德国亥姆霍兹慕尼黑中心2015年公开博士后招聘项目 International Postdoctoral Fellowship Program at Helmholtz Zentrum München, Germany Please find below the link to the poster announcing the international call for applications to the second round of the Postdoctoral Fellowship Program at Helmholtz Zentrum München, Germany: We would be very grateful if you bring our program to the attention of your young scientists and post this announcement at a bulletin board in your institution. As German Research Center for Environmental Health, Helmholtz Zentrum München pursues the goal of developing personalized medical approaches for the prevention and therapy of major common diseases such as diabetes mellitus and lung diseases. Helmholtz Zentrum München is a member of the Helmholtz Association, Germany's largest scientific organization. The program supports highly talented postdocs in the development of a competitive scientific profile for a successful scientific career in academic research or industry. For the PFP2015, we are recruiting postdocs for the following research subjects: • Mechanisms of soma-to-germline information transfer and transgenerational epigenetic inheritance (Institute of Experimental Genetics) • RNA processing splicing (Institute of Molecular Toxicology and Pharmacology) • High-dimensional integration of omics and phenotypic screening data (Institute of Computational Biology) • Deciphering the functional role of the proteasomal activator PA200 in vivo (Institute of Lung Biology and Disease) • Machine learning in high-dimensional biological data sets (Institute of Computational Biology) Talented postdocs who are accepted into the three-year program will focus on a research project and will be integrated into international and interdisciplinary research groups at the Center. An experienced research mentor and a personal coach will create an individual career plan together with the postdoctoral fellows and prepare them for their next career step in scientific leadership positions. Personal travel grants will enable them to meet up regularly with international colleagues to exchange ideas and to build up international networks. In addition to a modular training program for acquiring leadership qualifications, the postdoctoral fellows will receive professional assistance in acquiring external funding. The deadline for applications is April 15, 2015. Shortlisted candidates will be invited to attend our interview days on July 1-3, 2015 in Munich. Application guidelines and further information can be found on our website: www.helmholtz-muenchen.de/fellows Please do not hesitate to contact us if you want further information. Thank you in advance for your support in advertising our program. With kind regards Dr. Monika Beer and Dr. Arlett Heiber Program Planning and Management Scientific Education and Training Phone: +49 89 3187 3409 Fax: +49 89 3187 3372 Email: arlett.heiber@helmholtz-muenchen.de -------------------------------------------------------------------------------- Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Ingolstauml;dter Landstr. 1 85764 Neuherberg www.helmholtz-muenchen.de
吸烟有害健康这早就是常识,然后对于习惯了吸烟者而言,烟瘾难止。 早一天放弃吸烟,早一天有益身体,这个观念却还没有深入人心。现在亥姆霍兹慕尼黑中心的一个主要由华人科学家构成的团队从以往的阵列数据KORA中找出可靠科学证据:只要放弃吸烟,立刻可以从代谢组学的水平上发现损害恢复的客观证据。 http://www.helmholtz-muenchen.de/en/news/press-releases-2013/press-release/article/21007/index.html Smoking Cessation Can Reverse Smoking-Related Changes in MetabolitesNeuherberg, March 4, 2013. Stopping smoking can significantly reverse smoking-associated changes in metabolite concentrations. Quitting smoking reduce disease risks including cardiovascular diseases. These results are found by scientists from Helmholtz Zentrum München based on analysis in a population-based cohort study. The findings were published in the journal “BMC Medicine”. Foto (l.t.r.): Zhonghao Yu, Dr. Rui Wang-Sattler, Tao Xu Smoking causes health problems and induces changes in metabolite concentrations, which are reversible after stopping smoking. These results are consistent with decreased risk of cardiovascular diseases, such as myocardial infarction after smoking cessation. Scientists from the Research Unit of Molecular Epidemiology (AME), the Institute of Experimental Genetics (IEG) and the Institute of Epidemiology II (EPI II) at Helmholtz Zentrum München analyzed over 1,200 blood samples of the population-based cohort KORA (Cooperative Health Research in the Region of Augsburg). Metabolite profiles and smoking status were recorded at both baseline and at the follow-up seven years later. The team led by Dr. Rui Wang-Sattler, Tao Xu, Zhonghao Yu, Prof. Dr. Jerzy Adamski and Prof. Dr. Annette Peters, identified 21 smoking-related metabolites, mainly from amino acid and lipid pathways. Among them, 19 metabolites were found to be reversible had the smokers given up smoking. Furthermore, the smoking-related metabolites from the urea cycle and from modified lipids, such as phosphatidylcholine, were also shown as risk factors for cardiovascular diseases. The scientists thus demonstrated the remarkable benefits of smoking cessation in reducing health problems. The affected metabolic pathways elucidate further health consequences of smoking. “Our study demonstrates metabolomics as a powerful tool in systems biology with which we could investigate how the lifestyle and environmentally related to diseases”, said Dr. Wang-Sattler, head of the research group “Metabolism” in AME. Environmental factors and lifestyle play a key role in the pathogenesis of diseases that are widespread in Germany, such as cardiovascular diseases and diabetes mellitus. The goal of Helmholtz Zentrum München is to develop new approaches for the diagnosis, treatment and prevention of the major diseases.
亥姆霍兹慕尼黑中心及德国糖尿病中心王瑞博士所在的团队率先发现并在最新一期《分子系统生物学》杂志上报导了三种可用于诊断早期糖尿病的生物标志物。此前尚从未有人找出过可供早期糖尿病诊断的相应标志物。 这是一个由王瑞所负责的亥姆霍兹慕尼黑中心的分子表观遗传学团队与该中心 Jerzy Adamski教授负责的 基因组分析中心暨代谢组学平台的 共同合作的成果。两种标志物可以用于判断患病风险。 http://www.helmholtz-muenchen.de/en/news/press-releases-2012/press-release/article/19841/index.html Wang-Sattler, R et al.(2012) Novel biomarkers for pre-diabetes identified by metabolomics, Molecular Systems Biology (8): doi:10.1038/msb.2012.43 —————————————————————— First diagnostic markers for pre-diabetes discovered Neuherberg, 25.09.2012. Detecting a predisposition to type 2 diabetes and preventing the disease before it develops is possible based on a current study by scientists at the Helmholtz Zentrum München. In the latest edition of Molecular Systems Biology they describe for the first time three biomarkers that can indicate pre-diabetes. Image: (from the left side to the right): Dr. Ana Messias, Prof. Annette Peters, Dr. Rui Wang-Sattler The current study by scientists at the Helmholtz Zentrum München and the German Center for Diabetes Research, which appears in the latest edition of the renowned journal Molecular Systems Biology, reports for the first time on new biomarkers of pre-diabetes. Up to now, no specific biomarkers have been available for the early form of diabetes, one of the most important common diseases. headed by Dr. Rui Wang-Sattler, who leads a working group in the Research Unit of Molecular Epidemiology, and Professor Jerzy Adamski, Head of Genome Analysis Center and the metabolomics platform at Helmholtz Zentrum München, identified identified three new biomarkers of pre-diabetes, two of which predicted the risk of the disease in individuals. “As the concentration of the biomarkers in blood are indicative of pre-diabetes, our study suggests that preventive measures can be taken,” says corresponding author Dr. Wang-Sattler, explaining the impact of the new discovery. If type 2 diabetes is diagnosed in early stages, such as pre-diabetes, disease development can be arrested or even prevented. Between about 8-10% of the German population suffers from type 2 diabetes mellitus, a disorder of glucose metabolism. New approaches to the diagnosis, therapy and prevention of this common disease are the scientific objectives of the Helmholtz Zentrum München. For the study, Dr. Wang-Sattler collaborated with several institutes at the Helmholtz Zentrum München, two partners from the German Center for Diabetes Research, the German Diabetes Center in Düsseldorf, and the German Institute of Human Nutrition in Potsdam-Rehbrücke. Further information Database and scientific team Metabolomics analysis was used to identify biomarkers from the KORA (Cooperative Health Research in the Augsburg Region) cohort and verified with data from the EPIC (European Prospective Investigation into Cancer and Nutrition) study. Dr. Rui Wang-Sattler and Mr. Zhonghao Yu of the Research Unit Molecular Epidemiology (acting Head, Prof. Annette Peters) cooperated with Dr. Ana Messias (Institute of Structural Biology), Prof. Thomas Meitinger (Director, Institute of Human Genetics), Prof. Martin Hrabě de Angelis (Director, Institute for Experimental Genetics), Prof. Jerzy Adamski (Head of the Genome Analysis Center) and Prof. Annette Peters (Director, Institute of Epidemiology II). The study was led by Dr. Christian Herder and Prof. Michael Roden at the German Diabetes Center in Düsseldorf. Original Publication Wang-Sattler, R et al.(2012) Novel biomarkers for pre-diabetes identified by metabolomics, Molecular Systems Biology (8): doi:10.1038/msb.2012.43 Link to specialist publication The Helmholtz Zentrum München , the German Research Center for Environmental Health, pursues the goal of developing personalized medicine, i.e. a customized approach to the diagnosis, treatment and prevention of widespread diseases such as diabetes mellitus and lung disease. To that end, it investigates the interaction of genetics, environmental factors and lifestyle. The Helmholtz Zentrum München is headquartered in Neuherberg in the north of Munich. It has about 2,000 staff members and is a member of the Helmholtz Association, Germany’s largest scientific organization, a community of 18 scientific-technical and medical-biological research centers with some 34,000 staff members. The Helmholtz Zentrum München is a partner in the German Center for Diabetes Research. www.helmholtz-muenchen.de The German Center for Diabetes Research e.V. is a noational network combining diabetes experts from basic research, epidemiology and clinical applications. The members of the association are Helmholtz Zentrum München German Research Center for Environmental Health, the German Diabetes Center in Düsseldorf, the German Institute of Human Nutrition in Potsdam-Rehbrücke, the Paul Langerhans Institute of the Carl Gustav Carus University Hospital in Dresden and Helmholtz Zentrums München’s Institute of Diabetes Research and Metabolic Diseases the Eberhard Karl University of Tübingen. The aim of the DZD is to find answers to unsolved questions in diabetes research by adopting a novel, integrative approach and to make a significant contribution towards improving the prevention, diagnosis and treatment of diabetes mellitus. _______________________________________________________________________________ Specialist contact Dr. Rui Wang-Sattler, Department of Molecular Epidemiology, Helmholtz Zentrum München – the German Research Center for Environmental Health (GmbH), Ingolstädter Landstr. 1, 85764 Neuherberg - Tel: +49 89-3187-3978 - Fax: +49 89-3187-2428 -
慕尼黑归来,收获颇丰,简要记一笔。 国际催化大会 (International Congress on Catalysis , ICC) 是目前世界范围内规模最大、学术水平最高、影响最广泛的催化大会。国际催化学会理事会( The International Association for Catalysis Societies )每四年在不同国家和地区举办国际催化大会,迄今为止已经成功举办了十五届。 7 月 1-6 日,第十五届国际催化大会( 15th ICC )在德国慕尼黑举行,主题为 “From fundamental understanding to catalyst design and novel processes” 。 会议主席为: 德国慕尼黑工业大学化学系 Johannes A. Lercher 教授。 下一届国际催化大会将在中国北京举行。 本次大会收录的稿件约 2500 篇,其中选出口头报告 205 篇,其中来自我们中国的报告共有 22 篇,分别来自中科院大连化学物理研究所 5 篇,浙江大学 2 篇,中国石油大学(北京) 2 篇,华东理工大学 2 篇,华中科技大学,清华大学,南京大学,吉林大学,厦门大学,天津大学,兰州化学物理研究所,大连理工大学,北京化工大学,沈阳金属研究所各 1 篇。(通讯单位非国内的暂未计入 )(以上信息是小木虫上拷来的,会前统计的,未经核实,大概差不多吧)。 化物所的包信和,张涛,李灿等都是keynote报告,另外还有中石化的谢在库也做了报告。都去听了,一如既往的精彩! 这次会议除了每天两个大会报告外,分组的口头报告只有 5 个会场。因为口头报告数量的减少,比上届在韩国举行的报告质量有所提高。一路听下来,似乎大部分口头报告都是知名教授做的,很值得一听。值得一提的是会议首次采用了 Poster Symposia 的形式,从诸多的poster里面选出了部分poster,分 44 个专题举行了小组讨论和报告。每个选中的poster报告 5 分钟,讨论3分钟,有两个主持人主持讨论。因为选题范围比较专,参加的人都是对这个课题比较感兴趣的,所以效果还是不错。另外大会采用了E-poster的方式,会场有好几个区域摆放了好多台电脑,可以直接通过姓名及poster编号查找浏览想看的poster,非常方便。 一共 6 个大会报告,外加两个获奖的大会报告,其中一个是: Heinz Heinemann award ,获奖人是英国 University of Cardiff 大学的 G Hutchings教授 。该奖是以国际催化大会的发起人 Heinz Heinemann 命名的。获奖报告的题目是: catalysis using gold nanoparticles ,四年一次,世界范围内每次一个人。另外一个获奖报告是国际催化大奖( international catalysis award ),大家应该熟悉, 2004 年,李灿院士曾获得这个奖。本次获奖报告的题目是: catalysts liven and up close: heterogeneities in space and time, B.M. Weckhuysen, Ultrecht University/ NL 。 下面是大会报告的题目及报告人: OVERVIEW PLENARY LECTURES • Monday, July 2, 2012 09:30 Water splitting on heterogeneous photocatalysts K. Domen , University of Tokyo/J 13:50 Computational chemistry: a guide for understanding catalysts structure and function P. Sautet, Ecole Normale Supérieure of Lyon and CNRS/F • Tuesday, July 3, 2012 09:00 Engineering polyolefin solutions using advanced catalysis C. Kresge , Dow Chemical Company, Midland, MI/USA • Wednesday, July 4, 2012 09:00 Models in heterogeneous catalysis: what has been learned? H. Freund, Fritz-Haber-Institute, Berlin/D • Thursday, July 5, 2012 09:00 Progress towards understanding the relationships between catalyst composition and structure and catalyst activity and selectivity A. Bell, University of California, Berkeley, CA/USA • Friday, July 6, 2012 09:00 Design and study of molecular catalysts for small molecule activation and conversion R. Periana , The Scripps Research Institute, Jupiter, FL/USA 从大会的议题和大会报告的选题上可以看出主流的催化研究议题: 第一个报告是东京大学的 Domen 教授,他的成就是在光解水催化剂研究方面。主持人介绍的时候说这是一个可以获得诺贝尔奖的题目。从其余几个报告题目里,大家可以看出理论计算及模型反应在催化研究中的重要性,很多报告中都有涉及。生物质转化也是目前当仁不让的一个热门课题。 15th ICC 主要内容涵盖创新催化剂设计;催化机理研究;先进催化反应工程;能源和燃料催化;精细化学品催化合成;绿色可持续催化研究;工业催化等研究方向。 这是大会的会场图片,特别喜欢会场主席台上摆放的黄色的鲜花,煞是好看,可惜相机不好,没拍下来。下面附几张照片,大家将就着看看吧。 A.T Bell 和李灿院士给 Hutchings 授奖。 谈点自己的感受:几个大会报告中,我比较 Enjoy 的是 Hutchings 和 Bell 的报告,从实验上来看,其实他们做的实验都很常见,但是提升的高度却很很高。特别是 Hutchings ,从 concluding Remarks 来看,结论都很朴实的,但是却篇篇都是 Nature , Science 等级别的文章。听两个老人将毕生的科研结果及对科研的认识,娓娓道来,让人感受到科研的魅力和催化科学的神奇。另外B.M. Weckhuysen的获奖报告做的激情洋溢,从原子尺度到宏观尺度的原位表征工作做的非常漂亮,幻灯片做的真是让人叹为观止!报告听下来,很容易被这些顶尖科学家对催化工作的激情所感染! 两个主席, Leitner 说感谢慕尼黑工业大学的全体学生为会议做志愿者, Lercher 纠正说,应该说应该感激整个慕尼黑高校的学生。 闭幕式上李灿主席做总结发言, Muhler 宣布下一届世界催化会议将在北京举行,并播放了北京申办世界催化会议的宣传片。中国几代催化人努力争取,终于取得了世界催化大会的举办权,值得庆贺。 另外,会议期间发生了一个好玩的事情值得一记:由于口头报告的会场较少,经常发现去听的时候,会场已经满了,其中 14b 会场的保安特别认真,一旦满了以后,守在门口不让人进,只好在门口排队等着,出来一个放进去一个。这种情况很少见吧,德国人的认真可见一斑。有次在会场门口排队等候的时候偶遇 Bell 教授:他看到门口等了那么多人,很不解的问到: what's happening? 我就跟他说了下情况,他开玩笑的说:“ Even Me ?” …… 给个此次会议的地址链接, http://events.dechema.de/events/en/icc2012.html ,网站上有个好消息: Pictures / Impressions of the congress will be available till end of August .没去过的人也可以去浏览下啦!
像《苏菲的世界》的作者乔斯坦·贾德一样,我们是一群向孩子们传递哲学知识的人。在信息时代,我们希望能够借助您的力量建立起一个真正属于孩子的哲学王国…… 应征者需熟悉 HTML5 和 CSS3 协议(若能掌握 PHP5 或 Java 则更佳,但不作为硬性要求)。具体工作内容如下: 项目 A :儿童哲学项目网站 l 设计面向儿童的网站 l 网站框架需包括:文本,视频,音频,图像和游戏等内容 l 网页内容元素可供选择的要素有:技术,教育,数学、自然科学,机器人,哲学,当然还有我们项目的 logo ——一只名叫 Sophia Sophos 的猫头鹰 l 网站建议为三列设计,对 9-12 岁的儿童友好,且确保儿童可以建立新的帐户、博客等 l 已有的一些网站设计可以参见: www.toggolino.de , www.sesamestreet.org 等,但请不要照搬哦 一些总结性的提示: l 希望您能带来一些设计性的思路而不仅仅是技术编码支持 l 网站将在 DRUPAL 7 环境下运行 l 完成时间:不多于 4 周 l 预期酬劳: 150-300 欧元(或等值人民币,取决于设计效果) 项目 B : Quantius – 度量正义项目网站 l 设计 / 改进我们已有的项目网站: www.quantius.org l 网站框架需包括:文本,视频,音频,图像, Twitter ,数据库 / 博客等内容 l 网页内容元素可供选择的要素有:法律,数学、自然科学,机器人,哲学等 l 网站建议为三列设计,参见我们原来的网站 一些总结性的提示: l 希望您能带来一些设计性的思路而不仅仅是技术编码支持 l 网站将在 DRUPAL 7 环境下运行 l 完成时间:不多于 2 周 l 预期酬劳: 150 欧元左右(或等值人民币,取决于设计效果) 有意者请站内或同chadwick@126.com联系,并提供设计过的网站小样 J
已经不是第一次来这个城市了,不过还是第一次两个人来。老板也由此戏称,我的学术访问级别已经到达了如此的高度……虽然是无心,还是很高兴能够避开五一的“新纳粹”游行。到慕尼黑的时候,已经是5月4号的早上5:30了。每一次都会慨叹德国人的办事效率,几乎在你到达机场的同时托运行李就会在传送带上等候。然而更加令人惊奇的是,可爱的Zvi童鞋早就在机场等候我们的到来。 见到友人总是异常的开心,七七八八的在地铁上就聊起工作,聊起未来。不知不觉就到了公寓的驻地,一个叫做Leuchtenberg的地方。我们住的是一个犹太人经营的公寓,家里很干净。听说善良的房东太太为了欢迎我们的到来,竟然又重新粉刷了墙壁,买了新的洗碗机。家里的设施也是一应俱全,关键是很多布置、陈设都能透出一丝温馨。公寓离地铁地铁车站很近,周围还有三四家超市——相比之下,异国他乡的五十平米比鸟不拉屎的深圳可是强多了!第一天的主要任务就是收拾东西、熟悉环境和倒时差。吃过晚饭(多亏带了方便面)竟然决定走到市中心的Marienpl去看看,然后我们也真的拿着地图一点一点的做到了。德国的商店一般都是8-20点开门(周日还休息),而大部分人在这个时候都要上班。所以很多人就会到晚上去橱窗前去做eye shopping——当然店家也很配合:不但橱窗都灯火通明,所有的商品也都明码标价。第二天的任务依然如此,不过多了Zvi同学带我们寻找各处便利设施,比如能买到中国米的亚洲超市。 第三天就基本上不敢瞎跑了。因为第一天到慕尼黑,Zvi就带来一个噩耗:我需要在7号给这边的学生做一次Seminar——虽然早在来德国之前就知道我有这样一项工作,但从来都没想着有这么快。整个一天都在抓心挠肝地想如何组织课堂,如果用通俗的语言表明观点。Seminar的题目是“History and Philosophy of Machines and Automata: Or How to Climb the Ladder of Social and Individual Evolution”。课程面向的是TUM工科院系的学生,旨在提高他们作为科学家和工程师的人文素养——毕竟他们才是最有可能改变未来的一批人。多亏Robin同学到清华来访时的讲习班,才让我产生了Seminar的灵感。演讲的题目我引用了莎士比亚最著名的一句话,“To be or not to be”来探讨技术与社会之间的关系。整个讲座分成四部分,首先是最通俗和朴素的控制论观点,即技术在社会的控制之下乃至失控的风险;然后是技术如何被社会所建构/形塑,即用社会的一端去解释技术的一端;进而是社会技术想象的观点,强调技术和社会秩序的共同生产和演化;最后是去反思上述进路中所谈到的社会究竟为何物,是否存在一个技术-社会关系意义上的社会(部分内容参见下图)。 PPT做到晚上一点多,第二天早上起来又马上一遍遍的温习,毕竟这是我第一次在外国著名大学的课堂上去做如此长时段的演讲。可以说是功夫不负有心人,presentation做了一个多小时,看同学们的反馈也算是比较成功——虽然选课的同学几乎都是清一色的第三世界国家。然后比较奇怪的是,他们对老师表达感谢的方式不是鼓掌而是敲桌子,不知道的话还真容易吓一跳~ 对于我的报告,这边的老师反映也不错,还邀请我把这个写成一篇文章放在他们的一本书里出版。刚刚又那种无债一身轻的感觉,小夹板马上又给套上了……不过能够得到外国大学的肯定,还是很高兴滴。为了表示庆祝,我俩还特地跑到了著名的OEZ购物中心shopping,不过也没买到啥。但是令人振奋的消息就是买东西可以退税哇,咔咔! 今天约了Zvi同学去郊游,自带食物去酒庄,哈哈~ 好好体验一下西方人的生活方式。下周就要正式上班了,还不知道会面临怎样的挑战。You tell me