http://www.nature.com/neuro/journal/vaop/ncurrent/full/nn.2562.html Nature Neuroscience | Article Adenosine A1 receptors mediate local anti-nociceptive effects of acupuncture (Image from: http://pubs.acs.org/isubscribe/journals/cen/88/i23/html/8823scic1.html ) Nature Neuroscience Published online: 30 May 2010 Abstract Acupuncture is an invasive procedure commonly used to relieve pain . Acupuncture is practiced worldwide, despite difficulties in reconciling its principles with evidence-based medicine. We found that adenosine , a neuromodulator with anti-nociceptive properties, was released during acupuncture in mice and that its anti-nociceptive actions required adenosine A1 receptor expression. Direct injection of an adenosine A1 receptor agonist replicated the analgesic effect of acupuncture. Inhibition of enzymes involved in adenosine degradation potentiated the acupuncture-elicited increase in adenosine, as well as its anti-nociceptive effect. These observations indicate that adenosine mediates the effects of acupuncture and that interfering with adenosine metabolism may prolong the clinical benefit of acupuncture.
http://www.gopubmed.org/web/gopubmed/ acupuncture and fibromyalgia syndrome 105 documents semantically analyzed top author statistics 1 2 Top Years Publications 2007 14 2006 12 2005 10 2009 9 2008 9 2000 7 2010 6 2004 6 1999 6 1998 4 2001 3 2003 2 2002 2 1997 2 1992 2 1996 1 1995 1 1993 1 1991 1 1989 1 1 2 Top Countries Publications USA 36 United Kingdom 7 Germany 7 China 6 Sweden 6 Turkey 3 Switzerland 3 Spain 2 Brazil 2 Netherlands 2 Japan 1 Israel 1 France 1 Singapore 1 Russia 1 Belgium 1 Canada 1 1 2 3 Top Cities Publications Ann Arbor 7 Baltimore 5 Exeter 4 Essen 4 Beijing 3 Stockholm 3 Seattle 3 So Paulo 2 Diyarbak?r 2 Gainesville 2 Munich 2 Boston 2 Linkping 2 Geneva 2 Kyoto 1 Chicago 1 Cleveland 1 Toledo, Spain 1 Shijiazhuang 1 Madrid 1 1 2 3 1 2 3 4 Top Journals Publications Acupunct Med 5 Zhongguo Zhen Jiu 4 J Altern Complement Med 3 Rheumatology (oxford) 3 Best Pract Res Cl Rh 3 J Altern Complem Med 3 Ann Intern Med 3 Bmj 3 Am Fam Physician 2 Rheumatol Int 2 Altern Ther Health M 2 Mmw Fortschr Med 2 Curr Rheumatol Rep 2 Mayo Clin Proc 2 Clin Exp Rheumatol 2 Curr Pain Headache Rep 2 Eur J Pain 2 J Rheumatol Suppl 2 South Med J 2 Ugeskr Laeger 2 1 2 3 4 1 2 3 ... 27 Top Terms Publications Fibromyalgia 104 Humans 94 Acupuncture 85 Patients 61 Acupuncture Therapy 54 Syndrome 46 Treatment Outcome 31 Adult 30 Evaluation Studies as Topic 26 Middle Aged 26 Medicine 24 Complementary Therapies 24 Pain 24 Pain Measurement 23 Physics 19 Therapeutics 16 Acupuncture Analgesia 16 Fatigue 15 Randomized Controlled Trials as Topic 15 Exercise 15 1 2 3 ... 27 1 2 3 ... 13 Top Authors Publications Clauw D 4 Berman B 4 Swyers J 4 Lund I 3 Gracely R 3 Ernst E 3 Singh B 2 Imamura M 2 Gur A 2 Irnich D 2 Staud R 2 Lundeberg T 2 McLean S 2 Harris R 2 Williams D 2 Petzke F 2 Gerdle B 2 Sandberg M 2 Lindberg L 2 Buchwald D 2 1 2 3 ... 13 系统综述 http://plus.mcmaster.ca/EvidenceUpdates/MMA.aspx?ArticleID=33691 Langhorst J, Klose P, Musial F, et al. Efficacy of acupuncture in fibromyalgia syndrome--a systematic review with a meta-analysis of controlled clinical trials. Rheumatology (Oxford). 2010 Apr;49(4):778-88. Epub 2010 Jan 25. (Review) PMID: 20100789 ReadAbstract ReadComments DISCIPLINE RELEVANCE TO PRACTICE IS THIS NEWS? General Internal Medicine-Primary Care(US) General Practice(GP)/Family Practice(FP) Internal Medicine Rheumatology Special Interest - Pain -- Physician Print Save Article Email this article to a colleague Abstract OBJECTIVE: To systematically review the efficacy of acupuncture in fibromyalgia syndrome (FMS). METHODS: MEDLINE, PsychInfo, EMBASE, CAMBASE and the Cochrane Library were screened (through July 2009). The reference sections of original studies and systematic reviews for randomized controlled trials (RCTs) on acupuncture in FMS were searched. RESULTS: Seven RCTs with a median treatment time of 9 (range 6-25) sessions and 385 patients were included. Outcomes of interest were key symptoms of FMS, namely pain, fatigue, sleep disturbances, reduced physical function and side effects at post-treatment. Follow-up of two RCTs with a median follow-up of 26 weeks was available. Standardized mean differences (SMDs) comparing verum and control acupuncture were calculated. Strong evidence for the reduction of pain (SMD -0.25; 95% CI -0.49, -0.02; P = 0.04) was found at post-treatment. There was no evidence for the reduction of fatigue and sleep disturbances, or the improvement of physical function at post-treatment. There was no evidence for the reduction of pain and improvement of physical function at the latest follow-up. Subgroup analyses resulted in moderate evidence for a significant and small reduction of pain at post-treatment in studies with electro-stimulation and individualized acupuncture. Stratifying the type of controls (penetrating vs non-penetrating control acupuncture) did not change the results. Significant reduction of pain was only present in studies with risk of bias. Side effects were inconsistently reported. CONCLUSION: A small analgesic effect of acupuncture was present, which, however, was not clearly distinguishable from bias. Thus, acupuncture cannot be recommended for the management of FMS. Comments from Clinical Raters Rheumatology I have rated the relevance high but since many of my colleagues assert that they do not think fibromyalgia is a rheumatological disorder, they may disagree. Rheumatology This meta-analysis confirms that while acupuncture may be helpful for the select individual patient, we continue to lack evidence to advocate it as part of the generalized FMS treatment plan. Special Interest - Pain -- Physician Meta-analysis demonstrated small analgesic effect of acupuncture. Acupuncture could be recommended for fibromyalgia as an adjunct treatment modality. Special Interest - Pain -- Physician This meta-analysis of publications on the use of acupuncture showed what other meta-analyses show: often there are insufficient good quality publications from which to reach a conclusion. In this case, the meta-analysis showed that acupuncture probably has a small effect on pain but no significant effect on any other symptoms that fibromyalgia sufferers experience, and probably little clinical utility in the treatment of fibromyalgia. It also showed that the choice of a control treatment for acupuncture can be problematic and may explain the varied results in studies looking at acupuncture in the treatment of fibromyalgia, and in the study of acupuncture in the treatment of other medical conditions. Overall, this meta-analysis does not support the use of acupuncture in the treatment of fibromyalgia.
本文为博主原创的医学信息分析报告,特此说明。 信息分析平台: http://www.gopubmed.org/web/gopubmed/1?WEB01xepgx6zx8zl4IaI1I00f01000j10040001rl 检索策略:Acupuncture and transmitted infections 14 documents semantically analyzed Top Years Publications 1999 2 1993 2 2009 1 2006 1 2005 1 2002 1 2001 1 1997 1 1994 1 1990 1 1985 1 1974 1 Top Countries Publications South Korea 3 Brazil 2 USA 2 Taiwan 2 Hong Kong S.A.R., China 1 France 1 Japan 1 Top Cities Publications Seoul 2 Taipei 2 So Paulo 1 Namw?n 1 Hong Kong 1 Richmond 1 Paris 1 Albuquerque 1 Goinia 1 Top Journals Publications J Med Virol 2 Rev Soc Bras Med Trop 1 Am J Trop Med Hyg 1 Int J Dermatol 1 J Clin Microbiol 1 Acupunct Med 1 Presse Med 1 Am J Gastroenterol 1 J Korean Med Sci 1 Nippon Koshu Eisei Zasshi 1 Rev Saude Publica 1 Med Clin-barcelona 1 N Z Med J 1 1 2 3 4 Top Authors Publications Lee S 2 Wu J 2 Sheng W 2 Barone A 1 Cavalheiro N 1 De La Rosa A 1 Elagin S 1 Tengan F 1 Arajo E 1 Choi J 1 Kweon S 1 Shin M 1 Song H 1 Jeon D 1 Song H 1 Ryu H 1 Kim W 1 Oh C 1 Yun K 1 Woo P 1 1 2 3 4 1 2 3 ... 12 Top Terms Publications Humans 13 Viruses 11 Acupuncture 10 Hepatitis 10 Adult 10 Risk Factors 9 Hepatitis Viruses 8 Blood Transfusion 8 Sexuality 8 Pharmaceutical Preparations 8 Acupuncture Therapy 8 Hepatitis C 7 Hepacivirus 6 Sexually Transmitted Diseases 6 Prevalence 6 viral reproduction 5 Multivariate Analysis 5 Middle Aged 5 Hepatitis B 5 Street Drugs 4 1 2 3 ... 12 Where health is patriotism. Visit of New Zealand medical delegation to China: 20 August-9 September 1974. PMID: 4532204 Related Articles Authors: Hiddlestone, H J Journal: N Z Med J , Vol. 80 (529): 509-16 , 1974 No abstract given.
http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/edit_b.cgi 相关基因知识发现 Start A-Literature C-Literature B-list Filter Literature A-query: acupuncture and brain C-query: brain and mechanisms The B-list contains title words and phrases (terms) that appeared in both the A and the C literature. 189 articles appeared in both literatures and were not included in the process of computing the B-list but can be viewed here . The results of this search are saved under id # 9955 and can be accessed from the start page after you leave this session. There are 344 terms on the current B-list ( 173 are predicted to be relevant), which is shown ranked according to predicted relevance. The list can be further trimmed down using the filters listed in the left margin. To assess whether there appears to be a biologically significant relationship between the AB and BC literatures for specific B-terms, please select one or more B-terms and then click the button to view the corresponding AB and BC literatures. Use Ctrl to select multiple B-terms. Rank Prob B-term 10.99akt 20.99preproenkephalin 30.99vegf 40.99bdnf 50.99proenkephalin 60.99c jun 70.99caspase-9 80.99gdnf 90.99inos 100.99trka 110.99neurotrophin 120.99nt-3 130.99opioid receptor 140.99pi3k 150.99ghrelin 160.99c fos 170.98cd133 180.98nnos 190.98cb1 200.98immediate early gene 210.98dopamine receptor 220.98nts 230.98p300 240.98corticotropin releasing hormone 250.98trpm7 260.98pkc 270.98epileptiform 280.98transcription factor 290.98differentially expressed gene 300.98gnrh 310.98npy 320.98yb-1 330.98fosb 340.97early gene 350.97ca1 360.97jun 370.97somatostatin receptor 380.97neuropeptide y 390.97fibroblast growth factor 400.97gaba a receptor 410.97tnf alpha 420.97opiate receptor 430.97ngf 440.97il-1beta 450.97shr 460.97gfap 470.97akt pkb 480.97preproenkephalin gene 490.97bv2 500.96mek 510.96na k atpase 520.965-ht 530.96neurotensin 540.96pro opiomelanocortin 550.96nf e2 560.96cgmp 570.96crhr 580.96tyrosine hydroxylase 590.96cgrp 600.96neuropeptide 610.95crh 620.95tnf 630.95protooncogene 640.95gonadotropin releasing hormone 650.95fos 660.95related gene 670.95cytokine 680.95sii 690.95endothelin 700.95gaba a 710.94nmdar 720.94mri 730.94nf 740.94pet 750.94somatostatin 760.94orl1 770.94estrogen receptor 780.93alcohol withdrawal 790.93epilepsy 800.93cck 810.93thyrotropin releasing hormone 820.93il-6 830.92somatostatin receptor gene 840.92cholecystokinin 850.92angiotensinogen gene 860.92er alpha 870.91transporter 880.91pag 890.91gaba 900.91potassium channel 910.90cck b 920.90receptor gene 930.89arginine vasopressin 940.89c jun expression 950.89carpal tunnel syndrome 960.89app 970.88pkb 980.88pup 990.88bee 1000.88alzheimer disease 1010.88anxiety 1020.87senescence 1030.86ih 1040.863t 1050.85na 1060.85related gene brain 1070.85nadph 1080.85cd34 1090.84spike 1100.84obesity 1110.84pka 1120.83glutathione peroxidase 1130.83hz 1140.83dopa 1150.83dystonia 1160.83sod 1170.83gh 1180.83lobe 1190.83oxytocin 1200.83mu 1210.82protein kinase 1220.81inducible 1230.81cytokine production 1240.81gracile 1250.80hsp70 1260.80parkinson disease 1270.80theta 1280.79glioma 1290.78locus 1300.78gene coding 1310.78angiotensinogen 1320.77oncogene c 1330.76si 1340.76tcm 1350.76gene encoding 1360.76gad 1370.75ach 1380.75ah 1390.75calcitonin gene related 1400.75gene related peptide 1410.74chat 1420.74gene brain 1430.73lh 1440.73trh 1450.73oncogene 1460.72d1 1470.71ca2 1480.71axis 1490.70cue 1500.70thioredoxin 1510.69camp 1520.69pars 1530.66expression gene 1540.66superoxide dismutase 1550.65mitochondrial 1560.64pain 1570.64p130 1580.63task 1590.63lc 1600.62cpp 1610.62d2 1620.60atpase 1630.58spatial 1640.58retinitis pigmentosa 1650.57polycystic ovary syndrome 1660.57csf 1670.57prolactin 1680.56kappa 1690.55gut 1700.54ca 1710.54chi 1720.53cord 1730.52vasoactive intestinal peptide 1740.52ache 1750.51spastic 1760.50wave 1770.50eye 1780.49gene related 1790.49slow 1800.48fiber 1810.47gene 1820.46leu 1830.46mda 1840.45pf 1850.443h 1860.43gene transfer 1870.42nervous 1880.42killer 1890.41li 1900.38kinase 1910.38obese 1920.37sun 1930.36death 1940.36signal 1950.35arc 1960.34cat 1970.33acetylcholinesterase 1980.33diabetes 1990.33samp 2000.33pcr 2010.32inositol 2020.32male 2030.322a 2040.30met 2050.28phosphodiesterase 2060.27e2 2070.26da 2080.26succinate dehydrogenase 2090.26enhancement 2100.25damage 2110.25ct 2120.25region 2130.24yin yang 2140.24gate 2150.23mice 2160.22atp 2170.22acth 2180.22a5 2190.22delta 2200.20bi 2210.19pro 2220.18coma 2230.17calcitonin 2240.16ear 2250.16protein 2260.16cycle 2270.15sep 2280.14term 2290.14area 2300.14insulin 2310.13receptor 2320.13abnormal 2330.13esterase 2340.13alpha 2350.13healthy human 2360.12beta 2370.12ion 2380.11st 2390.113b 2400.10face 2410.10er 2420.10hypertension 2430.09neuro 2440.08sera 2450.08signal processing 2460.08ehf 2470.08early 2480.08beta hydroxylase 2490.07sp 2500.073d 2510.07tail 2520.07cor 2530.07cell 2540.07novel 2550.06domain 2560.06gamma 2570.06not 2580.06time 2590.06pc 2600.05limb 2610.05mask 2620.05sea 2630.05disc 2640.05asthma 2650.05sn 2660.05rna 2670.05ne 2680.05weight 2690.04dr 2700.04activity 2710.04hand 2720.04inhibitor 2730.04po 2740.04gyri 2750.04dd 2760.03peroxidase 2770.03ep 2780.03blind 2790.03point 2800.03du 2810.03pig 2820.02immune response 2830.02cold 2840.02men 2850.02base 2860.02segment 2870.02pilot 2880.01dance 2890.01line 2900.01al 2910.01dog 2920.01san 2930.01co 2940.01dehydrogenase 2950.01skin 2960.01amp 2970.01mode 2980.01induced enhancement 2990.01ring 3000.01a1 3010.01rest 3020.01bl 3030.01rib 3040.01vs 3050.00light 3060.00red 3070.00year 3080.00secretion 3090.00ci 3100.00collagen 3110.00april 3120.00modification 3130.00ex 3140.00past 3150.00re 3160.00care 3170.00hot 3180.00grain 3190.00variant 3200.00non 3210.00large 3220.00simple 3230.00ac 3240.00nei 3250.00group 3260.00man 3270.00low 3280.00pre 3290.00phosphatase 3300.00double 3310.00wind 3320.00vi 3330.00fact 3340.00end 3350.00membrane 3360.00b 3370.00or 3380.00c 3390.00ten 3400.00fire 3410.00net 3420.00penetration 3430.00cardinal 3440.00section Restrict by semantic categories? job id # 9955 started Tue Feb 9 05:01:05 2010 Max_citations: 50000 Stoplist: /var/www/html/arrowsmith_uic/data/stopwords_pubmed Ngram_max: 3 9955 Search ARROWSMITH A A_query_raw: acupuncture and brain Tue Feb 9 05:02:04 2010 A query = acupuncture and brain started Tue Feb 9 05:02:04 2010 A query resulted in 1596 titles 9955 Search ARROWSMITH C 9955 Search ARROWSMITH C C_query_raw: brain and mechanisms Tue Feb 9 05:03:05 2010 C: brain and mechanisms 78574 A: pubmed_query_A 1596 AC: ( acupuncture and brain ) AND ( brain and mechanisms ) 189 C query = brain and mechanisms started Tue Feb 9 05:03:06 2010 C query resulted in 50000 titles A AND C query resulted in 189 titles 5606 B-terms ready on Tue Feb 9 05:06:39 2010 Sem_filter: Genes Molecular Sequences, and Gene Protein Names 344 B-terms left after filter executed Tue Feb 9 05:11:07 2010 B-list on Tue Feb 9 05:14:14 2010 1 akt 2 preproenkephalin 3 vegf 4 bdnf 5 proenkephalin 6 c jun 7 caspase-9 8 gdnf 9 inos 10 trka 11 neurotrophin 12 nt-3 13 opioid receptor 14 pi3k 15 ghrelin 16 c fos 17 cd133 18 nnos 19 cb1 20 immediate early gene 21 dopamine receptor 22 nts 23 p300 24 corticotropin releasing hormone 25 trpm7 26 pkc 27 epileptiform 28 transcription factor 29 differentially expressed gene 30 gnrh 31 npy 32 yb-1 33 fosb 34 early gene 35 ca1 36 jun 37 somatostatin receptor 38 neuropeptide y 39 fibroblast growth factor 40 gaba a receptor 41 tnf alpha 42 opiate receptor 43 ngf 44 il-1beta 45 shr 46 gfap 47 akt pkb 48 preproenkephalin gene 49 bv2 50 mek 51 na k atpase 52 5-ht 53 neurotensin 54 pro opiomelanocortin 55 nf e2 56 cgmp 57 crhr 58 tyrosine hydroxylase 59 cgrp 60 neuropeptide 61 crh 62 tnf 63 protooncogene 64 gonadotropin releasing hormone 65 fos 66 related gene 67 cytokine 68 sii 69 endothelin 70 gaba a 71 nmdar 72 mri 73 nf 74 pet 75 somatostatin 76 orl1 77 estrogen receptor 78 alcohol withdrawal 79 epilepsy 80 cck 81 thyrotropin releasing hormone 82 il-6 83 somatostatin receptor gene 84 cholecystokinin 85 angiotensinogen gene 86 er alpha 87 transporter 88 pag 89 gaba 90 potassium channel 91 cck b 92 receptor gene 93 arginine vasopressin 94 c jun expression 95 carpal tunnel syndrome 96 app 97 pkb 98 pup 99 bee 100 alzheimer disease 101 anxiety 102 senescence 103 ih 104 3t 105 na 106 related gene brain 107 nadph 108 cd34 109 spike 110 obesity 111 pka 112 glutathione peroxidase 113 hz 114 dopa 115 dystonia 116 sod 117 gh 118 lobe 119 oxytocin 120 mu 121 protein kinase 122 inducible 123 cytokine production 124 gracile 125 hsp70 126 parkinson disease 127 theta 128 glioma 129 locus 130 gene coding 131 angiotensinogen 132 oncogene c 133 si 134 tcm 135 gene encoding 136 gad 137 ach 138 ah 139 calcitonin gene related 140 gene related peptide 141 chat 142 gene brain 143 lh 144 trh 145 oncogene 146 d1 147 ca2 148 axis 149 cue 150 thioredoxin 151 camp 152 pars 153 expression gene 154 superoxide dismutase 155 mitochondrial 156 pain 157 p130 158 task 159 lc 160 cpp 161 d2 162 atpase 163 spatial 164 retinitis pigmentosa 165 polycystic ovary syndrome 166 csf 167 prolactin 168 kappa 169 gut 170 ca 171 chi 172 cord 173 vasoactive intestinal peptide Start A-Literature C-Literature B-list Filter Literature AB literature B-term BC literature acupuncture and brain akt brain and mechanisms 1: Age-related decrease in constructive activation of Akt/ PKB in SAMP10 hippocampus.2009 Add to clipboard 2: Astrocyte-conditioned medium protecting hippocampal neurons in primary cultures against corticosterone-induced damages via PI3-K /Akt signal pathway.2006 Add to clipboard 3: Potentiation of Akt and suppression of caspase-9 activations by electroacupuncture after transient middle cerebral artery occlusion in rats.2002 Add to clipboard 4: Enhanced expression of phospho -Akt by electro-acupuncture in normal rat brain.2002 Add to clipboard 1: Expression of PTEN and phosphorylated Akt in human cholesteatoma epithelium.2009 Add to clipboard 2: Kaempferol induces cell death through ERK and Akt- dependent down-regulation of XIAP and survivin in human glioma cells.2009 Add to clipboard 3: Progesterone potentiates calcium release through IP3 receptors by an Akt- mediated mechanism in hippocampal neurons.2009 Add to clipboard 4: Insulin-like growth factor-1 promotes G(1)/S cell cycle progression through bidirectional regulation of cyclins and cyclin-dependent kinase inhibitors via the phosphatidylinositol 3-kinase /Akt pathway in developing rat cerebral cortex.2009 Add to clipboard 5: Insulin activates the PI3K -Akt survival pathway in vulnerable neurons following global brain ischemia.2009 Add to clipboard 6: Selective CB2 receptor agonism protects central neurons from remote axotomy-induced apoptosis through the PI3K /Akt pathway.2009 Add to clipboard 7: ADAM17 promotes breast cancer cell malignant phenotype through EGFR-PI3K -AKT activation.2009 Add to clipboard 8: RIP1 activates PI3K -Akt via a dual mechanism involving NF-kappaB-mediated inhibition of the mTOR-S6K-IRS1 negative feedback loop and down-regulation of PTEN.2009 Add to clipboard 9: An involvement of BDNF and PI3-K /Akt in the anti-apoptotic effect of memantine on staurosporine-evoked cell death in primary cortical neurons.2009 Add to clipboard 10: Electrical stimulation of the cerebral cortex exerts antiapoptotic, angiogenic, and anti-inflammatory effects in ischemic stroke rats through phosphoinositide 3-kinase /Akt signaling pathway.2009 Add to clipboard 西医病症知识发现 http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/edit_b.cgi Start A-Literature C-Literature B-list Filter Literature A-query: acupuncture and brain C-query: brain and mechanisms The B-list contains title words and phrases (terms) that appeared in both the A and the C literature. 189 articles appeared in both literatures and were not included in the process of computing the B-list but can be viewed here . The results of this search are saved under id # 9955 and can be accessed from the start page after you leave this session. There are 40 terms on the current B-list ( 22 are predicted to be relevant), which is shown ranked according to predicted relevance. The list can be further trimmed down using the filters listed in the left margin. To assess whether there appears to be a biologically significant relationship between the AB and BC literatures for specific B-terms, please select one or more B-terms and then click the button to view the corresponding AB and BC literatures. Use Ctrl to select multiple B-terms. Rank Prob B-term 10.98epileptiform 20.965-ht 30.95related gene 40.93alcohol withdrawal 50.93epilepsy 60.89carpal tunnel syndrome 70.88alzheimer disease 80.88anxiety 90.86ih 100.85related gene brain 110.84obesity 120.83dystonia 130.80parkinson disease 140.79glioma 150.75calcitonin gene related 160.75gene related peptide 170.64pain 180.63lc 190.58retinitis pigmentosa 200.57polycystic ovary syndrome 210.54ca 220.52ache 230.51spastic 240.49gene related 250.49slow 260.42nervous 270.38obese 280.36death 290.36signal 300.35arc 310.33diabetes 320.18coma 330.10hypertension 340.08signal processing 350.05asthma 360.04activity 370.03blind 380.02cold 390.00red 400.00wind Restrict by semantic categories? job id # 9955 started Tue Feb 9 05:01:05 2010 Max_citations: 50000 Stoplist: /var/www/html/arrowsmith_uic/data/stopwords_pubmed Ngram_max: 3 9955 Search ARROWSMITH A A_query_raw: acupuncture and brain Tue Feb 9 05:02:04 2010 A query = acupuncture and brain started Tue Feb 9 05:02:04 2010 A query resulted in 1596 titles 9955 Search ARROWSMITH C 9955 Search ARROWSMITH C C_query_raw: brain and mechanisms Tue Feb 9 05:03:05 2010 C: brain and mechanisms 78574 A: pubmed_query_A 1596 AC: ( acupuncture and brain ) AND ( brain and mechanisms ) 189 C query = brain and mechanisms started Tue Feb 9 05:03:06 2010 C query resulted in 50000 titles A AND C query resulted in 189 titles 5606 B-terms ready on Tue Feb 9 05:06:39 2010 Sem_filter: Genes Molecular Sequences, and Gene Protein Names 344 B-terms left after filter executed Tue Feb 9 05:11:07 2010 Viewed B-terms Tue Feb 9 05:15:54 2010 akt Sem_filter: Disorders 40 B-terms left after filter executed Tue Feb 9 05:20:41 2010 B-list on Tue Feb 9 05:23:43 2010 1 epileptiform 2 5-ht 3 related gene 4 alcohol withdrawal 5 epilepsy 6 carpal tunnel syndrome 7 alzheimer disease 8 anxiety 9 ih 10 related gene brain 11 obesity 12 dystonia 13 parkinson disease 14 glioma 15 calcitonin gene related 16 gene related peptide 17 pain 18 lc 19 retinitis pigmentosa 20 polycystic ovary syndrome 21 ca 22 ache 23 spastic 24 gene related 25 slow 26 nervous 27 obese 28 death 29 signal 30 arc 31 diabetes 32 coma 33 hypertension 34 signal processing 35 asthma 36 activity 37 blind 38 cold 39 red 40 wind Start A-Literature C-Literature B-list Filter Literature AB literature B-term BC literature acupuncture and brain epilepsy brain and mechanisms 1: 2009 Add to clipboard 2: 2009 Add to clipboard 3: The effect of electroacupuncture on spontaneous recurrent seizure and expression of GAD(67) mRNA in dentate gyrus in a rat model of epilepsy .2008 Add to clipboard 4: Effect of electroacupuncture stimulation of hindlimb on seizure incidence and supragranular mossy fiber sprouting in a rat model of epilepsy .2008 Add to clipboard 5: Epilepsy , electroacupuncture and the nucleus of the solitary tract.2006 Add to clipboard 6: 1999 Add to clipboard 7: 1997 Add to clipboard 8: 1995 Add to clipboard 9: Effect of electroacupuncture on the level of preproenkephalin mRNA in rat during penicillin-induced epilepsy .1994 Add to clipboard 10: 1990 Add to clipboard 1: Evaluation of transport of common antiepileptic drugs by human multidrug resistance-associated proteins (MRP1, 2 and 5) that are overexpressed in pharmacoresistant epilepsy .2010 Add to clipboard 2: Abnormal self-location and vestibular vertigo in a patient with right frontal lobe epilepsy .2010 Add to clipboard 3: Physiologically Based Pharmacokinetic/Pharmacodynamic Animal-to-Man Prediction of Therapeutic Dose in a Model of Epilepsy .2010 Add to clipboard 4: Deep brain stimulation in epilepsy : what is next?2010 Add to clipboard 5: Posttraumatic epilepsy .2010 Add to clipboard 6: Aging models of acute seizures and epilepsy .2010 Add to clipboard 7: Altered Spontaneous Neuronal Activity of the Default-Mode Network in Mesial Temporal Lobe Epilepsy .2010 Add to clipboard 8: Kainate receptors in epilepsy and excitotoxicity.2009 Add to clipboard 9: LAMA2 stop-codon mutation: merosin-deficient congenital muscular dystrophy with occipital polymicrogyria, epilepsy and psychomotor regression.2009 Add to clipboard 10: Nodular heterotopia: a neuropathological study of 24 patients undergoing surgery for drug-resistant epilepsy .2009 Add to clipboard 11: Posttraumatic epilepsy after controlled cortical impact injury in mice.2009 Add to clipboard
http://www.gopubmed.org/web/gopubmed/1?WEB0105ikg454tcbmIrI1I00f01000j10040001rl 1 of 14,822 documents semantically analyzed top author statistics Term: 1917 Description: year 1917 Top Years Publications 1917 1 Top Journals Publications Am J Public Health (n Y) 1 Top Authors Publications Hill H 1 documents Title: ACUPUNCTURE : THE BEST METHOD OF VACCINATION. 针灸:接种最好的方法 PMID: 18009641 Related Articles Authors: Hill, H W Journal: Am J Public Health (N Y) , Vol. 7 (3): 301-2 , 1917 No abstract given. 针灸研究文献计量分析如下: 从美国PUBMED数据库中检索到针灸研究的总文献量14822篇,最早的文献报道是1917年《美国公共卫生杂志》的针灸:接种最好的方法。中国、美国、英国、日本的研究论文数量为前四名。北京、上海、首尔、广州、天津的研究论文数量为前五名。中医杂志、中国针灸、针刺研究、美国中医杂志的针灸研究论文报道量为前四名。主要研究主题为:针灸、针灸疗法、针灸穴位、电针、针刺麻醉、电刺激、灸术、疼痛测定等等。 14,822 documents semantically analyzed top author statistics 1 2 3 4 Top Years Publications 2009 1,080 2008 1,005 2007 938 2006 874 2005 780 2004 575 2003 521 2002 513 2001 426 1999 339 1990 336 1992 332 1987 330 1988 326 2000 325 1985 321 1998 319 1993 317 1989 313 1991 312 1 2 3 4 1 2 3 4 5 Top Countries Publications China 3,448 USA 1,522 United Kingdom 551 Japan 407 South Korea 381 Germany 372 Taiwan 267 Sweden 214 Canada 155 Australia 140 Italy 123 Austria 117 Brazil 79 Norway 68 France 64 Hong Kong S.A.R., China 59 Spain 52 Israel 52 Switzerland 51 Netherlands 50 1 2 3 4 5 1 2 3 ... 48 Top Cities Publications Beijing 805 Shanghai 431 Seoul 216 Guangzhou 181 Tianjin 162 Chengdu 145 Wuhan 134 New York 118 Nanjing 116 London 110 Boston 109 Taipei 100 Tokyo 79 Baltimore 76 Exeter 74 Zhengzhou 71 Kyoto 70 Hangzhou 69 Munich 62 Harbin 61 1 2 3 ... 48 1 2 3 ... 110 Top Journals Publications J Tradit Chin Med 1,129 Zhongguo Zhen Jiu 1,090 Zhen Ci Yan Jiu 850 Am J Chinese Med 362 Acupuncture Electro 328 J Altern Complem Med 268 Acupunct Med 266 Zhongguo Zhong Xi Yi Jie He Za Zhi 178 Minerva Med 137 Pain 125 Vopr Kurortol Fizioter Lech Fiz Kult 121 Neurosci Lett 117 Complement Ther Med 109 Am J Chin Med (gard City N Y) 107 J Altern Complement Med 94 Zhong Xi Yi Jie He Za Zhi 88 Sheng Li Xue Bao 85 Zh Nevropatol Psikhiatr Im S S Korsakova 85 Chinese Med J-peking 80 Jama-j Am Med Assoc 80 1 2 3 ... 110 1 2 3 ... 557 Top Terms Publications Humans 11,016 Acupuncture 10,139 Acupuncture Therapy 8,880 Adult 4,675 Patients 3,992 Middle Aged 3,736 Acupuncture Points 3,411 Animals 2,817 Electroacupuncture 2,392 Aged 2,128 Medicine 2,111 Evaluation Studies as Topic 1,821 Therapeutics 1,815 Needles 1,734 Pain 1,585 Rats 1,408 Treatment Outcome 1,407 Adolescent 1,407 Analgesia 1,298 Control Groups 1,298 1 2 3 ... 557 1 2 3 ... 1669 Top Authors Publications Han J 93 Ernst E 75 Berman B 56 Wu G 53 Lundeberg T 52 Cao X 50 Linde K 49 Lao L 39 Macpherson H 37 Melchart D 35 Wu B 35 Xu W 35 Litscher G 33 Omura Y 32 Rosted P 30 Lin J 30 Vickers A 29 Kaptchuk T 28 Willich S 28 Brinkhaus B 28 1 2 3 ... 1669
http://www.gopubmed.org/web/gopubmed/1?WEB0105ikg454tcbmI2I1I00f01000j10040001rl 1,596 documents semantically analyzed top author statistics 1 2 Top Years Publications 2009 117 2008 113 2007 113 2006 84 2005 69 1985 66 1990 60 2002 49 2004 49 1986 49 1996 46 2003 44 1993 44 1989 44 1988 43 1992 41 1995 40 1987 40 1991 38 1994 37 1 2 1 2 Top Countries Publications China 622 USA 117 South Korea 75 Japan 63 Taiwan 29 Austria 20 Germany 15 United Kingdom 15 Sweden 13 Hong Kong S.A.R., China 11 Spain 8 Italy 7 Turkey 5 Brazil 5 Denmark 4 India 4 Russia 4 Portugal 3 Singapore 2 France 2 1 2 1 2 3 ... 9 Top Cities Publications Beijing 157 Shanghai 141 Seoul 48 Guangzhou 39 Wuhan 34 Tianjin 33 Nanjing 21 Tokyo 19 Irvine 18 Zhengzhou 15 Hangzhou 15 Graz 15 Boston 13 Chengdu 13 Chongqing 12 Kyoto 12 Hong Kong 11 Shenyang 9 Suzhou 9 New York 7 1 2 3 ... 9 1 2 3 ... 18 Top Journals Publications Zhen Ci Yan Jiu 279 Acupuncture Electro 102 Zhongguo Zhen Jiu 85 Neurosci Lett 70 J Tradit Chin Med 67 Sheng Li Xue Bao 65 Am J Chinese Med 47 Zhongguo Zhong Xi Yi Jie He Za Zhi 37 Brain Res 34 Biull Eksp Biol Med 28 Zhongguo Yao Li Xue Bao 23 Neurol Res 17 Int J Neurosci 16 Brain Res Bull 16 J Altern Complem Med 16 Pain 15 Chinese Med J-peking 14 Zh Nevropatol Psikhiatr Im S S Korsakova 13 Med Hypotheses 12 Neuroimage 12 1 2 3 ... 18 1 2 3 ... 225 Top Authors Publications Han J 49 Cao X 34 Xu W 28 Wu G 26 Chen Z 24 Reshetniak V 22 Durinian R 19 Yin Q 18 Wang S 16 Liu X 16 Litscher G 15 Wang Y 14 Longhurst J 13 Cheng J 13 Xue S 13 Kim E 12 Zhou Z 12 Bragin E 11 Shim I 10 Tian J 10 1 2 3 ... 225 1 2 3 ... 204 Top Terms Publications Animals 1,009 Acupuncture 958 Acupuncture Therapy 773 Electroacupuncture 692 Humans 661 Rats 638 Acupuncture Points 487 Analgesia 386 Brain 373 Neurons 358 Adult 333 Electric Stimulation 308 Pain 308 Acupuncture Analgesia 301 Rats, Sprague-Dawley 237 Patients 218 Middle Aged 185 Hypothalamus 168 Needles 167 Anxiety 166 1 2 3 ... 204 1 of 1,596 documents semantically analyzed top author statistics Term: 1971 Description: year 1971 Top Years Publications 1971 1 Top Journals Publications Jama-j Am Med Assoc 1 Top Authors Publications Dimond E 1 Top Terms Publications Medicine, Chinese Traditional 1 Acupuncture Analgesia 1 Medicine, Traditional 1 Asian Continental Ancestry Group 1 Acupuncture 1 Medicine 1 Anesthesia 1 Acupuncture Therapy 1 Thyroidectomy 1 Thyroid Neoplasms 1 Stomach Ulcer 1 Middle Aged 1 Meperidine 1 Humans 1 China 1 Castration 1 Brain Neoplasms 1 Anesthesia, Local 1 Adult 1 Adenoma 1 documents Title: Acupuncture anesthesia. Western medicine and Chinese traditional medicine. PMID: 5171142 Related Articles Authors: Dimond, E G Journal: JAMA , Vol. 218 (10): 1558-63 , 1971 No abstract given. Pubmed MeSH: Acupuncture Therapy , Adenoma , Adult , Anesthesia, Local , Brain Neoplasms , Castration , China , Humans , Meperidine , Middle Aged , Stomach Ulcer , Thyroid Neoplasms , Thyroidectomy Wikipedia: Acupuncture , Anesthesia , Asian , Chinese , Chinese traditional medicine , Ethnomedicine , Folk medicine , Folk remedies , Folk remedy , Home remedies , Home remedy , Indigenous medicine , Japanese , Japanese Metabolism , Koreans , Medicine , Medicine, chinese traditional , Medicine, traditional , Mongoloid Race , Traditional Chinese Medicine , Traditional medicine http://news.sciencenet.cn/htmlnews/2010/2/228239.shtm 英研究显示针灸可引起大脑神经变化 英国研究人员日前报告说,利用现代科学手段检查中国传统针灸的效果,发现它可以引起大脑相应部位神经的变化,这有助于分析针灸的作用原理。 英国约克大学等机构的研究人员在新一期美国学术期刊《脑研究》( Brain Research )上报告说,17名受试者接受了手上合谷穴针灸,并同时接受大脑扫描。合谷穴位于手背虎口下方。研究人员发现,在那些认为有得气感觉的受试者中,与处理疼痛有关的大脑某部位神经出现活动降低的情况。 得气是指针灸过程中患者产生的酸、麻、胀等感觉,被认为是针灸取得效果的重要条件。如果针灸时患者没有得气而只是感觉疼痛,那么针灸效果可能不佳。本次研究发现,在仅感觉疼痛的患者中,大脑相关部位的神经出现复杂变化:一些部位的神经活动增强,而另一些部位的神经活动减弱。 参与研究的休麦克弗森说,这项研究提供了的科学证据说明,针灸可引起大脑产生一些特殊变化,这有助于理解针灸复杂的作用原理。 更多阅读 英国约克大学相关报道(英文) http://www.york.ac.uk/news-and-events/news/2010/acupuncture/ York study maps the effects of acupuncture on the brain Posted on 4 February 2010 Important new research about the effects of acupuncture on the brain may provide an understanding of the complex mechanisms of acupuncture and could lead to a wider acceptability of the treatment. The study, by researchers at the University of York and the Hull York Medical School published in Brain Research , indicates that acupuncture has a significant effect on specific neural structures. When a patient receives acupuncture treatment, a sensation called deqi can be obtained; scientific analysis shows that this deactivates areas within the brain that are associated with the processing of pain. These results provide objective scientific evidence that acupuncture has specific effects within the brain Dr Hugh Macpherson Dr Hugh MacPherson, of the Complementary Medicine Research Group in the Universitys Department of Health Sciences, says: These results provide objective scientific evidence that acupuncture has specific effects within the brain which hopefully will lead to a better understanding of how acupuncture works. Neuroscientist Dr Aziz Asghar, of the York Neuroimaging Centre and the Hull York Medical School, adds: The results are fascinating. Whether such brain deactivations constitute a mechanism which underlies or contributes to the therapeutic effect of acupuncture is an intriguing possibility which requires further research. Last summer, following research conducted in York, acupuncture was recommended for the first time by the National Institute for Health and Clinical Excellence (NICE) as a treatment option for NHS patients with lower back pain. NICE guidelines now state that GPs should consider offering a course of acupuncture comprising a maximum of 10 sessions over a period of up to 12 weeks for patients with this common condition. Current clinical trials at the University of York are investigating the effectiveness and cost-effectiveness of acupuncture for Irritable Bowel Syndrome (IBS) and for depression. Recent studies in the US have also shown that acupuncture can be an effective treatment for migraines and osteoarthritis of the knee. The York team believe that the new research could help to clear the way for acupuncture to be more broadly accepted as a treatment option on the NHS for a number of medical conditions. var addthis_config = { services_exclude: 'print' } Notes to editors: The paper Acupuncture needling sensation: The neural correlates of deqi using fMRI, Asghar, A.U.R., et al is available at http://dx.doi.org/10.1016/j.brainres.2009.12.019 . The research also involved scientists at University College London and the University of Southampton . More about the University of Yorks Department of Health Sciences at www.york.ac.uk/healthsciences/ . More about the Hull York Medical School at www.hyms.ac.uk/ . More about the York Neuroimaging Centre at www.ynic.york.ac.uk/