美加州2010年秋季Kavili计算神经科学会议视频集锦 Kavli 2010年9－11月 ttp://online.itp.ucsb.edu/online/neuro10/ 参加会议的都是理论神经和神经生理学领域的的牛人 有视频录像 对神经科学的学生学者来说，这是不错的锻炼听力和开拓自己知识面的会议视频集 Time Speaker Title 9/20, 10:15 a.m. All Greeting Salutations from Adrienne, David Fred 9/20, 10:30 a.m. John Hopfield Princeton, IAS How Have Experiment and Theory Informed Each Other in the Past 25 Years? 9/20, 2:00 p.m. Karl Deisseroth Stanford Experimental Approaches to Psychiatric Disorders 9/21, 9:00 a.m. David Kleinfeld UCSD KITP Primer on Classical Brain Connectivity 9/21, 11:00 a.m. Van Wedeen Harvard Med. Tracing Neuronal Connections on an Areal Basis with DTI 9/21, 1:45 p.m. David Heeger NYU Spatiotemporal Dynamics of Activity in Human Visual Cortex 9/21, 4:00 p.m. R. Clay Reid Harvard Med. Experimental Approaches to Delineating Signal Pathways 9/22, 9:00 a.m. Anirvan Ghosh UCSD Molecular Approaches to Unraveling Circuits 9/22, 11:00 a.m. Stephen Smith Stanford Med. Synaptic Architecture of the Brain 9/22, 1:45 p.m. Chuck Stevens Salk Inst. KITP Principles That Govern the Structure of Arbors 9/22, 4:00 p.m. Adrienne Fairhall UW KITP Open Theoretical Issues and the Potential Impact of New Technologies 9/23, 9:00 a.m. Ralph Greenspan Neurosciences Inst. The Present and Future Face of Behavioral Genetics 9/23, 11:00 a.m. Dmitri Chklovskii Howard Hughes Med. KITP Hold That Thought: Networks that Support Persistence 9/23, 1:45 p.m. Axel Nimmerjahn Stanford Optical Imaging of Cell Dynamics in Behaving Animals 9/23, 4:00 p.m. Richard Hahnloser ETH KITP Neural Theory and Practice of Song Learning 9/24, 9:00 a.m. Edward Callaway Salk Inst. Rabies-based Tools to Elucidate Circuits and Link Connectivity to Function 9/24, 11:00 a.m. Srinivas Turaga MIT KITP Constructing the Connectome to Deconstruct the Brain 9/27, 10:00 a.m. Winfried Denk MPI Structural Neurobiology, The New Old Bottleneck 09/27, 12:15 p.m. Fred Wolf MPI KITP Perturbing Neural Circuit Dynamics KITP Blackboard Lunch 9/28, 9:30 a.m. Jimmy Zhou Yale Cholinergic Network in the Retina: From Development to Computation 9/28, 11:00 a.m. Alla Karpova Howard Hughes Med. Optimizing Behavior in Variable and Competitive Environments 9/28, 2:30 p.m. All Organizational Meeting 9/29, 9:30 a.m. Elad Schneidman Weizmann Inst. KITP Correlated Neural Population Codes and Optimal Networks 9/29, 11:00 a.m. Stephen Baccus Stanford Understanding Inhibitory Circuits in the Retina 9/30, 9:30 a.m. David Perkel UW Functions and Mechanisms of Behavioral Variability During Motor Learning 9/30, 11:30 a.m. Anne Churchland Cold Spring Harbor Laboratory Spiking Variability as a Window into Neural Computation 9/30, 2:00 p.m. All Group Discussion: High Order Correlations and Maximum Entropy Models of Population Activity in Retina and Cortex 10/01, 9:30 a.m. Jason Kerr MPI KITP Release the Hounds: Imaging Activity in Neuronal Populations in the Freely Moving Animal 10/01, 11:00 a.m. Albert Compte IDIBAPS KITP A Sensory-executive Circuit Model for Visual Selective Attention 10/01, 2:00 p.m. Eran Mukamel Harvard KITP Shaky, Spiky and Sharp: Neural Visual Inference for Hyperacuity amid Fixational Eye Movements 10/04, 10:00 a.m. Jeffrey Magee Howard Hughes Inst. Processing and Storage in Neuronal Dendrites 10/04, 12:00 p.m. Jeffrey Magee Howard Hughes Inst. Processing and Storage in Neuronal Dendrites, Cont'd 10/04, 3:30 p.m. Raoul-Martin Memmesheimer Radboud University, Nijmegen KITP Nonlinear Dendrites, Hippocampal Ripples, and Association of Spike Patterns 10/05, 9:30 a.m. Mark Ellisman UCSD Multiscale Imaging of the Nervous System: Where's the Dark Matter? 10/05, 11:00 a.m. Robert Gütig Hebrew Univ. KITP Spike-timing Based Neuronal Information Processing: Applications to Vision and Speech 10/06, 9:30 a.m. Jackie Schiller Technion Non Linear Dendritic Integration in Neocortical Pyramidal Neurons 10/06, 11:00 a.m. Guoqiang Bi University of Science and Technology of China Self-organizing Plasticity in Small Neuronal Networks 10/07, 9:30 a.m. Peter Latham Univ. College KITP Probabilistic Inference in Networks of Spiking Neurons 10/07, 11:00 a.m. Surya Ganguli UCSF KITP Compressive Sensing Tutorial 10/07, 3:30 p.m. Tao Hu Howard Hughes Medical Institute KITP Estimating Conectomes with Compressed Sensing 10/07, 4:00 p.m. Fleur Zeldenrust UvA KITP Characterizing Neurons in Networks with Noisy Input 10/08, 9:30 a.m. Elisha Moses Weizmann Inst. KITP Architecture and Computation in Neuronal Networks 10/08, 11:00 a.m. Sophie Denève ENS KITP Bayesian Approaches to Dynamics and Coding in Single Neurons and Networks 10/11, 4:00 p.m. William Spain UW Adaptation of Spike Timing Precision: Implications for Sound Localization 10/12, 9:30 a.m. Michael Gutnick Hebrew Univ. KITP Sodium Channels and Excitability in Neocortical Pyramidal Neurons 10/12, 11:00 a.m. Charles Wilson Univ. Texas Neuronal Dynamics in the Subthalamic Nucleus 10/13, 9:30 a.m. David McCormick Yale Med. Neocortical Network Dynamics 10/13, 11:00 a.m. Herbie Levine UCSD KITP Biophysical Models of Complex Neuronal Components 10/13, 2:00 p.m. Fred Wolf MPI KITP Single Neuron Dynamics for Retaining and Destroying Network Information 10/14, 9:30 a.m. David Golomb Ben Gurion Univ. KITP Short-term Synaptic Plasticity, Interneurons, and Cortical Responses 10/14, 11:00 a.m. Dirk Trauner Univ. Munich Teaching Old Receptors New Tricks 10/14, 2:00 p.m. Andrea Hasenstaub Salk Inst. KITP Fast-spiking Interneurons, Network Dynamics, and Response Flexibility 10/15, 9:30 p.m. Michael Famulare UW KITP Deriving the Spike Code from Single Neuron Dynamics 10/15, 11:30 a.m. Ben Strowbridge Case Western KITP Cellular Mechanisms of Persistent Activity in the Hippocampus and Olfactory Bulb 10/18, 10:00 a.m. Mayank Mehta UCLA KITP Relating Plasticity, Place Cells, Oscillations and Sleep 10/18, 2:00 p.m. Group Discussion Is Stimulus Reconstruction an Important Criterion for Choosing Single Neuron Models? 10/18, 3:30 p.m. Surya Ganguli UCSF Fisher Information, Compressed Sensing, and the Origins of Short-term Sequence Memory in Neuronal Networks 10/19, 9:30 a.m. Massimo Scanziani UCSD Excitation and Inhibition in Cortical Space 10/19, 11:00 a.m. Michael Hausser Univ. College London KITP Temporal Sequence Processing in Cortical Neurons 10/19, 2:00 p.m. All Normalization Models 10/20, 9:30 a.m. Rainer Friedrich Friedrich Miescher Inst. Dynamics and Discrete Network States in the Olfactory System 10/20, 11:00 a.m. Theo Geisel Univ. Gottingen/MPI KITP Phase Transitions towards Self-organized Criticality in Networks of Neurons with Dynamical Synapses 10/20, 4:00 p.m. Group Discussion Network Dynamics in Olfactory Processing 10/21, 9:30 a.m. Alex Reyes NYU Stimulus-dependent Switching of Excitatory/Inhibitory Configurations in Neural Networks 10/21, 11:00 a.m. Kenneth Miller Columbia Contrast-dependent Center-surround Interactions "Normalizing" Nonlinearities in Visual Cortex: A Simple Unified Circuit Model 10/21, 4:00 p.m. Livia deHoz Hebrew Univ. KITP Sensory Memory in the Auditory Cortex of Behaving Rodents 10/22, 9:30 a.m. Michale Fee MIT Localizing and Understanding Dynamics in Neural Circuits 10/22, 11:00 a.m. Sara Solla NWU Med. KITP Effective Connectivity Reveals Induced Network Reorganization in Behaving Animals 10/25, 10:00 a.m. David Kleinfeld UCSD KITP Welcome and Introduction to Neurovascular Coupling 10/25, 10:30 a.m. Martin Lauritzen Univ. Copenhagen So Many Signals: How the Vasculature Feeds the Brain 10/25, 2:30 p.m. Brian MacVicar UBC Regulation of Cerebral Blood Vessels by Astrocytes and the Influence of Metabolism 10/26, 9:30 a.m. Frank Kirchhoff Univ. Saarland Two-photon Imaging and Genetic Models to Study Glial Function in Vivo 10/26, 11:00 a.m. Edith Hamel Montreal Neurological Institute Neuronal Networks in the Control of Cerebral Blood Flow 10/26, 2:30 p.m. Pablo Blinder UCSD Illuminating the Angiotome 10/26, 3:15 p.m. Andy Shih UCSD Single-vessel Strokes 10/27, 9:30 a.m. Bruno Weber Univ. Zurich Cerebral Blood Flow and Metabolism: Feeding a Hungry Organ 10/27, 11:00 a.m. All Open Discussion 10/28, 9:30 a.m. David Hansel CNRS KITP Selective Persistent States in Balanced Networks 10/28, 11:00 a.m. Ila Fiete Univ. Texas, Austin Path Integration and Position Encoding in Grid Cells 10/28, 3:30 p.m. Carl vanVreeswijk Univ. Paris Descartes KITP Emerging Techniques for the Analysis of Network Dynamics 11/01, 3:30 p.m. Robert Froemke NYU KITP Long-term Cortical Synaptic Plasticity Improves Sensory Perception 11/02, 9:30 a.m. Matthias Kaschube Princeton KITP Nature, Nurture, Nonlinearity 11/02, 11:00 a.m. Tim Murphy UBC Synapse and Circuit Level Plasticity after Stroke 11/03, 9:30 a.m. Siegrid Lwel Friedrich-Schiller-Universitt, Jena KITP The Dynamic Architecture of the Cortex during Development and after Lesions 11/03, 11:00 a.m. Gordon Fishell NYU The Requirement for Neuronal Activity for Cortical Interneuron Development 11/04, 9:30 a.m. Venkatesh Murthy Harvard Univ. KITP Synaptic Circuits and Odor Processing in the Mouse Olfactory System 11/04, 11:00 a.m. Botond Roska Friedrich Miescher Inst. Retinal Hardware 11/04, 4:00 p.m. Julijana Gjorgjieva Univ. of Cambridge KITP Plasticity in Developing Circuits Driven by Spontaneous Activity 11/05, 9:00 a.m. Andrew Huberman UCSD Mechanisms for Wiring up Visual Circuits 11/05, 10:30 a.m. Vijay Balasubramanian Univ. Penn Principles of Population Coding: Maps, Parallel Channels, Interactions 11/08, 10:00 a.m. Peter Strick Univ. Pittsburgh 'Old' and 'New' M1: A Tale of Two Cortical Motor Areas 11/08, 1:30 p.m. Group Discussion Emerging Techniques: Perspectives and Challenges 11/08, 3:30 p.m. Chris Fang-Yen Univ. of Penn Optical Dissection of Worm Behavior 11/09, 9:30 a.m. Mark vanRossum Univ. Edinburgh KITP Weight Dependent Synaptic Plasticity Rules 11/10, 9:30 a.m. Yoram Burak Harvard KITP Models of Neural Inference under Dynamic Transformations 11/10, 11:00 a.m. Ehud Ahissar Weizmann Inst. Closed Loop Perception in Whisking Rats and Humans 11/10, 2:00 p.m. Discussion Covariance methods and single neurons 11/10, 3:30 p.m. Yasser Roudi NTNU KITP Mean Field Theory for Non-equilibrium Network Reconstruction 11/11, 9:30 a.m. Alexander Gail German Primate Center The Frontoparietal Sensorimotor Loop for Reaching 11/11, 11:30 a.m. All Wrap-up Discussion
科研生涯与实验室： http://www.rockefeller.edu/labheads/mcewen/mcewen-lab.php Bruce S McEwen Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, New York, USA Head of Section: Physiology Neural Homeostasis Home page http://www.rockefeller.edu/labheads/mcewen/mcewen-lab.php 研究成果与论著： http://www.rockefeller.edu/labheads/mcewen/publications.php 部分论著与科研绩效： http://scholar.google.com/scholar?hl=enq=Bruce+S+McEwenbtnG=Searchas_sdt=2000as_ylo=as_vis=0 BS McEwen - The New England Journal of Medicine, 1998 - endo.gr This article reviews the long-term effect of the physiologic response to stress, which I refer to as allostatic load. 2 Allostasis the ability to achieve stability through change 3 is critical to survival. Through allostasis, the autonomic nervous system, the hypothalamicpituitary ... Cited by 2171 - Related articles - Cached - BL Direct - All 10 versions The neuroendocrinology of stress and aging: the glucocorticoid cascade hypothesis RM Sapolsky, LC Krey, BS McEwen - Science's SAGE KE, 2002 - sageke.sciencemag.org Abstract: Over the past 5 yr, we have examined some of the sharpest edges of the pathology of aging. We have studied the capacity of aged organisms to respond appropriately to stress and the capacity of stress to cumulatively damage aging tissue. The idea of a relationship ... Cited by 1131 - Related articles - All 6 versions Stress and hippocampal plasticity angelfire.com BS McEwen - Annual review of neuroscience, 1999 - Annual Reviews ? Abstract The hippocampus is a target of stress hormones, and it is an especially plastic and vulnerable region of the brain. It also responds to gonadal, thyroid, and adrenal hormones, which modulate changes in synapse formation and dendritic structure and regulate dentate ... Cited by 890 - Related articles - BL Direct - All 9 versions Estrogen actions in the central nervous system endojournals.org BS McEwen , SE Alves - Endocrine reviews, 1999 - Endocrine Soc GONADAL hormones affect the nervous system in ways that extend beyond their essential actions of regulating gonadotropin and PRL secretion and modulating sexual behavior. For example, estrogens and androgens have been reported to influence verbal fluency, ... Cited by 849 - Related articles - BL Direct - All 8 versions Proliferation of granule cell precursors in the dentate gyrus of adult monkeys is diminished by stress pnas.org P Tanapat, BS McEwen , G Flgge, E - Proceedings of the , 1998 - National Acad Sciences Although granule cells continue to be added to the dentate gyrus of adult rats and tree shrews, this phenomenon has not been demonstrated in the dentate gyrus of adult primates. To determine whether neurons are produced in the dentate gyrus of adult primates, adult ... Cited by 748 - Related articles - BL Direct - All 15 versions Gonadal steroids regulate dendritic spine density in hippocampal pyramidal cells in adulthood jneurosci.org , CS Woolley, M Frankfurt, BS McEwen - Journal of , 1990 - Soc Neuroscience ... Elizabeth Gould, Catherine S . Woolley, Maya Frankfurt, and Bruce S . McEwen Laboratory of Neuroendocrinology, The Rockefeller University, New York, New York 10021 Gonadal steroids are known to influence hippocampal phys- iology in adulthood. ... Cited by 710 - Related articles - All 5 versions Stress and the individual: mechanisms leading to disease BS McEwen , E Stellar - Archives of Internal Medicine, 1993 - Am Med Assoc Objective This article presents a new formulation of the relationship between stress and the processes leading to disease. It emphasizes the hidden cost of chronic stress to the body over long time periods, which act as a predisposing factor for the effects of acute, stressful life events. It ... Cited by 785 - Related articles - BL Direct - All 3 versions Stress and cognitive function BS McEwen , RM Sapolsky - Current Opinion in Neurobiology, 1995 - Elsevier Stress affects cognition in a number of ways, acting rapidly via catecholamines and more slowly via glucocorticoids. Catecholamine actions involve beta adrenergic receptors and also availability of glucose, whereas glucocorticoids biphasically modulate synaptic plasticity over hours ... Cited by 755 - Related articles - All 5 versions Neurogenesis in the dentate gyrus of the adult tree shrew is regulated by psychosocial stress and NMDA receptor activation cjb.net E Gould, BS McEwen , P Tanapat, LAM Galea, - Journal of , 1997 - neuro.cjb.net These studies were designed to determine whether adult neurogenesis occurs in the dentate gyrus of the tree shrew, an animal phylogenetically between insectivores and primates, and to explore the possibility that this process is regulated by stressful experiences and NMDA ... Cited by 722 - Related articles - BL Direct - All 11 versions Prolonged glucocorticoid exposure reduces hippocampal neuron number: implications for aging jneurosci.org RM Sapolsky, LC Krey, BS McEwen - Journal of Neuroscience, 1985 - Soc Neuroscience The hippocampus of the rat loses neurons with age, a loss which may eventuate in some of the functional impairments typical of senescence. Cumulative exposure to cotticoster- one (CORT) over the lifespan may be a cause of this neuronal loss, as it is prevented by ... Cited by 667 - Related articles - All 5 versions
科研学术生涯： http://www.hhmi.org/research/investigators/walter_bio.html http://f1000biology.com/about/biography/485380228309395 Peter Walter University of California, San Francisco, USA Head of Section: Cell Biology Membranes Sorting 研究团队与实验室： http://walterlab.ucsf.edu/Site/Home.html 发表论著与科研成果： http://walterlab.ucsf.edu/Site/Publications%202001-present.html Walter P. (2010) Walking along the Serendipitous Path of Discovery. Molecular Biology of the Cell. 21: 15-17. (pdf) Doolittle MH, Neher SB, Ben-Zeev On, Jo L-l, Gallagher CM, Hosseini M, Yin F, Wong H, Walter P, Pterfy M. (2010) Lipase Maturation Factor LMF1, membrane topology and interaction with lipase proteins in the endoplasmic reticulum. J Biological Chemistry. 284: 33623-33633. (pdf) Schuck S, Prinz WA, Thorn KS, Voss C Walter P. (2009) Membrane expansion alleviates endoplasmic reticulum stress independently of the unfolded protein response. J Cell Biology. 187: 525-536. (pdf) Hollien J, Lin JH, Li H, Stevens H, Walter P Weissman JS. (2009)Regulated Ire1-dependent decay of messenger RNAs in mammalian cells. J Cell Biology. 186: 323-331. (pdf) Bradshaw N, Neher SB, Booth DS, and Walter P. (2009) Signal sequences activate the catalytic switch of SRP RNA. Science. 323(5910): 127-130. (pdf with supplemental) Frhlich F, Moreira K, Aguilar PS, Hubner NC, Mann M, Walter P, and Walther TC. (2009) A genome-wide screen for genes affecting eisosomes reveals Nce102 function in sphingolipid signaling. J Cell Biol. 185(7): 1227-42. (pdf) (supplemental) Kornmann B, Currie E, Collins SR, Schuldiner M, Nunnari J, Weissman JS, and Walter P. (2009) An ER-Mitochondria Tethering Complex Revealed by a Synthetic Biology Screen. Science. 325: 477-481. (pdf) (supplemental) So AY, de la Fuente E, Walter P, Schuman M, and Bernales S. (2009) The unfolded protein response during prostate cancer development. Cancer Metastasis Rev. 28: 219-223. (pdf) Jonikas MC, Collins SR, Denic V, Oh E, Quan EM, Schmid V, Weibezahn J, Schwappach B, Walter P, Weissman JS, and Schuldiner M. (2009) Comprehensive characterization of genes required for protein folding in the endoplasmic reticulum. Science. 323: 1693-1697. (pdf) (supplemental) Lisbona F, Rojas-Rivera D, Thielen P, Zamorano S, Todd D, Martinon F, Glavic A, Kress C, Lin JH, Walter P, Reed JC, Glimcher LH, and Hetz C. (2009) BAX inhibitor-1 is a negative regulator of the ER stress sensor IRE1alpha. Mol Cell. 33: 679-691. (pdf) Aragon T, van Anken E, Pincus D, Serafimova IM, Korennykh AV, Rubio CA, and Walter P. (2008) Messenger RNA targeting to endoplasmic reticulum stress signalling sites. Nature. 457: 736-740. (pdf) (supplemental 1) (supplemental 2) Korennykh AV, Egea PF, Korostelev AA, Finer-Moore J, Zhang C, Shokat KM, Stroud RM, and Walter P. (2008) The unfolded protein response signals through high-order assembly of Ire1. Nature. 457: 687-693. (pdf) (supplemental) Moreira KE, Walther TC, Aguilar PS, Walter P. (2008) Pil1 Controls Eisosome Biogenesis. Mol. Biol. Cell. 20: 809-818. (pdf) (supplemental) (movie) Lin JH, Li H, Zhang Y, Ron D, Walter P. (2008) Divergent Effects of PERK and IRE1 Signaling on Cell Viability. PLoS ONE. 4: e4170. (pdf) Egea PF, Tsuruta H, de Leon GP, Napetchnig J, Walter P, Stroud RM. (2008) Structures of SRP receptor from the Archaeon Pyrococcs furiosus . PLoS ONE 3(11): e3619. (pdf) Egea PF, Napetchnig J, Walter P, Stroud RM. (2008) Structures of SRP54 and SRP19, the two proteins that organize the ribonucleic core of the signal recognition particle from Pyrococcus furiosus . PLoS ONE 3(10): e3528. (pdf) Engel A, and Walter, P. (2008) Membrane lysis during biological membrane fusion: collateral damage by misregulated fusion machines. Journal of Cell Biology. 183(2): 181-186 . (pdf) Neher, S.B., Bradshaw, N., Floor, S.N., Gross, J.D., and Walter, P. (2008) SRP RNA controls a conformational switch regulating the SRP-SRP receptor interaction. Nature Structural and Molecular Biology. 15(9): 916-923 . (pdf) Raff, M., Johnson, A., and Walter, P. (2008) Painful Publishing. Science. 321: 36. (pdf) Guo, Y., Walther, T.C., Rao, M., Stuurman, N., Goshima, G., Terayama, K., Wong, J.S., Vale, R.D., Walter, P., and Farese, R.V. (2008) Functional genomic screen reveals genes involved in lipid-droplet formation and utilization. Nature. 453: 657-661 . (pdf) Walther TC, Aguilar PS, Frohlich F, Chu F, Moreira K, Burlingame AL, and Walter P. (2008) Pkh-kinases control eisosome assembly and organization. EMBO. 26: 4946-4955 . (pdf) Ron D and Walter P. (2007) Signal integration in the endoplasmic reticulum unfolded protein response. Nature Reviews Molecular Cell Biology. 8: 519-529. (pdf) Bernales S, Schuck S, Walter P. (2007) ER-Phagy: Selective autophagy of the endoplasmic reticulum. Autophagy. 3: 285-287. (pdf) Lin, J.H., Walter, P., and Yen, T.S.B.(2007) Endoplasmic Reticulum Stress in Disease Pathogenesis. Annual Review of Pathology. 3: 399-425 . (pdf) Lin, J.H., Li, H., Yasumura, D.., Cohen, H.R., Zhang, C., Panning, B,. Shokat,K.M., LaVail, M.M., and Walter, P. (2007) IRE1 Signaling Affects Cell Fate During the Unfolded Protein Response. Science. 318: 944-949 . (pdf) Bradshaw, N. and Walter, P. (2007) The SRP RNA links conformational changes in the SRP to protein targeting. Mol Biol Cell. 18: 2728-2734 . (pdf) Reyes, C.L., Rutenber, E., Walter, P., and Stroud, R.M. (2007) X-ray Structures of the Signal Recognition Particle Receptor Reveal Targeting Cycle Intermediates. PLoS ONE. 7:e607. (pdf) Shan, S., Chandrasekar, S. and Walter, P. (2007) Conformational changes in the GTPase modules of SRP and its receptor drive initiation of protein translocation. Journal of Cell Biology. 178: 611-620. (pdf) Heiman, M., Engel, A. and Walter, P. (2007) The Golgi-resident protease Kex2 acts in conjunction with Prm1 to facilitate cell fusion during yeast mating. Journal of Cell Biology 176 (2): 209-222. (pdf) Aguilar, P., Engel, A. and Walter, P. (2007) The plasma membrane proteins Prm1 and Fig1 ascertain fidelity of membrane fusion during yeast mating. Molecular Biology of the Cell 18: 547-556. (pdf) Bernales, S., McDonald, K.L., and Walter P. (2006) Autophagy counterbalances Endoplasmic Reticulum Expansion during the Unfolded Protein Response. PLoS Biology 4(12): e423. (pdf) (synopsis) Bernales, S., Papa, F.R., and Walter P. (2006) Intracellular Signaling by the Unfolded Protein Response. Annual Review of Cell and Developmental Biology 22: 487-508. (pdf) Walther, T., Brickner, J., Aguilar, P., Bernales, S., Pantoja, C., and Walter, P. (2006) Eisosomes define static sites of endocytosis. Nature 439: 998-1003. (pdf) Credle, J., Finer-Moore, J., Papa, F., Stroud, R., and Walter, P. (2005) On the mechanism of sensing unfolded protein in the endoplasmic reticulum. Proc Natl Acad Sciences 102: 18773-84. (pdf) Egea, P.F., Stroud, R.M., and Walter, P. (2005) Targeting proteins to membranes: structure of the signal recognition particle. Current Opinion in Structural Biology 15: 213-220. (pdf) Kaiser, S.E., Brickner, J.H., Reilein, A.R., Fenn, T.D., Walter, P. and Brunger, A.T. (2005) Structural basis of FFAT Motif-mediated ER targeting. Structure 13(7): 1035-45. (pdf) 部分著作与科研绩效： http://scholar.google.com/scholar?hl=enq=Peter+WalterbtnG=Searchas_sdt=2000as_ylo=as_vis=0 Signal recognition particle contains a 7 S RNA essential for protein translocation across the endoplasmic reticulum ucsf.edu P Walter , G Blobel - Nature, 1982 - walterlab.ucsf.edu Nature Vol. 299 21 October 1982 691 The possible changes both of kisO and s would therefore lead to higher d values at glacial periods. Anyway, the influence of variations of klsO and s for the first part of the water cycle is small. The effect of a more hypothetical slope change at ... Cited by 914 - Related articles - All 11 versions Functional and genomic analyses reveal an essential coordination between the unfolded protein response and ER-associated degradation cell.com Patil, L Wodicka, DJ Lockhart, JS Weissman, P Walter - Cell, 2000 - Elsevier The unfolded protein response (UPR) regulates gene expression in response to stress in the endoplasmic reticulum (ER). We determined the transcriptional scope of the UPR using DNA microarrays. Rather than regulating only ER-resident chaperones and phospholipid ... Cited by 786 - Related articles - BL Direct - All 26 versions Signal sequence recognition and protein targeting to the endoplasmic reticulum membrane P Walter , AE Johnson - Annual review of cell biology, 1994 - Annual Reviews ... MEMBRANE Peter Walter Department of Biochemistry and Biophysics, University of California, San Francisco, California 94143-0448 Arthur E. Johnson Department of Chemistry and Biochemistry, University of Oklahoma, Norman, Oklahoma 73019 ... Cited by 629 - Related articles - All 4 versions Signal integration in the endoplasmic reticulum unfolded protein response utoronto.ca D Ron, P Walter - Nature Reviews Molecular Cell Biology, 2007 - nature.com The endoplasmic reticulum (ER) responds to the accumulation of unfolded proteins in its lumen (ER stress) by activating intracellular signal transduction pathways cumulatively called the unfolded protein response (UPR). Together, at least three mechanistically distinct arms of ... Cited by 587 - Related articles - BL Direct - All 10 versions Translocation of proteins across the endoplasmic reticulum. I. Signal recognition protein (SRP) binds to in-vitro-assembled polysomes synthesizing secretory protein rupress.org P Walter , I Ibrahimi, G Blobel - Journal of Cell Biology, 1981 - jcb.rupress.org ABSTRACT An 11S protein composed of six polypeptide chains was previously purified from a salt extract of dog pancreas microsomal membranes and shown to be required for translocation of nascent secretory protein across the microsomal membrane ( Walter and Blobel 1980 ... Cited by 527 - Related articles - All 8 versions Intracellular signaling from the endoplasmic reticulum to the nucleus: the unfolded protein response in yeast and mammals ucsd.edu C Patil, P Walter - Current opinion in cell biology, 2001 - Elsevier Cellular survival of endoplasmic reticulum stress requires the unfolded protein response (UPR), a stress response first elucidated genetically in yeast. While we continue to refine our knowledge of the yeast system, especially the breadth and significance of the ... Cited by 487 - Related articles - BL Direct - All 17 versions Essential cell biology tu-darmstadt.de Bray, A Johnson, J Lewis, M Raff, K Roberts, P Walter , - 2004 - ulb.tu-darmstadt.de Chapter 1 Panel 1-1 Panel 1-2 How We Know ... Chapter 2 How We Know Panel 2-1 Panel 2-2 Panel 2-3 Panel 2-4 Panel 2-5 Panel 2-6 Panel 2-7 ... Chapter 3 Panel 3-1 How We Know ... Chapter 4 Panel4-1 How We Know Panel 4-2 Panel 4-3 ; Panel 4-4 Panel 4-5 Panel 4-6 Cited by 504 - Related articles - View as HTML - All 4 versions Preparation of microsomal membranes for cotranslational protein translocation P Walter , G Blobel - Methods in Enzymology, 1983 - Elsevier ... This article is not included in your organization's subscription. However, you may be able to access this article under your organization's agreement with Elsevier. Peter Walter and Gnter Blobel. Available online 29 November 2003. Excerpt. Note:This is a one-page preview only. ... Cited by 478 - Related articles - All 2 versions Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase ucsf.edu JS Cox, CE Shamu, P Walter - Cell, 1993 - Elsevier The transcription of genes encoding soluble proteins that reside in the endoplasmic reticulum (ER) is induced when unfolded proteins accumulate in the ER. Thus, an intracellular signal transduction pathway must exist that mediates communication between the ER lumen and the nucleus. ... Cited by 480 - Related articles - BL Direct - All 10 versions Model for signal sequence recognition from amino-acid sequence of 54 K subunit of signal recognition particle ucsf.edu , MA Poritz, K Strub, PJ Hoben, S Brenner, P Walter - Nature, 1989 - walterlab.ucsf.edu LETTERS TO NATURE Consensus SRP54 E.coli 48К h DP FTS Y N-RAS, human EF-Tu, E.COI G 108 G 107 G 425 G 301 G 10 G 18 G_ xxx X Ь Q LQ VN VN AGGV HVDH G К t/s G К т G К т G К s G К т G К s G К т D XX G N К X D 190 D T s G 248 T К L D 190 D TA G 248 T К V D ... Cited by 372 - Related articles - All 8 versions
http://www.gopubmed.org/web/ 655 documents semantically analyzed top author statistics 1 2 Top Years Publications 2009 93 2007 80 2008 76 2006 56 2005 53 2003 46 2004 45 2002 37 2001 37 2000 26 1999 26 1998 16 2010 15 1997 13 1995 8 1996 7 1994 6 1991 3 1992 2 1988 2 1 2 1 2 3 Top Countries Publications USA 130 China 74 Germany 71 Japan 58 South Korea 30 India 30 United Kingdom 26 France 24 Spain 23 Canada 21 Russia 19 Italy 16 Thailand 12 Australia 10 Taiwan 9 Brazil 9 Austria 9 Sweden 8 Netherlands 8 Switzerland 5 1 2 3 1 2 3 ... 15 Top Cities Publications Hyderabad 22 Moscow 15 Beijing 14 Daejeon 12 Seoul 11 Tokyo 11 Kunming 10 Bangkok 10 Jena 9 Nanjing 8 Peoria 7 Kiel 6 Tsukuba 5 Hangzhou 5 Berlin 5 Davis 5 Jeju 5 Oxford 5 Wien 5 Berkeley 5 1 2 3 ... 15 1 2 3 ... 10 Top Journals Publications Int J Syst Evol Micr 188 Evolution 31 Int J Syst Bacteriol 30 Wei Sheng Wu Xue Bao 24 Mol Phylogenet Evol 15 Appl Environ Microb 13 Syst Appl Microbiol 11 Anton Leeuw Int J G 11 P Natl Acad Sci Usa 11 Bmc Evol Biol 9 Fems Yeast Res 9 P Roy Soc Lond B Bio 9 Mol Biol Evol 8 Arch Microbiol 7 Extremophiles 6 Mol Ecol 6 Genetics 6 J Evolution Biol 6 Fems Microbiol Lett 5 Mycol Res 5 1 2 3 ... 10 1 2 3 ... 165 Top Terms Publications Phylogeny 540 Genes 351 DNA, Ribosomal 311 RNA, Ribosomal, 16S 297 Sequence Analysis, DNA 229 Genes, rRNA 227 DNA, Bacterial 225 Animals 221 DNA 200 Phenotype 184 Evolution 180 Base Composition 135 Base Sequence 129 Fatty Acids 126 Bacteria 119 Species Specificity 114 Sequence Analysis 109 Soil Microbiology 108 Cluster Analysis 104 Bacterial Typing Techniques 102 1 2 3 ... 165 1 2 3 ... 137 Top Authors Publications Schumann P 17 Stackebrandt E 17 Srinivas T 12 Ramana C 11 Kroppenstedt R 11 Imhoff J 10 Sasikala C 10 Tindall B 7 Nakase T 7 Kumar P 7 Li W 6 Kudo T 6 Rainey F 6 Bonch-Osmolovskaya E 6 Tamura T 6 Hirsch P 6 Kawasaki H 5 Lee S 5 Pyun Y 5 Takahashi Y 5 1 2 3 ... 137 最新研究报道 Proc Natl Acad Sci U S A. 2010 Apr 20;107(16):7353-8. Epub 2010 Apr 5. Contrasting genetic paths to morphological and physiological evolution. Liao BY , Weng MP , Zhang J . Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, Miaoli County 350, Taiwan, Republic of China. liaoby@nhri.org.tw Abstract The relative importance of protein function change and gene expression change in phenotypic evolution is a contentious, yet central topic in evolutionary biology. Analyzing 5,199 mouse genes with recorded mutant phenotypes, we find that genes exclusively affecting morphological traits when mutated (dubbed morphogenes) are grossly enriched with transcriptional regulators, whereas those exclusively affecting physiological traits (dubbed physiogenes) are enriched with channels, transporters, receptors, and enzymes. Compared to physiogenes, morphogenes are more likely to be essential and pleiotropic and less likely to be tissue specific. Morphogenes evolve faster in expression profile, but slower in protein sequence and gene gain/loss than physiogenes. Thus, morphological and physiological changes have a differential molecular basis; separating them helps discern the genetic mechanisms of phenotypic evolution. PMID: 20368429 PMCID: PMC2867737 Publication Types, MeSH Terms Publication Types: Research Support, N.I.H., Extramural Research Support, N.I.H., Intramural MeSH Terms: Animals Computational Biology/methods Databases, Genetic Evolution, Molecular* Gene Expression Profiling* Gene Expression Regulation Genomics Humans Mice Models, Biological Models, Genetic Mutation Nucleic Acid Hybridization Oligonucleotide Array Sequence Analysis Phenotype LinkOut - more resources Full Text Sources: HighWire Press EBSCO Swets Information Services
标签: 生理学
