这个观点实际上与我去年的文章是类似的，我们去年提出的观点是内源性氢是一种抗氧化物质，这个文章的观点是有些糖尿病药物，可抑制能量物质吸收，有一个明显的副作用是大肠内产生气体，这类药物往往具有器官保护作用。过去一直不明白为什么这样。日本学者提出的这个观点，我是非常同意。过去1年我们课题组多次讨论到这个话题。可惜我们没有把这个观点形成文章。真的十分可惜。 Hypothesis Are the effects of -glucosidase inhibitors on cardiovascular events related to elevated levels of hydrogen gas in the gastrointestinal tract? References and further reading may be available for this article. To view references and further reading you must purchase this article. Yoshihiko Suzuki a , Motoaki Sano c , , , Kentaro Hayashida c , Ikuroh Ohsawa a , b , Shigeo Ohta a and Keiichi Fukuda c a Department of Biochemistry and Cell Biology, Institute of Development and Aging Science, Graduate School of Medicine, Nippon Medical School, Kawasaki City 211-8533, Japan b The Center of Molecular Hydrogen Medicine, Institute of Development and Aging Science, Graduate School of Medicine, Nippon Medical School, Kawasaki City 211-8533, Japan c Department of Regenerative Medicine and Advanced Cardiac Therapeutics, Keio University School of Medicine, Tokyo 160-8582, Japan Received 20 April 2009; revised 28 May 2009; accepted 31 May 2009. Available online 8 June 2009. Abstract The major side-effect of treatment with -glucosidase inhibitors, flatulence, occurs when undigested carbohydrates are fermented by colonic bacteria, resulting in gas formation. We propose that the cardiovascular benefits of -glucosidase inhibitors are partly attributable to their ability to neutralise oxidative stress via increased production of H 2 in the gastrointestinal tract. Acarbose, which is an -glucosidase inhibitor, markedly increased H 2 production, with a weaker effect on methane production. Our hypothesis is based on our recent discovery that H 2 acts as a unique antioxidant, and that when inhaled or taken orally as H 2 -dissolved water it ameliorates ischaemiareperfusion injury and atherosclerosis development. Keywords: -Glucosidase inhibitors; Type 2 diabetes; Hydrogen gas; Antioxidant Article Outline 1. Introduction 2. Molecular hydrogen (H 2 ) acts as a novel antioxidant 3. Unexpected benefit of flatulence caused by -glucosidase inhibitors 4. Conclusion Conflict of interest statement Acknowledgements References Fig. 1.Effects of acarbose on the levels of exhaled H 2 and CH 4 . The values shown in the bar graphs are meansS.D. View Within Article Table 1. Eleven healthy volunteers (10 males and 1 female) were administered acarbose at a dosage of 300mg/day (100mg three times a day) for 4 days under free-feeding conditions. Exhaled gas was collected in an aluminium bag at the point of mid-expiration at the indicated time-points (i.e., morning, before lunch, 2h after lunch, before retiring), both before and after acarbose treatment. The exhaled gas samples were injected into the Breath Gas Analyzer to measure the H 2 and CH 4 concentrations. View Within Article Corresponding author. Address: Department of Regenerative Medicine and Advanced Cardiac Therapeutics, Keio University School of Medicine, 35 Shinanomachi Shinjuku-ku, Tokyo 160-8582, Japan. Fax: +81 3 5363 3875. 全文下在这里 111
标签: 糖尿病药物
