日前,第7届环黄海镁合金国际研讨会 (7th Pan-Yellow Sea Rim International Symposium on Magnesium Alloys and their Applications (YSR7))已经在沈阳正式启动,会议时间:2012年10月14-18日,会议地点:沈阳市,中科院金属研究所。会议官方网址: www.YSR7.org . 会议主要由 中、日、韩及台湾地区相关单位学者就镁合金材料研发、材料结构性能及其表征、制备加工成形技术、表面处理、应用与产业化学术交流与合作等相关方面进行交流讨论。 环黄海国际镁合金系列研讨会由日本熊本大学河村能人教授发起,2006年以来已在日本、韩国、中国和我国台湾召开6次,参加单位主要有日本熊本大学国际镁合金研究中心、九州大学、日本东北大学、日本镁合金协会、韩国仁川工业技术研究所、 Korea Institute of Industrial Technology ( 光州)、 Yonsei University、 浦项集团、中国科学院金属研究所、上海交通大学、台湾大学、台湾镁合金协会等单位学者参加。几年来增进了相互了解和合作,取得了很好的效果。 本次会议将由中科院金属研究所组织,中国大陆方面的中科院金属研究所、上海交通大学、重庆大学材料学院、东北大学、北京大学工学院、山西闻喜银光镁业集团、哈尔滨工业大学材料学院、北京科技大学、北京工业大学、中北大学等单位著名镁合金学者获邀请参加会议做大会主题报告 (Keynote lecture)和邀请报告(Invited lecture)。 会议正在征文,有意者请参看官网进行联系或提交论文摘要。
分享一下2012年5月16日Biotronik公司在其网站上发布他们对镁合金药物洗脱支架的12个月临床(欧洲多中心,6个月和12个月2组共46个患者)随访结果,与去年发布的6个月结果相比,Twelve-month results from the BIOSOLVE-I study with the DRug Eluting Absorbable Metal Scaffold (DREAMS) demonstrate safety and confirm vessel vasomotion.这对做可降解金属的同仁们会是个鼓励。 pdf下载在这里 BIOTRONIK_PR%20BIOSOLVE-I_EuroPCR_EN.pdf http://www.biotronik.de/wps/wcm/connect/int_web/biotronik/newsroom/press_releases?p=http://www.biotronik.de/wps/wcm/connect/int_web/biotronik/newsroom/press_releases/press_release_biosolve_ipw=770pt = At one year, DREAMS demonstrated a low 7.0% rate of target lesion failure with no death or scaffold thrombosis. The target lesion revascularization rate was 4.7%. The analysis showed an in-scaffold late lumen loss of 0.52 mm, which was further reduced from the 6-month results. Vasoreactivity at 12 months did not significantly change from the 6-month results, suggesting that the natural physiology of the vessels was already restored after 6 months of healing and could be sustained. “The reduction of the 12-month late lumen loss is likely due to plaque regression and late expansive remodeling. At 6 months, we have already seen that vasomotion is restored, so the new results verify that the vessels are naturally adapting to accommodate flow,” said Professor Haude. “Additionally, we could further validate that the return of natural vessel angulation that we saw at 6 months was maintained also at 12 months. These results suggest a real restoration of the vessel’s natural architecture.” DREAMS is made of a proprietary magnesium alloy coated with a matrix of a bioabsorbable polymer and paclitaxel to inhibit neointimal cell proliferation within the first few months after scaffold implantation. Mechanical properties of the magnesium alloy allow deployment of the device to be comparable to conventional metallic stents. “The particularly positive feature of the magnesium scaffold is its nice conformability to the vessel wall. A few months after DREAMS implantation, the artery is able to regain its original shape and physiology. This is the main benefit of the magnesium scaffold over the more rigid polymer-based platforms,” Professor Haude added. “These positive one-year results confirm that we are working in the right direction. BIOTRONIK continues to invest in our DREAMS program as we believe that bringing vascular restoration therapy to patients without changing the way physicians implant a scaffold is important to the adoption of this technology,” stated Alain Aimonetti, Vice President of Sales and Marketing at BIOTRONIK Vascular Intervention. “An improvement of late lumen loss between 6 and 12 months shows us that the values become more predictable over time. It makes sense, especially for the bioabsorbable scaffolds, to focus on long-term outcomes and not so much on short-term results,” Aimonetti concluded. “We see huge potential for DREAMS since it combines deployment and postdilatation properties and long-term outcomes comparable to DES with the additional benefits of vascular restoration therapy. About the BIOSOLVE-I Clinical Trial The BIOSOLVE-I first-in-man study is a prospective, multicenter, nonrandomized, European, first-in-man clinical trial evaluating the safety and efficacy of DREAMS. Forty-six patients were enrolled in two cohorts that evaluated the primary endpoint of target lesion failure (TLF) at 6 months for cohort 1 and at 12 months for cohort 2. About the DRug Eluting Absorbable Metal Scaffold (DREAMS) DREAMS is part of a revolutionary new treatment option for patients with coronary artery disease . In contrast to existing permanent stents, this device is based on a slow-absorbing, high-strength magnesium backbone. The vessel is not caged as it would be with a permanent implant, thus the artery is able to resume its natural physiology. This novel treatment concept opens a new area of vascular restoration therapy. Properties of the proprietary magnesium alloy allow a straightforward deployment of the device, comparable to conventional metallic stents. BIOTRONIK’s DREAMS is coated with antiproliferative paclitaxel to inhibit excess tissue growth during the healing process. The company has announced next-generation platforms under development using the BIOlute coating from the Orsiro hybrid drug-eluting stent featuring sirolimus as the active compound. About BIOTRONIK SE Co. KG As one of the world’s leading cardiovascular medical device companies, with several million implanted devices, BIOTRONIK is represented in over 100 countries with its global workforce of more than 5,600 employees. Known for having its fingers on the pulse of the medical community, BIOTRONIK assesses the challenges physicians face and provides the best solutions for all phases of patient care, ranging from diagnosis and treatment to patient management. Quality, innovation and clinical excellence define BIOTRONIK and its growing success—and deliver confidence and peace of mind to physicians and their patients worldwide.
现为重庆大学材料科学与工程学院教授 主要研究方向 镁合金(塑性变形机制与织构控制、搅拌摩擦加工与焊接、腐蚀与降解)、生物陶瓷等。 科研项目 主持国家自然科学基金“人牙釉质纳米微晶中心暗线磷酸八钙/羟基磷灰石界面结构研究”和重庆市自然科学基金“纳米生物磷酸盐的制备与表征”,参与国家自然 科学基金重大项目“金属材料塑性变形微观组织结构多尺度表征”、国家973重大项目子课题“镁合金塑性变形机理及塑性加工理论研究”等。 论文及专著 已发表学术论文50余篇,其中被SCI收录30余篇,他引近200次,撰写专著1本。 近几年代表性论文: Liu Dejia, Xin Renlong et al., "Microstructure and mechanical properties of friction stir welded dissimilar Mg alloys of ZK60-AZ31", Materials Science and Engineering A, in press. Song Bo, Xin Renlong et al., “Improving Tensile and Compressive Properties of Magnesium Alloy Plates by Pre- Cold Rolling”, Scripta Materialia, 2012, 66: 1061-1064. Xin Renlong, Li Bo et al., "Correlation between texture variation and transverse tensile behavior of friction-stir-processed AZ31 Mg alloy", Metallurgical and Materials Transactions A, 2012, 43: 2500-2508. Xin Renlong, Luo Yuanming et al., “Texture effect on corrosion behavior of AZ31 Mg alloy in simulated physiological environment”, Materials Letters, 2012, 72: 1-4. Wang Bingshu, Xin Renlong et al., “Effect of crystal orientation on the mechanical properties and strain hardening behavior of magnesium alloy AZ31 during uniaxial compression”, Materials Science and Engineering A, 2012, 534: 588-593. Wang Bingshu, Xin Renlong et al., “Strain rate and texture effects on microstructural characteristics of AZ31 Mg alloy during compression”, Scripta Materialia, 2012, 32: 239-242. Xin Renlong, Song Bo et al., “Effect of aging precipitation on mechanical anisotropy of an extruded Mg–Y–Nd alloy”, Materials and Design, 2012, 34: 384-388. Xin Renlong, Li Bo et al., “Influence of Texture on Corrosion Rate of AZ31 Mg Alloy in 3.5 wt.% NaCl”, Materials and Design, 2011, 32: 4548-4552. Xin Renlong, Li Ling et al., “Structural examination of ageing precipitation in a Mg-Y-Nd alloy at different temperatures”, Materials Characterization, 2011, 62: 535-539. Wang Maoyin, Xin Renlong et al., “Effect of initial texture on dynamic recrystallization of AZ31 Mg alloy during hot rolling”, Materials Science and Engineering A, 2011, 528: 2941-2951. Xin Renlong, Leng Yang et al., “HRTEM study of the mineral phases in human cortical bone”. Advanced Engineering Materials, 2010, 12: B552-B557. Xin Renlong, Zhang Qiyi et al., “Identification of the wollastonite phase in sintered 45S5 bioglass and its effect on in vitro bioactivity”, Journal of Non-crystalline Solids, 2010, 356: p. 1180-1184. Xin Renlong, Yu Kaifeng et al., “Ultrastructure characterization of hydroxyapatite nanoparticles synthesized by EDTA-assisted hydrothermal method”, Journal of Materials Science, 2009, 44: 4205-4209. Ren Fuzeng, Xin Renlong et al., “Characterization and structural analysis of zinc-substituted hydroxyapatites”, Acta Biomaterialia, 2009, 5: 3141-3149. 辛仁龙,刘庆,“镁合金塑性变形力学行为与微观组织研究进展”,中国材料进展,2011年第30卷第2期,16-28。 宋波,辛仁龙等,“析出沉淀相对镁合金变形机理影响的研究进展”,中国有色金属学报,2011, 11: 2019-2731. 辛仁龙,冷扬等,“体内磷酸钙沉积晶体结构的透射电镜研究”,电子显微学报,2009年第28卷第4期,380-383。 辛仁龙,汪炳叔等,“形变镁合金微观组织与织构的EBSD研究”,电子显微学报,2008年第27卷第6期,495-498。 Xin Renlong, Leng Yang et al., “Ultrastructure Study of Hydroxyapatite Precipitation on Ceramic Surfaces in Dog Model”, Materials Science and Engineering C, 2008, 28(8): p. 1255-1259. Xin Renlong, Leng Yang et al., “In situ TEM examinations of octacalcium phosphate to hydroxyapatite transformation”, Journal of Crystal Growth, 2006, 289(1): p. 339-344. Xin Renlong, Leng Yang et al., “A comparative study of calcium phosphate formation on bioceramics in vitro and in vivo”, Biomaterials, 2005, 26(33): p. 6477-6486. 学术专著: Xin Renlong and Leng Yang, “Formation of Calcium Phosphates in Biological System”, VDM Verlag, November 2009. 备注: 欢迎各位同学报考我的硕士和博士研究生,特别欢迎有镁合金腐蚀背景,或者有比较好的力学或者数学基础的同学报考。 请与我联系,我的Email:rlxin@cqu.edu.cn 谢谢!