http://www.bioon.com/biology/cancer/410690.shtml 美国最新研究成果显示，经常锻炼身体可降低男性患前列腺癌的风险。 美国杜克大学医学中心科研人员在9月刊的《泌尿学杂志》上报告说，这一结论是他们跟踪调查190名男性后得出的。调查发现，久坐不动的人要比经常保持适度活动的人更容易罹患前列腺癌，所谓适度活动是指每周慢走数小时。此外，经常适度锻炼身体还有助于缓解前列腺癌患者的病情。 报告主要作者安东涅尼说，随着运动量增加，患前列腺癌的风险会随之降低。 前列腺癌是仅次于肺癌的男性常见癌症，全球每年约有25万名男性死于前列腺癌。（ 生物谷 Bioon.com） 生物谷推荐原始出处： The Journal of Urology 16 September 2009 doi:10.1016/j.juro.2009.07.028 Exercise and Prostate Cancer Risk in a Cohort of Veterans Undergoing Prostate Needle Biopsy Jodi A. Antonelliae, Lee W. Jonesb, Lionel L. Ba?ezae, Jean-Alfred Thomasae, Kelly Andersonae, Loretta A. Taylorae, Leah Gerberae, Tiffany Andersonef, Catherine Hoyoc, Delores Grantf, Stephen J. Freedlandade a Duke Prostate Center, Division of Urologic Surgery, Duke University Medical Center, Durham, North Carolina b Robert Preston Tisch Brain Tumor Center, Duke University Medical Center, Durham, North Carolina c Department of Surgery, Department of Community and Family Medicine, Duke University Medical Center, Durham, North Carolina d Department of Pathology (SJF), Duke University Medical Center, Durham, North Carolina e Section of Urology, Department of Surgery, Durham Veterans Affairs Medical Center, Durham, North Carolina f JLC-Biomedical/Biotechnology Research Institute, Cancer Research Program, North Carolina Central University, Durham, North Carolina Purpose Epidemiological and molecular evidence suggest potential associations between exercise and prostate cancer risk reduction. We further characterized this relationship by examining exercise and cancer risk among men undergoing prostate needle biopsy. Materials and Methods A total of 190 men who underwent prostate biopsy at the Durham Veterans Affairs Medical Center completed a questionnaire on current exercise behavior. Participants were asked average frequency of mild, moderate and strenuous intensity exercise in a typical week, as well as average duration as assessed by the Godin Leisure Time Exercise Questionnaire. Total current exercise was calculated in terms of metabolic equivalent task hours per week. Primary outcome measures were prostate biopsy result and Gleason sum. Results After adjusting for age, race, body mass index, prostate specific antigen, digital rectal examination, family history, previous prostate biopsy and comorbidity score, men who reported 9 or more metabolic equivalent task hours per week of exercise were significantly less likely to have cancer on biopsy (OR 0.35, CI 0.170.75, p = 0.007). Furthermore, among men with malignant biopsy results, reporting moderate exercise (3 to 8.9 metabolic equivalent task hours weekly) was associated with a lower risk of high grade disease (Gleason 7 or greater, OR 0.14, CI 0.020.94, p = 0.04). Conclusions To our knowledge, these results provide the first evidence of an association between exercise and prostate cancer risk as well as grade at diagnosis in men scheduled to undergo prostate biopsy. Specifically moderate exercise was associated with a lower risk of prostate cancer and in men with cancer, lower grade disease. Further investigation using an objective measure of exercise in a larger sample size is required to confirm these findings. 1 2 Top Years Publications 2006 11 2005 10 2002 8 2001 8 2008 7 2007 7 1998 6 2004 5 1999 5 2003 4 2000 4 1997 4 2009 3 1995 3 1994 2 1992 2 1989 2 1987 2 1996 1 1993 1 1 2 Top Countries Publications USA 53 Canada 7 Australia 6 Japan 4 Sweden 4 Norway 3 Denmark 2 France 2 China 2 Morocco 1 Greece 1 Philippines 1 Netherlands 1 Italy 1 Finland 1 Taiwan 1 Switzerland 1 1 2 3 Top Cities Publications Boston 10 Los Angeles 4 Bethesda 4 New York 3 Aioi 3 Atlanta 3 Ann Arbor 3 Calgary 3 Copenhagen 2 Portland 2 Pittsburgh 2 Baltimore 2 San Francisco 2 Lyon 2 Troms 2 Chicago 2 Athens 1 Edmonton 1 Springfield, IL, USA 1 Charlottesville 1 1 2 3 1 2 3 4 Top Journals Publications Cancer Epidem Biomar 7 Cancer Cause Control 5 Cancer 4 J Urology 4 Int J Cancer 3 Am J Clin Nutr 2 Clin J Oncol Nurs 2 Urology 2 Med J Australia 2 Urol Clin N Am 2 Am J Epidemiol 2 Ann Ny Acad Sci 2 Med Sci Sport Exer 2 Cancer Res 2 Sports Med 2 Med Oncol Tumor Pharmacother 2 Bmc Cancer 1 Int J Mol Med 1 J Phys Act Health 1 East Mediterr Health J 1 1 2 3 4 1 2 3 ... 19 Top Authors Publications Giovannucci E 9 Rimm E 5 Willett W 5 Stampfer M 5 Courneya K 3 Barnard R 3 Kawachi I 3 Friedenreich C 3 Gann P 3 Thune I 3 Greenspan S 2 Bacon C 2 Mittleman M 2 Glaesser D 2 Platz E 2 Leitzmann M 2 Moyad M 2 Thun M 2 Aronson W 2 Lukanova A 2 1 2 3 ... 19 1 2 3 ... 39 Top Terms Publications Risk Factors 96 Prostatic Neoplasms 96 Exercise 96 Humans 95 Prostatism 93 Prostatitis 93 Prostate 93 Men 58 Aged 52 Physics 51 Middle Aged 51 Motor Activity 46 Life Style 35 Adult 34 Incidence 28 Patients 27 Neoplasms 27 Confidence Intervals 26 Body Mass Index 24 Obesity 24 1 2 3 ... 39
标签: 锻炼身体
