最新文献报道 Methods Mol Biol. 2010;609:113-28. Enzyme databases. Schomburg D , Schomburg I . Department of Bioinformatics and Biochemistry, Technische Universitt Carolo-Wilhelmina zu Braunschweig, Braunschweig, Germany. Abstract Enzymes are catalysts for the chemical reactions in the metabolism of all organisms and play a key role in the regulation of metabolic steps within the cells, as drug targets, and in a wide range of biotechnological applications. With respect to reaction type, they are grouped into six classes, namely oxidoreductases, transferases, hydrolases, lyases, and ligases. EC-Numbers are assigned by the IUBMB. Enzyme functional databases cover a wide range of properties and functions, such as occurrence, kinetics of enzyme-catalyzed reactions, structure, or metabolic function. BRENDA stores a large variety of different data for all classified enzymes whereas KEGG, MEROPS, MetaCyc, REBASE, CAzy, ESTHER, PeroxiBase, and KinBase specialize in either certain aspects of enzyme function or specific enzyme classes, organisms, or metabolic pathways. Databases covering enzyme nomenclature are ExplorEnz, SIB-ENZYME, and IntEnz. PMID: 20221916 MeSH Terms, Substances MeSH Terms: Animals Catalysis Computer Graphics Data Mining* Databases, Protein* Enzymes/chemistry Enzymes/classification* Enzymes/genetics Enzymes/metabolism Humans Internet Kinetics Protein Conformation Software Structure-Activity Relationship Systems Biology* Systems Integration Terminology as Topic* User-Computer Interface Substances: Enzymes LinkOut - more resources Full Text Sources: Springer http://www.gopubmed.org/web/gopubmed/ Enzyme databases 7,586 documents semantically analyzed top author statistics 1 2 Top Years Publications 2009 716 2004 701 2005 694 2003 617 2007 604 2006 596 2008 582 2002 475 2001 419 2000 358 1999 323 1998 252 1997 223 1996 208 2010 205 1995 199 1994 176 1993 90 1991 55 1992 47 1 2 1 2 3 4 5 Top Countries Publications USA 2,630 United Kingdom 674 Germany 586 Japan 441 France 355 Canada 338 China 261 Italy 222 Australia 182 Spain 170 Switzerland 131 Netherlands 130 India 115 Sweden 113 Brazil 92 South Korea 87 Denmark 72 Belgium 69 Israel 67 Austria 61 1 2 3 4 5 1 2 3 ... 50 Top Cities Publications London 158 Bethesda 107 Boston 103 Cambridge 102 San Diego 94 San Francisco 94 Heidelberg 90 Tokyo 89 Beijing 81 New York 76 Toronto 76 Paris 73 Montreal 65 Seattle 65 Baltimore 62 Berlin 59 Los Angeles 57 Madrid 54 Shanghai 50 Cambridge, USA 49 1 2 3 ... 50 1 2 3 ... 68 Top Journals Publications Nucleic Acids Res 305 J Biol Chem 201 Proteins 175 J Med Chem 174 J Mol Biol 172 Bioinformatics 140 Proteomics 137 Plant Physiol 134 P Natl Acad Sci Usa 112 Gene 105 Protein Sci 102 Bmc Bioinformatics 97 Bmc Genomics 81 J Proteome Res 79 Biochem Bioph Res Co 78 J Bacteriol 75 Febs Lett 74 J Chem Inf Model 73 Genomics 65 Biochem J 59 1 2 3 ... 68 1 2 3 ... 985 Top Terms Publications Proteins 4,160 Humans 3,546 Genes 2,901 Enzymes 2,801 Amino Acid Sequence 2,468 Animals 2,378 Genomics 1,738 Genome 1,728 Base Sequence 1,389 Amino Acids 1,300 Models, Molecular 1,158 Sequence Homology, Amino Acid 1,119 DNA 1,117 Binding Sites 1,070 Sequence Alignment 1,050 Computational Biology 966 Peptides 963 Patients 890 Pharmaceutical Preparations 858 Phylogeny 848 1 2 3 ... 985 1 2 3 ... 1605 Top Authors Publications Koonin E 39 Thornton J 37 Karp P 29 Bujnicki J 20 Chou K 19 Aravind L 18 Bork P 17 Kanehisa M 15 Kane C 15 Skolnick J 15 Rawlings N 14 Roberts R 14 Goto S 14 Barrett A 14 Kikuno R 14 Nagase T 14 Ohara O 14 Langer T 13 Babbitt P 13 Neamati N 13 1 2 3 ... 1605