院士专家 姓 名: 孙汉董 学 科: 药物化学 电话/传真: 0871-5223251 电子邮件: hdsun@mail.kib.ac.cn 通讯地址: 云南省昆明市蓝黑路132号 650201 更多信息: 简历: 1958-1962,云南大学化学系,有机合成专业,学士 1980.10-1982.04,日本德岛大学药学部,研修 1988.05-10 日本京都大学药学部,药学博士 1983-1989,中国科学院昆明植物研究所,副研究员 1989.06,中国科学院昆明植物研究所,研究员 1984-1996,中国科学院昆明植物研究所,植物化学开放研究室主任 1990-1994,中国科学院昆明植物研究所,所长兼党委书记 1996年至今,中国科学院昆明植物研究所,植物化学与西部植物资源持续利用国家重点实验室学术委员会副主任 2003年11月,中国科学院院士 2006年至今,中国科学院昆明植物研究所学术委员会主任 主要从事药用和天然香科的植物资源、植物化学以及新药开发的基础和应用基础研究,是我国天然香料化学的主要学术带头人之一。到2005年止,在国内外学术刊物上共发表论文500余篇,被SCI收录的论文有260余篇,出版著作3部,申请国内外专利16项,有20余项科研成果分获国家、科学院和省部级奖励。至今已培养博士18人、硕士14人,在读博士8人,现任《Phytomedicine》、《Tetrahedron》等10种国内外学术刊物的编委或地区审稿人。2002年获得云南省自然科学奖一等奖,2002年获“云南省先进工作者”荣誉称号,2003年获“全国五一劳动奖章”。 研究领域: 植物化学、天然药物化学 社会任职: 获奖及荣誉: 2008年获云南省突出贡献奖。 1995.12,“西南地区资源开发与发展战略研究”获国家科技进步奖,国家科技部二等奖; 1998.12,“中国樟属植物资源及芳香成分”中国科学院三等奖; 2002.12,“香茶菜属植物二萜成分及生物活性的研究”获云南省自然科学奖一等奖; 1987.04,“云南省首届有突出贡献的优秀专业技术人才” ; 1990.10,中国科学院“优秀研究生导师”; 1998.10,中国科学院“优秀研究生导师”; 2003.04,“全国五一劳动奖章”; 2005.07,“中国科学院优秀研究生指导教师”; 2006.07,“中国科学院优秀研究生指导教师”; 2006.07,中国科学院“宝洁优秀研究生导师”; 代表论著: 1.孙汉董,许云龙,姜北,香茶菜属植物二萜化合物,科学出版社,2001. 2. 程必强,喻学俭,丁靖垲,孙汉董,云南香料植物资源及其利用,云南科技出版社,2001. 3. 于德泉,吴毓林,天然产物化学进展(第一章,二萜化合物研究进展由孙汉董,黎胜红撰写),化学工业出版社,2005. 代表性论文如下: 1.河南省医学科学研究所,河南医学院,云南植物研究所(化学部分由孙汉董撰写),一种新的抗肿瘤物质——冬凌草素,科学通报,1978, 23(1):53-56. 2.Tetsuro Fujita, Sun Han-dong, Yoshio Takeda, Yoshinori Minami, Teruyoshi Marunaka, Lin Zhong-wen, Xu Yun-long. Structure of phyllostachysin A: Novel Antineoplastic Diterpenoid from Rabdosia phyllostachys. J. Chem. Soc. Chemical. Communincation, 1985: 1738-1739. 4.孙汉董,中国香料植物资源. 云南植物研究,《植物资源研究专集》(增刊I),1988: 77-88;香料香精化妆品,1988, 3: 1-14; 香料(日本),2000,207: 110-118. 5.Sun Han-dong, Qiu Sheng-xiang, Lin Long-ze, Zhang Rong-ping, Zhou Yasheen, Zheng Qi-tai, Michael E. Johnson, Harry H. S. Fong, Norman R. Farnsworth and Geoffrey A. Cordell. Crystal structure of a 1:1 complex of Natural diterpenoids: Absolute configurations and unambiguous NMR spectral assignments of neoangustifolin and epinodosinol. Journal of Natural Product, 1997, 60(3): 203-206. 6.Sun Han-dong, Qin Sheng-xiong, B. Lobkovsky emil, Lin Long-ze, Norman R. Farhsworth, Jon Clardy and Harry H. S. Fong, Crystal and Molecular Structures of a natural equimolecular mixture of two epimeric diterpenes. Tetrahedron, 2001, 57(1): 65-70. 7.Li Rong-tao, Zhao Qin-shi, Li Sheng-hong, Han Quan-bin, Sun Han-dong*, Lu Yang , Zhang Li-li , and Zheng Qi-tai, Micrandilactone A, a novel triterpene from Schisandra micrantha. Organic Letters, 2003, 5: 1023-1026. 8.Shen Yun-heng, Li Sheng-hong, Li Rong-tao, Han Quan-bin, Zhao Qin-shi, Liang Li, Sun Han-dong*, Lu Yang, Cao Peng, Zheng Qi-tai. Coriatone and corianlactone, two novel sesquiterpenes from Coriaria nepalensis. Organic Letters, 2004, 6 (10): 1593-1595. 9.Han Quan-bin, Lu Yang, Zhang Li-li, Zheng Qi-tai, Sun Han-dong*. Novel ent-kaurane dimers from Isodon rubescens var. rubescens. Tetrehedron Letters, 2004, 45 (13): 2833-2837. 10.Li Sheng-hong, Wang Jia, Niu Xue-mei, Shen Yun-heng, Zhang Hong-jie, Sun Han-dong*, Li Ma-lin, Tian Qin-e, Lu Yang, Cao Peng, Zheng Qi-tai. Maoecrystal V, cytotoxic diterpenoid with a novel C-19 skeleton from Isodon eriocalyx (Dunn.) Hara. Organic Letters, 2004, 6 (23): 4327-4330. 11.Pu Jian-xin, Xiao Wei-lie, Lu Yang, Li Rong-tao, Li Hong-mei, Li Xian, Zhao Qin-shi, Zheng Qi-tai, Sun Han-dong*. Kadlongilactones A and B, two novel triterpene dilactones from Kadsura longipedunculata possessing a unique skeleton. Organic Letters, 2005, 7(22): 5079-5082. 12.Li Rong-tao, Han Quan-bin, Zheng Yong-tang, Wang Rui-rui, Yang Liu-meng, Lu Yang, Zheng Qi-tai, Zhao Qin-shi, Sun Han-dong*. Structure and anti-HIV activity of micrandilactones B and C, new nortriterpenoids possessing a unique skeleton from Schisandra micrantha. Chemical Communications. 2005, 23: 2936-2938. 13.Li Rong-tao, Xiao Wei-lie, Shen Yun-heng, Zhao Qin-shi, Sun Han-dong*. Structure characterization and possible bioggenesis of three new families of nortriterpenoids: Schisanartane, schiartane, and 18-norschiartane. Chemistry-A European Journal. 2005, 11 (10): 2989-2996. 14.Xiao Wei-lie, Li Rong-tao, Li Sheng-hong, Li Xiao-li, Sun Han-dong*, Zheng Yong-tang, Wang Rui-rui, Lu Yang, Zheng Qi-tai. Lancifodilactone F: A novel nortriterpenoid possessing a unique skeleton from Schisandra lancifolia and its anti-HIV activity. Organic Letters 2005, 7 (7): 1263-1266. 15.Sun Han-dong*, Huang Sheng-xiong, Han Quan-bin. Diterpenoids from Isodon species and their biological activities. Natural Product reports, 2006, 23: 673-698. 16.Huang Sheng-xiong, Xiao Wei-lie, Li Li-mei, Li Sheng-hong, Zhou Yan, Ding Li-sheng, Lou Li-guang, and Sun Han-dong*. Bisrubescensins A-C: Three New Dimeric ent-Kauranoids Isolated from Isodon rubescens, Organic Letters, 2006, 8(6): 1157-1160. 17.Huang Sheng-xiong, Yang Li-bin, Xiao Wei-lie, Lei Chun, Liu Jing-ping, Lu Yang, Weng Zhi-ying, Li Li-mei, Li Rong-tao, Yu Jun-lin, Zheng Qi-tai, and Sun Han-dong*. Wuweizidilactones A-F: Novel Highly Oxygenated Nortriterpenoids with Unusual Skeletons Isolated from Schisandra chinensis. Chemistry-A European Journal, 2007, 13, 4816-4822. 18. Li Li-mei, Li Guo-you, Ding Li-sheng, Lei Chun, Yang Li-bin, Zhao Yong, Weng Zhi-ying, Li Sheng-hong, Huang Sheng-xiong, Xiao Wei-lie, Han Quan-bin, Sun Han-dong*. Sculponins A-C, three new 6,7-seco-ent-kauranoids from Isodon sculponeatus. Tetrahedron Letters. 2007, 48(52): 9100-9103. 19. Wang Lan, Zhao W-l, Yan J-S, Liu P, Sun H-P, Zhou G-B, Weng Z-Y, Wu W-L, Weng X-Q, Sun X-J, Chen Zhu*, Sun Han-dong* and Chen Sai-juan*, Eriocalyxin B induces apoptosis of t(8;21) leukemia cells through NF-kappa B and MAPK signaling pathways and triggers degradation of AML1-ETO oncoprotein in a caspase-3-dependent manner. Cell Death and Differentiation, 2007, 14 (2): 306-317. 20. Wei-Lie Xiao, Rong-Tao Li, Sheng-Xiong Huang, Jian-Xin Pu, Han-Dong Sun*, Triterpenoids from the Schisandraceae family, Natural Product Reports, 2008, 25, 871-891. 21. Wei-Lie Xiao, Chun Lei, Jie Ren, Tou-Gen Liao, Jian-Xin Pu, Charles U. Pittman Jr., Yang Lu, Yong-Tang Zheng, Hua-Jie Zhu*, Han-Dong Sun*, Structure Elucidation and Theoretical Investigation of Key Steps in the Biogenetic Pathway of Schisanartane Nortriterpenoids by Using DFT Methods, Chemistry-A European Journal, 2008, 14 (36), 11584-11592. 22. Chun Lei, Sheng-Xiong Huang, Ji-Jun Chen, Li-Bin Yang, Wei-Lie Xiao, Yin Chang, Yang Lu, Hao Huang, Jian-Xin Pu, Han-Dong Sun*, Propindilactones E–J, Schiartane Nortriterpenoids from Schisandra propinqua var. Propinqua, J. Nat. Prod., 2008, 71 (7), 1228-1232. 23. Li-Mei Li, Guo-You Li, Li-Sheng Ding, Li-Bin Yang, Yong Zhao, Jian-Xin Pu, Wei-Lie Xiao, Quan-Bin Han, and Han-Dong Sun*, ent-Kaurane Diterpenoids from Isodon nervosus, J. Nat. Prod., 2008, 71, 684-688. 24. Xue-Mei Gao, Jian-Xin Pu, Sheng-Xiong Huang, Liu-Meng Yang, Hao Huang, Wei-Lie Xiao,Yong-Tang Zheng, Han-Dong Sun*, Lignans from Kadsura angustifolia, J. Nat. Prod., 2008, 71, 558-563. 25. Jian-Xin Pu, Liu-Meng Yang, Wei-Lie Xiao, Rong-Tao Li, Chun Lei, Xue-Mei Gao, Sheng-Xiong Huang, Sheng-Hong Li, Yong-Tang Zheng, Hao Huang, Han-Dong Sun*, Compounds from Kadsura heteroclita and Related anti-HIV activity, Phytochemistry, 2008, 69 (5), 1266-1272. 26. Li-Bin Yang, Jing Yang, Li-Mei Li, Chun Lei, Yong Zhao, Sheng-Xiong Huang, Wei-Lie Xiao, Quan-Bin Han, Jian-Xin Pu, Han-Dong Sun*, Symmetric and asymmetric ent-kaurane dimmers isolated from Isodon japonicus, Tetrahedron Letters, 2008, 49, 3574-3577. 27. Wei-Lie Xiao, Sheng-Xiong Huang, Rui-Rui Wang, Jia-Liang Zhong, Xue-Mei Gao, Fei He, Jian-Xin Pu, Yang Lu, Yong-Tang Zheng, Qi-Tai Zheng, Han-Dong Sun*, Nortriterpenoids and lignans from Schisandra sphenanthera, Phytochemistry, 2008, 69, 2862-2866. 28. Xue-Mei Gao, Jian-Xin Pu, Wei-Lie Xiao, Sheng-Xiong Huang, Li-Guang Lou, Han-Dong Sun*, Kadcoccilactones K–R, triterpenoids from Kadsura coccinea, Tetrahedron, 2008, 64, 11673-11679. 承担科研项目情况: 1.国家自然科学基金:五种香茶菜属植物的化学和生物活性成分研究(0701B51211)和五种四川、西藏产五味子属药用植物的化学成分及抗艾滋病活性研究 (0801691211) 2.云南省新药研发科技项目:治疗艾滋病中药、天然药物1类新药五味子素胶囊的临床前研究(0703C01211)和抗癌中药、天然药物一类新药毛萼乙素注射剂的临床前研究 3.国家自然科学基金重点:五味子科植物新奇化合物的发现及生物活性研究(0801901211) 4.NSFC-云南联合基金(重点项目):云南特有香茶菜属植物中抗癌活性成分及其作用机制研究(0801901211) 5.973项目:中国特有植物和微生物药用活性物质的基础研究(2009CB522303)和具有干细胞调控活性的天然产物的挑选和收集(2009CB940900)