http://www.gopubmed.org/web/gopubmed/1?WEB012h9gs00tw7q6I2I1I00f01000j10040001rl Thin and Breast Cancer 589 documents semantically analyzed 1 2 3 Top Years Publications 2008 36 2002 32 2006 31 2005 30 2007 29 2000 27 1995 26 2009 24 2003 24 1999 23 1998 23 1996 21 2001 20 2004 19 1997 17 1993 16 1989 14 1982 14 1992 12 1973 10 1 2 3 1 2 3 Top Countries Publications USA 172 Japan 35 Germany 30 United Kingdom 26 Italy 24 France 16 Canada 15 Poland 12 Australia 10 Taiwan 8 South Korea 8 Greece 8 China 8 Turkey 7 Netherlands 6 Spain 6 Austria 6 Israel 4 Sweden 4 Belgium 4 1 2 3 1 2 3 ... 12 Top Cities Publications Houston 17 New York 13 Ann Arbor 8 Tokyo 8 Seoul 6 Paris 6 Athens 6 London 6 Toronto 5 Berlin 5 Bethesda 5 Taipei 4 Rochester 4 Mnster 4 Frederick 4 Nashville 4 Osaka 4 Philadelphia 4 Milan 4 Innsbruck 4 1 2 3 ... 12 1 2 3 ... 17 Top Journals Publications Med Phys 11 Radiology 10 Plast Reconstr Surg 9 Breast Cancer Res Tr 9 J Steroid Biochem 9 Am J Clin Pathol 8 Acta Cytol 8 Int J Cancer 8 Cancer Res 8 Am J Surg Pathol 7 Anticancer Res 7 Phys Med Biol 7 J Clin Endocr Metab 7 Steroids 6 Anal Chem 5 Tumori 5 Am J Pathol 5 Carcinogenesis 5 Pathol Int 4 Chem Res Toxicol 4 1 2 3 ... 17 1 2 3 ... 123 Top Authors Publications Pasqualini J 5 Phillips D 5 Brinton L 5 Forrest A 5 Chetrite G 4 Ogawa Y 4 Nishioka A 4 Yoshida S 4 Cabot M 4 Squartini F 4 Sarnelli R 4 Wo?czyński S 3 Bisceglia M 3 Halas N 3 Foudray A 3 Philippe J 3 Sneige N 3 Pawlik A 3 Czerny B 3 Teister M 3 1 2 3 ... 123 1 2 3 ... 175 Top Terms Publications Humans 534 Breast Neoplasms 520 Thinness 364 Neoplasms 214 Patients 208 Tissues 198 Middle Aged 189 Chromatography, Thin Layer 183 Carcinoma 173 Adult 159 Aged 134 Evaluation Studies as Topic 128 Diagnosis 120 Women 108 Animals 93 Chromatography 86 Cell Line 84 Biopsy 84 Breast 80 Sensitivity and Specificity 71 1 2 3 ... 175 最新研究报道 http://news.sciencenet.cn//htmlnews/2010/4/230997.shtm 研究发现消瘦女孩长大后患乳癌风险更大 据国外媒体5月15日报道，瑞典斯德哥尔摩卡罗林斯卡医学院的研究发现，消瘦的女孩日后更有可能患上乳癌。与小时候较胖的女孩相比，7岁时身材较瘦的女孩长大后患乳癌的风险更大。科学家还发现，小时候稍胖的女孩患难以攻克的肿瘤的概率较小。 该研究报告发表在《乳癌研究》（ Breast Cancer Research ）杂志上，研究为把童年时旧照片作为评估女性乳癌风险的方法铺平了道路。瑞典科学家对6000名女性进行了研究，其中半数女性为乳癌患者，科学家依据她们7岁时体型消瘦、中等或较胖分为三组。判断基础为这些女性的旧照片和她们的记忆。研究人员惊讶地发现，小时候较胖的女性绝经期患乳癌的风险较小。之前的研究显示，肥胖的女性更易患乳癌，而且她们死于乳癌的风险高达50%。 科学家不确定瘦女孩易患乳癌的原因是什么。他们表示，新发现可能对判断女性乳癌风险具有重要意义。负责这项研究的李景梅(音译)说：小时候较胖的女孩患乳癌的风险较低，这似乎违反直觉，因为新生儿体重较重和成年人体质指数较高已显示会增加乳癌风险。促成这种保护效果的机制仍是未知数。鉴于存在的这些联系和旧照片中儿童体型透露的信息，儿童的胖瘦对构建乳癌风险或者预后模式有着潜在的用途。 更多阅读 哥伦比亚广播公司相关报道（英文）
http://www.gopubmed.org/web/gopubmed/4?WEB0rlv2e4q0tbfkIgI1I00f01000j10040001rl multivitamin and breast cancer 27 documents semantically analyzed Top Years Publications 2009 5 2008 5 2003 3 2007 2 2004 2 1999 2 1998 2 1992 2 2010 1 2006 1 2005 1 2001 1 Top Countries Publications USA 20 Sweden 1 Netherlands 1 United Kingdom 1 Canada 1 South Korea 1 Australia 1 Finland 1 Top Cities Publications New York 3 Seattle 3 Boston 3 Burlington, VT, USA 2 Los Angeles 2 Stockholm 1 Wageningen 1 London 1 Quebec City 1 Seoul 1 Nashville 1 San Diego 1 Rockville 1 Minneapolis 1 Chapel Hill 1 Atlanta 1 Philadelphia 1 Turku 1 Top Journals Publications Am J Clin Nutr 6 Cancer 2 Cancer Epidem Biomar 2 Public Health Nutr 1 Cancer Epidemiol Biomarkers Prev 1 Arch Intern Med 1 Am J Epidemiol 1 J Clin Oncol 1 Int J Cancer 1 Breast Cancer Res Tr 1 Cancer Res 1 Int J Obesity 1 J Nutr 1 Cancer J 1 Ca-cancer J Clin 1 Jama-j Am Med Assoc 1 Child Nerv Syst 1 Environ Health Persp 1 Environ Mol Mutagen 1 Acta Oncol 1 1 2 3 ... 16 Top Terms Publications Breast Neoplasms 24 Humans 24 Women 20 Middle Aged 20 Vitamins 18 Dietary Supplements 17 Risk Factors 14 Aged 14 Confidence Intervals 13 Adult 13 Questionnaires 10 Neoplasms 10 Prospective Studies 10 Folic Acid 10 Diagnosis 9 Postmenopause 9 Incidence 8 Case-Control Studies 8 Cohort Studies 8 Risk 7 1 2 3 ... 16 1 2 3 ... 7 Top Authors Publications Willett W 3 Zhang S 2 Gammon M 2 Wetmur J 2 Teitelbaum S 2 Britton J 2 Neugut A 2 Santella R 2 Branda R 2 Colditz G 2 Arslan A 2 Preston-Martin S 2 Pogoda J 2 Muller B 2 Lubin F 2 Modan B 2 Holly E 2 Filippini G 2 Cordier S 2 Peris Bonet R 2 1 2 3 ... 7 最新研究报道 http://news.sciencenet.cn//htmlnews/2010/4/230536.shtm 瑞典研究：复合维生素片或增加乳腺癌风险 瑞典研究人员发现，每日服用复合维生素片的中老年女性比不服用者罹患乳腺癌的几率高近两成。他们强调，虽然研究发现两者间存在关联，但并未证明保健品直接导致乳腺癌。 这一研究结果刊载于最新一期《美国临床营养学杂志》（ American Journal of Clinical Nutrition ）。 几率高 斯德哥尔摩卡罗琳医学院研究人员跟踪调查逾3.5万名年龄在49岁至83岁间的瑞典女性，这些调查对象均非癌症患者。研究人员要求她们回答关于服用复合维生素片情况以及健康和生活习惯问题。 约10年后，974名调查对象经确诊患上乳腺癌。 综合考虑调查对象年龄、家族乳腺癌史、体重、进食水果蔬菜量、体育锻炼、吸烟饮酒习惯后，研究人员发现，服用复合维生素的调查对象比不服用者罹患乳腺癌的几率高19%。 研究报告说：这些结果显示，服用复合维生素与罹患乳腺癌风险增加存在关联。 析原因 研究发现，复合维生素片服用人群罹患乳腺癌的几率总体而言较高，但对于个体而言，几率仍小。调查期间，9017名服用者中293人罹患乳腺癌。 英国《每日邮报》4月6日援引研究人员的话报道，调查结果并未证明复合维生素片是患乳腺癌风险增加的罪魁祸首。不过，这一结果令人担忧，需要深入调查。 至于服用复合维生素片与乳腺癌几率增加存在关联的原因，研究人员说，动物实验显示，B族维生素中的叶酸与乳腺癌有关，但人体测试结果不一：有些试验显示服用叶酸补充剂的女性罹患乳腺癌风险较高，有些则显示两者无关。 先前研究发现，服用复合维生素片的绝经前女性，乳房密度比不服用者高，即乳房中脂肪较少，而腺体和结缔组织较多。乳房密度高意味着罹患乳腺癌几率高。 推食补 保健品一年市场价值约7.65亿美元。据统计，约一半美国成人、近四分之一英国成人日常服用保健品，多为复合维生素片。 不少专家认为，进食复合维生素片并不能促进身体健康，药补不如食补。 英国癌症研究会科学信息主管卡特阿尼说：与先前数项研究一样，这一研究结果增加了复合维生素片事实上对健康并无益处的证据。大多数人可以通过健康均衡饮食，多吃水果蔬菜获取各种身体必需的营养成分。 美国科学卫生理事会医学顾问吉尔贝罗斯建议，除非营养失调，否则不必服用复合维生素片，当然，如果你很想服用复合维生素片，这项研究不是停服的原因。 http://www.dailymail.co.uk/health/article-1263787/Do-multivitamin-pills-raise-risk-breast-cancer-Tumour-threat-20--says-study.html Do multivitamin pills raise the risk of breast cancer? Tumour threat up by 20%, says study By Pat Hagan Last updated at 4:34 PM on 06th April 2010 Comments ( 29 ) Add to My Stories Worry: Experts want more studies. (Posed by model) Women who take a daily multivitamin pill to ward off illness may actually be increasing their risk of breast cancer, according to a study. Researchers found middle-aged and older women who regularly took supplements were almost 20 per cent more likely to develop a tumour. They stressed the findings did not prove vitamin pills were to blame for an increase in cancer cases, as it is possible women may be compensating for an unhealthy lifestyle that puts them at increased risk. However, the experts warned the results were worrying and called for in-depth studies to determine whether or not multivitamins are safe. They believe supplements may trigger tumour growth by increasing the density of breast tissue, a known risk factor for cancer. Studies suggest taking supplements containing vitamins and minerals may increase breast tissue by more than 5 per cent. It is also possible folic acid found in multivitamin pills could be a factor, as studies suggest high doses may promote tumour growth. Experts from the Karolinska Institute in Stockholm, Sweden, tracked more than 35,000 women aged between 49 and 83 over a ten-year period. They found those who regularly took multivitamins were 19 per cent more likely to have developed a breast tumour. Even when researchers took account of whether the women smoked, took much exercise, or had a family history of the disease - all strong risk factors - they still found a significant link with multivitamin use. They told the American Journal of Clinical Nutrition: 'These results suggest multivitamin use is associated with an increased risk of breast cancer. This is of concern and merits further investigation.' More... Healthier lifestyles 'would cut cancer rates by a third' For those struggling to lose weight there is a perfect excuse... it is all down to genes Researchers stressed that, on an individual basis, the risks to women remain small and the vast majority of vitamin users will not develop cancer. In the study, women did not say what brands of vitamins they took - they simply reported whether or not they took them. The study could also be flawed as it relies on women to recall whether they took the pills in the past. Studies that ask people to describe past behaviour are vulnerable to a well-known statistical phenomenon called recall bias. It is estimated nearly a quarter of all UK adults take antioxidant supplements or multivitamins on a regular basis. The market for supplements is worth 500million a year. But in 2007 a study of nearly 300,000 men found those taking supplements more than once a day were 32 per cent more likely to develop an aggressive form of prostate cancer. And a 2008 Copenhagen University investigation found high doses of vitamin A, vitamin E and beta-carotene appeared to increase the chances of an early death. Every year around 40,000 women in Britain are diagnosed with breast cancer, the equivalent of more than 100 a day. A woman has a one in nine chance of developing the disease at some point in her life. Kat Arney, Cancer Research UK's science information manager, said last night: 'Like several other recent studies, this research adds to the evidence that multivitamins may not actually be beneficial for your health. 'Most can get all the nutrients they need from a healthy balanced diet, rich in fruit and vegetables.' Dr Gilbert Ross, medical director for the American Council on Science and Health, said: 'If you really want to take multivitamins, this study is no reason to stop. Of course, on the other hand, I would advise anyone concerned that there is no good health or medical reason to take multivitamin supplements, except in rare cases of malnutrition.' The Health Supplements Information Service, funded by supplements manufacturers, said: 'This does not provide any proof that multivitamins are linked to breast cancer. 'Given the low intakes of micronutrients in women across the UK and the continuing lack of improvement in our national dietary patterns, a multivitamin can make an important contribution to the vitamin and mineral intake in this population group.' Read more: http://www.dailymail.co.uk/health/article-1263787/Do-multivitamin-pills-raise-risk-breast-cancer-Tumour-threat-20--says-study.html#ixzz0kNYdwNIe
最新研究动态 http://news.xinhuanet.com/english2010/health/2010-03/31/c_13232098.htm BEIJING, March 31 (Xinhuanet) -- A latest study shows that mammographic breast cancer screening can save between 2 and 2.5 lives for every over diagnosed case, scientists said on Wednesday as quoted by the Reuters. Stephen Duffy of Queen Mary, University of London, who led the study, conducted two studies into the risk-benefit balance of screening programs. Results from one of them, published in the Journal of Medical Screening, showed a substantial and significant reduction in breast cancer deaths due to mammographic breast cancer screening with between 2 and 2.5 lives saved for every overdiagnosed case. http://www.gopubmed.org/web/gopubmed/4?WEB0hlpkpiefx8wcIgItI0 mammographic breast cancer screening Mammography 3,859 of 4,499 documents semantically analyzed Term: Mammography Description: Radiographic examination of the breast. Synonyms: Mammographies 1 2 3 Top Years Publications 2006 203 2002 202 2007 185 2005 181 2001 181 2000 180 1997 179 2008 174 2004 168 1998 164 2003 162 1999 162 2009 154 1996 151 1995 149 1994 148 1992 132 1993 126 1991 114 1989 111 1 2 3 1 2 3 4 Top Countries Publications Vietnam 1 Kuwait 1 Serbia 1 Armenia 1 Cambodia 1 Myanmar 1 Colombia 1 1 2 3 4 1 2 3 ... 26 Top Cities Publications New York 103 Toronto 92 Boston 83 London 74 Ann Arbor 68 San Francisco 59 Philadelphia 59 Seattle 54 Houston 54 Chicago 54 Florence 49 Nottingham 47 Durham 45 Nijmegen 42 Los Angeles 37 Cambridge 36 Sydney 35 Seoul 35 Milan 29 Rome 28 1 2 3 ... 26 1 2 3 ... 28 Top Journals Publications Radiology 327 Am J Roentgenol 211 Cancer 134 Clin Radiol 107 Radiol Med (torino) 95 Cancer Epidem Biomar 92 Med Phys 77 Brit J Radiol 68 Acad Radiol 61 Breast Cancer Res Tr 57 Eur J Radiol 52 J Med Screen 48 J Natl Cancer I 48 Breast J 43 Rofo-fortschr Rontg 43 Eur Radiol 38 Am J Surg 36 Am Surgeon 36 Breast Cancer Res 35 Acta Radiol 35 1 2 3 ... 28 1 2 3 ... 141 Top Terms Publications Mammography 3,851 Humans 3,813 Breast Neoplasms 3,810 Middle Aged 2,388 Adult 1,882 Aged 1,707 Women 1,705 Patients 1,673 Diagnosis 1,446 Biopsy 1,228 Evaluation Studies as Topic 1,186 Carcinoma 1,146 Mass Screening 960 Breast 890 Sensitivity and Specificity 692 Neoplasms 665 Retrospective Studies 617 Aged, 80 and over 547 Breast Diseases 541 Risk Factors 520 1 2 3 ... 141 1 2 3 ... 572 Top Authors Publications Helvie M 63 Boyd N 58 Sickles E 55 Tabr L 50 Duffy S 49 Yaffe M 47 Dershaw D 41 Ciatto S 40 Kopans D 39 Evans A 35 Hendriks J 34 Kerlikowske K 31 Ellis I 31 Pinder S 29 Liberman L 28 Bassett L 26 Wilson A 25 Stomper P 25 Fishell E 24 Chan H 24 1 2 3 ... 572
最新参考文献： http://news.sciencenet.cn//htmlnews/2010/3/230163.shtm 美国密歇根大学放射肿瘤学教授洛里皮尔斯和他的研究小组在对来自澳大利亚、西班牙、以色列和美国的655名乳腺癌患者的调查后发现，在患上该病15年后，选择切除乳房的患者疾病复发率只有6%，而那些保留乳房的女性的乳腺癌复发率则高达24%。 分析平台： http://www.gopubmed.org/web/gopubmed/1?WEB0lk3678z9vqtqI25I1I00f01000j10040001rl 检索策略： Breast Neoplasms and Mastectomy and Survival Rate 分析结果： 2,001 documents semantically analyzed 1 2 Top Years Publications 2006 106 2005 105 2000 102 2004 98 2002 94 2008 93 1998 92 2007 88 1994 88 1992 87 2009 85 2003 82 1995 79 1997 78 1990 78 1991 74 1999 72 1993 67 2001 64 1996 63 1 2 1 2 3 4 Top Countries Publications USA 611 Japan 133 France 118 Italy 105 Germany 97 United Kingdom 91 China 53 Netherlands 51 Canada 50 Australia 36 Austria 32 Switzerland 31 Denmark 28 Sweden 22 Turkey 22 Hungary 21 Spain 17 Poland 15 Taiwan 15 South Korea 15 1 2 3 4 1 2 3 ... 21 Top Cities Publications Houston 76 New York 59 Philadelphia 46 Paris 44 Milan 43 Boston 40 Tokyo 29 New Haven 24 Pittsburgh 23 Beijing 23 London 22 Chicago 22 Wien 21 Amsterdam 21 Osaka 20 Royal Oak 19 Toronto 18 Budapest 18 Heidelberg 18 Bethesda 15 1 2 3 ... 21 1 2 3 ... 18 Top Journals Publications Cancer 153 Int J Radiat Oncol 137 J Clin Oncol 77 Ann Surg Oncol 57 Breast Cancer Res Tr 46 Eur J Surg Oncol 39 Eur J Cancer 36 J Surg Oncol 36 Am J Surg 33 Radiother Oncol 33 Ann Surg 32 Strahlenther Onkol 31 Am Surgeon 31 Arch Surg-chicago 26 Ann Oncol 25 Gan To Kagaku Ryoho 24 Breast Cancer 23 Zhonghua Zhong Liu Za Zhi 23 Br J Surg 21 Brit J Cancer 21 1 2 3 ... 18 1 2 3 ... 114 Top Terms Publications Breast Neoplasms 1,994 Humans 1,991 Patients 1,742 Mastectomy 1,535 Survival Rate 1,454 Middle Aged 1,402 Adult 1,187 Recurrence 1,128 Aged 1,092 Neoplasms 906 Surgery 867 Neoplasm Recurrence, Local 859 Mastectomy, Segmental 807 Combined Modality Therapy 780 Prognosis 767 Radiotherapy 676 Neoplasm Staging 663 Drug Therapy 662 Carcinoma 655 Women 654 1 2 3 ... 114 1 2 3 ... 389 Top Authors Publications Singletary S 37 McNeese M 32 Haffty B 32 Solin L 31 Hunt K 30 Buchholz T 29 Ames F 27 Kurer H 25 Buzdar A 25 Hortobagyi G 24 Strom E 23 Vicini F 22 Fisher B 22 Schultz D 21 Veronesi U 20 Kinne D 20 Ross M 18 Bonadonna G 18 Rosen P 18 Harris J 17 1 2 3 ... 389
本文为博主原创的医学信息分析报告，特此说明。 该项目的信息连接： http://wwwcf.nlm.nih.gov/hsr_project/view_hsrproj_record.cfm?PROGRAM_CAME=home_projNLMUNIQUE_ID=20091136SEARCH_FOR = 项目名称：Clinical and economic evaluation of breast MRI for high-risk screening 研究年限：2008 - 2013年 该项目的相关主题： Breast /* pathology Breast Neoplasms /* diagnosis / pathology Cost-Benefit Analysis Decision Support Techniques Early Detection of Cancer False Positive Reactions Female Heterozygote Humans Magnetic Resonance Imaging /* economics /* utilization Mass Screening /* instrumentation / methods Models, Economic Monte Carlo Method Mutation 信息分析平台连接： http://www.gopubmed.org/web/gopubmed/1?WEB0pg9d2c44i4gwI1aI1I00f01000j10040001rl 检索策略：Cost and breast and MRI 分析结果： 168 documents semantically analyzed 1 2 Top Years Publications 2008 21 2009 17 2006 15 2005 14 2007 12 2001 10 2000 10 2003 9 1999 8 2004 7 1998 7 2002 6 1997 6 1996 5 1995 4 1994 4 1991 3 1989 3 2010 2 1993 1 1 2 Top Countries Publications USA 79 Germany 17 United Kingdom 12 Italy 11 Canada 4 France 4 Norway 4 Netherlands 3 Japan 3 Thailand 2 Austria 2 Greece 2 Sweden 2 Australia 1 Saudi Arabia 1 South Korea 1 Singapore 1 Ireland 1 Gambia 1 1 2 3 4 Top Cities Publications Philadelphia 7 Houston 6 New York 6 Boston 5 Milan 5 Los Angeles 4 Stanford 4 Kingston upon Hull 3 Rome 3 San Francisco 3 Seattle 3 Berlin 3 London 3 Dallas 3 Winnipeg 2 Bangkok 2 Atlanta 2 Chicago 2 Tampa 2 Wien 2 1 2 3 4 1 2 3 ... 6 Top Journals Publications Radiology 7 Magn Reson Imaging Clin N Am 6 Acad Radiol 5 Rofo-fortschr Rontg 4 Eur Radiol 4 Lancet 3 Magn Reson Imaging 3 Radiol Med (torino) 3 Breast J 3 Ajr Am J Roentgenol 3 Jama 3 Radiologe 3 Ann Surg Oncol 3 Ann Oncol 3 Tumori 3 Can Assoc Radiol J 3 Ieee T Med Imaging 3 Radiol Clin N Am 3 Q J Nucl Med 3 Plast Reconstr Surg 3 1 2 3 ... 6 1 2 3 ... 37 Top Authors Publications Leach M 5 Gilbert F 4 Easton D 4 Padhani A 4 Turnbull L 4 Orel S 4 Evans D 3 Pointon L 3 Warren R 3 Silverstein M 2 Vicini F 2 Kopans D 2 Paulsen K 2 Berman C 2 Deutinger M 2 Benditte-Klepetko H 2 Esserman L 2 Brown J 2 Dixon A 2 Eeles R 2 1 2 3 ... 37 1 2 3 ... 41 Top Terms Publications Humans 158 Magnetic Resonance Imaging 148 Breast Neoplasms 145 Mammography 102 Patients 97 Magnetic Resonance Spectroscopy 90 Evaluation Studies as Topic 65 Diagnosis 63 Sensitivity and Specificity 53 Women 50 Mass Screening 48 Middle Aged 46 Cost-Benefit Analysis 44 Biopsy 42 Neoplasms 42 Adult 41 Tissues 34 Breast 32 Neoplasm Staging 30 Methods 28 1 2 3 ... 41
http://www.gopubmed.org/web/gopubmed/WEB10O00f01000j100300.y 199 documents semantically analyzed top author statistics 1 2 Top Years Publications 2008 25 2006 23 2004 21 2005 17 2007 14 2009 13 2003 12 1996 9 2000 8 2001 7 2002 5 1980 5 1999 4 1998 4 2010 3 1994 3 1976 3 1997 2 1995 2 1993 2 1 2 1 2 Top Countries Publications USA 91 United Kingdom 15 France 7 Italy 6 Spain 6 Germany 5 Canada 5 Australia 4 China 3 Denmark 2 South Korea 2 Japan 2 India 2 Ireland 2 Austria 1 Brazil 1 Mexico 1 Argentina 1 Thailand 1 Portugal 1 1 2 1 2 3 4 5 Top Cities Publications Boston 13 New York 10 Columbus 7 London 5 Milan 5 Rockville 4 Seattle 3 Berlin 3 Leicester 3 Minneapolis 2 Stony Brook 2 Portland 2 Bengbu 2 Buffalo 2 Chapel Hill 2 Melbourne 2 Atlanta 2 Salt Lake City 2 Barcelona 2 New Haven 2 1 2 3 4 5 1 2 3 ... 7 Top Journals Publications Jama 8 Cancer Epidem Biomar 7 Cancer Res 6 Int J Oncol 4 Lancet 4 Breast Cancer Res 4 J Natl Cancer Inst 4 Oncol Rep 4 Brit J Cancer 4 Am J Epidemiol 4 Prostag Oth Lipid M 4 Biochem Pharmacol 3 Carcinogenesis 3 Clin Cancer Res 3 J Cell Biochem 3 Cancer Cause Control 3 Bmc Cancer 3 J Am Geriatr Soc 3 J Natl Cancer I 3 Radiother Oncol 3 1 2 3 ... 7 1 2 3 ... 83 Top Terms Publications Aspirin 196 Humans 187 Breast Neoplasms 168 Pharmaceutical Preparations 94 Anti-Inflammatory Agents, Non-Steroidal 83 Women 67 Neoplasms 67 Middle Aged 65 Risk Factors 63 Aged 54 Patients 48 Incidence 45 Confidence Intervals 43 Animals 42 Prostaglandin-Endoperoxide Synthases 39 Adult 39 Cyclooxygenase Inhibitors 37 Risk 34 Chemoprevention 34 Evaluation Studies as Topic 33 1 2 3 ... 83 1 2 3 ... 37 Top Authors Publications Buring J 6 Powles T 6 Neville A 6 Manson J 5 Lee I 5 Harris R 5 Easty G 5 Zhang S 4 Neugut A 4 Cook N 4 Dowsett M 4 Easty D 4 Gallus S 3 Schatzkin A 3 Reddy B 3 Slattery M 3 La Vecchia C 3 Ridker P 3 Beebe-Donk J 3 Hennekens C 3 1973年就就有研究报道 2 of 199 documents semantically analyzed top author statistics Term: 1973 Description: year 1973 Top Years Publications 1973 2 Top Journals Publications Brit J Cancer 1 Lancet 1 Top Authors Publications Neville A 1 Powles T 1 Clark S 1 Easty D 1 Easty G 1 Stoll B 1 1 2 Top Terms Publications Breast Neoplasms 2 Indomethacin 2 Aspirin 2 Mice 2 Humans 2 Animals 2 Neoplasms 1 Time Factors 1 Neoplasm Metastasis 1 Mice, Inbred BALB C 1 Lactates 1 Hypercalcemia 1 Hydrogen-Ion Concentration 1 Carcinoma 256, Walker 1 Calcium Radioisotopes 1 Calcium 1 Bone Resorption 1 Bone Neoplasms 1 Bone and Bones 1 Rats 1 1 2 documents Title: The inhibition by aspirin and indomethacin of osteolytic tumor deposits and hypercalcaemia in rats with Walker tumour, and its possible application to human breast cancer . PMID: 4759939 Related Articles Authors: Powles, T J , Clark, S A , Easty, D M , Easty, G C , Neville, A M Journal: Br J Cancer , Vol. 28 (4): 316-21 , 1973 No abstract given. Pubmed MeSH: Animals , Bone Neoplasms , Bone Resorption , Bone and Bones , Calcium , Calcium Radioisotopes , Carcinoma 256, Walker , Humans , Hydrogen-Ion Concentration , Hypercalcemia , Lactates , Mice , Mice, Inbred BALB C , Neoplasm Metastasis , Time Factors Wikipedia: Acetylsalicylic Acid , Aspirin , Benign neoplasm , Breast Cancer , Breast neoplasms , Cancer , Cancer of breast , Ecotrin , Indocid , Indocin , Indometacin , Indomethacin , Neoplasm , Tumor , ZORprin Title: Indomethacin in breast cancer . PMID: 4124563 Related Articles Authors: Stoll, B A Journal: Lancet , Vol. 2 (7825): 384 , 1973 No abstract given. Pubmed MeSH: Aged , Animals , Aspirin , Humans , Mice , Rats Wikipedia: Breast Cancer , Breast neoplasms , Cancer of breast , Indocid , Indocin , Indometacin , Indomethacin 最新研究论文 http://news.sciencenet.cn//htmlnews/2010/2/228462.shtm 美研究称定期服阿司匹林可防乳腺癌复发 （图片来自Getty Images） 美国研究人员2月16日说，接受早期乳腺癌治疗的女性定期服用阿司匹林可降低复发或死亡风险。 按研究人员说法，这是首次发现阿司匹林可显著降低乳腺癌复发风险。 低成本 美国哈佛大学医学院研究人员米歇尔霍姆斯及其团队自1976年起持续30年随访参加护士健康研究项目的4164名女护士。 调查期间，341名护士死于乳腺癌。 研究人员发现，接受早期乳腺癌治疗的患者服用阿司匹林后，癌细胞扩散和死于乳腺癌的风险均降低50%。 这项研究首次发现，阿司匹林可显著降低接受早期乳腺癌治疗的女性体内癌细胞扩散以及死亡风险，霍姆斯说，如果这些发现在其他临床试验中得到验证，服用阿司匹林可能成为又一种简单、低成本和相对安全的工具，助罹患乳腺癌的女性活得更久、更健康。 定期服 这项研究所获结果由最新一期《临床肿瘤学杂志》（ Journal of Clinical Oncology ）刊载。 霍姆斯及其团队发现，乳腺癌患者如每星期服用阿司匹林2至5天，体内癌细胞扩散和死于乳腺癌的风险分别降低60%和71%。 相比之下，每星期服用阿司匹林6至7天的乳腺癌患者癌细胞扩散风险降低43%，死于乳腺癌风险降低64%。 霍姆斯等人说，与阿司匹林同属一类的其他非类固醇抗炎药或可降低乳腺癌癌细胞扩散或癌症死亡风险，但现阶段相关研究数据尚不足以提供确切答案。 探药理 研究人员说，尚不确定阿司匹林和其他非类固醇抗炎药以何种方式对肿瘤施以影响，但影响方式可能是减少炎症。 他们举例说，先前其他研究项目所获数据显示，阿司匹林和非类固醇抗炎药布洛芬可降低罹患结肠癌风险。 相比癌症化学疗法药物，阿司匹林副作用较小。它还可能预防结肠癌、心血管疾病和中风，研究人员说。它对激素依赖性肿瘤和非激素依赖性肿瘤均可施以影响。 但霍姆斯团队强调，鉴于产生副作用的风险，乳腺癌患者不应在接受放射治疗或化疗期间服用阿司匹林。另外，阿司匹林可引发胃出血，患者应在医生指导下服用。 更多阅读 路透社相关报道（英文） 《临床肿瘤学杂志》相关论文摘要（英文） 研究发现：健康人服用阿司匹林弊大于利 http://www.reuters.com/article/idUSTRE61F56Q20100216 var adsrc = 'us.reuters/news/health/article;' + (typeof(seg)=='undefined'?'':seg) + 'type=leaderboard;sz=728x90;tile=1;vbc=verizon;articleID=USTRE61F56Q20100216;ord=' + (typeof(tmstmp)!='undefined'?tmstmp:12345) + '?'; 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WASHINGTON (Reuters) - Breast cancer survivors who take aspirin regularly may be less likely to die or have their cancer return, U.S. researchers reported Tuesday. Health The study of more than 4,000 nurses showed that those who took aspirin -- usually to prevent heart disease -- had a 50 percent lower risk of dying from breast cancer and a 50 percent lower risk that the cancer would spread. This is the first study to find that aspirin can significantly reduce the risk of cancer spread and death for women who have been treated for early stage breast cancer, said Dr. Michelle Holmes of Harvard Medical School, who led the study published in the Journal of Clinical Oncology. If these findings are confirmed in other clinical trials, taking aspirin may become another simple, low-cost and relatively safe tool to help women with breast cancer live longer, healthier lives, Holmes added in a statement. Holmes and her team studied 4,164 female registered nurses taking part in the Nurses' Health Study, an ongoing analysis of a wide range of health issues. They started in 1976, looking at who took aspirin, watching for breast cancer and all causes of death until 2006. Over this time, 341 of the nurses died of breast cancer. Women who took aspirin two to five days a week had a 60 percent reduced risk of their cancer spreading and a 71 percent lower risk of breast cancer death. Six to seven aspirins a week lowered the risk of spread by 43 percent and the risk of breast cancer death by 64 percent. Most of the women were taking low-dose aspirin to prevent heart attacks and stroke. Other drugs in the same class as aspirin also apparently lowered the risks, too. These drugs, called non-steroidal inflammatory drugs or NSAIDs, include ibuprofen and naproxen but not acetaminophen, also known as paracetamol. But there was not enough data on these drugs to give a clear answer. The researchers said they are not sure how aspirin and other NSAIDS may affect tumors but it could be by lowering inflammation. Other studies have shown that aspirin and ibuprofen can lower colon cancer risk, for instance. Aspirin has relatively benign adverse effects compared with cancer chemotherapeutic drugs and may also prevent colon cancer, cardiovascular disease, and stroke, the researchers wrote. It affected both estrogen-positive tumors and those not fueled by the hormone. Holmes' team stressed that patients should not take aspirin while undergoing radiation or chemotherapy because of the risk of side effects. And aspirin can cause stomach bleeding so it should not be taken without a doctor's supervision. (Editing by Cynthia Osterman ) http://jco.ascopubs.org/cgi/content/abstract/JCO.2009.22.7918v1 JCO Early Release, published online ahead of print Feb 16 2010 Journal of Clinical Oncology, 10.1200/JCO.2009.22.7918 Received February 25, 2009 Accepted December 9, 2009 Aspirin Intake and Survival After Breast Cancer Michelle D. Holmes, * Wendy Y. Chen, Lisa Li, Ellen Hertzmark, Donna Spiegelman, and Susan E. Hankinson From the Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School; Department of Medical Oncology, Dana-Farber Cancer Institute; and Departments of Epidemiology and Biostatistics, Harvard School of Public Health, Boston, MA. * To whom correspondence should be addressed. E-mail: michelle.holmes@channing.harvard.edu
标签: 乳腺癌
