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生长激素受体缺陷与癌症和糖尿病的理论知识发现
xupeiyang 2011-12-17 05:05
拜读了 张彦斌 博友的博文，做了知识发现，供大家参考。 生长激素受体有缺陷的人，虽然个子长不高，但一辈子不会得癌症和糖尿病！ 知识发现平台 http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/edit_b.cgi Start A-Literature C-Literature B-list Filter Literature A-query: Growth hormone receptor deficiency C-query: cancer and diabetes The B-list contains title words and phrases (terms) that appeared in both the A and the C literature. 26 articles appeared in both literatures and were not included in the process of computing the B-list but can be viewed here . The results of this search are saved under id # 16949 and can be accessed from the start page after you leave this session. There are 1411 terms on the current B-list (发现有关生长激素受体缺陷与癌症和糖尿病的理论知识概念347个，对相关科研有参考意义 are predicted to be relevant), which is shown ranked according to predicted relevance. The list can be further trimmed down using the filters listed in the left margin. To assess whether there appears to be a biologically significant relationship between the AB and BC literatures for specific B-terms, please select one or more B-terms and then click the button to view the corresponding AB and BC literatures. Use Ctrl to select multiple B-terms. http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/view_b_txt.cgi?ID=16949 AC: ( Growth hormone receptor deficiency ) AND ( cancer and diabetes ) 26 C query = cancer and diabetes started Fri Dec 16 14:41:01 2011 C query resulted in 23593 titles A AND C query resulted in 26 titles 4996 B-terms ready on Fri Dec 16 14:43:51 2011 Sem_filter: Concepts Ideas 1411 B-terms left after filter executed Fri Dec 16 14:48:24 2011 B-list on Fri Dec 16 14:52:53 2011 1 ghrelin level 2 igf binding 3 androgen deprivation 4 insulin insulin growth 5 recombinant human growth 6 igf system 7 transducer activator transcription 8 growth factor system 9 proliferator activated receptor 10 gh deficiency effect 11 signal transducer activator 12 expression insulin growth 13 novel mutation 14 effect gh replacement 15 vascular endothelial growth 16 insulin release 17 growth hormone therapy 18 androgen deprivation therapy 19 glycemic control 20 25-hydroxyvitamin d 21 cardiovascular risk 22 deprivation therapy prostate 23 growth factor binding 24 i igf binding 25 cooperative growth study 26 hormone refractory prostate 27 national cooperative growth 28 suprasellar 29 insulin sensitivity 30 hormone insulin growth 31 suppressor cytokine 32 refractory prostate cancer 33 gh insulin growth 34 ins-1 cell 35 cag repeat 36 ins-1 37 expression insulin 38 releasing hormone receptor 39 growth hormone replacement 40 signaling pancreatic beta 41 gh responsiveness 42 i insulin growth 43 repeat polymorphism 44 splice site mutation 45 small cell lung 46 regulation insulin growth 47 deprivation therapy 48 hypoxia inducible 49 hepatoma cell line 50 hypothalamic pituitary 51 tamoxifen therapy 52 ppargamma activation 53 insulin binding 54 hypothalamic hamartoma 55 expression leptin 56 hypothalamic neuropeptide y 57 growth hormone secretion 58 splice site 59 genome wide 60 ret ptc1 61 insulin sensitivity beta 62 genetically engineered mouse 63 p450 oxidoreductase deficiency 64 chronic kidney 65 advanced prostate cancer 66 igf igf binding 67 treatment cushing 68 early stage prostate 69 serum insulin growth 70 hypoxia inducible factor 71 g protein alpha 72 nf kappab 73 beta cell function 74 channel insulin 75 expression igf i-induced 76 euthyroid 77 receptor insulin growth 78 treatment growth hormone 79 defect insulin 80 beta cell replication 81 treatment cushing disease 82 mammary stem cell 83 activation phosphatidylinositol 3-kinase 84 volumetric bone 85 circulating insulin growth 86 familial isolated 87 splice variant 88 factor igf binding 89 signaling pancreatic 90 vitamin d metabolism 91 role insulin growth 92 systematic review meta 93 expression leptin receptor 94 index growth hormone 95 small cell 96 human insulin growth 97 expression profile 98 insulin action 99 leptin action 100 effect gh 101 factor signaling 102 defect insulin receptor 103 quality life 104 mammary epithelial cell 105 treatment growth 106 treatment insulin 107 treatment pituitary adenoma 108 inhibit growth breast 109 effect insulin growth 110 oral glucose 111 cloning expression 112 estrogen postmenopausal 113 sensitivity beta cell 114 response gh replacement 115 beta cell 116 advanced prostate 117 pancreatic cancer cell 118 hormone binding 119 pituitary adrenal 120 neuroendocrine differentiation 121 erbb-3 expression 122 protein alpha subunit 123 dmba induced mammary 124 bone mineral density 125 receptor variant 126 c elegans 127 gastric inhibitory 128 signaling aging 129 risk marker 130 polycystic 131 liver specific 132 increase insulin 133 somatomedin level 134 mouse model thyroid 135 katp channel 136 binding thyroid hormone 137 transgenic growth 138 review meta analysis 139 c ebpbeta 140 hormone receptor expression 141 cell cycle arrest 142 stimulate beta cell 143 expression growth 144 increase adipose 145 leptin expression 146 expression nitric oxide 147 endometrial 148 increased insulin 149 overexpression 150 responsive element 151 obstructive sleep 152 regulation growth hormone 153 isolated growth hormone 154 adipose differentiation 155 insulin growth 156 hormone treatment 157 ret 158 effect growth hormone 159 treated insulin growth 160 growth hormone release 161 meta analysis 162 abnormal growth hormone 163 long term estrogen 164 prostate cancer progression 165 calorie restriction 166 expression rat 167 expression thyroid hormone 168 mammary adenocarcinoma 169 model thyroid 170 leptin regulation 171 gestational 172 treatment pituitary 173 therapy prostate cancer 174 treatment gh 175 increased insulin sensitivity 176 igf1 level 177 lifespan 178 binding protein growth 179 large cohort 180 precocious 181 necrosis factor alpha 182 systolic 183 downstream akt 184 androgen deprivation increase 185 hormone deficiency effect 186 estrogen deficiency 187 fibroblast growth 188 hormone growth 189 hormone beta receptor 190 melatonin deficiency 191 translation initiation 192 effect insulin 193 inhibit growth 194 cause pituitary 195 kindred 196 beta cell specific 197 activation protein kinase 198 vitamin d endocrine 199 full length 200 mouse model 201 human growth 202 regulation growth 203 term effect insulin 204 stage renal disease 205 increased cardiovascular risk 206 cancer cell line 207 endometrial cancer cell 208 islet beta cell 209 insulin release pancreatic 210 adrenocortical function 211 serum concentration insulin 212 role growth 213 expression prostate cancer 214 therapy insulin 215 expression peroxisome proliferator 216 postmenopausal 217 co activator 218 young overweight 219 level insulin sensitivity 220 interleukin-6 expression 221 ovarian response 222 null mice 223 early gene expression 224 c src 225 modulation igf 226 caloric restriction 227 expression thyroid 228 sex hormone binding 229 lipoprotein metabolism 230 growth prostate cancer 231 acth release 232 cardiovascular 233 severe insulin 234 therapy breast cancer 235 calorie 236 intrauterine growth 237 radiotherapy 238 ovarian germ cell 239 pituitary cell line 240 hormone binding globulin 241 disruption steroid 242 chinese 243 highly conserved 244 regulation peroxisome proliferator 245 binding growth 246 linear growth 247 advanced 248 molecular weight adiponectin 249 total high molecular 250 model thyroid cancer 251 ppargamma activation a 252 translational perspective 253 growth factor alpha 254 growth factor beta 255 longevity 256 end stage renal 257 p450 expression 258 function anterior pituitary 259 severe insulin resistance 260 receptor modulator 261 ligand binding 262 endothelial function 263 treatment osteoporosis 264 complex genetic 265 nuclear ribonucleoprotein 266 i expression 267 deficiency acromegaly 268 level gh 269 acromegaly induced 270 syndrome severe insulin 271 allogeneic bone marrow 272 intravenous dexamethasone 273 diabetes model 274 mrna expression 275 cancer treatment 276 therapy breast 277 ribonucleic acid expression 278 targeted disruption 279 modulation estrogen receptor 280 adrenal 281 transgenic mouse model 282 ablation thyroid 283 effect octreotide 284 pancreatic 285 oxygen species 286 growth response 287 multiple hormone 288 effect thyroid 289 suppressor 290 hypothalamic 291 releasing hormone analog 292 novel therapeutic 293 effect thyroid hormone 294 ca2 channel 295 expression pituitary 296 colony stimulating 297 voltage dependent 298 growth puberty 299 growth breast cancer 300 insulin responsiveness 301 nuclear localization 302 cell cycle progression 303 dose growth hormone 304 human endometrial 305 adult onset 306 high throughput 307 i level 308 growth study 309 density young 310 increased cardiovascular 311 nodular 312 growth factor level 313 estrogen deprivation 314 successful treatment cushing 315 gonadal 316 localization prolactin 317 glucose deprivation 318 length polymorphism 319 induced expression 320 adrenal response 321 ovarian 322 growth breast 323 risk factor 324 thyroid hormone beta 325 cell growth differentiation 326 thyroid hormone action 327 reactive oxygen 328 cancer growth 329 mammary carcinoma growth 330 treatment breast cancer 331 expression neuronal 332 systematic review 333 gonadotropin treatment 334 modulation glucose 335 signaling cause 336 level insulin 337 severe growth 338 binding globulin 339 mammary tumorigenesis 340 protein expression 341 premature ovarian 342 role fibroblast growth 343 ectopic 344 lesson mouse model 345 ureteral 346 hgh level 347 liver growth 参考文献 癌症研究的一个简单且重大的进展 http://blog.sciencenet.cn/home.php?mod=spaceuid=590130do=blogid=519240
个人分类: 知识发现|7502 次阅读|0 个评论
肌肉与代谢——“施瓦辛格小鼠”
热度 1 sportmuscle 2011-5-26 22:17
肌肉与代谢——“施瓦辛格小鼠” 最近刚卸任的州长施瓦辛格，闹出不少的绯闻。做州长的施瓦辛格并没有给众人留下显赫的政绩，到是他强壮的肌肉及绯闻会给人留下不少的话题。 但你们想到过吗？在实验室里，小老鼠也可以变身鼠中“施瓦辛格”？依赖于肌肉蛋白质合成。在骨骼肌蛋白质代谢中，促进蛋白质的激素包括睾酮、胰岛素，以及相关生长因子胰岛素生长因子（IGF-1）及异构体机械生长因子（MGF）等。还有抑制肌肉生长的肌肉抑制素（myostatin）等。在肌肉的生长及壮大方面维持平衡。通常抗阻力量练习及优质蛋白质补充有助于肌肉壮大，肌肉尤其对机械运动刺激更敏感。利用特定的遗传差异，科学家创造了小鼠中的"施瓦辛格"，它的肌肉质量超过普通小鼠四倍。该研究成果有助于探索人类肌肉萎缩症、艾滋病以及癌症引起的肌肉损失。通过转基因技术，一方面可以通过变异—让它们不能制造肌肉抑制素（myostatin），但却能大量生产卵泡抑制蛋白（follistatin）。由于肌肉抑制素会限制肌肉发育，因此缺乏它的小鼠会多长肌肉；同时，卵泡抑制蛋白会影响抑制肌肉发育的蛋白起作用，也就是说，两方面因素都促使小鼠的肌肉更多更强壮，该方面已经在养殖业应用，如动物的产肉量增加。还可以通过IGF-1基因改造，让肌肉一块块地隆起，或外源性补充类固醇激素，曾被一些力量项目的运动员采用。 通过这类技术制造的“施瓦辛格鼠”与正常鼠的肌纤维存在很大不同，前者肌纤维的大小超过后者的两倍，多117%，而且在数量上也比后者多73%。研究人员认为，在缺乏肌肉抑制素的条件下卵泡抑制蛋白仍然能够促进肌肉发育，这说明小鼠体内存在不止一种肌肉调控机制。如果生物学家能够在人体内确定更多的卵泡抑制蛋白可以绑定的蛋白，就有望导致新的促进人类肌肉发育或者维持肌肉的药物出现。此外，新的研究成果的意义还在于培育更加长肉的家畜。不过，李塞金特别强调，他不希望新的研究成果成为运动员提升肌肉水平的工具。如果这类被大量应用，可能对整个生物界是一种灾难，但愿仅停留在实验室阶段。
3647 次阅读|2 个评论
生长激素与记忆研究信息分析与相关基因知识发现
xupeiyang 2010-1-17 14:18
http://www.gopubmed.org/web/gopubmed/1?WEB011ngmf2w487fI12I1I00f01000j10040001rl memory AND growth hormone 284 documents semantically analyzed top author statistics 1 2 Top Years Publications 2009 30 2005 29 2006 26 2008 21 2001 19 2007 18 2000 15 2002 14 2004 13 2003 13 1998 12 1995 8 1997 6 1994 6 1987 6 1990 5 1999 4 1984 4 1992 3 1991 3 1 2 1 2 Top Countries Publications USA 94 Germany 20 Netherlands 20 United Kingdom 15 Japan 13 Sweden 13 Italy 12 Canada 10 Spain 9 Australia 7 France 6 Hungary 4 China 4 South Korea 3 Argentina 2 Brazil 2 Denmark 2 Mexico 2 Serbia 2 Belgium 2 1 2 1 2 3 ... 7 Top Cities Publications Amsterdam 11 Winston-Salem 10 Lbeck 9 London 7 Uppsala 6 New York 6 Irvine 6 Madrid 5 Gothenburg 4 Bethesda 4 Melbourne 4 Baltimore 4 Utrecht 4 Boston 4 Budapest 3 New Haven 3 Seattle 3 Tokyo 3 Turin 3 Stanford 3 1 2 3 ... 7 1 2 3 ... 10 Top Journals Publications Psychoneuroendocrino 10 J Neurosci 9 Growth Horm Igf Res 6 Horm Behav 5 Eur J Endocrinol 5 Neuroscience 4 Neuroendocrinology 4 Horm Res 4 Neuropsychobiology 4 Behav Brain Res 3 Life Sci 3 Front Neuroendocrin 3 Neurobiol Aging 3 Eur J Neurosci 3 P Natl Acad Sci Usa 3 J Clin Endocr Metab 3 Prog Brain Res 3 Exp Cell Biol 3 J Endocrinol 2 Neurosci Lett 2 1 2 3 ... 10 1 2 3 ... 58 Top Authors Publications Deijen J 11 Born J 8 Drent M 8 Sonntag W 7 Arwert L 6 Koppeschaar H 5 Van Dam P 5 Fehm H 5 Csaba G 5 Nyberg F 4 Alemn A 4 De Haan E 4 Nmeth G 4 Ghigo E 3 Falleti M 3 Maruff P 3 Bartke A 3 Ingram R 3 Veltman D 3 Le Grevs M 3 1 2 3 ... 58 1 2 3 ... 137 Top Terms Publications Hormones 239 Humans 167 Growth Hormone 161 Animals 146 growth hormone receptor binding 142 Adult 99 learning 79 Patients 72 learning or memory 70 Memory 65 Rats 63 Neurons 62 Hippocampus 60 Insulin-Like Growth Factor I 54 Aging 51 Human Growth Hormone 50 Anxiety 48 hippocampus development 47 Brain 45 Cognition 43 1 2 3 ... 137 http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/umls.cgi?task=filterID=5757 Start A-Literature C-Literature B-list Filter Literature Semantic Filters This filter can be used to focus your search on B-terms that belong to certain semantic categories by selecting them below. You may also expand categories by clicking on the corresponding + button, and select from the subcategories. Activities Behaviors Anatomy Chemicals Drugs Concepts Ideas Devices Disorders Genes Molecular Sequences, and Gene Protein Names Geographic Areas Living Beings Objects Occupations Organizations Phenomena Physiology Procedures Keep B-terms that do not exist in the medical thesaurus Start A-Literature C-Literature B-list Filter Literature A-query: memory AND growth hormone C-query: adolescence The B-list contains title words and phrases (terms) that appeared in both the A and the C literature. 19 articles appeared in both literatures and were not included in the process of computing the B-list but can be viewed here . The results of this search are saved under id # 5757 and can be accessed from the start page after you leave this session. There are 134 terms on the current B-list ( 32 are predicted to be relevant), which is shown ranked according to predicted relevance. The list can be further trimmed down using the filters listed in the left margin. To assess whether there appears to be a biologically significant relationship between the AB and BC literatures for specific B-terms, please select one or more B-terms and then click the button to view the corresponding AB and BC literatures. Use Ctrl to select multiple B-terms. Rank Prob B-term 10.96vegf 20.96ghrelin 30.95leptin 40.92erk1 50.91bdnf 60.88estrogen receptor beta 70.88estrogen receptor alpha 80.87p300 90.84immediate early gene 100.83hpa 110.83e knockout mice 120.80bdnf gene 130.78clock gene 140.73growth hormone receptor 150.72gh 160.72igf-1 170.70apolipoprotein e 180.65early growth response 190.65tbi 200.65corticotropin releasing hormone 210.61diabetes mellitus 220.60cd4 230.57igf i 240.56diabetes 250.55anxiety 260.54trh 270.54glucocorticoid receptor 280.52subunit gene 290.52igf 300.51endothelin 310.49beta gene 320.46ncam 330.45ca1 340.44estrogen receptor 350.43gene transcript 360.43cell adhesion molecule 370.43trait 380.39cytokine 390.39spatial learning 400.35meta 410.33factor gene 420.27tyrosine hydroxylase 430.26hrt 440.25neuropeptide 450.25gene early 460.22life span 470.22task 480.20growth hormone 490.20ngf 500.19ms 510.18insulin growth factor 520.18spatial 530.17pcb 540.17somatostatin 550.17bee 560.16isoform 570.13body weight 580.13span 590.13clock 600.13g protein 610.11growth factor gene 620.10sex 630.10healthy human 640.09mass 650.09men 660.09hydroxylase gene 670.07olfactory 680.07renal failure 690.06alzheimer disease 700.06white 710.06male 720.06weight 730.05ant 740.05axis 750.05novel 760.04chat 770.04year 780.04acth 790.03erk 800.03prolactin 810.03death 820.03inducible 830.03gamma subunit 840.03domain 850.02old 860.02impact 870.02l1 880.02term 890.02area 900.02immune response 910.01insulin 920.01kinase 930.01box 940.01low 950.01gene 960.01early 970.00phospholipase 980.00time 990.00eye 1000.00atp 1010.00or 1020.00reduced expression 1030.00mitochondrial 1040.00dr 1050.00nervous 1060.00programmed cell death 1070.00ad 1080.00gut 1090.00delta 1100.00region 1110.00signal 1120.00desert 1130.00line 1140.00secretion 1150.00gamma 1160.00san 1170.00camp 1180.00gas 1190.00key 1200.00mice 1210.00a2 1220.00arm 1230.00lacking 1240.00bad 1250.00protein 1260.00des 1270.00receptor 1280.00alpha 1290.00beta 1300.00man 1310.00not 1320.00cell 1330.00fate 1340.00activity Restrict by semantic categories? Start A-Literature C-Literature B-list Filter Literature AB literature B-term BC literature memory AND growth hormone vegf adolescence 1: VEGF is necessary for exercise-induced adult hippocampal neurogenesis.2003 Add to clipboard 1: Differential regulation of VEGF after final oocyte maturation with GnRH agonist versus hCG: a rationale for OHSS reduction.2009 Add to clipboard 2: VEGF -C and VEGF R-3 in a series of lymphangiomas: is superficial lymphangioma a true lymphangioma?2009 Add to clipboard 3: Association of VEGF polymorphisms with childhood asthma, lung function and airway responsiveness.2009 Add to clipboard 4: The prognostic significance of VEGF -C and VEGF -A in non-Hodgkin lymphomas.2009 Add to clipboard 5: Analysis of VEGF , Flt-1, Flk-1, nestin and MMP-9 in relation to astrocytoma pathogenesis and progression.2009 Add to clipboard 6: Analysis of germline variants in CDH1, IGFBP3, MMP1, MMP3, STK15 and VEGF in familial and sporadic renal cell carcinoma.2009 Add to clipboard 7: 2009 Add to clipboard 8: VEGF expression as a prognostic marker in osteosarcoma.2009 Add to clipboard 9: Effects of VEGF on phenotypic severity in children with hereditary hemorrhagic telangiectasia.2009 Add to clipboard 10: Association of VEGF genetic polymorphisms with the clinical characteristics of non-Hodgkin's lymphoma.2009 Add to clipboard 11: Resolution of persistent exudative retinal detachment in a case of Sturge-Weber syndrome with anti -VEGF administration.2009 Add to clipboard 12: Expression of VEGF and VEGF receptors in childhood precursor B-cell acute lymphoblastic leukemia evaluated by immunohistochemistry.2009 Add to clipboard 13: Compressive force induces VEGF production in periodontal tissues.2009 Add to clipboard 14: Functional polymorphisms in transforming growth factor-beta-1 (TGF{beta}-1) and vascular endothelial growth factor (VEGF ) genes modify risk of renal parenchymal scarring following childhood urinary tract infection.2009 Add to clipboard 15: Effects of VEGF and FGF2 on the revascularization of severed human dental pulps.2008 Add to clipboard 16: The potential clinical relevance of serum vascular endothelial growth factor (VEGF ) and VEGF -C in recurrent papillary thyroid carcinoma.2008 Add to clipboard 17: Novel single nucleotide polymorphism of the VEGF gene as a risk predictor for gastroduodenal ulcers.2008 Add to clipboard 18: Impairment of microcirculation in juvenile idiopathic arthritis - studies by nailfold videocapillaroscopy and correlation with serum levels of sICAM and VEGF .2008 Add to clipboard 19: Vascular endothelial growth factor (VEGF )-C - a potent risk factor in children diagnosed with stadium 4 neuroblastoma.2008 Add to clipboard 20: 2008 Add to clipboard 以下是发现的相关基因知识概念，科研人员在科研选题和研究中可以参考，哪些研究主题有研究意义和价值？ memory AND growth hormone vegf adolescence job id # 5757 started Sun Jan 17 04:48:25 2010 Max_citations: 50000 Stoplist: /var/www/html/arrowsmith_uic/data/stopwords_pubmed Ngram_max: 3 5757 Search ARROWSMITH A A_query_raw: memory AND growth hormoneSun Jan 17 04:50:31 2010 A query = memory AND growth hormone started Sun Jan 17 04:50:31 2010 A query resulted in 284 titles 5757 Search ARROWSMITH C C_query_raw: adolescence Sun Jan 17 04:51:34 2010 C: adolescence 1332295 A: pubmed_query_A 284 AC: ( memory AND growth hormone ) AND ( adolescence ) 19 C query = adolescence started Sun Jan 17 04:51:35 2010 C query resulted in 50000 titles A AND C query resulted in 19 titles 1590 B-terms ready on Sun Jan 17 04:54:19 2010 Sem_filter: Genes Molecular Sequences, and Gene Protein Names 134 B-terms left after filter executed Sun Jan 17 05:01:29 2010 Viewed B-terms Sun Jan 17 05:02:11 2010 vegf B-list on Sun Jan 17 05:03:26 2010 1 vegf 2 ghrelin 3 leptin 4 erk1 5 bdnf 6 estrogen receptor beta 7 estrogen receptor alpha 8 p300 9 immediate early gene 10 hpa 11 e knockout mice 12 bdnf gene 13 clock gene 14 growth hormone receptor 15 gh 16 igf-1 17 apolipoprotein e 18 early growth response 19 tbi 20 corticotropin releasing hormone 21 diabetes mellitus 22 cd4 23 igf i 24 diabetes 25 anxiety 26 trh 27 glucocorticoid receptor 28 subunit gene 29 igf 30 endothelin 31 beta gene 32 ncam 33 ca1 34 estrogen receptor 35 gene transcript 36 cell adhesion molecule 37 trait 38 cytokine 39 spatial learning 40 meta 41 factor gene 42 tyrosine hydroxylase 43 hrt 44 neuropeptide 45 gene early 46 life span 47 task 48 growth hormone 49 ngf 50 ms 51 insulin growth factor 52 spatial 53 pcb 54 somatostatin 55 bee 56 isoform 57 body weight 58 span 59 clock 60 g protein 61 growth factor gene 62 sex 63 healthy human 64 mass 65 men 66 hydroxylase gene 67 olfactory 68 renal failure 69 alzheimer disease 70 white 71 male 72 weight 73 ant 74 axis 75 novel 76 chat 77 year 78 acth 79 erk 80 prolactin 81 death 82 inducible 83 gamma subunit 84 domain 85 old 86 impact 87 l1 88 term 89 area 90 immune response 91 insulin 92 kinase 93 box 94 low 95 gene 96 early 97 phospholipase 98 time 99 eye 100 atp 101 or 102 reduced expression 103 mitochondrial 104 dr 105 nervous 106 programmed cell death 107 ad 108 gut 109 delta 110 region 111 signal 112 desert 113 line 114 secretion 115 gamma 116 san 117 camp 118 gas 119 key 120 mice 121 a2 122 arm 123 lacking 124 bad 125 protein 126 des 127 receptor 128 alpha 129 beta 130 man 131 not 132 cell 133 fate 134 activity http://news.sciencenet.cn//htmlnews/2010/1/227331.shtm 生长激素补充疗法可预防大鼠记忆缺陷 美国研究人员在一项研究中发现，对于患有生长激素缺乏症的大鼠，如果在青春期阶段采用生长激素补充疗法，可以防止它们长大后出现记忆缺陷。 美国韦克福雷斯特大学医学院和俄克拉何马大学健康科学中心的科学家共同完成了这项研究。有关成果可能用于人类，帮助生长激素缺乏症患者避免成年后记忆缺陷的折磨。这项研究成果发表于英国《内分泌学杂志》（ Journal of Endocrinology ）1月刊。 生长激素缺乏症是指因垂体前叶分泌的生长激素不足而导致的生长发育障碍。患有原发性生长激素缺乏症的哺乳动物在出生数周后，生长发育就会明显迟缓，成年后会出现记忆缺陷。 科学家将患有生长激素缺乏症的大鼠分为３组。第一组大鼠在青春期（第四周至十四周）被注射生长激素，第二组仅补充盐水，第三组从第四周开始终生不断补充生长激素，然后在不同生长期将上述３组大鼠与健康大鼠进行记忆力比较。 结果发现，大鼠成年后，只有第二组大鼠的记忆力明显弱于正常组。 科学家认为，对大鼠来说，在青春期采用补充生长激素的办法可以预防生长激素缺乏症引发的成年后记忆缺陷，而青春期后继续补充生长激素则没有进一步效果。 更多阅读 《内分泌学杂志》发表论文摘要（英文） http://joe.endocrinology-journals.org/cgi/content/abstract/204/1/31?maxtoshow=HITS=10hits=10RESULTFORMAT=author1=Michelle+Nicolle+andorexactfulltext=andsearchid=1FIRSTINDEX=0sortspec=relevanceresourcetype=HWCIT Journal of Endocrinology (2010) 204 , 31-36 DOI: 10.1677/JOE-09-0323 2010 Society for Endocrinology This Article Full Text Full Text (PDF) All Versions of this Article: JOE-09-0323v1 204/1/31 most recent Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Google Scholar Articles by Nieves-Martinez, E Articles by Nicolle, M M PubMed PubMed Citation Articles by Nieves-Martinez, E Articles by Nicolle, M M E Nieves-Martinez 1 ,* , W E Sonntag 5 ,* , A Wilson 2 , A Donahue 2 , D P Molina 3 , J Brunso-Bechtold 1 ,3 and M M Nicolle 1 ,2 ,4 Early-onset GH deficiency results in spatial memory impairment in mid-life and is prevented by GH supplementation 1 Neuroscience Program 2 Physiology and Pharmacology 3 , Neurobiology and Anatomy 4 Department of Internal Medicine, Section of Gerontology, Wake Forest University Health Sciences, Medical Center Boulevard, Winston-Salem, North Carolina 27157-1083, USA 5 Reynolds Oklahoma Center on Aging, Oklahoma University Health Sciences Center, Oklahoma City, Oklahoma 73104, USA (Correspondence should be addressed to M M Nicolle; Email: mnicolle@wfubmc.edu