terahertz 刘桂锋 许教授，最近对知识发现感兴趣，有时间多指点，谢谢。 刘老师，您好。 http://arrowsmith.psych.uic.edu/arrowsmith_uic/index.html 主要用于生物医学领域的知识发现，我不太了解国内外其他学科领域有没有知识发现的系统？我觉得情报界对信息检索与分析已经非常熟悉并重视，但对知识发现不太熟悉和应用。因此我多做些实例介绍，希望科研人员，特别是情报人员能多研究和应用。 人体身高是患癌的风险因素，国际研究文献分析 http://blog.sciencenet.cn/home.php?mod=spaceuid=280034do=blogquickforward=1id=711450 Start A-Literature C-Literature B-list Filter Literature A-query: body height C-query: cancer The B-list contains title words and phrases (terms) that appeared in both the A and the C literature. 2922 articles appeared in both literatures and were not included in the process of computing the B-list but can be viewed here . The results of this search are saved under id # 6307 and can be accessed from the start page after you leave this session. There are 1491 terms on the current B-list (发现 413 个遗传基因、蛋白质方面的知识概念，对科研人员也许有所启发和参考价值are predicted to be relevant), which is shown ranked according to predicted relevance. The list can be further trimmed down using the filters listed in the left margin. To assess whether there appears to be a biologically significant relationship between the AB and BC literatures for specific B-terms, please select one or more B-terms and then click the button to view the corresponding AB and BC literatures. Use Ctrl to select multiple B-terms. 知识发现平台 http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/edit_b.cgi 详细信息 http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/view_b_txt.cgi?ID=6307 job id # 6307 started Fri Jul 26 03:39:59 2013 Max_citations: 50000 Stoplist: /var/www/arrowsmith_uic/data/stopwords_pubmed Ngram_max: 3 A_query_raw: body height Fri Jul 26 03:40:19 2013 A query = body height started Fri Jul 26 03:40:38 2013 C_query_raw: body height Fri Jul 26 03:40:40 2013 C: body height 55383 A query resulted in 50000 titles A: pubmed_query_A 55383 AC: ( body height ) AND ( body height ) 55383 C_query_raw: cancer Fri Jul 26 03:40:58 2013 C: cancer 2824670 A: pubmed_query_A 55383 AC: ( body height ) AND ( cancer ) 2922 C_query_raw: cancer Fri Jul 26 03:41:01 2013 C: cancer 2824670 A: pubmed_query_A 55383 AC: ( body height ) AND ( cancer ) 2922 C query = cancer started Fri Jul 26 03:41:02 2013 C query resulted in 50000 titles A AND C query resulted in 2922 titles 32160 B-terms ready on Fri Jul 26 03:43:47 2013 Sem_filter: Genes Molecular Sequences, and Gene Protein Names 1491 B-terms left after filter executed Fri Jul 26 03:44:41 2013 B-list on Fri Jul 26 03:48:56 2013 1 adiponectin 2 fdg 3 pten 4 leptin 5 fat mass 6 promoter polymorphism 7 metabolic syndrome 8 rankl 9 leptin receptor 10 genome wide 11 body mass index 12 hepcidin 13 fmr1 14 microrna 15 jak2 16 polymorphism promoter 17 codon polymorphism 18 polymorphism promoter region 19 ghrelin 20 homeobox 21 single nucleotide polymorphism 22 uncoupling protein 23 bone mineral density 24 sp1 25 promoter polymorphism associated 26 microsatellite 27 ptpn11 28 adiposity 29 calcium sensing receptor 30 aromatase 31 igf i 32 sglt1 33 stat5b 34 ppar gamma 35 hip 36 autophagy 37 gonadotropin releasing hormone 38 igf 39 glut4 40 nod2 41 methylenetetrahydrofolate reductase 42 tandem repeat 43 cftr 44 gstm1 45 igf2 46 cyp2c19 47 igfbp-3 48 methylenetetrahydrofolate reductase gene 49 genome scan 50 fgfr3 51 estrogen receptor 52 nf kappab 53 flt-1 54 cannabinoid receptor 55 melanocortin receptor 56 follistatin 57 cyp2c9 58 ucp2 59 estrogen receptor alpha 60 minisatellite 61 mthfr 62 androgen receptor gene 63 cyp3a 64 mri 65 homeobox gene 66 bdnf 67 lip 68 dax-1 69 cyp19a1 70 contrast enhancement 71 pet 72 body mass 73 hiv 74 socs3 75 nf1 76 androgen receptor 77 exon skipping 78 hrt 79 caspase-9 80 cystatin c 81 diabetes mellitus 82 adrenomedullin 83 timp-1 84 caga 85 leptin gene 86 inflammatory bowel disease 87 receptor gene 88 e polymorphism 89 igfbp-2 90 gdnf 91 gene promoter 92 transcription factor 93 quantitative trait locus 94 sms 95 gli3 96 sox10 97 leptin receptor gene 98 e gene polymorphism 99 hdl 100 caspase-3 101 shc 102 ku 103 ppargamma 104 nsd1 105 myogenin 106 h19 107 myostatin 108 intron 109 genome screen 110 pcr 111 signal regulated kinase 112 glycogen synthase 113 cdk6 114 apolipoprotein e 115 rct 116 yo 117 cyp1a2 118 han 119 osterix 120 runx2 121 ivf 122 pthrp 123 cystatin 124 myostatin gene 125 related gene 126 cytokine 127 hyperparathyroidism 128 eralpha 129 lean body mass 130 exon 131 statin 132 ppar 133 pfos 134 genomic 135 gnas 136 plgf 137 flap 138 hyperinsulinemia 139 q11 140 adiponectin receptor 141 femur 142 mxa 143 snp 144 kruppel factor 145 vitamin d receptor 146 homeodomain protein 147 socs2 148 insulin growth factor 149 collagen induced arthritis 150 lhrh 151 sox10 gene 152 gene family 153 homeobox containing 154 diabetes 155 gene patient 156 growth factor gene 157 gh 158 p53 159 esr2 160 twin 161 q13 162 lh 163 intron polymorphism 164 tnfr2 165 notch1 166 parathyroid hormone 167 collagen gene 168 cyp2b6 169 gnrh 170 mmp-2 171 lmna 172 endothelin 173 node 174 mb 175 pomc 176 promoter 177 anti mullerian hormone 178 lamin 179 estrogen receptor gene 180 g protein 181 intronic 182 fsh 183 promoter haplotype 184 growth hormone receptor 185 tcm 186 functional polymorphism promoter 187 cytokine gene 188 cd34 189 gene cluster 190 ct 191 igfbp-1 192 genome 193 gene col2a1 194 bone morphogenetic protein 195 xa 196 dmh 197 20s 198 cyp17 199 flnb 200 trpv4 201 protein tyrosine phosphatase 202 tgfbeta 203 visfatin 204 g polymorphism 205 candidate gene 206 fasting blood glucose 207 apelin 208 il-6 209 aromatase gene 210 high mobility group 211 transferrin receptor 212 hypercholesterolemia 213 sib 214 cleft lip 215 nph 216 premature ovarian failure 217 egfr 218 cyp1a1 219 precocious 220 celiac disease 221 multiple endocrine neoplasia 222 hmga2 223 immediate early gene 224 rna 225 cag 226 gene encoding 227 dopamine receptor 228 lfa-1 229 race 230 orbit 231 comt 232 apolipoprotein b 233 promoter methylation 234 irs-1 235 ras 236 mc4r 237 tnfalpha 238 promoter region 239 tgf beta 240 meld 241 microsatellite analysis 242 promoter activity 243 apoptosis related gene 244 cd40 245 nail 246 alu 247 ck 248 balloon 249 atrioventricular septal defect 250 polycystic ovary syndrome 251 corticotropin releasing hormone 252 tyrosine phosphatase 253 gerd 254 nijmegen breakage syndrome 255 receptor promoter 256 pparalpha 257 cathepsin k 258 epidermal growth factor 259 obese 260 timp-2 261 copy 262 promoter human 263 rdna 264 fat 265 diabetic nephropathy 266 cytochrome p-450 267 growth hormone 268 laminin 269 adducin 270 tyrosine kinase 271 pth 272 foxc1 273 polymorphism gene 274 lon 275 calpastatin 276 igf-1 277 pdgfra 278 gene environment 279 sirt1 280 seckel syndrome 281 insulin receptor 282 gpcr 283 fasn 284 receptor kinase 285 hsp70 286 dkk1 287 aryl hydrocarbon receptor 288 bmp4 289 bmp-2 290 t4 291 opioid receptor 292 alpha promoter 293 ret 294 gpr30 295 mitochondrial gene 296 glucocorticoid receptor 297 gene expressed 298 p22 299 susceptibility gene 300 signal peptide 301 killer 302 str 303 tgf beta1 304 rev 305 enhancer 306 igfbp-4 307 genomic imprinting 308 apoe 309 gene promoter associated 310 perilipin 311 lean 312 reductase gene 313 fabp2 314 crest 315 long bone 316 igfbp3 317 kinase 318 3d 319 icam-1 320 calpain 321 er alpha 322 codon 323 milk 324 guar 325 factor beta1 gene 326 interleukin 327 cyp11b2 328 sun 329 mmp-9 330 noggin 331 tsh 332 cpap 333 obesity 334 cx43 335 early gene 336 proinsulin 337 klotho 338 chloride channel 339 alpha gene 340 28s 341 e genotype 342 gene chinese 343 sir 344 vldl 345 hyperlipidemia 346 icp 347 alopecia 348 p11 349 factor i 350 col2a1 351 gene familial 352 s100b 353 prolactin 354 copd 355 bph 356 vein 357 sos 358 corn 359 neuropeptide y 360 progesterone receptor 361 carpal tunnel syndrome 362 body weight 363 gene association 364 bak 365 trait 366 ggn 367 hmg coa reductase 368 alfa 369 glucose transporter 370 fibroblast growth factor 371 mscs 372 chi 373 pain 374 connexin 375 tcr 376 domain 377 glutathione s transferase 378 igf1r 379 ghrh 380 lepr 381 hydrocephalus 382 essential tremor 383 opg 384 chd 385 ish 386 polo 387 gen 388 calcitonin receptor 389 klotho gene 390 p21 391 ida 392 decorin 393 cd4 394 tnf alpha 395 ob 396 enpp1 397 ldl 398 human genome 399 apolipoprotein a 400 allele polymorphism 401 esr1 402 ppardelta 403 renal failure 404 ru486 405 whi 406 receptor gene expression 407 breakpoint 408 limb 409 bf 410 titan 411 peroxisome 412 fasting glucose 413 novel gene RANKL与身高研究有3篇文献；与癌症研究有11篇文献。 Start A-Literature C-Literature B-list Filter Literature AB literature B-term BC literature body height rankl cancer 1: In peripubertal girls, artistic gymnastics improves areal bone mineral density and femoral bone geometry without affecting serum OPG /RANKL levels. 2011 Add to clipboard 2: Serum osteoprotegrin (OPG) and receptor activator of nuclear factor kappaB (RANKL ) in healthy children and adolescents. 2009 Add to clipboard 3: Relationships between osteoprotegerin (OPG), receptor activator of nuclear factor kappaB ligand (RANKL ), and growth hormone (GH) secretory status in short children. 2009 Add to clipboard 1: Bone metastases in gastric cancer follow a RANKL -independent mechanism. 2013 Add to clipboard 2: Targeting RANKL in breast cancer : bone metastasis and beyond. 2013 Add to clipboard 3: Progesterone drives mammary secretory differentiation via RankL -mediated induction of Elf5 in luminal progenitor cells. 2013 Add to clipboard 4: RANKL Synthesized by Both Stromal Cells and Cancer Cells Plays a Crucial Role in Osteoclastic Bone Resorption Induced by Oral Cancer . 2013 Add to clipboard 5: Differential Expression of the RANKL /RANK/OPG System Is Associated with Bone Metastasis in Human Non-Small Cell Lung Cancer . 2013 Add to clipboard 6: CCN3 promotes prostate cancer bone metastasis by modulating the tumor-bone microenvironment through RANKL -dependent pathway. 2013 Add to clipboard 7: Progesterone /RANKL Is a Major Regulatory Axis in the Human Breast. 2013 Add to clipboard 8: A statistical approach for optimization of RANKL overexpression in Escherichia coli: Purification and characterization of the protein. 2013 Add to clipboard 9: RANKL Signaling and Osteoclastogenesis Is Negatively Regulated by Cardamonin. 2013 Add to clipboard 10: RANKL /RANK/MMP-1 Molecular Triad Contributes to the Metastatic Phenotype of Breast and Prostate Cancer Cells In Vitro. 2013 Add to clipboard 11: RANKL promotes the growth of decidual stromal cells in an autocrine manner via CCL2/CCR2 interaction in human early pregnancy. 2013 Add to clipboard RANKL的定义与相关知识和信息如下： Receptor Activator for Nuclear Factor- κ B Ligand （核因子 κ B受体活化因子配体），又名为TNF-related activation-induced cytokine (TRANCE)，TNF相关激活诱导细胞因子；osteoprotegerin ligand (OPGL), 骨保护素配体 osteoclast differentiation factor（ODF ），破骨细胞分化因子。 为避免不同命名在学术上引起不便，美国骨矿研究学会(ASBMR)将其标准化命名为RANKL。 http://baike.baidu.com/view/1174734.htm Not to be confused with RANK , the osteoclast cell-surface receptor that binds to RANKL. "TRANCE" redirects here. For other uses, see Trance (disambiguation) . Receptor activator of nuclear factor kappa-B ligand (RANKL), also known as tumor necrosis factor ligand superfamily member 11 (TNFSF11), TNF-related activation-induced cytokine (TRANCE), osteoprotegerin ligand (OPGL), and osteoclast differentiation factor (ODF), is a protein that in humans is encoded by the TNFSF11 gene . Critical for adequate bone metabolism, this surface-bound molecule (also known as CD254) found on osteoblasts serves to activate osteoclasts , which are the cells involved in bone resorption . Osteoclastic activity is triggered via the osteoblasts' surface-bound RANKL activating the osteoclasts' surface-bound receptor activator of nuclear factor kappa-B (RANK) . Function RANKL is a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. RANKL also has a function in the immune system, where it is expressed by T helper cells and is thought to be involved in dendritic cell maturation. This protein was shown to be a dendritic cell survival factor and is involved in the regulation of T cell -dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor 6 ( TRAF6 ), which indicated this protein may have a role in the regulation of cell apoptosis . Animal models Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Clinical significance Bone Overproduction of RANKL is implicated in a variety of degenerative bone diseases, such as rheumatoid arthritis and psoriatic arthritis . The first FDA-approved RANKL inhibitor was denosumab (to treat osteoporosis in post menopausal women). Breast cancer Treatment with medroxyprogesterone acetate (MPA), a synthetic progestin that is used in birth control pills and hormone replacement therapy, is associated with an increased risk of developing breast cancer . MPA causes a substantial induction of RANKL in mammary-gland epithelial cells while deletion of RANKL decreases the incidence MPA-induced breast cancer. Hence inhibition of RANKL has potential for the prevention and treatment of breast cancer. See also Cluster of differentiation RANK Osteoprotegerin Osteoimmunology References ^ Wong BR, Rho J, Arron J, Robinson E, Orlinick J, Chao M, Kalachikov S, Cayani E, Bartlett FS, Frankel WN, Lee SY, Choi Y (October 1997). "TRANCE is a novel ligand of the tumor necrosis factor receptor family that activates c-Jun N-terminal kinase in T cells". J. Biol. Chem. 272 (40): 25190–4. doi : 10.1074/jbc.272.40.25190 . PMID 9312132 . ^ Anderson DM, Maraskovsky E, Billingsley WL, Dougall WC, Tometsko ME, Roux ER, Teepe MC, DuBose RF, Cosman D, Galibert L (November 1997). "A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function". Nature 390 (6656): 175–9. doi : 10.1038/36593 . PMID 9367155 . ^ a b "Entrez Gene: TNFSF11 tumor necrosis factor (ligand) superfamily, member 11" . ^ Schramek D, Leibbrandt A, Sigl V, Kenner L, Pospisilik JA, Lee HJ, Hanada R, Joshi PA, Aliprantis A, Glimcher L, Pasparakis M, Khokha R, Ormandy CJ, Widschwendter M, Schett G, Penninger JM (November 2010). "Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancer". Nature 468 (7320): 98–102. doi : 10.1038/nature09387 . PMID 20881962 . ^ Gonzalez-Suarez E, Jacob AP, Jones J, Miller R, Roudier-Meyer MP, Erwert R, Pinkas J, Branstetter D, Dougall WC (November 2010). "RANK ligand mediates progestin-induced mammary epithelial proliferation and carcinogenesis". Nature 468 (7320): 103–7. doi : 10.1038/nature09495 . PMID 20881963 . Further reading Whyte M (2006). "The long and the short of bone therapy". N Engl J Med 354 (8): 860–3. doi : 10.1056/NEJMe068003 . PMID 16495400 . link Buckley KA, Fraser WD (2003). "Receptor activator for nuclear factor kappaB ligand and osteoprotegerin: regulators of bone physiology and immune responses/potential therapeutic agents and biochemical markers.". Ann. Clin. Biochem. 39 (Pt 6): 551–6. doi : 10.1258/000456302760413324 . PMID 12564836 . Jeffcoate W (2005). "Vascular calcification and osteolysis in diabetic neuropathy-is RANK-L the missing link?". Diabetologia 47 (9): 1488–92. doi : 10.1007/s00125-004-1477-5 . PMID 15322748 . Collin-Osdoby P (2005). "Regulation of vascular calcification by osteoclast regulatory factors RANKL and osteoprotegerin.". Circ. Res. 95 (11): 1046–57. doi : 10.1161/01.RES.0000149165.99974.12 . PMID 15564564 . Whyte MP, Mumm S (2005). "Heritable disorders of the RANKL/OPG/RANK signaling pathway.". Journal of musculoskeletal neuronal interactions 4 (3): 254–67. PMID 15615493 . Clohisy DR, Mantyh PW (2005). "Bone cancer pain and the role of RANKL/OPG.". Journal of musculoskeletal neuronal interactions 4 (3): 293–300. PMID 15615497 . Anandarajah AP, Schwarz EM (2006). "Anti-RANKL therapy for inflammatory bone disorders: Mechanisms and potential clinical applications.". J. Cell. Biochem. 97 (2): 226–32. doi : 10.1002/jcb.20674 . PMID 16240334 . Baud'huin M, Duplomb L, Ruiz Velasco C, et al. (2007). "Key roles of the OPG-RANK-RANKL system in bone oncology.". Expert Rev Anticancer Ther 7 (2): 221–32. doi : 10.1586/14737140.7.2.221 . PMID 17288531 . Yogo K, Ishida-Kitagawa N, Takeya T (2007). "Negative autoregulation of RANKL and c-Src signaling in osteoclasts.". J. Bone Miner. Metab. 25 (4): 205–10. doi : 10.1007/s00774-007-0751-2 . PMID 17593489 . Boyce BF, Xing L (2007). "Biology of RANK, RANKL, and osteoprotegerin." . Arthritis Res. Ther . 9 Suppl 1: S1. doi : 10.1186/ar2165 . PMC 1924516 . PMID 17634140 . McClung M (2007). "Role of RANKL inhibition in osteoporosis." . Arthritis Res. Ther . 9 Suppl 1: S3. doi : 10.1186/ar2167 . PMC 1924518 . PMID 17634142 . External links RANKL Signaling Pathway RANKL Protein at the US National Library of Medicine Medical Subject Headings (MeSH) v t e PDB gallery 1s55 : Mouse RANKL Structure at 1.9A Resolution v t e Proteins : clusters of differentiation (see also list of human clusters of differentiation ) 1-50 CD1 a-c 1A 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50 51-100 CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 - CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100 101-150 CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150 151-200 CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 ( a d e i k ) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200 201-250 CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 ( a b ) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249 251-300 CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299 301-350 CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350 v t e Cell signaling : cytokines By family Chemokine CCL CCL1 CCL2 /MCP-1 CCL3 /MIP-1α CCL4 /MIP-1β CCL5 /RANTES CCL6 CCL7 CCL8 CCL9 CCL11 CCL12 CCL13 CCL14 CCL15 CCL16 CCL17 CCL18 CCL19 CCL20 CCL21 CCL22 CCL23 CCL24 CCL25 CCL26 CCL27 CCL28 CXCL CXCL1 /KC CXCL2 CXCL3 CXCL4 CXCL5 CXCL6 CXCL7 CXCL8/IL8 CXCL9 CXCL10 CXCL11 CXCL12 CXCL13 CXCL14 CXCL15 CXCL16 CXCL17 CX3CL CX3CL1 XCL XCL1 XCL2 TNF TNFA Lymphotoxin TNFB/LTA TNFC/LTB TNFSF4 TNFSF5/CD40LG TNFSF6 TNFSF7 TNFSF8 TNFSF9 TNFSF10 TNFSF11 TNFSF13B EDA Interleukin Type I (grouped by receptor subunit) γ-chain IL2 / IL15 IL4 / IL13 IL7 IL9 IL21 β-chain IL3 IL5 GM-CSF IL6 like/ gp130 IL6 IL11 IL27 IL30 IL31 +non IL OSM LIF CNTF CTF1 IL-12 family / IL12RB1 IL12 IL23 IL27 IL35 Other IL14 IL16 IL32 IL34 Type II IL 10 family IL10 / IL22 IL19 IL20 IL24 IL26 Interferon type III IL28/IFNL2+3 IL29/IFNL1 Interferon I IFNA1 IFNA2 IFNA4 IFNA5 IFNA6 IFNA7 IFNA8 IFNA10 IFNA13 IFNA14 IFNA16 IFNA17 IFNA21 IFNB1 IFNK IFNW1 II IFNG Ig superfamily IL-1 family : IL1A/IL1F1 IL1B/IL1F2 1Ra/IL1F3 IL1F5 IL1F6 IL1F7 IL1F8 IL1F9 IL1F10 33/IL1F11 18/IL1G IL 17 family IL17 / IL25 ( IL17A ) Other Hematopoietic KITLG Colony-stimulating factor SPP1 By function/ cell proinflammatory cytokine IL1 TNFA Monokine Lymphokine T h 1 IFNG TNFB T h 2 IL4 IL5 IL6 IL10 IL13 B trdu : iter ( nrpl / grfl / cytl / horl ), csrc ( lgic , enzr , gprc , igsr , intg , nrpr / grfr / cytr ), itra ( adap , gbpr , mapk ), calc , lipd ; path ( hedp , wntp , tgfp + mapp , notp , jakp , fsap , hipp , tlrp ) This article incorporates text from the United States National Library of Medicine , which is in the public domain . Retrieved from " http://en.wikipedia.org/w/index.php?title=RANKLoldid=555789422 " Categories : Human proteins Cytokines Clusters of differentiation http://en.wikipedia.org/wiki/RANKL
Start A-Literature C-Literature B-list Filter Literature A-query: matrix metalloproteinase 13 C-query: articular chondrocytes and osteoarthrit... The B-list contains title words and phrases (terms) that appeared in both the A and the C literature. 172 articles appeared in both literatures and were not included in the process of computing the B-list but can be viewed here . The results of this search are saved under id # 1678 and can be accessed from the start page after you leave this session. There are 333 terms on the current B-list (发现遗传基因相关知识概念94个，对科研选题和进行中的科研工作有一定启发作用和参考价值 are predicted to be relevant) , which is shown ranked according to predicted relevance. The list can be further trimmed down using the filters listed in the left margin. To assess whether there appears to be a biologically significant relationship between the AB and BC literatures for specific B-terms, please select one or more B-terms and then click the button to view the corresponding AB and BC literatures. Use Ctrl to select multiple B-terms. http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/edit_b.cgi job id # 1678 started Mon Jul 9 21:52:31 2012 Max_citations: 50000 Stoplist: /var/www/arrowsmith_uic/data/stopwords_pubmed Ngram_max: 3 A_query_raw: matrix metalloproteinase 13Mon Jul 9 21:52:39 2012 A query = matrix metalloproteinase 13 started Mon Jul 9 21:52:47 2012 A query resulted in 1578 titles C_query_raw: matrix metalloproteinase 13 Mon Jul 9 21:53:14 2012 C: matrix metalloproteinase 13 1578 A: pubmed_query_A 1578 AC: ( matrix metalloproteinase 13 ) AND ( matrix metalloproteinase 13 ) 1578 C_query_raw: articular chondrocytes and osteoarthritis Mon Jul 9 21:54:00 2012 C: articular chondrocytes and osteoarthritis 2398 A: pubmed_query_A 1578 AC: ( matrix metalloproteinase 13 ) AND ( articular chondrocytes and osteoarthritis ) 172 C_query_raw: articular chondrocytes and osteoarthritis Mon Jul 9 21:54:31 2012 C: articular chondrocytes and osteoarthritis 2398 A: pubmed_query_A 1578 AC: ( matrix metalloproteinase 13 ) AND ( articular chondrocytes and osteoarthritis ) 172 C query = articular chondrocytes and osteoarthritis started Mon Jul 9 21:54:47 2012 C query resulted in 2398 titles A AND C query resulted in 172 titles 2873 B-terms ready on Mon Jul 9 21:56:35 2012 Sem_filter: Genes Molecular Sequences, and Gene Protein Names 333 B-terms left after filter executed Mon Jul 9 21:59:52 2012 B-list on Mon Jul 9 22:00:51 2012 1 cox-2 2 jnk 3 akt 4 vegf 5 erk1 6 beta catenin 7 smad 8 aggrecan 9 toll receptor 10 wnt 11 synovial fibroblast 12 smad3 13 map kinase 14 mmp-2 15 timp-1 16 leptin 17 signal regulated kinase 18 tissue inhibitor metalloproteinase 19 oncostatin m 20 c jun 21 adiponectin 22 promoter polymorphism 23 fibromodulin 24 matrix metalloproteinase 25 adamts-4 26 timp 27 mmp-9 28 cdna 29 jak stat 30 matrix gene 31 c fos 32 endostatin 33 p38 34 collagen induced arthritis 35 chemokine 36 nf kappab 37 cd44 38 bone morphogenetic protein 39 il-1beta 40 caspase-3 41 rankl 42 il-6 43 il-1 44 ap-1 45 promoter region 46 cathepsin k 47 gadd45beta 48 sox9 49 transcription factor 50 mmp-1 51 metalloproteinase gene 52 mmp-13 53 igf i 54 matrix metalloproteinase gene 55 rheumatoid synovial 56 leukemia inhibitory factor 57 erk 58 tgf beta1 59 caspase-8 60 ccn2 61 tgf beta 62 acl 63 human synovial 64 igf 65 interleukin 66 mmp-3 67 protein kinase c 68 jun 69 timp-2 70 bcl-2 71 pthrp 72 estrogen receptor 73 ctgf 74 endo180 75 fibroblast growth factor 76 bmp 77 mmp 78 disintegrin 79 collagen gene 80 tnf alpha 81 glucocorticoid receptor 82 hyaluronan synthase 83 mmp13 84 tlr4 85 cathepsin b 86 p53 87 bmp-2 88 hip 89 pth 90 proteoglycan 91 related oncogene alpha 92 metalloprotease 93 catabolic gene 94 estrogen receptor alpha http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/view_b_txt.cgi?ID=1678 研究实例： Start A-Literature C-Literature B-list Filter Literature AB literature B-term BC literature matrix metalloproteinase 13 cox-2 articular chondrocytes and os... 1: Differential down-regulation of COX-2 and MMP-13 in human skin fibroblasts by glucosamine-hydrochloride.2009 Add to clipboard 2: The effects of selective COX-2 inhibitor/celecoxib and omega-3 fatty acid on matrix metalloproteinases, TIMP-1, and laminin-5gamma2-chain immunolocalization in experimental periodontitis.2008 Add to clipboard 1: TAK1 mediates the collagen-II-dependent induction of the COX-2 gene and PGE2 release in primary human chondrocytes.2010 Add to clipboard 2: Dynamic compression inhibits fibronectin fragment induced iNOS and COX-2 expression in chondrocyte/agarose constructs.2009 Add to clipboard 3: COX-2 and iNOS are critical in advanced glycation end product-activated chondrocytes in vitro.2009 Add to clipboard 4: Effects of advanced glycation end products on the expression of COX-2 , PGE2 and NO in human osteoarthritic chondrocytes.2008 Add to clipboard 5: Long-term NSAID treatment directly decreases COX-2 and mPGES-1 production in the articular cartilage of patients with osteoarthritis.2008 Add to clipboard 6: Avocado soybean unsaponifiables (ASU) suppress TNF-alpha, IL-1beta, COX-2 , iNOS gene expression, and prostaglandin E2 and nitric oxide production in articular chondrocytes and monocyte/macrophages.2007 Add to clipboard 7: NF-kappaBp65-specific siRNA inhibits expression of genes of COX-2 , NOS-2 and MMP-9 in rat IL-1beta-induced and TNF-alpha-induced chondrocytes.2006 Add to clipboard 8: Selective COX-2 inhibitor regulates the MAP kinase signaling pathway in human osteoarthritic chondrocytes after induction of nitric oxide.2005 Add to clipboard 9: Cross talk between COX-2 inhibitor and hyaluronic acid in osteoarthritic chondrocytes.2004 Add to clipboard 10: COX-2 , NO, and cartilage damage and repair.2000 Add to clipboard 11: Tetracycline up-regulates COX-2 expression and prostaglandin E2 production independent of its effect on nitric oxide.1999 Add to clipboard http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/show_sentences.cgi 研究动态文献： 关节炎中的表观遗传学基因开关 http://www.ebiotrade.com/newsf/2012-7/201279105548935.htm
http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/edit_b.cgi Start A-Literature C-Literature B-list Filter Literature A-query: Schizophrenia C-query: Chinese populations The B-list contains title words and phrases (terms) that appeared in both the A and the C literature. 507 articles appeared in both literatures and were not included in the process of computing the B-list but can be viewed here . The results of this search are saved under id # 2674 and can be accessed from the start page after you leave this session. There are 1970 terms on the current B-list (690个 are predicted to be relevant相关基因知识概念), which is shown ranked according to predicted relevance. The list can be further trimmed down using the filters listed in the left margin. To assess whether there appears to be a biologically significant relationship between the AB and BC literatures for specific B-terms, please select one or more B-terms and then click the button to view the corresponding AB and BC literatures. Use Ctrl to select multiple B-terms. http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/view_b_txt.cgi?ID=2674 job id # 2674 started Wed Oct 26 21:22:14 2011 Max_citations: 50000 Stoplist: /var/www/html/arrowsmith_uic/data/stopwords_pubmed Ngram_max: 3 2674 Search ARROWSMITH A A_query_raw: Schizophrenia Wed Oct 26 21:22:22 2011 A query = Schizophrenia started Wed Oct 26 21:22:23 2011 A query resulted in 50000 titles 2674 Search ARROWSMITH C C_query_raw: Chinese populations Wed Oct 26 21:23:17 2011 C: Chinese populations 31912 A: pubmed_query_A 95282 AC: ( Schizophrenia ) AND ( Chinese populations ) 507 C query = Chinese populations started Wed Oct 26 21:23:19 2011 C query resulted in 31912 titles A AND C query resulted in 507 titles 26544 B-terms ready on Wed Oct 26 21:29:21 2011 Sem_filter: Genes Molecular Sequences, and Gene Protein Names 1970 B-terms left after filter executed Wed Oct 26 21:42:16 2011 Sem_filter: Genes Molecular Sequences, and Gene Protein Names 1970 B-terms left after filter executed Wed Oct 26 21:43:42 2011 Sem_filter: Genes Molecular Sequences, and Gene Protein Names C_query_raw: Wed Oct 26 21:47:03 2011 C: A: pubmed_query_A 95282 AC: ( Schizophrenia ) AND ( ) 95282 A_query_raw: Wed Oct 26 21:47:06 2011 1970 B-terms left after filter executed Wed Oct 26 22:09:38 2011 Sem_filter: Genes Molecular Sequences, and Gene Protein Names 1970 B-terms left after filter executed Wed Oct 26 22:17:34 2011 Sem_filter: Genes Molecular Sequences, and Gene Protein Names 1970 B-terms left after filter executed Wed Oct 26 22:21:52 2011 B-list on Wed Oct 26 22:22:33 2011 1 adiponectin 2 drb1 3 microsatellite marker 4 toll receptor 5 promoter polymorphism 6 hla drb1 7 serotonin transporter gene 8 methylenetetrahydrofolate reductase gene 9 genome scan 10 fmr1 11 dqb1 12 gstt1 13 cyp2d6 14 cannabinoid receptor 15 polymorphism promoter 16 quantitative trait loci 17 vntr 18 akt 19 mthfr 20 polymorphism promoter region 21 short tandem repeat 22 hla dqb1 23 gstp1 24 single nucleotide polymorphism 25 dopamine transporter gene 26 drd4 27 promoter polymorphism associated 28 dqb1 allele 29 gene promoter polymorphism 30 tandem repeat polymorphism 31 d2 receptor gene 32 fmr1 gene 33 mthfr gene 34 e polymorphism 35 d4 receptor gene 36 5-ht2a receptor gene 37 microsatellite 38 gstm1 39 beta3 subunit gene 40 transporter gene 41 cyp2d6 gene 42 polymorphism intron 43 gnb3 44 kcnh2 45 trinucleotide repeat 46 vntr polymorphism 47 beta3-adrenergic receptor gene 48 ctla-4 49 snp marker 50 gene alzheimer disease 51 gene parkinson disease 52 drd4 gene 53 exon polymorphism 54 2a receptor gene 55 htr2a 56 pink1 57 methylenetetrahydrofolate reductase 58 tryptophan hydroxylase gene 59 cox-2 60 slc6a4 61 tp53 62 tandem repeat 63 drd2 gene 64 cyp2d6 allele 65 receptor gene cnr1 66 grin2b 67 cnr1 68 cyp2c19 69 drb1 gene 70 catechol o-methyltransferase gene 71 5-ht2a 72 receptor 2a gene 73 mitochondrial dna sequence 74 ghrelin 75 rapd 76 dinucleotide repeat 77 intron polymorphism 78 drd2 79 polymorphic microsatellite 80 brca2 81 drb1 allele 82 estrogen receptor alpha 83 wnt 84 leptin 85 factor bdnf gene 86 cc16 87 lepr gene 88 promoter haplotype 89 hla a 90 oprm1 91 gene alcohol dependence 92 functional polymorphism promoter 93 bdnf 94 microsatellite polymorphism 95 gene bipolar 96 association interleukin-1 gene 97 hla drb1 allele 98 cb1 99 cannabinoid receptor gene 100 dopamine receptor gene 参考文献 AJP：精神分裂症易感基因ZNF804A具新的功能突变 精神分裂症是困扰人类的重大精神疾病之一，且具有很强的遗传性。近年来，随着全基因组关联性分析（Genome-wideassociationstudy,GWAS）的逐步开展，人们已经报道了一系列的精神分裂症易感基因。ZNF804A是最近首先在欧洲人群中通过病例-对照研究发现的一个精神分裂症易感基因。然而，随后在中国人群中的验证研究却报道了不一致的结果。为了探究ZNF804A在中国人群中是否是精神分裂症的易感基因，昆明动物研究所宿兵研究员的实验室（博士研究生李明）通过与云南省精神病医院和玉溪市第二人民医院合作，对这两个地区的2207份病例-对照样本进行了系统的遗传学分析。 研究发现，在欧洲人群中报道的ZNF804A的一个同精神分裂症显著相关的序列多态位点（rs1344706）在研究的云南样本中并不与精神分裂症相关。但是，他们在前人没有关注的ZNF804A基因调控区却发现了两个新的相关位点（rs359895和rs1021042）。进一步的功能实验证明，在rs359895位点的序列突变会增强ZNF804A基因调控区同广谱转录因子Sp1的结合力，从而上调ZNF804A的转录。这一结果同临床上报道的精神分裂症病人大脑中ZNF804A表达升高的现象是一致的。他们的研究发现了一个新的ZNF804A功能突变。这个突变可能是中国人群中导致精神分裂症发生的重要遗传因素之一。该研究结果发表于国际精神病学著名刊物《AmericanJournalofPsychiatry》（刊物 影响因子 ，12.76）（ 生物谷 Bioon.com） http://www.bioon.com/biology/postgenomics/504307.shtml
标签: 遗传基因
