检索策略:cancer and arsenic trioxide (("neoplasms" OR "neoplasms" OR "cancer" ) AND ("arsenic trioxide" OR "arsenic trioxide" )) AND Research Support, N I H, Extramural http://www.ncbi.nlm.nih.gov/pubmed 检索结果 115篇 pubmed_result (1) 115.txt 研究项目实例: Blood. 2005 May 15;105(10):4004-12. Epub 2005 Jan 27. Vitamin C protects HL60 and U266 cells from arsenic toxicity. Karasavvas N , Cárcamo JM , Stratis G , Golde DW . Source Memorial Sloan-Kettering Cancer Center, Box 451, 1275 York Ave, New York, NY 10021, USA. Abstract Although there is no compelling evidence that vitamin C has antitumor activity in humans, clinical trials are testing the hypothesis that ascorbic acid (AA) will enhance the efficacy of arsenic trioxide (As2O3) in myeloma. In vitro, AA cytotoxicity depends on its interaction with free transition metal ions in culture media leading to the generation of H2O2 and other reactive oxygen species (ROSs). Therefore, to circumvent the extracellular in vitro pro-oxidant effects of AA, we loaded HL60, U266, and RPMI-8226 cells with vitamin C by incubation with dehydroascorbic acid (DHA). Loading cells in this manner resulted in prominent, dose-dependent protection of As2O3-treated cells as measured by viability, colony formation, and apoptosis assays. Glutathione depletion enhanced cell sensitivity to the cytotoxic effects of As2O3 and vitamin C loading provided protection. AA was found to generate cytotoxic concentrations of H2O2 in culture medium without cells and copper/iron chelators inhibited this reaction. However, AA did not generate H2O2 in simple buffer or human plasma. Direct incubation with AA resulted in increased intracellular ROSs, whereas DHA incubation decreased it. These results clarify an apparent paradox and indicate that vitamin C loading in HL60, U266, and RPMI-8226 cells ameliorates As2O3 cytotoxicity. PMID:15677571 PMCID:PMC1895087 Free PMC Article Images from this publication. See all images (7) Free text The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version. Destroy user interface control Publication Types, MeSH Terms, Substances, Grant Support Publication Types Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. MeSH Terms Arsenic/metabolism Arsenic/toxicity* Ascorbic Acid/metabolism Ascorbic Acid/pharmacology* Biological Transport Cell Line, Tumor Cell-Free System Glutathione/metabolism HL-60 Cells Humans Hydrogen Peroxide/metabolism Oxidation-Reduction Reactive Oxygen Species/metabolism Substances Reactive Oxygen Species Ascorbic Acid Glutathione Arsenic Hydrogen Peroxide Grant Support R01 CA30388/CA/NCI NIH HHS/United States The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version. Destroy user interface control LinkOut - more resources Full Text Sources HighWire Europe PubMed Central PubMed Central Medical Arsenic - MedlinePlus Health Information Vitamin C - MedlinePlus Health Information Molecular Biology Databases ARSENIC, ELEMENTAL - HSDB HYDROGEN PEROXIDE - HSDB ASCORBIC ACID - HSDB SODIUM ASCORBATE - HSDB
Wen Chen, Fuzhang Wang . A method of fundamental solutions without fictitious boundary. Engineering Analysis with Boundary Elements 34(5):530-532, 2010 ( SCI Impact Factor : 1.531) Wen Chen, Ji Lin, Fuzhang Wang . Regularized meshless method for nonhomogeneous problems . Engineering Analysis with Boundary Elements 35(2):253-257, 2011 ( SCI Impact Factor: 1.531) Ji Lin, Wen Chen, Fuzhang Wang . A new investigation into regularization techniques for the method of fundamental solutions. Mathematics and Computers in Simulation (Published Online 2010) DOI: 10.1016/j.matcom.2010.10.030 ( SCI Impact Factor : 0.946) If you are interested in these papers and cannot access to them from the web, pleasecontact me by email wfz1984@gmail.com 江苏省 2009 年度普通高校研究生科研创新计划,声波问题的快速无网格法研究, 项目负责人 , 2009.09-2010.09 (已完成)
科研人员应当特别关注正在进行中的科研项目(2010 - 2014年的在研项目,有些项目研究时间可能更远)。 在研项目具有前瞻性,将会产生最新的科研成果、科研动态与进展,是最重要的科研情报,科研人员应当密切关注,及时跟踪与自己的研究领域相关的科研信息。把握自己的研究方向,及时调整研究思路和研究内容。掌握国内外在研项目对自己科研选题极为重要,只了解已发表的文献信息在科研中就太滞后啦。 科技信息机构的信息专业人员应当了解国内外有无本学科领域的在研项目数据库、信息检索系统、信息门户平台等,为科研人员提供重要的科研情报与信息支持。 目前,国内还没有一个在研科技项目数据库可供检索查阅,在CNKI平台查阅比较方便。 可查阅的相关信息: 完成时间 资助发文数 申请专利数 科技成果数 资助经费总额数 请见: http://elib.cnki.net/grid2008/ 在研项目检索实例: 请见:http://elib.cnki.net/grid2008/DetailProject/DetailViewMore.aspx?type=sametable=1id=162106006 请见: http://elib.cnki.net/grid2008/DetailProject/DetailView.aspx?projectid=163230001 【项目名称】 年轻新基因在果蝇发育和进化中的作用 【项目编号】 30930056 【项目目标】 【项目关键词】 基因;果蝇; 【项目承办单位】 中国科学院昆明动物研究所 【项目负责人】 王文 【项目来源】 国家自然科学基金项目 【涉及学科】 生物学; 【科研经费】 180万 【所属大项目】 【项目参与研究人员】 【项目参与研究机构】 【项目成果摘要】 【发布单位】 国家自然科学基金委员会 【发布时间】 2008-11-21 【申请截止时间】 2009-03-20 【立项时间】 2010-01 【完成时间】 2013-12 【申请条件】 【联系方式】 【项目信息来源】 国外医学(卫生)系统的在研项目信息平台如下: HSRProj (Health Services Research Projects in Progress) Information about ongoing health services research and public health projects 网站地址 http://wwwcf.nlm.nih.gov/hsr_project/display_result_page.cfm?type=Search_Fieldssearch_for=aids%20%20CFID=4585513CFTOKEN=e97362a864a10f20-6AF17D34-FE45-9E23-446B1548D5198DE7 科研人员可以了解到详细的相关信息: 项目名称 Closing the research-to-practice gap in cardiac care for minority and low income populations 研究者 Investigator: Olomu, Adesuwa B 研究机构 Place: College of Human Medicine, Michigan State University, A110 East Fee Hall East, Lansing, MI 48824 研究者电话 Investigator Phone: (517) 432-9241 电子信箱 Email Address: ade.olomu@ht.msu.edu Performing Organization: College of Human Medicine, Michigan State University 实施机构 Performing Organization URL: http://humanmedicine.msu.edu/ 电话 Phone Number: (517) 353-1730 资助机构 Supporting Agency: Agency for Healthcare Research and Quality (AHRQ) 资助机构网站 Supporting Agency URL: http://www.ahrq.gov/ 立项日期 Initial Year: 2009 完成日期 Final Year: 2014 基金编号 Grant Support: K08HS018104-0109 协议类型 Award Type: Contract 项目摘要 Abstract: This proposal describes a 5-year training program to foster an academic career in health services research. The principal investigator is a general internist and Associate Professor of Medicine at Michigan State 主题词 Mesh Terms: African Americans Biomedical Research Cardiology /* methods /* organization administration Community Health Services / organization administration Coronary Disease / ethnology /* therapy Diffusion of Innovation Evidence-Based Medicine Health Services Accessibility Health Services Research Humans Michigan Minority Groups Poverty Practice Guidelines as Topic Software 国家 Country: United States 州 State: Michigan (MI) 邮政编码 Zip Code: 48824 UI: HSRP20094107 项目进展 Project Status: 正在研究中 Ongoing