吸烟有害健康这早就是常识,然后对于习惯了吸烟者而言,烟瘾难止。 早一天放弃吸烟,早一天有益身体,这个观念却还没有深入人心。现在亥姆霍兹慕尼黑中心的一个主要由华人科学家构成的团队从以往的阵列数据KORA中找出可靠科学证据:只要放弃吸烟,立刻可以从代谢组学的水平上发现损害恢复的客观证据。 http://www.helmholtz-muenchen.de/en/news/press-releases-2013/press-release/article/21007/index.html Smoking Cessation Can Reverse Smoking-Related Changes in MetabolitesNeuherberg, March 4, 2013. Stopping smoking can significantly reverse smoking-associated changes in metabolite concentrations. Quitting smoking reduce disease risks including cardiovascular diseases. These results are found by scientists from Helmholtz Zentrum München based on analysis in a population-based cohort study. The findings were published in the journal “BMC Medicine”. Foto (l.t.r.): Zhonghao Yu, Dr. Rui Wang-Sattler, Tao Xu Smoking causes health problems and induces changes in metabolite concentrations, which are reversible after stopping smoking. These results are consistent with decreased risk of cardiovascular diseases, such as myocardial infarction after smoking cessation. Scientists from the Research Unit of Molecular Epidemiology (AME), the Institute of Experimental Genetics (IEG) and the Institute of Epidemiology II (EPI II) at Helmholtz Zentrum München analyzed over 1,200 blood samples of the population-based cohort KORA (Cooperative Health Research in the Region of Augsburg). Metabolite profiles and smoking status were recorded at both baseline and at the follow-up seven years later. The team led by Dr. Rui Wang-Sattler, Tao Xu, Zhonghao Yu, Prof. Dr. Jerzy Adamski and Prof. Dr. Annette Peters, identified 21 smoking-related metabolites, mainly from amino acid and lipid pathways. Among them, 19 metabolites were found to be reversible had the smokers given up smoking. Furthermore, the smoking-related metabolites from the urea cycle and from modified lipids, such as phosphatidylcholine, were also shown as risk factors for cardiovascular diseases. The scientists thus demonstrated the remarkable benefits of smoking cessation in reducing health problems. The affected metabolic pathways elucidate further health consequences of smoking. “Our study demonstrates metabolomics as a powerful tool in systems biology with which we could investigate how the lifestyle and environmentally related to diseases”, said Dr. Wang-Sattler, head of the research group “Metabolism” in AME. Environmental factors and lifestyle play a key role in the pathogenesis of diseases that are widespread in Germany, such as cardiovascular diseases and diabetes mellitus. The goal of Helmholtz Zentrum München is to develop new approaches for the diagnosis, treatment and prevention of the major diseases.
亥姆霍兹慕尼黑中心及德国糖尿病中心王瑞博士所在的团队率先发现并在最新一期《分子系统生物学》杂志上报导了三种可用于诊断早期糖尿病的生物标志物。此前尚从未有人找出过可供早期糖尿病诊断的相应标志物。 这是一个由王瑞所负责的亥姆霍兹慕尼黑中心的分子表观遗传学团队与该中心 Jerzy Adamski教授负责的 基因组分析中心暨代谢组学平台的 共同合作的成果。两种标志物可以用于判断患病风险。 http://www.helmholtz-muenchen.de/en/news/press-releases-2012/press-release/article/19841/index.html Wang-Sattler, R et al.(2012) Novel biomarkers for pre-diabetes identified by metabolomics, Molecular Systems Biology (8): doi:10.1038/msb.2012.43 —————————————————————— First diagnostic markers for pre-diabetes discovered Neuherberg, 25.09.2012. Detecting a predisposition to type 2 diabetes and preventing the disease before it develops is possible based on a current study by scientists at the Helmholtz Zentrum München. In the latest edition of Molecular Systems Biology they describe for the first time three biomarkers that can indicate pre-diabetes. Image: (from the left side to the right): Dr. Ana Messias, Prof. Annette Peters, Dr. Rui Wang-Sattler The current study by scientists at the Helmholtz Zentrum München and the German Center for Diabetes Research, which appears in the latest edition of the renowned journal Molecular Systems Biology, reports for the first time on new biomarkers of pre-diabetes. Up to now, no specific biomarkers have been available for the early form of diabetes, one of the most important common diseases. headed by Dr. Rui Wang-Sattler, who leads a working group in the Research Unit of Molecular Epidemiology, and Professor Jerzy Adamski, Head of Genome Analysis Center and the metabolomics platform at Helmholtz Zentrum München, identified identified three new biomarkers of pre-diabetes, two of which predicted the risk of the disease in individuals. “As the concentration of the biomarkers in blood are indicative of pre-diabetes, our study suggests that preventive measures can be taken,” says corresponding author Dr. Wang-Sattler, explaining the impact of the new discovery. If type 2 diabetes is diagnosed in early stages, such as pre-diabetes, disease development can be arrested or even prevented. Between about 8-10% of the German population suffers from type 2 diabetes mellitus, a disorder of glucose metabolism. New approaches to the diagnosis, therapy and prevention of this common disease are the scientific objectives of the Helmholtz Zentrum München. For the study, Dr. Wang-Sattler collaborated with several institutes at the Helmholtz Zentrum München, two partners from the German Center for Diabetes Research, the German Diabetes Center in Düsseldorf, and the German Institute of Human Nutrition in Potsdam-Rehbrücke. Further information Database and scientific team Metabolomics analysis was used to identify biomarkers from the KORA (Cooperative Health Research in the Augsburg Region) cohort and verified with data from the EPIC (European Prospective Investigation into Cancer and Nutrition) study. Dr. Rui Wang-Sattler and Mr. Zhonghao Yu of the Research Unit Molecular Epidemiology (acting Head, Prof. Annette Peters) cooperated with Dr. Ana Messias (Institute of Structural Biology), Prof. Thomas Meitinger (Director, Institute of Human Genetics), Prof. Martin Hrabě de Angelis (Director, Institute for Experimental Genetics), Prof. Jerzy Adamski (Head of the Genome Analysis Center) and Prof. Annette Peters (Director, Institute of Epidemiology II). The study was led by Dr. Christian Herder and Prof. Michael Roden at the German Diabetes Center in Düsseldorf. Original Publication Wang-Sattler, R et al.(2012) Novel biomarkers for pre-diabetes identified by metabolomics, Molecular Systems Biology (8): doi:10.1038/msb.2012.43 Link to specialist publication The Helmholtz Zentrum München , the German Research Center for Environmental Health, pursues the goal of developing personalized medicine, i.e. a customized approach to the diagnosis, treatment and prevention of widespread diseases such as diabetes mellitus and lung disease. To that end, it investigates the interaction of genetics, environmental factors and lifestyle. The Helmholtz Zentrum München is headquartered in Neuherberg in the north of Munich. It has about 2,000 staff members and is a member of the Helmholtz Association, Germany’s largest scientific organization, a community of 18 scientific-technical and medical-biological research centers with some 34,000 staff members. The Helmholtz Zentrum München is a partner in the German Center for Diabetes Research. www.helmholtz-muenchen.de The German Center for Diabetes Research e.V. is a noational network combining diabetes experts from basic research, epidemiology and clinical applications. The members of the association are Helmholtz Zentrum München German Research Center for Environmental Health, the German Diabetes Center in Düsseldorf, the German Institute of Human Nutrition in Potsdam-Rehbrücke, the Paul Langerhans Institute of the Carl Gustav Carus University Hospital in Dresden and Helmholtz Zentrums München’s Institute of Diabetes Research and Metabolic Diseases the Eberhard Karl University of Tübingen. The aim of the DZD is to find answers to unsolved questions in diabetes research by adopting a novel, integrative approach and to make a significant contribution towards improving the prevention, diagnosis and treatment of diabetes mellitus. _______________________________________________________________________________ Specialist contact Dr. Rui Wang-Sattler, Department of Molecular Epidemiology, Helmholtz Zentrum München – the German Research Center for Environmental Health (GmbH), Ingolstädter Landstr. 1, 85764 Neuherberg - Tel: +49 89-3187-3978 - Fax: +49 89-3187-2428 -