Date: Sat, 18 Mar 2017 12:25:05 -0400 From: Numéro Cinq editor@numerocinqmagazine.com To: ME Subject: Re: production editor or Contst(s) Manager S, Thank you for writing. I want to make sure that you realize this is an unpaid parttime gig. And if you are okay with that, could you let me know how competent you are at Wordpress? All best, Douglas I promptly replied 3 emails to this short note. Little did I know that Douglas is Mr. Glover ! Feeling blessed, even if I blew UP my chance, by not knowing THE master I am conversing with... Love this writing by Cigale. http://numerocinqmagazine.com/2013/01/09/the-artful-artlessness-of-daniil-kharmstranslation-alex-cigale/ On another news: https://www.linkedin.com/pulse/silicon-valley-needs-get-schooled-christian-madsbjerg
西安交大成立Douglas C. Wallace线粒体表观与遗传学信息科学研究所 西安交通大学 DouglasC.Wallace 线粒体表观与遗传学信息科学研究所( Douglas C. Wallace-Institut for Mitochondrial and Epigenomic Information Sciences Xi’an Jiaotong University , DCW-IMEIS )揭牌成立。 Douglas C. Wallace 是美国科学院、艺术科学院、医学科学院三院院士,国际线粒体医学领域的顶尖学者。作为学校首个以外籍院士命名的研究机构,该研究所将结合国家需求,开展线粒体相关疾病的研究工作。 Douglas C. Wallace 院士,中国科学院院士杨焕明,西安交大副校长颜虹,生命学院院长刘健康及国内外 100 余名专家学者出席成立仪式。国际处处长梁莉主持会议。 在现场嘉宾的共同见证下, Douglas C. Wallace 院士、杨焕明院士、颜虹副校长、刘健康院长共同为西安交大 DCW-IMEIS 揭牌。 刘健康院长致欢迎辞。他代表学院欢迎与会领导、国内外专家学者莅临会议,并衷心感谢嘉宾们共同见证这一重要历史时刻,他说,你们会永远记得今天,因为它将被载入交大史册。 颜虹副校长为 Douglas C. Wallace 颁发西安交大名誉教授聘书并佩戴校徽。他指出,生命医药科学是西安交大计划优先发展的重要研究领域之一, DCW-IMEIS 研究所的成立,是学校创建世界一流大学进程中生命科学领域的重要里程碑,在促进国际化学术交流和加速推进生命医药科学发展等方面将发挥重 要作用。 杨焕明院士高度肯定双方协力共建工作,并对研究所未来发展前景充满信心。 Douglas C. Wallace 院士对研究所揭牌成立、受聘西安交大名誉教授表示诚挚的感谢。他谈到,生命医药科学新成果、新突破为提高人类生命质量创造条件。国际化生命医药科学的发展,其效益必将是长远、普世且普惠的。他表示,将与交大共同携手,站在这东西两半球共建线粒体医学研究的新篇章,为交大建成世界一流大学作出贡献。 线粒体生物学与医学国际学术研讨会同期举行, Douglas C. Wallace 院士,杨焕明院士等 20 余位中外专家学者做了主题报告。 附:Douglas C. Wallace 简介 Douglas C. Wallace , PhD Douglas Cecil Wallace (born November 6, 1946) is a geneticist and evolutionary biologist at the University of Pennsylvania and the Children's Hospital of Philadelphia in Pennsylvania. He pioneered the use of human mitochondrial DNA as a molecular marker. Career Wallace earned a Bachelor of Science in Genetics and Developmental Biology at Cornell University in Ithaca, New York in 1968, a Master of Philosophy in Microbiology and Human Genetics at Yale University in New Haven, Connecticut in 1972 and a Ph.D. in Microbiology and Human Genetics at Yale University in 1975. His dissertation was titled Cytoplasmic genetics in mammalian tissue culture cells. He remained at Yale University as a postdoctoral fellow until he was awarded a professorship (Assistant Professor) at the Stanford University School of Medicine in Stanford, California in 1976. In 1983 he became professor (Adjunct Professor) for Biochemistry, Anthropology and Pediatrics (Genetics) at the Emory University in Atlanta, Georgia. From 1996 to 2002,he was Chairperson and Senior Editor of the Mitochondrial DNA Locus- Specific Database for the Human Genome Organisation (HUGO). In 2002 he assumed a professorship of Molecular Genetics at the University of California, Irvine and founded the Center for Molecular and Mitochondrial Medicine and Genetics there. In 2006 he was awarded a visiting professorship at Academia Sinica in Taipei, Taiwan. In 2010 he became professor of Pathology and Laboratory Medicine at the University of Pennsylvania in Philadelphia and became the founding director of the Center for Mitochondrial and Epigenomic Medicine at the Children's Hospital of Philadelphia. Work Wallace is a pioneer in the study of mitochondrial DNA. Wallace and his colleagues introduced human mitochondrial genetics into the field of molecular genetics. In 1975, for the first time ever, Wallace could associate a genetic disorder with the mitochondrial DNA region (resistance to chloramphenicol) and in 1990 he described a mitochondrial DNA mutation as the cause of a particular form of myoclonic epilepsy. He has been instrumental in the study of the mitochondrial genome and has developed new methods for the analysis of mitochondrial DNA. Wallace and his colleagues demonstrated that human mitochondrial DNA is inherited exclusively from the mother and reconstructed the origin and ancient migration patterns of women using variations in mitochondrial DNA sequences. Honours and awards 1995 Membership of the National Academy of Sciences 2000 Passano Award (jointly with Giuseppe Attardi) 2004 Membership of the American Academy of Arts and Sciences 2009 Membership of the Institute of Medicine 2012 Gruber Prize in Genetics
今天早晨收到 Douglas 邮件,他的论文在线发表在 Systematic Biology 上。该论文 2011 年投稿,历经 3 次修稿。其中第三轮修改工作在我组做博士后期间完成。祝贺他和 Alfried 教授! Title: Resolving Ambiguity of Species Limits and Concatenation in Multi-locus Sequence Data for the Construction of Phylogenetic Supermatrices Authors: Douglas Chesters 1 , 2 , 3 and Alfried P. Vogler 1 , 2 Author Affiliations 1 Department of Entomology, Natural History Museum, London SW7 5BD, UK, 2 Division of Biology, Imperial College London, Silwood Park Campus, Ascot, Berkshire SL5 7PY, UK, Email: apv@nhm.ac.uk 3 Key Laboratory of Zoological Systematics and Evolution, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China, Email: dc.1984@yahoo.co.uk Author for correspondence: Dr Alfried P. Vogler 论文链接如下: http://sysbio.oxfordjournals.org/content/early/2013/02/15/sysbio.syt011.abstract Douglas 在博士期间运用生物信息学手段研究了大规模系统发育分析过程中出现的系列问题。在 2009 年 7 月获得博士学位后,他分别在捷克和英国两所大学短暂工作,参与国际鞘翅目“生命之树”研究。 他于 2011 年 7 月 5 日受我邀请加入研究组,成为研究组信息分析员。 Douglas Chesters 博士在研究组中,在以前采用分子数据对动物物种实现分子分类的研究基础上,结合组内现有研究基础与在研项目,以膜翅目蜜蜂总科作为主要研究对象,建立生物信息平台,以期构建在物种水平上含最大信息量的分子序列数据集,开展分子分类与分子系统学研究,实现蜜蜂总科昆虫的物种智能鉴定,并探讨物种之间的系谱关系。 关键问题: 1 、 基于分子信息,建立传粉蜜蜂物种界定标准、方法、流程。目前中国已经定名约 1000 种蜜蜂,但是据吴燕如研究员和国外相关蜜蜂专家预估,中国可能存在约 3000 种蜜蜂留待进一步发现。另外一方面,蜜蜂总科普遍存在隐存种现象,而传统分类或者生物学观察尽管可能通过细致的研究能够解决这一问题,但是可能会非常缓慢。分子分类和传统分类相结合,可能加快物种发现的进程。 2 、 针对分子分类或系统发育分析中的重要环节,构建蜜蜂总科含最大信息量的性状矩阵。分子分类或者重构系统发育的必要前提是性状矩阵。在这个矩阵中,行,比较典型的可以代表物种;列,则代表不同分子序列中的同源位点。通常对于大规模系统发育分析,不论是对行还是列的构建都尤为关键:首先,由于大量物种的测序很难针对相同的基因片断或采用标准化的引物,选用合适的基因片断对构建性状矩阵即变的很重要。其次,虽然增加物种取样密度是可取的,但增加密度的同时则容易带来缺失的分子序列信息位点从而影响最终构建得到的系统发育树与真实进化树的相似度。 相关技能和研究经历: 1 、 Douglas 博士建立了一套流程,可以将单个或者多个基因整合到大数据集中的可行性。 2 、 他处理了一些系统发育信息学分析过程中利用分子数据进行物种分类的新问题。目前已经出现仅用分子数据设定物种界限的工作,但是在用多位点信息时不一致的结果带来了很多方法学上的问题。这些问题的解决方法已经投稿到系统学著名杂志 Systematic Biology ,并被接收。 3 、 他确定了大规模 COI 数据中不同变换速率的影响。目前,他和合作者已经发现在鞘翅目中, COI 的不同变换速率大量存在,但由于去掉它们不利于产生合理的比对结果,因此这些不同变换速率是有利的。 COI 的趋同性与异质性特点并没有影响它们的应用,因此存在一定的可能性将它们整合到分子分类与分子系统学工作中。 相关方法与流程, Douglas 博士通过和不同类群专家合作,逐步推广到膜翅目中几个大的总科中。下阶段,他将以蜜蜂总科为主要研究对象,更深入研究大数据集在分子分类与分子系统学中我们将面临的问题,并探讨解决方案。就这部分问题, Douglas 博士已经完成 2 篇论文,并于 2013 年春节前投稿到进化生物学领域杂志。
2010年诺贝尔奖得主预测 位于美国缅因州巴港的杰克逊实验室 名誉高级科研人员 Douglas L. Coleman 获奖原因 因发现调节食欲和新陈代谢的激素致轻素而获奖 http://scholar.google.com.hk/scholar?hl=enq=DL+Coleman++obesity+btnG=Searchas_sdt=2000as_ylo=as_vis=0 Obese and diabetes: two mutant genes causing diabetes- obesity syndromes in mice DL Coleman - Diabetologia, 1978 - Springer Summary. The diabetes syndromes produced by the two single gene mutations, obese (ob), and diabetes (db) are identical when both genes are expressed on the same inbred background, whereas on different backgrounds the syndrome changes from a severe- ... Cited by 770 - Related articles - All 2 versions Effect of genetic background on the therapeutic effects of dehydroepiandrosterone (DHEA) in diabetes- obesity mutants and in aged normal mice. DL Coleman , RW Schwizer, EH Leiter - Diabetes, 1984 - Am Diabetes Assoc Dehydroepiandrosterone (DHEA) was fed at 0.1-0.4% in the diet to genetically diabetic (db/db) or obese (ob/ob) C57BL/KsJ (BL/Ks) or C57BL/6J (BL/6) mice. Treatment of BL/Ks-db/db or ob/ob mice with 0.4% DHEA prevented hyperglycemia, islet atrophy, and ... Cited by 296 - Related articles - All 5 versions Laboratory animals exhibiting obesity and diabetes syndromes L Herberg, DL Coleman - Metabolism, 1977 - Elsevier Spontaneous hyperglycemia, hyperinsulinemia and obesity are common features for at least one period of the life-time in some strains of mice. Both genetic and environmental factors are involved in the pathogenesis of the diabetes-like syndrome, making these strains ... Cited by 286 - Related articles - All 2 versions Diabetes- obesity syndromes in mice. DL Coleman - Diabetes, 1982 - ncbi.nlm.nih.gov 1. Diabetes. 1982;31(Suppl 1 Pt 2):1-6. Diabetes- obesity syndromes in mice. Coleman DL . Several different rodent models are available for metabolic studies on the development of diabetes. Although the abnormalities associated ... Cited by 251 - Related articles Fat (fat) and tubby (tub): two autosomal recessive mutations causing obesity syndromes in the mouse oxfordjournals.org DL Coleman , EM Eicher - Journal of Heredity, 1990 - Am Genetic Assoc From The Jackson Laboratory, Bar Harbor, Maine 04609. This research was funded in part by NIH research grants DK14461 (DLC), GM20919 and RR01183 (EME). We thank Christina Gott for originally noting the pro- genitor tubby male, Janice Southern for establishing the ... Cited by 159 - Related articles - All 7 versions Obesity genes: beneficial effects in heterozygous mice DL Coleman - Science, 1979 - sciencemag.org The mouse mutant genes obese (ob) and diabetes (db) cause similar obesity -diabetes states in homozygotes. These obesity syndromes are characterized by a more efficient conversion of food to lipid and, once stored, a slower rate of catabolism on fasting. Heterozygous mice, ... Cited by 94 - Related articles - All 3 versions Thermogenesis in diabetes- obesity syndromes in mutant mice DL Coleman - Diabetologia, 1982 - Springer Summary. The two mouse mutants, obese (ob) and diabetes (db), cause similar diabetes- obesity syn- dromes that are characterized by a marked increase in apparent metabolic efficiency with regard to utilizati- on of energy. A failure to thermoregulate in a normal fashion would ... Cited by 40 - Related articles - All 3 versions The influence of genetic background on the expression of the obese (Ob) gene in the mouse DL Coleman , KP Hummel - Diabetologia, 1973 - Springer ... 1. Bleisch, VR, :M;ayer, J., Dickie, MM,: Familial diabetes mellitus in mice associated with insulin re- sistance, obesity , and hyperplasia of the islets of Langerhans. Amer. J. Path. 28, 369--385 (1952). 2. Coleman , DL , ]~ ?.: The influence of genetic background on the expression of the obese (o5) gene in the mouse. Diabetologia, 9, 287-- 293 (1973). 5. Haessler, HA, Crawford, J. ]). : Alterations in the fatty acid composition of depot fat associated with obesity . Ann. RT. ... Cited by 437 - Related articles - All 2 versions Plasma corticosterone concentrations in diabetic (db) mice DL Coleman , DL Burkart - Diabetologia, 1977 - Springer ... 51, 598-646 (1971) 2. Marshall, NB, Andrus, SW, Mayer, J.: Organ weights in three forms of obesity . Amer. ... Endocrinology 93, 510-513 (1973) Hummel, KP, Coleman , DL , Lane, PW: The influence of genetic background on the expression of mutations at the dia- betes locus in the ... Cited by 43 - Related articles - All 2 versions Hyperinsulinemia in pre-weaning diabetes (db) mice DL Coleman , KP Hummel - Diabetologia, 1974 - Springer ... 610 DL Coleman and KP Hummel: Hyperinsulinemia in Pre-Weaning Diabetes (db) Mice Insulin resistance is a pronounced feature of diabetes mice which is recognizable as sooll as obesity becomes apparent and which increases with age, be- coming almost total in the later ... Cited by 77 - Related articles - All 2 versions Diabetes and Obesity : Thrifty Mutants? DL Coleman - Nutrition reviews, 1978 - interscience.wiley.com A limited number of reprints of this article may be obtained from he author THERE ARE NO REPRINTS OF UNSIGNED REVIEWS ... NUTRITION REVIEWS I VOL. 36, NO. 5 MAY 1978 128 ... 150 NUTR/T/ON REWEWS I VOL. 36, NO. 5 YAY 1078 Cited by 23 - Related articles - All 2 versions Acetone metabolism in mice: increased activity in mice heterozygous for obesity genes pnas.org DL Coleman - Proceedings of the National Academy of , 1980 - National Acad Sciences ABSTRACT Mice were found to convert acetone to lactate at appreciable rates. The conversion of acetone to gluconeogenic precursors could provide additional glycolytic intermediates that would allow the more complete utilization of lipid stores and increase survival time during ... Cited by 21 - Related articles - All 8 versions Antiobesity effects of etiocholanolones in diabetes (db), viable yellow (Avy), and normal mice DL COLEMAN - Endocrinology, 1985 - Endocrine Soc ... DOUGLAS L. COLEMAN ... Two metabolites of the adrenal steroid dehy-droepiandrosterone (DHEA), 3 -hydroxyetiocholanolone and 3-hydroxyetiocholanolone, were found to have antiobesity properties with respect to both prevention of the development of obesity as well as ... Cited by 31 - Related articles - All 3 versions Studies with the mutation, diabetes, in the mouse DL Coleman , KP Hummel - Diabetologia, 1967 - Springer ... 6 and 7). Degranulation of fi-cells is a consistent finding and apparently occurs as early as the onset of obesity as it is evident in the islets of 25-day old dia- betics. ... Page 4. Vol. 3, No. 2, 1967 DL COLEMAN and KP HUmMeL. Studies with the Mutation, Diabetes 241 ... Cited by 207 - Related articles - All 2 versions The influence of genetic background on expression of mutations at the diabetes locus in the mouse. I. C57BL/KsJ and C57BL/6J strains KP Hummel, DL Coleman , PW Lane - Biochemical genetics, 1972 - Springer ... Our studies emphasize the importance of genetic control in attempts to determine causes and courses of diseases such as diabetes or obesity . ... Diabetologia 6:252. Coleman , DL , and Hummel, KP (1967). Studies with the mutation, diabetes, in the mouse. Diabetologia 3:238. ... Cited by 133 - Related articles - All 2 versions Influence of genetic background on the expression of mutations at the diabetes locus in the mouse. II. Studies on background modifiers DL Coleman , KP Hummel - Contemporary topics in the study of , 1975 - Academic Press Cited by 34 - Related articles Insulin secretion in experimental obesity WJ Malaisse, F Malaisse-Lagae, DL Coleman - Metabolism, 1968 - Elsevier In mice rendered obese by adminitration of goldthioglucose, the pancreas increases both its store of insulin and its capacity to secrete insulin in vitro in response to glucose and theophylline in direct proportion to the actual body weight. In hereditarily obese mice ( ), the insulin ... Cited by 16 - Related articles - All 2 versions Lessons from studies with genetic forms of diabetes in the mouse* DL Coleman - Metabolism, 1983 - Elsevier ... References. DL Coleman , Diabetes- obesity syndromes in mice, Diabetes 31 (1982) (suppl 1), pp. 16. View Record in Scopus | Cited By in Scopus (167). ... DL Coleman , Obesity genes: Beneficial effects in heterozygous mice, Science 203 (1979), pp. 663664. ... Cited by 14 - Related articles - All 2 versions The effects of hypothalamics lesions in genetically diabetic mice DL Coleman , KP Hummel - Diabetologia, 1970 - Springer ... Amer. J. Physiol. 211, 229--231 (1966). 8. l?Ialaisse, WJ, Malaisse-Lagae, F., Coleman , DL : Insulin secretion in e:cperimental obesity . Metabolism 17, 802--807 (1968). 9. Mayer, J., French, RG, Zighera, CF, Barrnett, RJ : Hypothalamic obesity in the mouse. ... Cited by 27 - Related articles - All 2 versions