kn=65m=35910783r=NDU1MzI2NDEwOAS2b=2j=ODQ3OTUyMjkS1mt=1rt=0 ********************************************************************* Nature Reviews Molecular Cell Biology Impact Factor: 42.198* (*Journal Citation Reports, Thomson, 2008) ********************************************************************* =========================== ADVERTISEMENT =========================== Explore the T cell from any perspective. BD Biosciences offers a full range of flow cytometric tools to simplify studies of cytokines and phosphorylated proteins and give you more information and insight. Register today for free webinars and learn about our advanced tools for T-cell research. bdbiosciences.com/go/tcell http://links.ealert.nature.com/ctt?kn=64m=35910783r=NDU1MzI2NDEwOAS2b=2j=ODQ3OTUyMjkS1mt=1rt=0 =========================== ADVERTISEMENT =========================== Find over 5,000 vacancies across scientific disciplines as well as the latest job market news, career advice and more, only at... naturejobs.com http://links.ealert.nature.com/ctt?kn=56m=35910783r=NDU1MzI2NDEwOAS2b=2j=ODQ3OTUyMjkS1mt=1rt=0 ATTENTION EMPLOYERS! Stay up to date with Naturejobs advertising deadlines and upcoming features: http://links.ealert.nature.com/ctt?kn=82m=35910783r=NDU1MzI2NDEwOAS2b=2j=ODQ3OTUyMjkS1mt=1rt=0 or telephone: US: + 1 800 989 7718 EUR: +44 (0) 20 7843 4961 =========================== ADVERTISEMENT =========================== Scitable is Expanding We've expanded our vetted online science resources for your classroom. We now offer articles, resources and eBooks in genetics, cell biology and ecology. Create a virtual classroom today at http://links.ealert.nature.com/ctt?kn=52m=35910783r=NDU1MzI2NDEwOAS2b=2j=ODQ3OTUyMjkS1mt=1rt=0. ===================================================================== Nature Reviews Turns Ten Timely Content, Leading Authors, Enhanced Experience Access selected free content from Nature Reviews Genetics, Nature Reviews Molecular Cell Biology and Nature Reviews Neuroscience to celebrate the 10th anniversary of the Nature Reviews journals. http://links.ealert.nature.com/ctt?kn=49m=35910783r=NDU1MzI2NDEwOAS2b=2j=ODQ3OTUyMjkS1mt=1rt=0 ===================================================================== This month's FEATURED article: Cellular strategies for controlling protein aggregation Jens Tyedmers, Axel Mogk Bernd Bukau p777 | doi:10.1038/nrm2993 http://links.ealert.nature.com/ctt?kn=41m=35910783r=NDU1MzI2NDEwOAS2b=2j=ODQ3OTUyMjkS1mt=1rt=0 ===================================================================== From The Editors: From the editors p751 | doi:10.1038/nrm3005 http://links.ealert.nature.com/ctt?kn=40m=35910783r=NDU1MzI2NDEwOAS2b=2j=ODQ3OTUyMjkS1mt=1rt=0 ---------------------- RESEARCH HIGHLIGHTS ---------------------- Stem cells: Dividing with symmetry p752 | doi:10.1038/nrm3004 Intestinal stem cells divide symmetrically and stochastically adopt stem or differentiating fates. http://links.ealert.nature.com/ctt?kn=45m=35910783r=NDU1MzI2NDEwOAS2b=2j=ODQ3OTUyMjkS1mt=1rt=0 Stem cells: A balancing act p753 | doi:10.1038/nrm2990 Neural stem and progenitor cell populations are balanced by EGFR-Notch 1. http://links.ealert.nature.com/ctt?kn=43m=35910783r=NDU1MzI2NDEwOAS2b=2j=ODQ3OTUyMjkS1mt=1rt=0 JOURNAL CLUB Checking out the neighbourhood p753 | doi:10.1038/nrm3000 During pattern formation, cells undergo a dynamic phase of refinement. http://links.ealert.nature.com/ctt?kn=35m=35910783r=NDU1MzI2NDEwOAS2b=2j=ODQ3OTUyMjkS1mt=1rt=0 Protein degradation: Time for trimming p754 | doi:10.1038/nrm2997 Ubiquitin chain trimming by USP14 inhibits protein degradation in vitro and in vivo. http://links.ealert.nature.com/ctt?kn=32m=35910783r=NDU1MzI2NDEwOAS2b=2j=ODQ3OTUyMjkS1mt=1rt=0 Circadian rhythms: PARP1 feeds into clocks p754 | doi:10.1038/nrm2998 PARP1 acts in a pathway that links feeding to control of peripheral clocks. http://links.ealert.nature.com/ctt?kn=50m=35910783r=NDU1MzI2NDEwOAS2b=2j=ODQ3OTUyMjkS1mt=1rt=0 Cell cycle: Cycling through acetylation p755 | doi:10.1038/nrm3002 Identification of Hos1 as the deacetylase for the cohesin component Smc3. http://links.ealert.nature.com/ctt?kn=57m=35910783r=NDU1MzI2NDEwOAS2b=2j=ODQ3OTUyMjkS1mt=1rt=0 Cytoskeleton: Filopodia self-assemble p756 | doi:10.1038/nrm2991 An in vitro system shows that filopodia can self-assemble. http://links.ealert.nature.com/ctt?kn=54m=35910783r=NDU1MzI2NDEwOAS2b=2j=ODQ3OTUyMjkS1mt=1rt=0 Autophagy: In the hands of HMGB1 p756 | doi:10.1038/nrm2994 HMGB1 is a crucial regulator of autophagy. http://links.ealert.nature.com/ctt?kn=60m=35910783r=NDU1MzI2NDEwOAS2b=2j=ODQ3OTUyMjkS1mt=1rt=0 IN BRIEF Non-coding RNA | Apoptosis | Calcium p756 | doi:10.1038/nrm3001 http://links.ealert.nature.com/ctt?kn=25m=35910783r=NDU1MzI2NDEwOAS2b=2j=ODQ3OTUyMjkS1mt=1rt=0 In the news p757 | doi:10.1038/nrm3003 http://links.ealert.nature.com/ctt?kn=72m=35910783r=NDU1MzI2NDEwOAS2b=2j=ODQ3OTUyMjkS1mt=1rt=0 ---------------------- PROGRESS ---------------------- TRAPP complexes in membrane traffic: convergence through a common Rab Jemima Barrowman, Deepali Bhandari, Karin Reinisch and Susan Ferro-Novick p759 | doi:10.1038/nrm2999 Transport protein particle (TRAPP; also known as trafficking protein particle) complexes activate the GTPase Ypt1 or RAB1 to regulate membrane traffic in yeast and mammals, respectively. Two different TRAPP complexes tether coated vesicles during endoplasmic reticulum-Golgi and intra-Golgi traffic, respectively, and a third complex functions in autophagy. The TRAPP complexes thereby connect GTPase activation to unique membrane-tethering events. Abstract: http://links.ealert.nature.com/ctt?kn=26m=35910783r=NDU1MzI2NDEwOAS2b=2j=ODQ3OTUyMjkS1mt=1rt=0 Article: http://links.ealert.nature.com/ctt?kn=76m=35910783r=NDU1MzI2NDEwOAS2b=2j=ODQ3OTUyMjkS1mt=1rt=0 ---------------------- REVIEWS ---------------------- Article series: 10-year anniversary series http://links.ealert.nature.com/ctt?kn=4m=35910783r=NDU1MzI2NDEwOAS2b=2j=ODQ3OTUyMjkS1mt=1rt=0 Clocks not winding down: unravelling circadian networks Eric E. Zhang and Steve A. Kay p764 | doi:10.1038/nrm2995 Organisms can anticipate environmental changes owing to an intrinsic molecular clock. Our molecular understanding of circadian oscillators has advanced over the past decade with the deployment of systems biology approaches, enabling a multiscale view of circadian systems from the molecular level to the intact organism. Abstract: http://links.ealert.nature.com/ctt?kn=27m=35910783r=NDU1MzI2NDEwOAS2b=2j=ODQ3OTUyMjkS1mt=1rt=0 Article: http://links.ealert.nature.com/ctt?kn=80m=35910783r=NDU1MzI2NDEwOAS2b=2j=ODQ3OTUyMjkS1mt=1rt=0 Cellular strategies for controlling protein aggregation Jens Tyedmers, Axel Mogk and Bernd Bukau p777 | doi:10.1038/nrm2993 The aggregation of misfolded proteins is associated with the perturbation of cellular function and ageing. However, protein aggregation can also be a regulated process that deposits aggregates at specific cellular sites. This is protective as it facilitates aggregate solubilization, refolding and degradation by the protein quality-control network. Abstract: http://links.ealert.nature.com/ctt?kn=41m=35910783r=NDU1MzI2NDEwOAS2b=2j=ODQ3OTUyMjkS1mt=1rt=0 Article: http://links.ealert.nature.com/ctt?kn=1m=35910783r=NDU1MzI2NDEwOAS2b=2j=ODQ3OTUyMjkS1mt=1rt=0 Generating and navigating proteome maps using mass spectrometry Christian H. Ahrens, Erich Brunner, Ermir Qeli, Konrad Basler and Ruedi Aebersold p789 | doi:10.1038/nrm2973 Proteomes are typically analyzed by mass spectrometry, and recent advances have greatly increased the fraction of the proteome that can be identified and quantified in a single study. Mapping complete proteomes and using such maps for targeted quantitative proteomics will increase the impact of proteomics on biological and clinical research. Abstract: http://links.ealert.nature.com/ctt?kn=28m=35910783r=NDU1MzI2NDEwOAS2b=2j=ODQ3OTUyMjkS1mt=1rt=0 Article: http://links.ealert.nature.com/ctt?kn=15m=35910783r=NDU1MzI2NDEwOAS2b=2j=ODQ3OTUyMjkS1mt=1rt=0 The FERM domain: organizing the structure and function of FAK Margaret C. Frame, Hitesh Patel, Bryan Serrels, Daniel Lietha and Michael J. Eck p802 | doi:10.1038/nrm2996 Focal adhesion kinase (FAK) is a scaffold and tyrosine kinase protein that binds to itself and cellular partners through its four-point-one, ezrin, radixin, moesin (FERM) domain. Recent structural work reveals how regulatory proteins activate FAK by binding to its FERM domain, enabling it to coordinate diverse cellular responses. Abstract: http://links.ealert.nature.com/ctt?kn=39m=35910783r=NDU1MzI2NDEwOAS2b=2j=ODQ3OTUyMjkS1mt=1rt=0 Article: http://links.ealert.nature.com/ctt?kn=30m=35910783r=NDU1MzI2NDEwOAS2b=2j=ODQ3OTUyMjkS1mt=1rt=0 =========================== ADVERTISEMENT =========================== Nature Collections Super-Resolution Microscopy Produced by Nature Methods A collection of articles from several leaders in the field highlights the diversity of super-resolution microscopy techniques that have been developed. Read this nature collection for FREE for a limited time: http://links.ealert.nature.com/ctt?kn=46m=35910783r=NDU1MzI2NDEwOAS2b=2j=ODQ3OTUyMjkS1mt=1rt=0 Produced with support from: Nikon ===================================================================== You have been sent this Table of Contents Alert because you have opted in to receive it. 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NATURE REVIEWS MICROBIOLOGY November 2010 Volume 8 Number 11 Visit Nature Reviews Microbiology online to browse the journal. Now available at http://links.ealert.nature.com/ctt?kn=45m=35886209r=NDU1MzI2NDE0MgS2b=2j=ODQyNTMyNjAS1mt=1rt=0 Please note that you need to be a subscriber to enjoy full text access to Nature Reviews Microbiology online. To purchase a subscription, please visit: http://links.ealert.nature.com/ctt?kn=32m=35886209r=NDU1MzI2NDE0MgS2b=2j=ODQyNTMyNjAS1mt=1rt=0 Alternatively, to recommend a subscription to your library, please visit http://links.ealert.nature.com/ctt?kn=58m=35886209r=NDU1MzI2NDE0MgS2b=2j=ODQyNTMyNjAS1mt=1rt=0 ********************************************************************* Nature Reviews Microbiology Impact Factor: 17.644* *2009 Journal Citation Report (Thomson Reuters, 2010) ********************************************************************* =========================== ADVERTISEMENT =========================== Find over 5,000 vacancies across scientific disciplines as well as the latest job market news, career advice and more, only at... naturejobs.com http://links.ealert.nature.com/ctt?kn=53m=35886209r=NDU1MzI2NDE0MgS2b=2j=ODQyNTMyNjAS1mt=1rt=0 ATTENTION EMPLOYERS! Stay up to date with Naturejobs advertising deadlines and upcoming features: http://links.ealert.nature.com/ctt?kn=87m=35886209r=NDU1MzI2NDE0MgS2b=2j=ODQyNTMyNjAS1mt=1rt=0 or telephone: US: + 1 800 989 7718 EUR: +44 (0) 20 7843 4961 =========================== ADVERTISEMENT =========================== The Natureevents Directory 2011 http://links.ealert.nature.com/ctt?kn=14m=35886209r=NDU1MzI2NDE0MgS2b=2j=ODQyNTMyNjAS1mt=1rt=0 Inform a potential 1 million scientists about your scientific events. Contact us now to be included in the 12th edition of the Natureevents directory: c.paulsen@us.nature.com T: +1 202 626 2522 ===================================================================== This month's FEATURED article: Microorganisms and climate change: terrestrial feedbacks and mitigation options Brajesh K. Singh, Richard D. Bardgett, Pete Smith Dave S. Reay p779 | doi:10.1038/nrmicro2439 http://links.ealert.nature.com/ctt?kn=88m=35886209r=NDU1MzI2NDE0MgS2b=2j=ODQyNTMyNjAS1mt=1rt=0 ===================================================================== In this issue p753 | doi:10.1038/nrmicro2471 http://links.ealert.nature.com/ctt?kn=65m=35886209r=NDU1MzI2NDE0MgS2b=2j=ODQyNTMyNjAS1mt=1rt=0 Editorial: A Nobel endeavour p755 | doi:10.1038/nrmicro2470 A look back at the microbiologists who have won a Nobel Prize, and at those who have been overlooked, provides a wonderful view of the recent history of microbiology and reveals the central place of microbiology in past and current biological science. Abstract: http://links.ealert.nature.com/ctt?kn=7m=35886209r=NDU1MzI2NDE0MgS2b=2j=ODQyNTMyNjAS1mt=1rt=0 Article: http://links.ealert.nature.com/ctt?kn=67m=35886209r=NDU1MzI2NDE0MgS2b=2j=ODQyNTMyNjAS1mt=1rt=0 ---------------------- RESEARCH HIGHLIGHTS ---------------------- Bacterial physiology: Bacterial lipid rafts discovered p756 | doi:10.1038/nrmicro2455 The identification and characterization of bacterial lipid rafts and their role in the signalling pathways that regulate biofilm formation in Bacillus subtilis. http://links.ealert.nature.com/ctt?kn=79m=35886209r=NDU1MzI2NDE0MgS2b=2j=ODQyNTMyNjAS1mt=1rt=0 Virology: Severing the bud p757 | doi:10.1038/nrmicro2458 Influenza buds by an ESCRT-independent mechanism that involves the matrix protein M2. http://links.ealert.nature.com/ctt?kn=82m=35886209r=NDU1MzI2NDE0MgS2b=2j=ODQyNTMyNjAS1mt=1rt=0 Parasitology: Theileria survival and the spindle p757 | doi:10.1038/nrmicro2468 A new paper in PLoS Biology reveals the mechanism used by the apicomplexan parasite Theileria annulata to usurp the host cell mitotic apparatus. http://links.ealert.nature.com/ctt?kn=77m=35886209r=NDU1MzI2NDE0MgS2b=2j=ODQyNTMyNjAS1mt=1rt=0 Virology: Greasing the wheels of replication p758 | doi:10.1038/nrmicro2463 A screen for host factors involved in the formation of the dengue virus replication complex reveals links to localized fatty acid biosynthesis http://links.ealert.nature.com/ctt?kn=29m=35886209r=NDU1MzI2NDE0MgS2b=2j=ODQyNTMyNjAS1mt=1rt=0 Bacterial virulence: Gaining an edge in the gut p758 | doi:10.1038/nrmicro2464 Two articles identify the metabolic niches of two pathogens that provide them with a growth advantage. http://links.ealert.nature.com/ctt?kn=31m=35886209r=NDU1MzI2NDE0MgS2b=2j=ODQyNTMyNjAS1mt=1rt=0 Symbiosis: A helping hand p758 | doi:10.1038/nrmicro2466 A new paper in the ISME Journal provides the first evidence for a role of a bacterial type III secretion system (T3SS) in an interaction between a bacterium and a fungus. http://links.ealert.nature.com/ctt?kn=39m=35886209r=NDU1MzI2NDE0MgS2b=2j=ODQyNTMyNjAS1mt=1rt=0 IN BRIEF Plant disease resistance | Bacterial physiology | Genomics p759 | doi:10.1038/nrmicro2469 http://links.ealert.nature.com/ctt?kn=22m=35886209r=NDU1MzI2NDE0MgS2b=2j=ODQyNTMyNjAS1mt=1rt=0 ---------------------- NEWS AND ANALYSIS ---------------------- GENOME WATCH Genome annotation: man versus machine Nicola K. Petty p762 | doi:10.1038/nrmicro2462 Following on from last month's discussion of sequence assembly and correction, this month's Genome Watch examines genome annotation in the context of advances in second-generation sequencing. http://links.ealert.nature.com/ctt?kn=50m=35886209r=NDU1MzI2NDE0MgS2b=2j=ODQyNTMyNjAS1mt=1rt=0 DISEASE WATCH In the news p763 | doi:10.1038/nrmicro2467 Our monthly round up of infectious diseases news, which this month includes an outbreak of chikungunya fever in France, the origin of human malaria and the first description of an intrinsic mechanism of retrovirus recognition. http://links.ealert.nature.com/ctt?kn=48m=35886209r=NDU1MzI2NDE0MgS2b=2j=ODQyNTMyNjAS1mt=1rt=0 ---------------------- REVIEWS ---------------------- Protein glycosylation in bacteria: sweeter than ever Harald Nothaft and Christine M. Szymanski p765 | doi:10.1038/nrmicro2383 Glycosylation, the most abundant polypeptide chain modification in nature, was first identified in bacteria and archaea in the 1970s. Here, Nothaft and Szymanski review recent progress in our understanding of the bacterial N-glycosylation and O-glycosylation systems. Abstract: http://links.ealert.nature.com/ctt?kn=21m=35886209r=NDU1MzI2NDE0MgS2b=2j=ODQyNTMyNjAS1mt=1rt=0 Article: http://links.ealert.nature.com/ctt?kn=61m=35886209r=NDU1MzI2NDE0MgS2b=2j=ODQyNTMyNjAS1mt=1rt=0 Microorganisms and climate change: terrestrial feedbacks and mitigation options Brajesh K. Singh, Richard D. Bardgett, Pete Smith and Dave S. Reay p779 | doi:10.1038/nrmicro2439 Climate change can affect microbial processes, which are, in turn, known to affect greenhouse gas flux. Singh and colleagues review the feedback responses between climate change and terrestrial microbial processes and discuss the potential to exploit microorganisms to mitigate anthropogenic climate change. Abstract: http://links.ealert.nature.com/ctt?kn=88m=35886209r=NDU1MzI2NDE0MgS2b=2j=ODQyNTMyNjAS1mt=1rt=0 Article: http://links.ealert.nature.com/ctt?kn=56m=35886209r=NDU1MzI2NDE0MgS2b=2j=ODQyNTMyNjAS1mt=1rt=0 Organotypic 3D cell culture models: using the rotating wall vessel to study host-pathogen interactions Jennifer Barrila, Andrea L. Radtke, Aurlie Crabbe, Shameema F. Sarker, Melissa M. Herbst-Kralovetz, C. Mark Ott and Cheryl A. Nickerson p791 | doi:10.1038/nrmicro2423 Organotypic three-dimensional (3D) cell culture models are becoming more widely used in infectious-disease research, as they mimic the 3D architecture of in vivo tissues more faithfully than traditional 2D cell culture. Cheryl Nickerson and colleagues review one such 3D model system, the rotating wall vessel bioreactor, and its applications in the study of microbial pathogenesis and host-pathogen interactions. Abstract: http://links.ealert.nature.com/ctt?kn=19m=35886209r=NDU1MzI2NDE0MgS2b=2j=ODQyNTMyNjAS1mt=1rt=0 Article: http://links.ealert.nature.com/ctt?kn=64m=35886209r=NDU1MzI2NDE0MgS2b=2j=ODQyNTMyNjAS1mt=1rt=0 Identifying genetic markers of adaptation for surveillance of viral host jumps Kim M. Pepin, Sandra Lass, Juliet R. C. Pulliam, Andrew F. Read and James O. Lloyd-Smith p802 | doi:10.1038/nrmicro2440 Transmission of viruses between species can lead to severe disease in the new host. However, little is known about the requirements for cross-species transmission. Pepin and colleagues describe the experiments required to improve our understanding of this process and how this can identify markers that can be used to predict transmission. Abstract: http://links.ealert.nature.com/ctt?kn=24m=35886209r=NDU1MzI2NDE0MgS2b=2j=ODQyNTMyNjAS1mt=1rt=0 Article: http://links.ealert.nature.com/ctt?kn=90m=35886209r=NDU1MzI2NDE0MgS2b=2j=ODQyNTMyNjAS1mt=1rt=0 Developing vaccines to combat hookworm infection and intestinal schistosomiasis Peter J. Hotez, Jeffrey M. Bethony, David J. Diemert, Mark Pearson and Alex Loukas p814 | doi:10.1038/nrmicro2438 In terms of disability-adjusted life years, the disease burden resulting from hookworm infection and schistosomiasis is considerable. In this Review, Hotez and colleagues outline the pathology of these parasitic infections and discuss recent progress in vaccine development. Abstract: http://links.ealert.nature.com/ctt?kn=25m=35886209r=NDU1MzI2NDE0MgS2b=2j=ODQyNTMyNjAS1mt=1rt=0 Article: http://links.ealert.nature.com/ctt?kn=5m=35886209r=NDU1MzI2NDE0MgS2b=2j=ODQyNTMyNjAS1mt=1rt=0 ---------------------- PERSPECTIVES ---------------------- Article series: Applied and Industrial Microbiology http://links.ealert.nature.com/ctt?kn=38m=35886209r=NDU1MzI2NDE0MgS2b=2j=ODQyNTMyNjAS1mt=1rt=0 Nanobead-based interventions for the treatment and prevention of tuberculosis Gareth Griffiths, Bo Nystrom, Suraj B. Sable and Gopal K. Khuller p827 | doi:10.1038/nrmicro2437 Poor patient compliance and the spread of drug-resistant strains pose serious threats to anti-tuberculosis treatment regimens. In this Innovation article, Griffiths et al. review the potential advantages of using biodegradable nanoparticles as delivery systems for anti-tuberculosis drugs and vaccines. Abstract: http://links.ealert.nature.com/ctt?kn=26m=35886209r=NDU1MzI2NDE0MgS2b=2j=ODQyNTMyNjAS1mt=1rt=0 Article: http://links.ealert.nature.com/ctt?kn=9m=35886209r=NDU1MzI2NDE0MgS2b=2j=ODQyNTMyNjAS1mt=1rt=0 =========================== ADVERTISEMENT =========================== SUBSCRIBE to Nature Reviews Microbiology TODAY and receive your own personal copy delivered directly to your door each month. PLUS you will gain full online access to the entire archive since launch. http://links.ealert.nature.com/ctt?kn=32m=35886209r=NDU1MzI2NDE0MgS2b=2j=ODQyNTMyNjAS1mt=1rt=0 Nature Reviews Microbiology is the no. 1 monthly review journal in microbiology*. Ensure you have access. ===================================================================== You have been sent this Table of Contents Alert because you have opted in to receive it. 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NATURE REVIEWS NEUROSCIENCE October 2010 Volume 11 Number 10 Visit Nature Reviews Neuroscience online to browse the journal. Now available at http://links.ealert.nature.com/ctt?kn=99m=35805165r=NDU1MzI2NDEwNgS2b=2j=ODIzODAwNjIS1mt=1rt=0 Please note that you need to be a subscriber to enjoy full text access to Nature Reviews Neuroscience online. To purchase a subscription, please visit: http://links.ealert.nature.com/ctt?kn=81m=35805165r=NDU1MzI2NDEwNgS2b=2j=ODIzODAwNjIS1mt=1rt=0 Alternatively, to recommend a subscription to your library, please visit http://links.ealert.nature.com/ctt?kn=42m=35805165r=NDU1MzI2NDEwNgS2b=2j=ODIzODAwNjIS1mt=1rt=0 ********************************************************************* Nature Reviews Neuroscience Impact Factor: 26.483* *2009 Journal Citation Report (Thomson Reuters, 2010) ********************************************************************* =========================== ADVERTISEMENT =========================== Built by your needs - The new Olympus BX3 microscope system The time has come for life science microscopy, the way it's meant to be. Not just a new series of upright microscopes, the BX3 is a unique system that, for the first time, truly enables you to specify an imaging system that is built by your needs. Come and see how imagination has become reality: http://links.ealert.nature.com/ctt?kn=43m=35805165r=NDU1MzI2NDEwNgS2b=2j=ODIzODAwNjIS1mt=1rt=0 =========================== ADVERTISEMENT =========================== More choice. More confidence. Save 10% Get the right surface for every purpose with BD Matrigel , BD PuraMatrix , collagen types I to IV, fibronectin, osteopontin and vitronectin. And now, save 10% on a selection of these BD extracellular matrices. Life thrives on BD biological and synthetic surfaces. http://links.ealert.nature.com/ctt?kn=73m=35805165r=NDU1MzI2NDEwNgS2b=2j=ODIzODAwNjIS1mt=1rt=0 =========================== ADVERTISEMENT =========================== Salk Institute, Nature and the Fondation IPSEN present: Symposium on Biological Complexity: Emerging Concepts and Trends October 27-29, 2010 La Jolla, CA, USA Session topics: Cancer, Metabolism Physiology, Neuroscience, Immunology Virology, Plant Sciences and Stem Cells Developmental Biology. For more information and to register visit: http://links.ealert.nature.com/ctt?kn=59m=35805165r=NDU1MzI2NDEwNgS2b=2j=ODIzODAwNjIS1mt=1rt=0 ===================================================================== This month's FEATURED article: Ten years of Nature Reviews Neuroscience: insights from the highly cited Authors of the most highly cited NRN articles of the last 10 years - these articles will be freely accessible for 2 months. p718 | doi:10.1038/nrn2912 http://links.ealert.nature.com/ctt?kn=23m=35805165r=NDU1MzI2NDEwNgS2b=2j=ODIzODAwNjIS1mt=1rt=0 This issue celebrates 10 years of Nature Reviews Neuroscience. ===================================================================== From the editors p661 | doi:10.1038/nrn2930 http://links.ealert.nature.com/ctt?kn=21m=35805165r=NDU1MzI2NDEwNgS2b=2j=ODIzODAwNjIS1mt=1rt=0 ---------------------- RESEARCH HIGHLIGHTS ---------------------- Metabolism: An appetite for exercise p662 | doi:10.1038/nrn2926 Exercise reduces food intake through an interleukin-6 (IL-6)-mediated mechanism acting in the hypothalamus. http://links.ealert.nature.com/ctt?kn=18m=35805165r=NDU1MzI2NDEwNgS2b=2j=ODIzODAwNjIS1mt=1rt=0 Receptor physiology: It's the NMDA receptor, but not as we know it p663 | doi:10.1038/nrn2923 NR1/NR3-containing 'NMDA' receptors are expressed in vivo in myelin and can be activated by glycine alone http://links.ealert.nature.com/ctt?kn=16m=35805165r=NDU1MzI2NDEwNgS2b=2j=ODIzODAwNjIS1mt=1rt=0 IN BRIEF Techniques | Neurodevelopment | Stress | Neurodegenerative disease p663 | doi:10.1038/nrn2928 http://links.ealert.nature.com/ctt?kn=4m=35805165r=NDU1MzI2NDEwNgS2b=2j=ODIzODAwNjIS1mt=1rt=0 Neuroimmunology: Working memory takes its toll p664 | doi:10.1038/nrn2917 Toll-like receptor 3 signalling suppresses hippocampal neurogenesis and impairs working memory. http://links.ealert.nature.com/ctt?kn=95m=35805165r=NDU1MzI2NDEwNgS2b=2j=ODIzODAwNjIS1mt=1rt=0 Synaptic transmission: A closer look at presynaptic GABAB receptors p664 | doi:10.1038/nrn2925 Presynaptic GABAB receptors sense local variations in basal GABA levels and homeostatically regulate release probability at individual excitatory boutons. http://links.ealert.nature.com/ctt?kn=90m=35805165r=NDU1MzI2NDEwNgS2b=2j=ODIzODAwNjIS1mt=1rt=0 Proprioception: Sensational mechanics p665 | doi:10.1038/nrn2922 Transient receptor potential cation channel N1 is a mechanosensitive channel in fruitflies and nematode worms. http://links.ealert.nature.com/ctt?kn=88m=35805165r=NDU1MzI2NDEwNgS2b=2j=ODIzODAwNjIS1mt=1rt=0 Psychiatric disorders: Ketamine modifies mood through mTOR p666 | doi:10.1038/nrn2916 Ketamine-induced activation of mTOR signalling underlies its antidepressant effects. http://links.ealert.nature.com/ctt?kn=86m=35805165r=NDU1MzI2NDEwNgS2b=2j=ODIzODAwNjIS1mt=1rt=0 Neurodegenerative disease: New leads for Parkinson's disease p666 | doi:10.1038/nrn2918 Inhibitors of leucinerich repeat kinase 2 reduce neuronal damage in a mouse model of Parkinson's disease. http://links.ealert.nature.com/ctt?kn=64m=35805165r=NDU1MzI2NDEwNgS2b=2j=ODIzODAwNjIS1mt=1rt=0 Neuronglia interactions: Parting the waves p666 | doi:10.1038/nrn2927 Glia can discriminate patterns of synaptic activity and modulate synaptic plasticity through balanced A1 and A2 adenosine receptor activation. http://links.ealert.nature.com/ctt?kn=66m=35805165r=NDU1MzI2NDEwNgS2b=2j=ODIzODAwNjIS1mt=1rt=0 IN BRIEF Neurotransmission | Motor system | Metabolism | Dementia p667 | doi:10.1038/nrn2929 http://links.ealert.nature.com/ctt?kn=8m=35805165r=NDU1MzI2NDEwNgS2b=2j=ODIzODAwNjIS1mt=1rt=0 Addiction: Cracking the code of addiction p668 | doi:10.1038/nrn2921 regulation of MeCP2 by drugs of abuse contributes to behavioural and neural responses to the drugs http://links.ealert.nature.com/ctt?kn=74m=35805165r=NDU1MzI2NDEwNgS2b=2j=ODIzODAwNjIS1mt=1rt=0 ---------------------- INTERVIEW ---------------------- The Kavli prize winners p669 | doi:10.1038/nrn2900 Abstract: http://links.ealert.nature.com/ctt?kn=7m=35805165r=NDU1MzI2NDEwNgS2b=2j=ODIzODAwNjIS1mt=1rt=0 Article: http://links.ealert.nature.com/ctt?kn=38m=35805165r=NDU1MzI2NDEwNgS2b=2j=ODIzODAwNjIS1mt=1rt=0 ---------------------- PROGRESS ---------------------- Stress hormones and AMPA receptor trafficking in synaptic plasticity and memory Harmen J. Krugers, Casper C. Hoogenraad and Laurent Groc p675 | doi:10.1038/nrn2913 Glucocorticoid hormones modulate the acquisition and consolidation of memories of stressful events. Krugers and colleagues review recent evidence that glucocorticoids achieve this through rapid and persistent effects on AMPA receptors by activation of mineralocorticoid receptors and glucocorticoid receptors, respectively. Abstract: http://links.ealert.nature.com/ctt?kn=10m=35805165r=NDU1MzI2NDEwNgS2b=2j=ODIzODAwNjIS1mt=1rt=0 Article: http://links.ealert.nature.com/ctt?kn=31m=35805165r=NDU1MzI2NDEwNgS2b=2j=ODIzODAwNjIS1mt=1rt=0 ---------------------- REVIEWS ---------------------- Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders Giles E. Hardingham and Hilmar Bading p682 | doi:10.1038/nrn2911 Activation of NMDARs can both promote neuronal health and kill neurons. In this Review, Hardingham and Bading discuss the downstream effects of stimulation of synaptic NMDARs and extrasynaptic NMDARs that result in promotion of neuroprotection and cell death, respectively. Abstract: http://links.ealert.nature.com/ctt?kn=9m=35805165r=NDU1MzI2NDEwNgS2b=2j=ODIzODAwNjIS1mt=1rt=0 Article: http://links.ealert.nature.com/ctt?kn=30m=35805165r=NDU1MzI2NDEwNgS2b=2j=ODIzODAwNjIS1mt=1rt=0 Neural bases of the non-conscious perception of emotional signals Marco Tamietto and Beatrice de Gelder p697 | doi:10.1038/nrn2889 Emotional stimuli, such as a fear-expressing face, can be processed without being consciously perceived and can influence behaviour. Tamietto and de Gelder describe the subcortical pathway that processes such stimuli, and discuss whether subcortical versus cortical processing of stimuli translate into non-conscious versus conscious perception. Abstract: http://links.ealert.nature.com/ctt?kn=2m=35805165r=NDU1MzI2NDEwNgS2b=2j=ODIzODAwNjIS1mt=1rt=0 Article: http://links.ealert.nature.com/ctt?kn=57m=35805165r=NDU1MzI2NDEwNgS2b=2j=ODIzODAwNjIS1mt=1rt=0 ---------------------- PERSPECTIVES ---------------------- OPINION The crucial role of pulsatile activity of the HPA axis for continuous dynamic equilibration Stafford L. Lightman and Becky L. Conway-Campbell p710 | doi:10.1038/nrn2914 Lightman and Conway-Campbell review findings showing that, superimposed on its well-known circadian rhythm, the HPA axis shows ultradian, oscillatory activity. They describe how the resulting pulsatile release of glucocorticoids maintains optimal responsiveness of the HPA axis and the brain processes regulated by these hormones. Abstract: http://links.ealert.nature.com/ctt?kn=1m=35805165r=NDU1MzI2NDEwNgS2b=2j=ODIzODAwNjIS1mt=1rt=0 Article: http://links.ealert.nature.com/ctt?kn=53m=35805165r=NDU1MzI2NDEwNgS2b=2j=ODIzODAwNjIS1mt=1rt=0 VIEWPOINT Ten years of Nature Reviews Neuroscience: insights from the highly cited Liqun Luo, Eugenio Rodriguez, Karim Jerbi, Jean-Philippe Lachaux, Jacques Martinerie, Maurizio Corbetta, Gordon L. Shulman, Daniele Piomelli, Gina G. Turrigiano, Sacha B. Nelson, Marian Joels, E. Ronald de Kloet, Florian Holsboer, David M. Amodio, Chris D. Frith, Michelle L. Block, Luigi Zecca, Jau-Shyong Hong, Robert Dantzer, Keith W. Kelley and A. D. (Bud) Craig p718 | doi:10.1038/nrn2912 To celebrate the first 10 years of Nature Reviews Neuroscience, we invited the authors of the most cited article of each year to look back on the state of their field at the time of publication and the impact their article has had, and to discuss the questions that might be answered in the next 10 years. Abstract: http://links.ealert.nature.com/ctt?kn=3m=35805165r=NDU1MzI2NDEwNgS2b=2j=ODIzODAwNjIS1mt=1rt=0 Article: http://links.ealert.nature.com/ctt?kn=23m=35805165r=NDU1MzI2NDEwNgS2b=2j=ODIzODAwNjIS1mt=1rt=0 Erratum: Somatosensation in social perception Christian Keysers, Jon H. Kaas and Valeria Gazzola p726 | doi:10.1038/nrn2919 http://links.ealert.nature.com/ctt?kn=48m=35805165r=NDU1MzI2NDEwNgS2b=2j=ODIzODAwNjIS1mt=1rt=0 =========================== ADVERTISEMENT =========================== FREE ARTICLES FROM SciBX NEUROLOGY Targeting LRRK2 in Parkinson's disease Full text: http://links.ealert.nature.com/ctt?kn=19m=35805165r=NDU1MzI2NDEwNgS2b=2j=ODIzODAwNjIS1mt=1rt=0 PDF: http://links.ealert.nature.com/ctt?kn=41m=35805165r=NDU1MzI2NDEwNgS2b=2j=ODIzODAwNjIS1mt=1rt=0 DISEASE MODELS The role of prostatic basal cells in prostate cancer Full text: http://links.ealert.nature.com/ctt?kn=39m=35805165r=NDU1MzI2NDEwNgS2b=2j=ODIzODAwNjIS1mt=1rt=0 PDF: http://links.ealert.nature.com/ctt?kn=46m=35805165r=NDU1MzI2NDEwNgS2b=2j=ODIzODAwNjIS1mt=1rt=0 ENDOCRINE DISEASES Treating obesity with peripheral CNR1 inhibitors Full text: http://links.ealert.nature.com/ctt?kn=45m=35805165r=NDU1MzI2NDEwNgS2b=2j=ODIzODAwNjIS1mt=1rt=0 PDF: http://links.ealert.nature.com/ctt?kn=44m=35805165r=NDU1MzI2NDEwNgS2b=2j=ODIzODAwNjIS1mt=1rt=0 GET ACCESS TO MORE THAN 40 FREE ARTICLES from the SciBX Cover Story Archive http://links.ealert.nature.com/ctt?kn=14m=35805165r=NDU1MzI2NDEwNgS2b=2j=ODIzODAwNjIS1mt=1rt=0 ===================================================================== You have been sent this Table of Contents Alert because you have opted in to receive it. 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NATURE REVIEWS GENETICS October 2010 Volume 11 Number 10 Visit Nature Reviews Genetics online to browse the journal. Now available at http://links.ealert.nature.com/ctt?kn=64m=35800562r=Mzg0ODUxNzcyNQS2b=2j=ODIxNzczODES1mt=1rt=0 Please note that you need to be a subscriber to enjoy full text access to Nature Reviews Genetics online. To purchase a subscription, please visit: http://links.ealert.nature.com/ctt?kn=39m=35800562r=Mzg0ODUxNzcyNQS2b=2j=ODIxNzczODES1mt=1rt=0 Alternatively, to recommend a subscription to your library, please visit http://links.ealert.nature.com/ctt?kn=74m=35800562r=Mzg0ODUxNzcyNQS2b=2j=ODIxNzczODES1mt=1rt=0 Sign up to Twitter for updates from Nature Reviews Genetics: http://links.ealert.nature.com/ctt?kn=34m=35800562r=Mzg0ODUxNzcyNQS2b=2j=ODIxNzczODES1mt=1rt=0 ********************************************************************* Nature Reviews Genetics Impact Factor: 27.822* (*2009 Journal Citation Report (Thomson Reuters, 2010)) ********************************************************************* =========================== ADVERTISEMENT =========================== Rapid mutation profiling with Assay Explorer(TM) Take the stress out of assay design Access 650 mutations across 40 cancer genes Select a predesigned panel or choose your own mutations http://links.ealert.nature.com/ctt?kn=51m=35800562r=Mzg0ODUxNzcyNQS2b=2j=ODIxNzczODES1mt=1rt=0 ===================================================================== =========================== ADVERTISEMENT =========================== STOP CLONING! Buy pre-cloned promoters and 3'UTRs delivered in luciferase reporter vectors to measure promoter induction and miRNA function. Quantify promoter activation across any pathway including our experimentally-validated pathways regulated by nuclear receptors, CREB NFkB, P53 and more! Visit SwitchGear Genomics and explore our genome-wide, assay-ready promoter and UTR reporters. http://links.ealert.nature.com/ctt?kn=57m=35800562r=Mzg0ODUxNzcyNQS2b=2j=ODIxNzczODES1mt=1rt=0 ===================================================================== =========================== ADVERTISEMENT =========================== Nature Reviews Genetics Free Poster - Regulation of microRNA biogenesis, function and degradation This Poster by Jacek Krol, Inga Loedige and Witold Filipowicz illustrates the wide range of mechanisms that participate in the regulation of miRNAs at the levels of their biogenesis, function and degradation. Access the Poster FREE online! http://links.ealert.nature.com/ctt?kn=71m=35800562r=Mzg0ODUxNzcyNQS2b=2j=ODIxNzczODES1mt=1rt=0 Produced with support from: Regulus Therapeutics ===================================================================== This month's FEATURED article: Ten years of genetics and genomics: what have we achieved and where are we heading? Edith Heard, Sarah Tishkoff, John A. Todd, Marc Vidal, G?nter P. Wagner, Jun Wang, Detlef Weigel and Richard Young p723 | doi:10.1038/nrg2878 http://links.ealert.nature.com/ctt?kn=58m=35800562r=Mzg0ODUxNzcyNQS2b=2j=ODIxNzczODES1mt=1rt=0 ===================================================================== From the editors p663 | doi:10.1038/nrg2882 Nature Reviews Genetics turns 10 this month. What does the next decade hold? http://links.ealert.nature.com/ctt?kn=22m=35800562r=Mzg0ODUxNzcyNQS2b=2j=ODIxNzczODES1mt=1rt=0 Comment: Adaptation - not by sweeps alone Jonathan K. Pritchard and Anna Di Rienzo p665 | doi:10.1038/nrg2880 There has been recent progress in identifying selective sweeps underlying a range of adaptations. Jonathan Pritchard and Anna Di Rienzo argue that many adaptive events in natural populations may occur by polygenic adaptation, which would largely go undetected by conventional methods for detecting selection. http://links.ealert.nature.com/ctt?kn=25m=35800562r=Mzg0ODUxNzcyNQS2b=2j=ODIxNzczODES1mt=1rt=0 ---------------------- RESEARCH HIGHLIGHTS ---------------------- Development: Patterning factor poises genes for expression p668 | doi:10.1038/nrg2869 http://links.ealert.nature.com/ctt?kn=16m=35800562r=Mzg0ODUxNzcyNQS2b=2j=ODIxNzczODES1mt=1rt=0 Disease genetics: SNPs and the structural deficit p669 | doi:10.1038/nrg2871 http://links.ealert.nature.com/ctt?kn=19m=35800562r=Mzg0ODUxNzcyNQS2b=2j=ODIxNzczODES1mt=1rt=0 Regulatory elements: Predicting functional modules p669 | doi:10.1038/nrg2872 http://links.ealert.nature.com/ctt?kn=33m=35800562r=Mzg0ODUxNzcyNQS2b=2j=ODIxNzczODES1mt=1rt=0 Functional genomics: Vitamin D and disease p670 | doi:10.1038/nrg2873 http://links.ealert.nature.com/ctt?kn=7m=35800562r=Mzg0ODUxNzcyNQS2b=2j=ODIxNzczODES1mt=1rt=0 Genetic variation: Y variants tip the chromatin balance p670 | doi:10.1038/nrg2874 http://links.ealert.nature.com/ctt?kn=10m=35800562r=Mzg0ODUxNzcyNQS2b=2j=ODIxNzczODES1mt=1rt=0 Gene expression: Small but dominant RNA p670 | doi:10.1038/nrg2875 http://links.ealert.nature.com/ctt?kn=12m=35800562r=Mzg0ODUxNzcyNQS2b=2j=ODIxNzczODES1mt=1rt=0 IN BRIEF Human genomics | Development | Population genetics | Genetics of gene expression p671 | doi:10.1038/nrg2876 http://links.ealert.nature.com/ctt?kn=79m=35800562r=Mzg0ODUxNzcyNQS2b=2j=ODIxNzczODES1mt=1rt=0 Small RNAs: Targeting transcripts for destruction p672 | doi:10.1038/nrg2870 http://links.ealert.nature.com/ctt?kn=42m=35800562r=Mzg0ODUxNzcyNQS2b=2j=ODIxNzczODES1mt=1rt=0 IN BRIEF Functional genomics | Quantitative traits | Complex disease | Cancer genomics p672 | doi:10.1038/nrg2877 http://links.ealert.nature.com/ctt?kn=91m=35800562r=Mzg0ODUxNzcyNQS2b=2j=ODIxNzczODES1mt=1rt=0 ---------------------- REVIEWS ---------------------- Article series: Applications of next-generation sequencing http://links.ealert.nature.com/ctt?kn=56m=35800562r=Mzg0ODUxNzcyNQS2b=2j=ODIxNzczODES1mt=1rt=0 Evaluating genome-scale approaches to eukaryotic DNA replication David M. Gilbert p673 | doi:10.1038/nrg2830 This article reviews the increasing range of genome-scale methods that are being used to analyse eukaryotic DNA replication. Studies in different species and of replication timing or origin location have yielded varying degrees of success; technical hurdles remain, but important biological insights have been gained. Abstract: http://links.ealert.nature.com/ctt?kn=90m=35800562r=Mzg0ODUxNzcyNQS2b=2j=ODIxNzczODES1mt=1rt=0 Article: http://links.ealert.nature.com/ctt?kn=54m=35800562r=Mzg0ODUxNzcyNQS2b=2j=ODIxNzczODES1mt=1rt=0 Article series: Applications of next-generation sequencing http://links.ealert.nature.com/ctt?kn=56m=35800562r=Mzg0ODUxNzcyNQS2b=2j=ODIxNzczODES1mt=1rt=0 Advances in understanding cancer genomes through second-generation sequencing Matthew Meyerson, Stacey Gabriel and Gad Getz p685 | doi:10.1038/nrg2841 Cancer is fundamentally a disease of the genome and so high-throughput sequencing technologies offer great potential for improving our understanding of the biology and treatment of cancer. Experimental strategies, computational approaches and cancer-specific considerations for detecting different types of genomic alterations are discussed. Abstract: http://links.ealert.nature.com/ctt?kn=88m=35800562r=Mzg0ODUxNzcyNQS2b=2j=ODIxNzczODES1mt=1rt=0 Article: http://links.ealert.nature.com/ctt?kn=62m=35800562r=Mzg0ODUxNzcyNQS2b=2j=ODIxNzczODES1mt=1rt=0 Genomics and the future of conservation genetics Fred W. Allendorf, Paul A. Hohenlohe and Gordon Luikart p697 | doi:10.1038/nrg2844 This article discusses how genomic techniques are expected to provide new insights into important problems in conservation and to allow questions to be addressed that have previously not been tractable. The authors also offer advice on choosing the most appropriate genomic approaches for studying different aspects of conservation. Abstract: http://links.ealert.nature.com/ctt?kn=87m=35800562r=Mzg0ODUxNzcyNQS2b=2j=ODIxNzczODES1mt=1rt=0 Article: http://links.ealert.nature.com/ctt?kn=66m=35800562r=Mzg0ODUxNzcyNQS2b=2j=ODIxNzczODES1mt=1rt=0 Advances in understanding tissue regenerative capacity and mechanisms in animals Kenneth D. Poss p710 | doi:10.1038/nrg2879 What determines whether a tissue or organism can regenerate? What are the cellular sources of regeneration? How are regenerative signals initiated and targeted, and what controls proliferation and patterning during regeneration? Studies in a range of model systems are addressing these key questions. Abstract: http://links.ealert.nature.com/ctt?kn=86m=35800562r=Mzg0ODUxNzcyNQS2b=2j=ODIxNzczODES1mt=1rt=0 Article: http://links.ealert.nature.com/ctt?kn=68m=35800562r=Mzg0ODUxNzcyNQS2b=2j=ODIxNzczODES1mt=1rt=0 ---------------------- PERSPECTIVES ---------------------- VIEWPOINT Ten years of genetics and genomics: what have we achieved and where are we heading? Edith Heard, Sarah Tishkoff, John A. Todd, Marc Vidal, Gunter P. Wagner, Jun Wang, Detlef Weigel and Richard Young p723 | doi:10.1038/nrg2878 To celebrate the first 10 years of Nature Reviews Genetics, we asked eight leading researchers for their views on the key developments in genetics and genomics in the past decade and the prospects for the future. Abstract: http://links.ealert.nature.com/ctt?kn=58m=35800562r=Mzg0ODUxNzcyNQS2b=2j=ODIxNzczODES1mt=1rt=0 Article: http://links.ealert.nature.com/ctt?kn=69m=35800562r=Mzg0ODUxNzcyNQS2b=2j=ODIxNzczODES1mt=1rt=0 OPINION Tackling the widespread and critical impact of batch effects in high-throughput data Jeffrey T. Leek, Robert B. Scharpf, Hector Corrada Bravo, David Simcha, Benjamin Langmead, W. Evan Johnson, Donald Geman, Keith Baggerly and Rafael A. Irizarry p733 | doi:10.1038/nrg2825 Batch effects can lead to incorrect biological conclusions but are not widely considered. The authors show that batch effects are relevant to a range of high-throughput 'omics' data sets and are crucial to address. They also explain how batch effects can be mitigated. Abstract: http://links.ealert.nature.com/ctt?kn=20m=35800562r=Mzg0ODUxNzcyNQS2b=2j=ODIxNzczODES1mt=1rt=0 Article: http://links.ealert.nature.com/ctt?kn=81m=35800562r=Mzg0ODUxNzcyNQS2b=2j=ODIxNzczODES1mt=1rt=0 =========================== ADVERTISEMENT =========================== SUBSCRIBE to Nature Reviews Genetics TODAY and receive your own personal copy delivered directly to your door each month. PLUS you will gain full online access to the entire archive since launch. http://links.ealert.nature.com/ctt?kn=39m=35800562r=Mzg0ODUxNzcyNQS2b=2j=ODIxNzczODES1mt=1rt=0 Nature Reviews Genetics is the no. 1 monthly review journal in genetics and heredity*. Ensure you have access. ===================================================================== You have been sent this Table of Contents Alert because you have opted in to receive it. 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For further technical assistance, please contact our registration department: registration@nature.com For print subscription enquiries, please contact our subscription department: subscriptions@nature.com For other enquiries, please contact our customer feedback department: feedback@nature.com Nature Publishing Group | 75 Varick Street, 9th Floor | New York | NY 10013-1917 | USA Nature Publishing Group's worldwide offices: London - Paris - Munich - New Delhi - Tokyo - Melbourne - San Diego - San Francisco - Washington - New York - Boston Macmillan Publishers Limited is a company incorporated in England and Wales under company number 785998 and whose registered office is located at Brunel Road, Houndmills, Basingstoke, Hampshire RG21 6XS. (c) Copyright 2010 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.
NATURE REVIEWS MICROBIOLOGY October 2010 Volume 8 Number 10 Visit Nature Reviews Microbiology online to browse the journal. Now available at http://links.ealert.nature.com/ctt?kn=19m=35799024r=NDU1MzI2NDE0MgS2b=2j=ODIxNDgxMDUS1mt=1rt=0 Please note that you need to be a subscriber to enjoy full text access to Nature Reviews Microbiology online. To purchase a subscription, please visit: http://links.ealert.nature.com/ctt?kn=84m=35799024r=NDU1MzI2NDE0MgS2b=2j=ODIxNDgxMDUS1mt=1rt=0 Alternatively, to recommend a subscription to your library, please visit http://links.ealert.nature.com/ctt?kn=28m=35799024r=NDU1MzI2NDE0MgS2b=2j=ODIxNDgxMDUS1mt=1rt=0 ********************************************************************* Nature Reviews Microbiology Impact Factor: 17.644* *2009 Journal Citation Report (Thomson Reuters, 2010) ********************************************************************* =========================== ADVERTISEMENT =========================== Studying Microbiomes? Apply for a PhyloTech Grant. Have an innovative idea and 15 - 20 gut, skin, airway, or other samples? Submit your proposal to win a free project with PhyloTech -- your gateway to comprehensive, sensitive, and fast microbiome analysis, using the award-winning PhyloChip assay. Proposals will be reviewed by scientific panel. Send grant application today; be ready to publish findings in weeks. http://links.ealert.nature.com/ctt?kn=5m=35799024r=NDU1MzI2NDE0MgS2b=2j=ODIxNDgxMDUS1mt=1rt=0 =========================== ADVERTISEMENT =========================== The Gel Doc EZ imager from Bio-Rad delivers high-quality gel images and analysis with ease and accuracy. Simply slide in the sample tray, press a single button, and you'll get publication-ready images in just seconds. Its compact size also frees up bench space. To learn more, go to http://links.ealert.nature.com/ctt?kn=55m=35799024r=NDU1MzI2NDE0MgS2b=2j=ODIxNDgxMDUS1mt=1rt=0. http://links.ealert.nature.com/ctt?kn=89m=35799024r=NDU1MzI2NDE0MgS2b=2j=ODIxNDgxMDUS1mt=1rt=0 =========================== ADVERTISEMENT =========================== Unmissable Dermatology Podcasts from Journal of Investigative Dermatology Join us for the latest basic and clinical research in cutaneous biology and skin disease from the #1 Dermatology journal*. Listen now at http://links.ealert.nature.com/ctt?kn=26m=35799024r=NDU1MzI2NDE0MgS2b=2j=ODIxNDgxMDUS1mt=1rt=0 *2009 Journal Citation Report (Thomson Reuters, 2010) =========================== ADVERTISEMENT =========================== This month's FEATURED article: Interactions between bacterial pathogens and mitochondrial cell death pathways Thomas Rudel, Oliver Kepp and Vera Kozjak-Pavlovic p693 | doi:10.1038/nrmicro2421 http://links.ealert.nature.com/ctt?kn=56m=35799024r=NDU1MzI2NDE0MgS2b=2j=ODIxNDgxMDUS1mt=1rt=0 ===================================================================== In this issue p675 | doi:10.1038/nrmicro2450 http://links.ealert.nature.com/ctt?kn=35m=35799024r=NDU1MzI2NDE0MgS2b=2j=ODIxNDgxMDUS1mt=1rt=0 Editorial: Biting back against rabies p676 | doi:10.1038/nrmicro2451 World Rabies Day, on 28 September, focuses our attention on a horrific, preventable disease that still kills tens of thousands of people each year. Abstract: http://links.ealert.nature.com/ctt?kn=77m=35799024r=NDU1MzI2NDE0MgS2b=2j=ODIxNDgxMDUS1mt=1rt=0 Article: http://links.ealert.nature.com/ctt?kn=37m=35799024r=NDU1MzI2NDE0MgS2b=2j=ODIxNDgxMDUS1mt=1rt=0 ---------------------- RESEARCH HIGHLIGHTS ---------------------- Innate immunity: TRIM5 : the tie that binds p677 | doi:10.1038/nrmicro2447 TRIM5 can restrict the spread of SIV in a natural setting, as it does in cell culture. http://links.ealert.nature.com/ctt?kn=49m=35799024r=NDU1MzI2NDE0MgS2b=2j=ODIxNDgxMDUS1mt=1rt=0 Bacterial physiology: Life on the ropes p678 | doi:10.1038/nrmicro2441 EHEC and EPEC produce large macromolecular structures that exhibit adhesive and cytopathic properties and might act as a substratum for biofilm formation. http://links.ealert.nature.com/ctt?kn=51m=35799024r=NDU1MzI2NDE0MgS2b=2j=ODIxNDgxMDUS1mt=1rt=0 HIV: Crucial crossing p678 | doi:10.1038/nrmicro2443 A recent PLoS Pathogens paper provides direct evidence to support the hypothesis that the systemic immune activation that occurs during chronic HIV-1 infection is linked to the translocation of microbial products from the intestinal lumen. http://links.ealert.nature.com/ctt?kn=46m=35799024r=NDU1MzI2NDE0MgS2b=2j=ODIxNDgxMDUS1mt=1rt=0 Bacterial pathogenicity: Vitamin B6 hits H. pylori sweet spot p678 | doi:10.1038/nrmicro2444 The vitamin B6-dependent glycosylation of flagella is required for full Helicobacter pylori motility and virulence. http://links.ealert.nature.com/ctt?kn=8m=35799024r=NDU1MzI2NDE0MgS2b=2j=ODIxNDgxMDUS1mt=1rt=0 IN BRIEF Antimicrobials | Microbial ecology | Symbiosis p679 | doi:10.1038/nrmicro2449 http://links.ealert.nature.com/ctt?kn=76m=35799024r=NDU1MzI2NDE0MgS2b=2j=ODIxNDgxMDUS1mt=1rt=0 Bacterial pathogenesis: Messing up the membrane p680 | doi:10.1038/nrmicro2442 Vibrio parahaemolyticus VPA0450 contributes to host cell death by interfering with phosphatidylinositol signalling. http://links.ealert.nature.com/ctt?kn=15m=35799024r=NDU1MzI2NDE0MgS2b=2j=ODIxNDgxMDUS1mt=1rt=0 Bacterial physiology: Bacillus takes the temperature p680 | doi:10.1038/nrmicro2445 Bacillus subtilis uses a ruler-like mechanism to sense temperature according to membrane thickness. http://links.ealert.nature.com/ctt?kn=18m=35799024r=NDU1MzI2NDE0MgS2b=2j=ODIxNDgxMDUS1mt=1rt=0 ---------------------- NEWS AND ANALYSIS ---------------------- GENOME WATCH Seeking perfection Thomas D. Otto p681 | doi:10.1038/nrmicro2446 This month's Genome Watch discusses ways to automatically produce 'base-perfect' genome sequences. http://links.ealert.nature.com/ctt?kn=23m=35799024r=NDU1MzI2NDE0MgS2b=2j=ODIxNDgxMDUS1mt=1rt=0 DISEASE WATCH In the news p682 | doi:10.1038/nrmicro2448 Our monthly round up of infectious diseases news, which this month includes an antisense therapy for Ebola virus infection, a transcriptional signature for active tuberculosis, and the spread of carbapenem antibiotic resistance. http://links.ealert.nature.com/ctt?kn=21m=35799024r=NDU1MzI2NDE0MgS2b=2j=ODIxNDgxMDUS1mt=1rt=0 ---------------------- REVIEWS ---------------------- The ParMRC system: molecular mechanisms of plasmid segregation by actin-like filaments Jeanne Salje, Pananghat Gayathri and Jan Lowe p683 | doi:10.1038/nrmicro2425 The plasmid-encoded ParMRC system is one of the best characterized plasmid segregation systems and comprises just three components: an actin-like protein, ParM, a DNA-binding adaptor protein, ParR, and a centromere-like region, parC. Here, the authors review the molecular mechanisms by which the components of this system interact to achieve bipolar DNA segregation. Abstract: http://links.ealert.nature.com/ctt?kn=75m=35799024r=NDU1MzI2NDE0MgS2b=2j=ODIxNDgxMDUS1mt=1rt=0 Article: http://links.ealert.nature.com/ctt?kn=33m=35799024r=NDU1MzI2NDE0MgS2b=2j=ODIxNDgxMDUS1mt=1rt=0 Interactions between bacterial pathogens and mitochondrial cell death pathways Thomas Rudel, Oliver Kepp and Vera Kozjak-Pavlovic p693 | doi:10.1038/nrmicro2421 Pathogenic bacteria have evolved numerous effectors and toxins to specifically interact with host cell death signalling pathways, many of which act directly at the mitochondria. Here, Thomas Rudel and colleagues summarize our understanding of the interactions between bacterial pathogens and mitochondrial cell death pathways. Abstract: http://links.ealert.nature.com/ctt?kn=56m=35799024r=NDU1MzI2NDE0MgS2b=2j=ODIxNDgxMDUS1mt=1rt=0 Article: http://links.ealert.nature.com/ctt?kn=30m=35799024r=NDU1MzI2NDE0MgS2b=2j=ODIxNDgxMDUS1mt=1rt=0 Article series: Applied and Industrial Microbiology http://links.ealert.nature.com/ctt?kn=88m=35799024r=NDU1MzI2NDE0MgS2b=2j=ODIxNDgxMDUS1mt=1rt=0 Microbial electrosynthesis - revisiting the electrical route for microbial production Korneel Rabaey and Rene A. Rozendal p706 | doi:10.1038/nrmicro2422 Electrical current can be used to drive microbial metabolism, opening the door to a range of applications, including the electricity-driven synthesis of chemical compounds. Here, Rabaey and Rozendal introduce the principle of microbial electrosynthesis and discuss the associated challenges and opportunities. Abstract: http://links.ealert.nature.com/ctt?kn=79m=35799024r=NDU1MzI2NDE0MgS2b=2j=ODIxNDgxMDUS1mt=1rt=0 Article: http://links.ealert.nature.com/ctt?kn=36m=35799024r=NDU1MzI2NDE0MgS2b=2j=ODIxNDgxMDUS1mt=1rt=0 Advantages and limitations of current network inference methods Riet De Smet and Kathleen Marchal p717 | doi:10.1038/nrmicro2419 Network inference is the construction of biological networks using an algorithm to assess biological data. Many different programs taking various approaches are available, and here De Smet and Marchal review these programs and provide a guide to using the right one for a particular data set. Abstract: http://links.ealert.nature.com/ctt?kn=80m=35799024r=NDU1MzI2NDE0MgS2b=2j=ODIxNDgxMDUS1mt=1rt=0 Article: http://links.ealert.nature.com/ctt?kn=43m=35799024r=NDU1MzI2NDE0MgS2b=2j=ODIxNDgxMDUS1mt=1rt=0 ---------------------- ANALYSIS ---------------------- Evolution of diverse cell division and vesicle formation systems in Archaea Kira S. Makarova, Natalya Yutin, Stephen D. Bell and Eugene V. Koonin p731 | doi:10.1038/nrmicro2406 In this Analysis article, Makarova and colleagues provide an overview of the cell division and membrane budding systems of the Archaea. They show that at least four different systems regulate these processes, providing insight into the evolutionary history of archaeal and eukaryotic cells. Abstract: http://links.ealert.nature.com/ctt?kn=81m=35799024r=NDU1MzI2NDE0MgS2b=2j=ODIxNDgxMDUS1mt=1rt=0 Article: http://links.ealert.nature.com/ctt?kn=59m=35799024r=NDU1MzI2NDE0MgS2b=2j=ODIxNDgxMDUS1mt=1rt=0 ---------------------- PERSPECTIVES ---------------------- OPINION The origin of eukaryotes and their relationship with the Archaea: are we at a phylogenomic impasse? Simonetta Gribaldo, Anthony M. Poole, Vincent Daubin, Patrick Forterre and Celine Brochier-Armanet p743 | doi:10.1038/nrmicro2426 The evolutionary relationship between the Archaea and the Eukarya remains unclear. Here, Gribaldo and colleagues provide an overview of seven recent studies that investigate the problem but that reach different conclusions. Furthermore, they provide a framework for future studies. Abstract: http://links.ealert.nature.com/ctt?kn=82m=35799024r=NDU1MzI2NDE0MgS2b=2j=ODIxNDgxMDUS1mt=1rt=0 Article: http://links.ealert.nature.com/ctt?kn=69m=35799024r=NDU1MzI2NDE0MgS2b=2j=ODIxNDgxMDUS1mt=1rt=0 ---------------------- CORRESPONDENCE ---------------------- Correspondence: History of science is good for you Mathias Grote and Maureen A. O'Malley p752 | doi:10.1038/nrmicro2435-c1 http://links.ealert.nature.com/ctt?kn=66m=35799024r=NDU1MzI2NDE0MgS2b=2j=ODIxNDgxMDUS1mt=1rt=0 =========================== ADVERTISEMENT =========================== Nature Reviews Microbiology is the no. 1 monthly review journal in microbiology*. Ensure your institution has access by recommending a subscription to your library! http://links.ealert.nature.com/ctt?kn=101m=35799024r=NDU1MzI2NDE0MgS2b=2j=ODIxNDgxMDUS1mt=1rt=0 ===================================================================== You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: http://links.ealert.nature.com/ctt?kn=27m=35799024r=NDU1MzI2NDE0MgS2b=2j=ODIxNDgxMDUS1mt=1rt=0 (You will need to log in to be recognised as a nature.com registrant). 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At the end of my two lectures on scientific writing, I am sometimes asked: How should I deal with reviews that are critical? Well, I am prepared for such a question, in two ppt slides. 1. Allow yourself a break, and come back (to deal with the reviews) when you are no longer as upset; 2. Go over the comments carefully, and ask yourself if the reviewers indeed have valid points; 3. Assume the reviewers intend to make your paper better, which is true most of the time; 4. Answer honestly what you could and could not do --that's right, you don't have to do everything asked ; 5. Summarize the main points in the cover letter to the journal editor . What I do not include in those ppt slides are: 1. Do draft your responses as emotionally as you would like, using f-word, s-word, etc.; 2. Revise the draft many times to make sure the writing is clear; 3. After you get tired of seeing those colorful words, delete them and tune down your emotion; 4. Produce a final version of your reply as professional as you can. Good luck to you!
NATURE REVIEWS DRUG DISCOVERY June 2010 Volume 9 Number 6 Visit Nature Reviews Drug Discovery online to browse the journal. Now available at http://links.ealert.nature.com/ctt?kn=19m=34936816r=NDU1MzI2NDExMwS2b=2j=NzQ4NjI1MzkS1mt=1rt=0 Please note that you need to be a subscriber to enjoy full text access to Nature Reviews Drug Discovery online. To purchase a subscription, please visit: http://links.ealert.nature.com/ctt?kn=76m=34936816r=NDU1MzI2NDExMwS2b=2j=NzQ4NjI1MzkS1mt=1rt=0 Alternatively, to recommend a subscription to your library, please visit http://links.ealert.nature.com/ctt?kn=46m=34936816r=NDU1MzI2NDExMwS2b=2j=NzQ4NjI1MzkS1mt=1rt=0
Welcome to the Clinical Evidence email alert -May 2010 Dear Xu Peiyang , Since the last Clinical Evidence email alert we have updated4 systematic reviews, helping to keep you up to date with the latest evidence across a variety of medical conditions. You can access all the updated systematic reviews and evidence-based articles on the Clinical Evidence website. Kind regards, Dr Rubin Minhas Editor, Clinical Evidence BMJ Evidence Centre Featured update: Colorectal cancer New evidence from one systematic review indicates that preoperative radiotherapy in people with rectal cancer may be more effective than surgery alone at improving survival and recurrence. However, the review found that the improvement in survival was small (estimated increase in survival from 75% to 77% at 5 years and from 60% to 62% at 8 years), and there is evidence for significant late toxicity with preoperative radiotherapy compared with surgery alone. Visit the Clinical Evidence website to see the full review. Other systematic reviews updated this month: Ankle sprain Squamous cell carcinoma of the skin (non-metastatic) Pancreatic cancer To see the full list of updates on all the above conditions visit the Clinical Evidence website. Guest editorial: Application of meta-analysis in systematic reviews At Clinical Evidence , we present an overview of the best available evidence, with a view to answering clinical questions of interest. Frequently, the evidence we identify includes systematic reviews that have meta-analysed data from RCTs. Synthesising data from multiple small RCTs can improve confidence in the effects, or confirm the believed lack of effect, of a particular intervention, thereby accelerating acceptance or rejection of that treatment. However, as Carl Heneghan and Rafael Perera outline in their Editorial, producing a reliable meta-analysis may not always be as simple as combining all the RCTs for the treatment of interest. To read the full editorial click here . 12-step guide to a primary care systems approach for smoking cessation: FREE Featured Clinical Evidence resource In addition to up-to-date systematic reviews, the Clinical Evidence website also contains a range of resources and tools to help you practice evidence based medicine. Why not take a look at our report on smoking cessation , which includes a 12-step guide to a primary care systems approach for smoking cessation on Page 38? Click here to access the report. Register for your Clinical Evidence alerts If you have been forwarded this email and would like to receive the Clinical Evidence monthly alert, please register here. If Clinical Evidence has made a significant difference to your clinical practice, or if you have any other feedback about this alert, then please feel free to email us with yourcomments . About BMJ Group Privacy policy Terms and conditions Contact us The BMJ Group is one of the world's most trusted providers of medical information for doctors, researchers, health care workers and patients. The recipient should check this email and attachments for viruses because the BMJ Group accepts no liability for any damage caused by viruses. Emails sent or received by the BMJ Group may be monitored for size, traffic, distribution and content. Use of our content is governed by our website terms and conditions http://group.bmj.com/group/about/legal/terms . BMJ Publishing Group Limited trading as BMJ Group. A private limited company, registered in England and Wales under registration number 03102371. Registered office: BMA House, Tavistock Square, London WC1H 9JR, UK. To stop receiving these emails, unsubscribe here . Your unsubscribe request may take up to five working days to process.
NATURE REVIEWS IMMUNOLOGY June 2010 Volume 10 Number 6 Visit Nature Reviews Immunology online to browse the journal. Now available at http://links.ealert.nature.com/ctt?kn=83m=34916515r=NDU1MzI2NDExMQS2b=2j=NzQ0Njc3OTMS1mt=1rt=0 Please note that you need to be a subscriber to enjoy full text access to Nature Reviews Immunology online. To purchase a subscription, please visit: http://links.ealert.nature.com/ctt?kn=32m=34916515r=NDU1MzI2NDExMQS2b=2j=NzQ0Njc3OTMS1mt=1rt=0 Alternatively, to recommend a subscription to your library, please visit http://links.ealert.nature.com/ctt?kn=61m=34916515r=NDU1MzI2NDExMQS2b=2j=NzQ0Njc3OTMS1mt=1rt=0 ********************************************************************* Nature Reviews Immunology Impact Factor: 30.01* (*2008 Journal Citation Report (Thomson Reuters, 2009)) *********************************************************************
NATURE REVIEWS MOLECULAR CELL BIOLOGY June 2010 Volume 11 Number 6 Visit Nature Reviews Molecular Cell Biology online to browse the journal. Now available at http://links.ealert.nature.com/ctt?kn=11m=34914366r=NDU1MzI2NDEwOAS2b=2j=NzQ0MjE0MjES1mt=1rt=0 Please note that you need to be a subscriber to enjoy full text access to Nature Reviews Molecular Cell Biology online. To purchase a subscription, please visit: http://links.ealert.nature.com/ctt?kn=35m=34914366r=NDU1MzI2NDEwOAS2b=2j=NzQ0MjE0MjES1mt=1rt=0 Alternatively, to recommend a subscription to your library, please visit http://links.ealert.nature.com/ctt?kn=70m=34914366r=NDU1MzI2NDEwOAS2b=2j=NzQ0MjE0MjES1mt=1rt=0 ********************************************************************* Nature Reviews Molecular Cell Biology Impact Factor: 35.423* *2008 Journal Citation Report (Thomson Reuters, 2009)
NATURE REVIEWS GENETICS June 2010 Volume 11 Number 6 Visit Nature Reviews Genetics online to browse the journal. Now available at http://links.ealert.nature.com/ctt?kn=64m=34895286r=Mzg0ODUxNzcyNQS2b=2j=NzQwNzIwODkS1mt=1rt=0 Please note that you need to be a subscriber to enjoy full text access to Nature Reviews Genetics online. To purchase a subscription, please visit: http://links.ealert.nature.com/ctt?kn=39m=34895286r=Mzg0ODUxNzcyNQS2b=2j=NzQwNzIwODkS1mt=1rt=0 Alternatively, to recommend a subscription to your library, please visit http://links.ealert.nature.com/ctt?kn=74m=34895286r=Mzg0ODUxNzcyNQS2b=2j=NzQwNzIwODkS1mt=1rt=0 Sign up to Twitter for updates from Nature Reviews Genetics: http://links.ealert.nature.com/ctt?kn=33m=34895286r=Mzg0ODUxNzcyNQS2b=2j=NzQwNzIwODkS1mt=1rt=0
应读者要求，我选择和推荐的期刊信息。许培扬 NATURE REVIEWS MICROBIOLOGY June 2010 Volume 8 Number 6 Visit Nature Reviews Microbiology online to browse the journal. Now available at http://links.ealert.nature.com/ctt?kn=41m=34891771r=NDU1MzI2NDE0MgS2b=2j=NzM5Mzc4MDQS1mt=1rt=0 Please note that you need to be a subscriber to enjoy full text access to Nature Reviews Microbiology online. To purchase a subscription, please visit: http://links.ealert.nature.com/ctt?kn=32m=34891771r=NDU1MzI2NDE0MgS2b=2j=NzM5Mzc4MDQS1mt=1rt=0 Alternatively, to recommend a subscription to your library, please visit http://links.ealert.nature.com/ctt?kn=56m=34891771r=NDU1MzI2NDE0MgS2b=2j=NzM5Mzc4MDQS1mt=1rt=0
科学网编辑：这是信息资源推荐和介绍，不是转载。许培扬 Nature Reviews Microbioloy Focus on Antimicrobial Resistance Resistance to antimicrobials is becoming increasingly common, raising the concern that bacterial infections that can currently be controlled could become a major health threat again, as well as undermining efforts to combat diseases such as malaria. To highlight the problem of resistance to antimicrobials, Nature Reviews Microbiology present a set of specially commissioned articles that focus on key issues in the field. Visit http://links.ealert.nature.com/ctt?kn=6m=34873775r=Mzg0ODUxNzc1NgS2b=2j=NzM1NDcyMTYS1mt=1rt=0 to access the Focus.
Annual Reviews 2010年新添食品科学和技术分刊 （ Annual Review of Food Science and Technology ） 2010年的文章包括： Food Safety: What Can We Learn from Genomics? Mire Begley , Colin Hill Annual Review of Food Science and Technology - New (2010) Abstract | PDF (1041 KB) Genetics of Yeast Impacting Wine Quality Linda F. Bisson , Jonathan E. Karpel Annual Review of Food Science and Technology - New (2010) Abstract | PDF (815 KB) Phage and their Lysins as Biocontrol Agents for Food Safety Applications Brid Coffey , Susan Mills , Aidan Coffey , Olivia McAuliffe , R. Paul Ross Annual Review of Food Science and Technology - New (2010) Abstract | PDF (1453 KB) Fate of Starch in Food Processing: From Raw Materials to Final Food Products Jan A. Delcour , Charlotte Bruneel , Liesbeth J. Derde , Sara V. Gomand , Bram Pareyt , Joke A. Putseys , Edith Wilderjans , Lieve Lamberts Annual Review of Food Science and Technology - New (2010) Abstract | PDF (1231 KB) Genomic Evolution of Domesticated Microorganisms Grace Douglas , Todd R. Klaenhammer Annual Review of Food Science and Technology - New (2010) Abstract | PDF (1010 KB) A Promise Kept W. James Harper Annual Review of Food Science and Technology - New (2010) Abstract | PDF (2727 KB) Anthocyanins: Natural Colorants with Health-Promoting Properties Jian He , M. Monica Giusti Annual Review of Food Science and Technology - New (2010) Abstract | PDF (1277 KB) Whole Grains: Benefits and Challenges Julie Miller Jones , Jodi Engleson Annual Review of Food Science and Technology - New (2010) Abstract | PDF (1070 KB) Food Powders Flowability Characterization: Theory, Methods, and Applications Pablo Juliano , Gustavo V. Barbosa-Cnovas Annual Review of Food Science and Technology - New (2010) Abstract | PDF (1167 KB) Biochemistry and Genetics of Starch Synthesis Peter L. Keeling , Alan M. Myers Annual Review of Food Science and Technology - New (2010) Abstract | PDF (2386 KB) Water-Solids Interactions: Deliquescence Lisa J. Mauer , Lynne S. Taylor Annual Review of Food Science and Technology - New (2010) Abstract | PDF (1565 KB) Emulsion Design to Improve the Delivery of Functional Lipophilic Components David Julian McClements Annual Review of Food Science and Technology - New (2010) Abstract | PDF (2353 KB) Mechanisms of Microbial Hydrogen Disposal in the Human Colon and Implications for Health and Disease Noriko Nakamura , Henry C. Lin , Christopher S. McSweeney , Roderick I. Mackie , H. Rex Gaskins Annual Review of Food Science and Technology - New (2010) Abstract | PDF (1382 KB) Functional Oligosaccharides: Application and Manufacture R.A. Rastall Annual Review of Food Science and Technology - New (2010) Abstract | PDF (855 KB) Glass Transition Temperature and Its Relevance in Food Processing Yrj H. Roos Annual Review of Food Science and Technology - New (2010) Abstract | PDF (2118 KB) Food Formats for Effective Delivery of Probiotics Mary Ellen Sanders , Maria L. Marco Annual Review of Food Science and Technology - New (2010) Abstract | PDF (1000 KB) An Update on the Health Effects of Tomato Lycopene Erica N. Story , Rachel E. Kopec , Steven J. Schwartz , G. Keith Harris Annual Review of Food Science and Technology - New (2010) Abstract | PDF (1069 KB) Cross Linking Food Proteins for Improved Functionality Johanna Buchert , Dilek Ercili-Cura , Kristiina Kruus , Hairan Ma , Chiara Gasparetti , Evanthia Monogioudi , Greta Faccio , Harry Boer , Riitta Partanen , Emilia Selinheimo , Raija Lantto Annual Review of Food Science and Technology - New (2010) Abstract Nutrigenomics: What Does It Bring to Food Science? J. Bruce German Annual Review of Food Science and Technology - New (2010) Citation Melamine and its Degradants as Pet Food Contaminants George P. Daston Annual Review of Food Science and Technology - New (2010) Citation Applications of Food Biotechnology: The Case of Healthy Oils Anthony J. Kinney Annual Review of Food Science and Technology - New (2010) Citation Emerging Technologies in Food Processing Dietrich Knorr Annual Review of Food Science and Technology - New (2010) Citation Edible Packaging Material John M. Krochta , Theerajun Janjarasskul Annual Review of Food Science and Technology - New (2010) Citation Advances in Hyperspectral Imaging for Quality and Inspection of Food and Agricultural Products Renfu Lu Annual Review of Food Science and Technology - New (2010) Citation Pros and Cons of Mathematical Modeling of Pathogen Destruction Bradley P. Marks Annual Review of Food Science and Technology - New (2010) Citation Functional Genomics for Food Fermentation Processes Eddy J. Smid , Jeroen Hugenholtz Annual Review of Food Science and Technology - New (2010) Abstract
标签: Reviews
