胡家志 Background : Mr. Hu entered the PhD program at Peking University in 2006. His advisor is Dr. Daochun Kong. In his studies of mechanisms of DNA replication using multiple approaches, Mr. Hu made a major breakthrough that Dna2 cleavage of regressed nascent strands prevents fork reversal and thus stabilizes stalled forks to maintain genome stability during replication stress. Citation : Mr. Hu is a talented and hard working student with the ability to think and work independently. During the interview, he addressed all questions clearly, and has shown broad knowledge beyond his field of research. He is committed to his work. Overall, the committee thinks that he is clearly an outstanding graduate student. 王传超 Backgroun d : Mr. Wang received his BS from Ocean University of China in 2010, and is conducting his Ph.D. study in the field of anthropology under the direction of Dr. Hui Li at Fudan University. During the past two years, he mainly studied the origin and diversification of the Chinese and other East Asian populations utilizing genomic tools as well as archaeological, linguistic, historical, and ethnological methods. He also applied biostatistic and bioinformatic methods to investigate the development rules of the languages. Citation : Mr. Wang is an outstanding student and has accomplished significantly in a short period of time (He is only a second year student). He made a very good impression during the interview by offering clear and concise answers to all the questions. His broad knowledge in genomics and bioinformatics would benefit greatly for his future research in the field. His work is unique in China and is important for anthropology of Chinese. He demonstrated independent thinking and a strong desire to have a career in science. 黄鹏羽 Background : Mr. Huang received his BS from Huazhong University of Science and Technology University in 2008, and entered the PhD program in Institute of Biochemistry and Cell Biology (IBCB), Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, where he studies under Dr. Li-Jian Hui. His research focuses on cell reprogramming. His work showed that one can induce mouse mesenchymal fibroblasts directly into iHep cells by transduction of three hepatic transcription factors Foxa3, Gata4, HNF1a, and inactivation of P19Arf. iHep cells show typical epithelial morphology, express hepatic genes and acquire hepatocyte functions. Importantly, using fumarylacetoacetate hydrolase-deficient mice as a liver injury model, he showed that transplanted iHep cells could repopulate the liver and rescue recipients from death by restoring liver functions. This work provides a novel strategy to generate functional hepatocyte-like cells for liver engineering and regenerative medicine to treat liver diseases. Citation : Mr. Huang works hard and made an important breakthrough. His work is a milestone. He has in depth knowledge of his research area, and at the same time broad knowledge of life science research. He has some good ideas in his future plans, which reflects well on his own independent thinking. 杨 辉 Background : Mr. Yang received his bachelor’s degree in life sciences and biotechnology from Shanghai Jiao Tong University in 2007, and is conducting his Ph.D. research in the laboratory of Dr. Jinsong Li at the Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences. His research focuses on reprogramming in fertilization and somatic cell nuclear transfer (SCNT). He has successfully accomplished four projects, i.e. nuclear transfer with intact MII oocytes, fertilization ability of two-cell blastomeres, the role of Tet3 in epigenetic reprogramming and establishment of haploid embryonic stem cell. He has recently made a major breakthrough in transgenesis using haploid embryonic stem cells. He is exploring the possibility of using this approach to alter the genome of other species such as monkeys. Citation : Mr. Yang made many unique and crucial contributions to a series of important work in his group. His method is potentially a novel approach to generate genetically modified animals. He demonstrated good understanding about his field, and is especially knowledgeable about embryonic development. He gave sharp and precise answers to all the questions. 巴钊庆 Background : Mr. Ba entered the Ph.D. program in National Institute of Biological Science (NIBS)/Beijing Normal University in 2008. His advisor is Dr. Yijun Qi. He works on the mechanisms and functions of small RNA pathways in plants. He has conceived the ideas and worked on identification of miRNA targets through profiling AGO1-associated RNAs and the examination of the role of small RNAs in DSB repair. He wisely chose a well-established reporter system for assaying DSB repair efficiency in RNAi mutants, which led to the discovery that small RNAs (named diRNAs for DSB-induced small RNAs) are specifically produced from the sequences around the DSB site and that diRNAs are important for DSB repair.These findings represent a conceptual breakthrough of the mechanism of DSB repair. Citation : Mr. Ba did a lot of work and made breakthroughs in a unique system. His work revealed a novel mechanism of DNA repair, which may have a big impact in the field. He has broad knowledge of the field. His answers are clear. He was able to describe the novelty of his work, reflecting well on his own independent thinking. 杨 辉 Background : Mr. Yang received his BS from Huazhong University of Science and Technology University with a No. 1 ranking in his class. He began his Ph.D. study under the direction of Dr. Yue Xiong at Fudan University in 2008. He is involved in two highly competitive projects: 1) Investigating the effect of altered metabolites, especially the TCA metabolites, on changing epigenetics, and 2) identifying epigenetic biomarkers for clinical cancer diagnosis. Citation : Mr. Yang is very energetic and has recently obtained interesting results, which could expand his study into new directions and potentially make paradigm-shifting findings. He is very familiar with the general regulation of gene expression and is able to think quite independently. During the interview, he responded well to most questions. 张 丽 Background : Ms. Zhang received her BS degree from Sichuan University in 2008, and entered the Ph.D. program in National Institute of Biological Science (NIBS)/Peking Union Medical College in 2008. Her advisor is Dr. Feng Shao. Her work reveals a novel mechanism in bacterial inhibition of host innate immune defense, and for the first time shows that cysteine methylation, as a new posttranslational modification, can regulate eukaryotic signal transduction. Cysteine methylation in zinc-finger motifs of TAB2/3 by a bacterial effector called NleE disrupts ubiquitin-chain binding of TAB2/3 and subsequently blocks host NF-κB signaling. Citation : Ms. Zhang did an excellent job, and made a novel finding which can be considered as a “landmark”. She mastered the general biochemistry techniques. Her answers are clear and good. She is highly motivated and enthusiastic. 朱 书 Background : Mr. Zhu received his BS degree from University of Science Technology of China, and entered the Ph.D. program of Institute of Health Science, Shanghai Institutes for Biological Science, Chinese Academy of Sciences under the direction of Dr. Youcun Qian in 2006. His Ph.D. thesis is investigating molecular mechanism of development and pathogenesis of autoimmune diseases for potential therapeutic applications. He identified TRAF3 as the first receptor proximal negative regulator in IL-17 signaling and verified the in vivo function of TRAF3 in experimental autoimmune encephalomyelitis. He also contributed to another study on the role of IL-17RE on mucosal immunity. Citation : He discovered the role of miR-23b in regulation of autoimmune diseases. Collection of the disease tissues was a major effort. Systematical analyses led to the important findings mentioned above. He has a broad interest in autoimmune diseases, and he worked on several areas including some out of his own initiation. He made a good presentation, and showed enthusiasm in science. 赵 越 Background : Ms. Zhao received her BS degree from Nankai University in 2007, and is conducting her Ph.D. research in the laboratory of Dr. Feng Shao in the National Institute of Biological Science (NIBS)/Peking Union Medical College. Her project has been centered on how microbes activate the host inflammation pathway. She works on an inflammasome complex mediated by an NOD-Like receptor protein called NLRC4. She identified the NAIP family of NLR proteins as the inflammasome receptors for bacterial flagellin and the TTSS apparatus component. At the same time, she confirmed the presumed innate immune receptor function for the large NLR family of proteins. Citation : Ms. Zhao found out that the intracellular proteins from the pathogen bind to NLR, which triggers the caspase1 pathway. Her project required efforts and unique approaches to map the interactions between the receptor and the target. She appears to have read broadly so that she could apply multiple approaches to overcome the difficulty. She is knowledgeable, and can sometimes go beyond the current project. During the interview, she could address a broad range of questions, and is quite excited about her own work. 王 超 Background : Mr. Wang obtained his bachelor’s degree from Xiamen University in 2007, and is conducting his Ph.D. research in the laboratory of Dr. Zhizheng Wang at the Institute of Biophysics, Chinese Academy of Sciences. His research concerns the mechanism of action of human Protein disulfide isomerase (hPDI), a key enzyme involved in protein folding. He has made several findings during his doctoral research including 1) the major flexibility of the whole hPDI molecule is due to the intrinsic flexibility of the b’xa’ but not the ab region as in yeast PDI; 2) the oxidation of domain a’ releases the compact conformation and exposes the substrate binding residues to facilitate its high chaperone activity; and 3) he succeeded in producing high quality crystals and determining the 3D structures of hPDI at high resolution not only in the reduced but also in oxidized states. Citation : Mr. Wang is an energetic guy. He did good work and has excellent understanding of the implications as well as limitations of his work. The project dissects the structure of the protein and mapped a little more of the molecular mechanisms of the reactions. The work is a typical biochemical study of a protein. He can answer all of questions clearly with fluent English. 穆 宇 Background : Mr. Mu entered the Ph.D. program in Institute of Neurosicence, Shanghai Institutes for Biological Science, Chinese Academy of Science in 2008. His advisor is Dr. Jiulin Du. He is involved in investigating the role of visual input in modulating auditory signaling in the zebrafish. Through an elegant combination of zebrafish genetics, electrophysiological recording (in vivo whole-cell recording), and behavioral studies, he has shown the light stimulus within a critical time window of a few seconds prior to the onset of a sound stimulus that evoked startle responses in zebrafish larvae could enhance the startle responses by modulating the signal-to-noise ratio of the auditory nerve spiking activity and the synaptic efficacy of auditory nerve. This modulation was also shown to be mediated by specific group of dopamine neurons. He has recently developed an excellent behavioral paradigm for studying learning and memory in zebrafish. Citation : Mr. Mu designed a visual-auditory program in zebrafish and mapped the neuron modulation by using visual-auditory relationship. He showed potential for innovation, and has interesting ideas about new topics on virtual reality of perception. He did excellent work and knows his field very well. He was able to notice unexpected effects of the experimental conditions. He gives a very clear presentation to a complex study, and shows good enthusiasm in science. 冯 锋 Background ： Mr. Feng received his bachelor degree from Henan Agriculture University in 2005, and entered the Ph.D. program in the laboratory of Dr. Chaozu He at Tsinghua University in 2008. His project is to study the interaction of plants with pathogenic bacteria. He demonstrated that the Xcc effector protein AvrAC is able to inhibit both PTI and RPM1-specified ETI by targeting BIK1 and RIPK, two receptor-like cytoplasmic kinases that are known to mediate immune signaling in Arabidopsis. AvrAC is a uridine 5’-monophosphoate transferase that uridylylates the conserved serine and threonine residues in the activation loop of BIK1 and RIPK. Citation : Mr. Feng is dedicated to his work and showed some impressive accomplishments. He is knowledgeable in the field. He was able to notice unexpected results that helped the progress. His ways of thinking and description are straight forward. He has good knowledge about plant immune system. 李中伟 B ackground : Mr. Li received his bachelor degree from Sichuan University in 2007, and is conducting his Ph.D. research in the laboratory of Dr. Ye-Guang Chen at Tsinghua University. His major research interest is to investigate how transforming growth factor- and Wnt signaling is regulated. He found out that the mouse embryonic stem cell can be maintained without loss of pluripotency in culture medium supplemented with LIF and BMP (bone morphogenic protein). Moreover, BMP can upregulate the dual specific phosphatase DUSP9, which in turn dephosphorylates and inactivates ERK. Citation : He did an outstanding job to link two key pathways that have an effect on mESC maintenance, and this work made a step forward in defining the signal pathway. The progress is interesting and may lead to novel discoveries. He is knowledgeable and is able to come up with follow up experimental procedures when he observed interesting results. He is clear about what he knows or not. He has a broad mind about research. He offered a good presentation and responded well to questions. 都 浩 Background : Mr. Du received his Bachelor of Science degree from Huazhong Agricultural University in 2007 entered his Ph.D. program in Huazhong Agricultural University in 2008. His advisor is Dr. Lizhong Xiong. He was engaged in studying the molecular biology of resistance to hazards in rice. He studies the hormonal regulation of plants under the abiotic stress environment, epigenetic regulation, and biological rhythm regulation by using rice mutant screening. Citation : He works very hard and made a lot of progress covering a wide range of topics. He is able to define the mechanism of several gene functions. He is able to compare and contrast stress defense by plants and animals, which reflects his broad knowledge. He has a very clear mind and dedicated to the work. He is active as a student organizer in academic activities and a frequent visitor of RWMF blog. 顾天鹏 Background : Mr. Gu received his bachelor degree from Shandong University in 2007, and entered the Ph.D. program in the laboratory of Dr. Guoliang Xu at Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences in 2007. His research has focused on the mechanism of epigenetic reprogramming in the early mouse embryo. He first managed to raise an antibody specific for the oxidation product in DNA, 5hmC. With this antibody, he discovered that 5hmC is generated in the male pronucleus of fertilized eggs. Moreover, he demonstrated that oxidation of 5mC to 5hmC is mediated by the dioxygenase Tet3 in a gene-knockout model. Citation : The candidate can explain his body of work adequately. He carried out most of the biochemical work. He independently found out the approach to generate hmC specific antibody. His description was clear and precise. He is also modest. 姜小倩 Background : Ms. Jiang received her bachelor degree from Shaanxi University of Science and Technology in 2007, and entered the Ph.D. program in the laboratory of Dr. Shiheng Tao at Northwest Agriculture and Forestry University in 2007. Her research focuses on evolutionary biology using computer-simulation methods. She revealed that the mutation rate in asexual populations was determined by both population size and mutation effects. Furthermore, she found that in the ‘‘strong-selection weak mutation (SSWM)’’ regime or in the ‘‘clonal interference (CI)’’ regime, deleterious mutations rarely influence the distribution of ‘‘selection coefficients of the fixed mutations (SCFM)’’; while in the ‘‘multiple mutations’’ regime, the accumulation of deleterious mutations would lead to a decrease in fitness significantly. Citation : She was able to accomplish a complicated project and is productive. She is very independent as most of her work was done by herself. One interviewer thinks she has the potential for innovation. She is knowledgeable in many aspects. She answers questions clearly and is passionate about her research topic. Sayli Kong Background : Ms. Kong received her BS from Universiti Putra Malaysia and MS from National University of Singapore. She began her Ph.D. study under the direction of Dr. Edison T Liu at National University of Singapore in 2009. Her research focuses on estrogen receptor (ER) regulation and its impact on cellular biology. Using the workhorse MCF7 human mammary carcinoma cell as the study model, the genomewide binding events for estrogen receptor (ER) and its co-regulators, namely FOXA1 and GATA3, were mapped. Cellular reprogramming was regulated by the conjoint action of ERα, FOXA1 and GATA3 to a ligand inducible growth state. Growth and proliferation of breast cancer cells were shown to be related to the core estrogen responsive cassettes. Citation : The committee recognizes her outstanding productivity and was impressed of her academic maturity, well organized presentation and confidence in science. She demonstrated that she is independent, and passionate about her research and career. She knows her research field well beyond her own subject and has a good understanding about the mission of RWMF. She interacted with each of committee members well and answered challenging questions confidently and clearly. 详情请登录： http://www.raywumemorialfund.org/2012winner.php
THE RAY WU PRIZE The Ray Wu Prize for Excellence in Life Sciences is established to inspire Asia’s most promising young Ph.D. students to become future leaders in life sciences.Professor Ray Wu (1928-2008) was a world-renowned biologist who, in the 1970s, developed the first method for DNA sequencing and pioneered the recombinant DNA technology. In the later part of his career, he devoted to genetic engineering of rice.Professor Wu was a life-long advocate for developing life science research in Asia.In 1982, Professor Wu initiated the first large-scale exchange program in biology which brought over 400 students from China to obtain Ph.D. degrees in the US.The program opened the door for thousands of more Chinese students to study abroad and marked the beginning of Sino-US exchanges in life science research. This prize is dedicated in honor of Professor Ray Wu’s seminal contributions in training China’s new generation of biologists. Forty one prizes have been awarded so far. The Ray Wu Prize is awarded each year to graduate students for excell ence in life science research. The process for selection of recipients is outlined in the following sections. The Prize: The prize consists of USD $3000, a medal, a certificate, and a citation by the Ray Wu Memorial Fund (RWMF). Financial assistance for travel is available to the recipients for career advancement purposes. RWMF will serve as a liaison for the awardees who wish to seek consultation from established investigators as they develop their scientific careers. Ten or more awards may be made each year. Candidates from all geographical areas are encouraged to apply and special considerations will be given to semifinalists from each underrepresented major geographical area. Criteria: The Ray Wu Prize recognizes excellence in life science research by a graduate student for innovation, independent thinking, and dedication. Qualifications: A candidate must be a graduate student who is pursuing a degree of Doctor of Philosophy (PhD) in an institution located in mainland China, Hong Kong, Taiwan, or Singapore. The candidate must have advanced to candidacy in the PhD program by the deadline of application. Nomination: A candidate may be nominated by a faculty member of the institution from which the candidate plans to receive the PhD. The faculty member shall be a PhD mentor and is actively conducting life science research. Materials to be submitted: A candidate who wishes to be considered for this year's Ray Wu Prize must submit the following materials by the deadline for application: 1. A completed application form. (Please download the application form available below. Fill out in English or Chinese) http:// www.raywumemorialfund.org/application_process.php . The com pleted application form must be signed by the Dean of the School in which the candidate is currently enrolled to certify all materials as true and authentic. 2. A two page essay (English or Chinese) by the candidate in which the motivation of pursuing a PhD degree, personal interest in the current field of own research, and outlook for future career development should be addressed. 3. A progress report of the candidate's current PhD research project (limited to 3 pages, not counting references). 4. A current transcript of courses taken in the PhD program. 5. A list of publications 6. Copies of two representative published materials. 7. Awards or honors received. The candidate must collate items 1-7 in a single PDF file (limited to 10MB) in the right order. The name of the PDF file must be Familyname_Givenname_RWP2013.pdf (e.g. Chen_Xiaohua_RWP2013.pdf). Submit the PDF file by clicking the button below: Online Submission In addition, the candidate must request a letter of recommendation from the nominating faculty member (letter1), and two additional letters of recommendation from other faculty members who know the candidate well professionally (letter2 and letter3). The letter must be in an envelope sealed by each faculty member with candidate’s name on the back of the envelope, sent to: Dr. Yan Wu Mail Box 77 School of Life Sciences Peking University Beijing , China 100871. or sent directly by the faculty members via email to: raywuprize@pku.edu.cn . The name of the letters must be Familyname_Givenname_RWP2013_letter1(2 or 3).pdf (e.g. Chen_Xiaohua_RWP2013_letter1.pdf). Important Dates: March 31, 2013, deadline for applications to be received. April 30, 2013, notification of receipt of completed applications (by email or other means). August 31, 2013, completion of review. Award ceremony, to be announced. Website of Ray Wu Memorial Fund : http://www.raywumemorialfund.org/ The Ray Wu Prize committee Chair: Xiaodong Wang ( 王晓东 ) Director, National Institute of Biological Sciences, Beijing Members: Sheng Ding ( 丁胜 ) Professor,Universityof California, San Francisco Xinnian Dong ( 董欣年 ) Arts Sciences Endowed Professor of Biology, Duke University Xin-Yuan Fu( 傅新元 ) Professor, National University of Singapore Jun-Lin Guan ( 管俊林 ) Professor, University of Michigan Nancy Y. Ip ( 叶玉如 ) Head Chair Professor, Hong Kong University of Science and Technology Hsou-min Li ( 李秀敏 ) Research Fellow, Institute of Molecular Biology, Academia Sinica, Taiwan Yang Liu ( 刘阳 ) Charles B. de Nancrede Professor, University of Michigan Ming Luo ( 罗明 ) Professor, University of Alabama at Birmingham Hong Ma ( 马红 ) Dean and Professor, School of Life Sciences, Fudan University Yi Rao ( 饶毅 ) Dean and Professor, School of Life Sciences, Peking University Xiao-Hong Sun ( 孙晓红 ) Lew and Myra Ward Chair and Member, Oklahoma Medical Research Foundation Yue Xiong ( 熊跃 ) William R. Kenan, Jr. Professor,University of North Carolina Xian-Jie Yang （杨先洁） Professor, University of California, Los Angeles Weimin Zhong ( 钟伟民 ) Associate professor, Yale University
吴瑞奖学金 吴瑞教授（ 1928 — 2008 ），国际著名生物学家，在二十世纪七十年代发明了 DNA 测序的第一种方法，晚年专注于水稻基因工程研究。吴瑞教授一生致力于促进亚洲科学研究工作的发展，并于 1982 年在中国创建了生物学领域的国家公派留美 CUSBEA （即中美生物化学与分子生物学博士研究生）项目。 CUSBEA 项目历时 8 年，共选派了 422 名优秀学生赴美攻读博士学位。 CUSBEA 项目同时也推动了中美两国在生命科学研究领域中的学术交流。 吴瑞纪念基金会（ RWMF ）设立“吴瑞奖学金”，旨在鼓励博士研究生努力将自己塑造成未来生命科学领域的学术带头人，同时也纪念吴瑞教授在培养中国新一代生物学家方面所做出的杰出贡献。吴瑞奖学金至今已颁发逾四十人次。 奖励 ：包含奖金三千元美金、奖章、 奖状及证书。 获 奖人可向 吴瑞纪念基金会 申请与专业发展有关的旅费资助。 获 奖人在其科学生涯中如有需向资深研究员寻求咨询， 吴瑞纪念基金会 将帮助联系。 本奖项可每年颁发十人次以上 ( 对以往 获 奖人缺少地区的入围者给予优先考虑 ) 。 选拔标准 ：吴瑞奖学金奖励从事生命科学领域的 ， 有创新性、独立思考能力和专注奉献精神的博士研究生。 选拔条件 ：在中国大陆、香港、澳门、台湾及新加坡的大学或研究所攻读博士学位的在读学生均可提出申请。 在提交申请书截止日期之前，该生必须已经获得博士生资格。 提名 ：申请人应由 本 人导师提名。提名人须是高级研究人员，并且仍活跃在科学研究的第一线。 需要提交的材料 ：拟申请当年 ” 吴瑞奖学金 ” 的申请人须在申请截止日期之前提交下列材料 : 1. 申请书：登陆吴瑞纪念基金会官网下载 （ http://www.raywumemorialfund.org/application_process.php ） ，中文或英文填写。 申请书须由申请人当前所在单位的学院院长或研究所所长亲笔签名，以确认所提交全部材料内容属实且有效 ； 2. 限两页纸的自我介绍（中英文均可），内容主要阐述本人攻读博士学位的动机、 对目前所在研究领域的理解、 以及对未来职业生涯的设想； 3. 目前研究工作的进展状态小结（限三页纸，并列主要参考文献）； 4. 研究生学习阶段的课程成绩单； 5. 已发表著作的名录。 6. 两篇代表著作的复印件。 7. 已获奖励或荣誉称号证书复印件。 请将以上七项文件合并成为一个 PDF 文件（小于 10M ） , 文件命名 ( 必须用英文 ) 为： Familyname_Givenname_ RWP2013.pdf ( 例如 ： Chen_Xiaohua_RWP2013.pdf ) ，点 击 0nline Submission 在 线 提交。 8. 提名人的推荐信一封，以及了解申请人科研工作的其他高级研究人员的推荐信两封。三封推荐信由推荐人密封后直接邮寄给： 吴艳博士 北京大学 理科 4 号楼 生命科学学院 319 室 77# 信箱 中国 北京 100871 或发送邮件至： raywuprize@pku.edu.cn 推荐信命名 ( 必须用英文 ) 为： Familyname_Givenname_ RWP2013_letter1 (2 or 3).pdf ( 例如： Chen_Xiaohua_RWP2013_letter1.p df) 2013 “吴瑞奖学金”申请的时间安排： 提交申请材料截止日期： 2013 年 3 月 31 日。 基金会给申请人正式接受申请的通知（以 e-mail 或其它方式）： 2013 年 4 月 30 日。 公布 2013 年获奖人名单： 2013 年 8 月 31 日。 颁奖典礼：日期待定。 “吴瑞奖学金”网址 ： http://www.raywumemorialfund.org “吴瑞奖学金”评审委员会 主席 Xiaodong Wang ( 王晓东 ) Director, National Institute of Biological Sciences, Beijing 委员 Sheng Ding ( 丁胜 ) Professor, University of California, San Francisco Xinnian Dong ( 董欣年 ) Arts Sciences Endowed Professor of Biology, Duke University Xin-Yuan Fu ( 傅新元 ) Professor, National University of Singapore Jun-Lin Guan ( 管俊林 ) Professor, University of Michigan Nancy Y. Ip ( 叶玉如 ) Head Chair Professor, Hong Kong University of Science and Technology Hsou-min Li ( 李秀敏 ) Research Fellow, Institute of Molecular Biology, Academia Sinica, Taiwan Yang Liu ( 刘阳） Charles B. de Nancrede Professor, University of Michigan Ming Luo ( 罗明 ) Professor, University of Alabama at Birmingham Hong Ma ( 马红 ) Dean and Professor, School of Life Sciences, Fudan University Yi Rao ( 饶毅 ) Dean and Professor, School of Life Sciences, Peking University Xiao-Hong Sun ( 孙晓红 ) Lew and Myra Ward Chair and Member, Oklahoma Medical Research Foundation Yue Xiong ( 熊跃 ) William R. Kenan, Jr. Professor, University of North Carolina Xian-Jie Yang （ 杨先洁 ） Professor, University of California, Los Angeles Weimin Zhong ( 钟伟民 ) Associate professor, Yale University
2012 George E. Valley Jr. Prize Recipient Jinhui Chen (陈金辉)(我注:2012入选 首批青年拔尖人才支持计划 ) Chinese Academy of Science(中国科学院 上海应用物理研究所 ) Citation: " In recognition of his discovery of the first antimatter hypernucleus and his seminal contributions to the study of partonic matter using φ mesons produced in relativistic nuclear collisions. " 获奖原因:首次发现反超核物质核用相对论重离子核反应中用 φ介子对partonic物质的有创意的贡献. Selection Committee: Pierre Meystre, Chair; S. Tan; C. Callan; R. Byer; B. Barish 近日的好消息.陈同学获得了以上奖项.该奖据说是aps在全球毕业5年内的博士中遴选出来的.每年只授予一人,奖金若干.该奖从2002年至今,每两年评审一次,目前仅有六人获得. 祝陈同学蒸蒸日上. 如今不在一个地方,我就不说我们俩当时是一起读研,一起毕业,一个办公室的了. ps: winners in past years: 2010 George E. Valley Jr. Prize Recipient Shina Tan Georgia Institute of Technology 2008 George E. Valley Jr. Prize Recipient Paul Sorensen Brookhaven National Laboratory 2006 George E. Valley Jr. Prize Recipient Irfan Siddiqi University of California, Berkeley 2004 George E. Valley Jr. Prize Recipient Ivo Souza University of California, Berkeley 2002 George E. Valley Jr. Prize Recipient David Goldhaber-Gordon Stanford University
The Nobel Prize in Chemistry 2012 was awarded jointly to Robert J. Lefkowitz and Brian K. Kobilka "for studies of G-protein-coupled receptors (GPCR) http://www.nobelprize.org/nobel_prizes/chemistry/laureates/2012/ Robert J. Lefkowitz Born: 1943, New York, NY, USA Affiliation at the time of the award: Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC, USA Prize motivation: "for studies of G-protein-coupled receptors" Brian K. Kobilka Born: 1955, Little Falls, MN, USA Affiliation at the time of the award: Stanford University School of Medicine, Stanford, CA, USA Prize motivation: "for studies of G-protein-coupled receptors"
LURIE PRIZE OVERVIEW In 2013, the Foundation for the National Institutes of Health (FNIH) will present the first Lurie Prize, an annual award recognizing outstanding achievement by a promising young scientis t in biomedical research. The Prize amount is $100,000, to be used as the awardee chooses. It is made possible by a generous gift from FNIH board member Ann Lurie. The Awardee will be selected by a jury of six distinguished biomedical researchers, chaired by Solomon H. Snyder, M.D., Distinguished Service Professor of Neuroscience, Pharmacology Psychiatry, The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine. The Award will be presented to the selected scientist in the spring, 2013, in Washington, DC. NOMINATION CRITERIA Nominations are broadly solicited and can be made by any member of an accredited educational and/or scientific institution. There is no limitation on the number of nominations that may be made by a single nominator or institution. No institutional approval is required. Nominations are to be for an outstanding young biomedical investigator, who shall not have passed his/her 52nd birthday on April 12, 2013. Nomination materials must be in English. Nominations will not be accepted for candidates whose current location or permanent residence is in countries sanctioned by the U.S. Department of the Treasury, Office of Foreign Asset Control. See the current list of sanctions at http://www.treasury.gov/resource-center/sanctions/Programs/Pages/Programs.aspx .
THE RAY WU PRIZE The Ray Wu Prize for Excellence in Life Sciences is established to inspire Asia’s most promising young Ph.D. students to become future leaders in life sciences. Professor Ray Wu (1928-2008) was a world-renowned biologist who, in the 1970s, developed the first method for DNA sequencing and pioneered the recombinant DNA technology. In the later part of his career, he devoted to genetic engineering of rice. Professor Wu was a life-long advocate for developing life science research in Asia. In 1982, Professor Wu initiated the first large-scale exchange program in biology which brought over 400 students from China to obtain Ph.D. degrees in the US. The program opened the door for thousands of more Chinese students to study abroad and marked the beginning of Sino-US exchanges in life science research. This prize is dedicated in honor of Professor Ray Wu’s seminal contributions in training China’s new generation of biologists. Twenty one prizes have been awarded so far. The Ray Wu Prize is awarded each year to graduate students for excellence in life science research. The process for selection of recipients is outlined in the following sections. The Prize: The prize consists of USD $3000, a medal, a certificate, and a citation by the Ray Wu Memorial Fund (RWMF). Financial assistance for travel is available to the recipients for career advancement purposes. RWMF will serve as a liaison for the awardees who wish to seek consultation from established investigators as they develop their scientific careers. Ten or more awards may be made each year. Candidates from all geographical areas are encouraged to apply and special considerations will be given to semifinalists from each underrepresented major geographical area. Criteria: The Ray Wu Prize recognizes excellence in life science research by a graduate student for innovation, independent thinking, and dedication. Qualifications: A candidate must be a graduate student who is pursuing a degree of Doctor of Philosophy (PhD) in an institution located in mainland China, Hong Kong, Taiwan, or Singapore. The candidate must have advanced to candidacy in the PhD program by the deadline of application. Nomination: A candidate may be nominated by a faculty member of the institution from which the candidate plans to receive the PhD. The faculty member shall be a PhD mentor and is actively conducting life science research. Materials to be submitted: A candidate who wishes to be considered for this year’s Ray Wu Prize must submit the following materials by the deadline for application: 1. A completed application form. 2. A two page essay (English or Chinese) by the candidate in which the motivation of pursuing a PhD degree, personal interest in the current field of own research, and outlook for future career development should be addressed. 3. A progress report of the candidate’s current PhD research project (limited to 3 pages, not counting references). 4. A current transcript of courses taken in the PhD program. 5. A list of publications and copies of two representative published materials . 6. Awards or honors received. 7. A letter of recommendation from the nominating faculty member, and two additional letters of recommendation from other faculty members who know the candidate well professionally. The letter must be in an envelope sealed by each faculty member with candidate’s name on the back of the envelope, sent to: Yan Wu, Ph.D. Room 319, Science Building 4 School of Life Sciences Peking University Beijing , China 100871. 8. The application form is signed by the Dean of the School in which the candidate is currently enrolled to certify all materials as true and authentic. All application materials must be submitted online as PDF files except for letters of recommendation. Important Dates: March 31, 2012, deadline for applications to be received. April 30, 2012, notification of receipt of completed applications (by email or other means). August 30, 2012, completion of review. Award ceremony, to be announced. The Ray Wu Prize committee Chair: Xiaodong Wang ( 王晓东 ) Director, National Institute of Biological Sciences, Beijing Members: Sheng Ding ( 丁胜 ) Professor, University of California, San Francisco Xinnian Dong ( 董欣年 ) Arts Sciences Endowed Professor of Biology, Duke University Xin-Yuan Fu ( 傅新元 ) Professor, National University of Singapore Jun-Lin Guan ( 管俊林 ) Professor, University of Michigan Nancy Y. Ip ( 叶玉如 ) Head Chair Professor, Hong Kong University of Science and Technology Hsou-min Li ( 李秀敏 ) Research Fellow, Institute of Molecular Biology, Academia Sinica, Taiwan Yang Liu ( 刘阳 ) Charles B. de Nancrede Professor, University of Michigan Ming Luo ( 罗明 ) Professor, University of Alabama at Birmingham Hong Ma ( 马红 ) Dean and Professor, School of Life Sciences, Fudan University Yi Rao ( 饶毅 ) Dean and Professor, School of Life Sciences, Peking University Xiao-Hong Sun ( 孙晓红 ) Lew and Myra Ward Chair and Member, Oklahoma Medical Research Foundation Yue Xiong ( 熊跃 ) William R. Kenan, Jr. Professor, University of North Carolina Xian-Jie Yang （杨先洁） Professor, University of California, Los Angeles Weimin Zhong ( 钟伟民 ) Associate professor, Yale University
这项工作可能有希望得奖。 不过 AIC (activation induced cytidine daminase), MBD4, and GADD45A involved in DNA demethylation work had already been demonstrated in Zebra fish. Tet3 is also involved in active demethylation in ferilized egg （recent paper published in PNAS). 基本上化学机制是： C 5mC5hmC5hmUAP sitesDNA repair by BERC Hydroxylation of 5-Methylcytosine by TET1 Promotes Active DNA Demethylation in the Adult Brain References and further reading may be available for this article. To view references and further reading you must purchase this article. JunjieU. Guo 1 , 2 , Yijing Su 1 , 3 , Chun Zhong 1 , 3 , Guo-li Ming 1 , 2 , 3 and Hongjun Song 1 , 2 , 3 , , 1 Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA 2 The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA 3 Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA Received 31 October 2010; revised 23 January 2011; accepted 11 March 2011. Published online: April 14, 2011. Available online 14 April 2011. Summary Cytosine methylation is the major covalent modification of mammalian genomic DNA and plays important roles in transcriptional regulation. The molecular mechanism underlying the enzymatic removal of this epigenetic mark, however, remains elusive. Here, we show that 5-methylcytosine (5mC) hydroxylase TET1, by converting 5mCs to 5-hydroxymethylcytosines (5hmCs), promotes DNA demethylation in mammalian cells through a process that requires the base excision repair pathway. Though expression of the 12 known human DNA glycosylases individually did not enhance removal of 5hmCs in mammalian cells, demethylation of both exogenously introduced and endogenous 5hmCs is promoted by the AID (activation-induced deaminase)/APOBEC (apolipoprotein B mRNA-editing enzyme complex) family of cytidine deaminases. Furthermore, Tet1 and Apobec1 are involved in neuronal activity-induced, region-specific, active DNA demethylation and subsequent gene expression in the dentate gyrus of the adult mouse brain invivo. Our study suggests a TET1-induced oxidation-deamination mechanism for active DNA demethylation in mammals. Graphical Abstract Full-size image (41K) High-quality image (258K) Highlights ► 5mC hydroxylation promotes active DNA demethylation irrespective of CpG context ► Deamination and base excision repair are involved in 5hmC demethylation ► 5hmC demethylation is highly processive, transcription dependent, and strand biased ► Tet1 and Apobec1 regulate activity-induced DNA demethylation in the mouse brain Article Outline Introduction Results TET1 Promotes DNA Demethylation in Human Cells 5hmC in Both CpG and CpH Contexts Can Be Demethylated in Human Cells 5hmC Demethylation Requires the BER Pathway AID/APOBEC Deaminases Facilitate 5hmC Demethylation 5hmC Demethylation Recapitulates Properties of AID-Mediated Deamination TET1 and AID/APOBEC Deaminases Promote Region-Specific DNA Demethylation in the Adult Mouse Brain Tet1 and Apobec1 Are Involved in Neuronal Activity-Induced DNA Demethylation in the Adult Mouse Brain Discussion Experimental Procedures DNA Constructs Methylated Reporter Assay and Quantitative Analysis of DNA Methylation Detection and Quantification of 5hmC and 5hmU by Immunoblotting, ELISA, and Immunocytochemistry Methylation and Gene Expression Analysis of the Adult Mouse Dentate Gyrus Acknowledgements Further Reading Supplemental Information References
Ramanujan Prize awarded to Chinese mathematician ICTP's2010 Ramanujan Prize has been awarded to Professor Yuguang Shi of the School of Mathematical Sciences, Peking University. This was announced by International Centre for Theoretical Physics (ICTP) in Trieste, Italy on 28 January. The prize is in recognition of his outstanding contributions to the geometry of complete (noncompact) Riemannian manifolds, specifically the positivity of quasi-local mass and rigidity of asymptotically hyperbolic manifolds. The prize is also in acknowledgement of the substantial contribution that Professor Shi has made to mathematics in China through over 15 years of teaching and research. The Ramanujan Prize, which is funded by the Norwegian Niels Henrik Abel Memorial Fund, is awarded annually to a researcher from a developing country less than 45 years of age on 31 December of the year of the award, who has conducted outstanding research in a developing country. Researchers working in any branch of the mathematical sciences are eligible. The Prize carries a $15,000 cash award. ICTP awards the prize through a selection committee of five eminent mathematicians appointed in conjunction with the International Mathematical Union (IMU). The Ramanujan prize ceremony will take place at ICTP on10 May, during theSchool and Conference on Mathematics and Physics of Soft and Biological Matter, which runs from 2 - 13 May 2011. Srinivasa Ramanujan（拉马努金）是位富有传奇色彩的印度怪才数学家。当年G.H.Hardy（哈代）慧眼识珠的故事，为数学史增添荣光。 Hardy曾经说过的一句话：他看到Ramanujan写来的满是奇特数学公式的信，起初认为这应当又是一个民间数学骗子，但转念一想：有本事造出这类公式的骗子比数学天才更为罕见。 Ramanujan出生于印度南部，信奉婆罗门教。他应当是“数感”最好的诠释者：有一次Hardy去医院看望他，抱怨自己搭乘的出租车号码为1729：“是个乏味透顶的数字，是个不好的预兆。”Ramanujan安慰他：“不是的，先生，事实上它很有趣——它是可用两种方法表为两数立方和的最小自然数。”现在国际上主要有两项Ramanujan为名的奖：SASTRA Ramanujan Prize和The Ramanujan Prize。 SASTRA Ramanujan Prize由Ramanujan故乡的Shanmugha Arts, Science, TechnologyResearch Academy在2005年创立，颁发给与Ramanujan有相同数学兴趣的杰出数学家。Ramanujan的天才与寿命成反比，32岁即辞世，因此SASTRA特意将获奖者的年龄限制在32岁。2006年的获奖者是陶哲轩。 Ramanujan Prize是ICTP于2005年创立的，颁发给发展中国家的优秀数学家。获奖者的年龄限制在相对宽松45岁，但总体看来这奖以Ramanujan为名是很匪夷所思的事情。但这项奖的评奖委员会由IMU（International Mathematical Union）成员组成，算是很有权威性的；并且奖金为15,000美元，和SASTRA的10,000美元比起来更为慷慨。清华数学中心访问学者张伟荣获2010 SASTRA Ramanujan奖。
Nobel Prize killer Red-hat scholar-tyrant Yonghe Zhang American Huilin Institute, http://www.amhuilin.com/ In the technology society, Marx created a political regime as to the value of technology. Authorities with powers to act as technology and become Red-hat scholar-tyrant . Red-hat scholar-tyrant despite their ignorant and incompetent , as long as keeping their hats red by loyalty to their superior, they can loot or kill someone else's advanced achievements and maintain their own authority, forming of the cocoon, backwater situation. This is the technology source of corruption! China is so, the Soviet Union is all about.
Home FAQ Press Contact Us Nobel Prizes Alfred Nobel Educational Video Player Nobel Organizations Search 2010 Nobel Prize Announcements jQuery(document).ready(function() { $('#countdown_dashboard').countDown({ targetDate: { 'day': 11, 'month': 10, 'year': 2010, 'hour': 11, 'min': 00, 'sec': 0, 'utc': true } }); }); Economic Sciences Monday 11 October, 1:00 p.m. CET, 11:00 a.m. GMT, at the earliest. LIVE Webcast at Nobelprize.org! ECONOMIC SCIENCES Watch the live webcast from the Royal Swedish Academy of Sciences, Stockholm, Sweden, on Monday 11 October, 1:00 p.m. CET, 11:00 a.m. GMT, at the earliest. Following the announcement, an interview will be held with one of the Prize Committee members about the 2010 Prize in Economic Sciences. Freedom of Speech in China PEACE Among the many people campaigning for human rights in China, Liu Xiaobo, the 2010 Nobel Peace Prize Laureate, has become the most visible symbol of the struggle. A long-term exponent of non-violent protest, he is currently serving an 11-year prison term. Read more. Mario Vargas Llosa LITERATURE Peruvian by birth and a truly international citizen, the 2010 Nobel Laureate in Literature embraces multiple genres (novels, plays, essays), and politics too, in his commitment to social change. Read more. Molecule Makers CHEMISTRY Richard F. Heck, Ei-ichi Negishi and Akira Suzuki share the 2010 Nobel Prize in Chemistry for developing new, more efficient ways of linking carbon atoms together to build the complex molecules that are improving our everyday lives. Read more. Graphene: Carbon's New Face PHYSICS Imagine a sheet of material that's just one atom thick, yet super-strong, highly conductive, practically transparent and able to reveal new secrets of fundamental physics. That's graphene, isolated by Andre Geim and Konstantin Novoselov, 2010 Nobel Laureates in Physics. Read more. The Father of the Test Tube Baby MEDICINE Robert G. Edwards, the 2010 Nobel Laureate in Physiology or Medicine, battled societal and establishment resistance to his development of the in vitro fertilization procedure, which has so far led to the birth of around 4 million people. Read more. Facts on the Prize in Economic Sciences ECONOMIC SCIENCES The Sveriges Riksbank Prize in Economic Sciences in Memory of Alfred Nobel have been awarded every year since 1969. More facts about the Prize in Economic Sciences. Laureate Interviews ECONOMIC SCIENCES Discover the stories behind the Laureates in Economic Sciences. Watch a video interview! 2008 Laureate in Economic Sciences Paul Krugman discusses how science fiction made him become an economist. Finn Kydland discusses the combination of abstract thinking and practical experience needed in academic research. Watch Daniel McFadden talking about growing up on a North Carolina farm without electricity or running water. Why Trade? EDUCATIONAL The 1977 Prize in Economic Sciences was awarded for a theory showing that countries engage in and benefit from trade if their production resources differ from each other. Play the Trade Ruler Game and learn more! Play the Trade Ruler Game! 822 Nobel Laureates NOBEL PRIZE Between 1901 and 2009, the Nobel Prizes and the Prize in Economic Sciences were awarded 537 times to 829 people and organizations. With some receiving the Nobel Prize more than once, this makes a total of 802 individuals and 20 organizations. More Nobel Laureate Facts. Origin of the Nobel Prize ALFRED NOBEL On November 27, 1895 Alfred Nobel signed his last will and testament in Paris. See a slide show marking the major events and circumstances leading to the awarding of the first Nobel Prizes. See the Slide Show.
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