http://www.gopubmed.org/web/gopubmed/1?WEB019vlprx24so9nI1hIrI00h01000j100200010 Translational research and HIV vaccine 41 documents semantically analyzed Top Years Publications 2008 9 2009 6 2007 4 2010 3 1992 3 2006 2 2002 2 2001 2 2005 1 2003 1 2000 1 1999 1 1998 1 1997 1 1996 1 1995 1 1994 1 1987 1 Top Countries Publications USA 27 Belgium 3 Canada 2 Portugal 1 United Kingdom 1 Sweden 1 France 1 Italy 1 Denmark 1 Germany 1 1 2 Top Cities Publications New York 4 Frederick 3 Brussels 2 Durham 2 Tempe 2 Birmingham, USA 2 Philadelphia 2 Raleigh 1 Boston 1 Rochester, MN, USA 1 Duarte 1 Pittsburgh 1 Lisbon 1 Minneapolis 1 Pearl River 1 London 1 Adelphi 1 Garden City, NY, USA 1 Bethesda 1 Huddinge 1 1 2 1 2 Top Journals Publications J Virol 8 Vaccine 4 Retrovirology 3 Nature 2 Virology 2 Tuberculosis (edinb) 1 Clin Exp Immunol 1 J Virol Methods 1 Plos One 1 Clin Vaccine Immunol 1 Curr Top Microbiol 1 Curr Hiv Res 1 J Allergy Clin Immunol 1 J Clin Invest 1 Policy Polit Nurs Pract 1 J Immunol Methods 1 Semin Immunol 1 Lancet Infect Dis 1 Ann Pharm Fr 1 Curr Opin Infect Dis 1 1 2 1 2 3 ... 32 Top Terms Publications Vaccines 37 Vaccination 37 HIV 30 Humans 29 Viruses 26 Animals 24 Immunization 24 Immunity 24 HIV-1 22 Proteins 20 AIDS Vaccines 19 immune response 17 Antibodies 16 antigen binding 16 Genes 16 Protein Processing, Post-Translational 16 HIV Infections 14 T-Lymphocytes 14 Antigens 11 HIV Antibodies 11 1 2 3 ... 32 1 2 3 ... 14 Top Authors Publications Sowder R 2 Moore J 2 Maddon P 2 Olson W 2 Arthur L 2 Dean G 1 Howard K 1 Reckling S 1 Egan E 1 Olesen O 1 Lng H 1 Quaglio G 1 Barouch D 1 Kaufman D 1 Haynes B 1 Liao H 1 Levesque M 1 Nagel A 1 Dixon A 1 Zhang R 1 1 2 3 ... 14 相关研究报道: Wayne C. Koff说,增加支持临床转化研究的新资助机制对于研制一种成功的艾滋病疫苗是关键的。 Translational research key to HIV vaccine 来源: Nature 2010年3月11日 | EN Flickr/prashant_zi Expanding translational research is essential to develop a successful HIV vaccine, says Wayne C. Koff , chief scientific officer at the International AIDS Vaccine Initiative . HIV vaccine development has not kept up with basic science, says Koff. Research programmes to connect scientists working in viral immunology and HIV pathogenesis with vaccine-development tools are urgently needed, he says. This means dedicating resources to design a set of immunogens that create neutralising antibodies to prevent HIV infection and another set to elicit cellular immune responses to control infection. More investment in translational research, which has generally been limited to 35 year programmes for small academic consortia is needed. While public-sector funds have effectively fostered basic research, they have not attracted new talent to HIV vaccine research, created links with industry or fostered innovation in vaccine discovery. Koff calls for three new funding mechanisms to support translational research: 'young investigator awards' that offer 57 years of salary and flexible funding; inducements for biopharmaceutical investment, including advanced market commitments or intellectual property incentives; and direct support for research teams, amounting to ten per cent of annual investment in HIV vaccine research. Link to full article in Nature