1901-2019年诺贝尔生理学或医学奖一览表 诸平 2019 年度的诺贝尔生理学或医学奖得 主即将揭晓，尽管有不同的预测结果，但是究竟会花落谁家？一切都是未知数。在等待揭晓结果的同时，不妨让我们回顾以往的诺贝尔生理学或医学奖得主的相关信息，在怀旧中期待 2019 年度的诺贝尔生理学或医学奖的到来。2019诺贝尔奖奖金为900万瑞士克朗，约91.8万美元（ 9-million kronor，or $918,000）。现将所有诺贝尔生理学或医学奖得主相关链接摘引于下，自1901年以来到2019年之间，生理学或医学奖共颁奖109次，获奖者216人，更多信息详见如下摘引结果 。 All Nobel Laureates in Physiology or Medicine The Nobel Prize in Physiology or Medicine has been awarded 110 times to 219 Nobel Laureates between 1901 and 2019. Click on the links to get more information. The Nobel Prize in Physiology or Medicine 2019 William G. Kaelin Jr , Sir Peter J. Ratcliffe , and Gregg L. Semenza The Nobel Prize in Physiology or Medicine 2019 was awarded jointly to William G. Kaelin Jr, Sir Peter J. Ratcliffe and Gregg L. Semenza for their discoveries of how cells sense and adapt to oxygen availability. The Nobel Prize in Physiology or Medicine 2018 James P.Allison and Tasuku Honjo “for their discovery of cancer therapy by inhibition of negative immune regulation” The Nobel Prize in Physiology or Medicine 2017 Jeffrey C. Hall , Michael Rosbash and Michael W. Young “for their discoveries of molecular mechanisms controlling the circadian rhythm” The Nobel Prize in Physiology or Medicine 2016 Yoshinori Ohsumi “for his discoveries of mechanisms for autophagy” The Nobel Prize in Physiology or Medicine 2015 William C. Campbell and Satoshi ōmura “for their discoveries concerning a novel therapy against infections caused by roundworm parasites” Tu Youyou “for her discoveries concerning a novel therapy against Malaria” The Nobel Prize in Physiology or Medicine 2014 John O’Keefe , May-Britt Moser and Edvard I. Moser “for their discoveries of cells that constitute a positioning system in the brain” The Nobel Prize in Physiology or Medicine 2013 James E. Rothman , Randy W. Schekman and Thomas C. Südhof “for their discoveries of machinery regulating vesicle traffic, a major transport system in our cells” The Nobel Prize in Physiology or Medicine 2012 Sir John B. Gurdon and Shinya Yamanaka “for the discovery that mature cells can be reprogrammed to become pluripotent” The Nobel Prize in Physiology or Medicine 2011 Bruce A. Beutler and Jules A. Hoffmann “for their discoveries concerning the activation of innate immunity” Ralph M. Steinman “for his discovery of the dendritic cell and its role in adaptive immunity” The Nobel Prize in Physiology or Medicine 2010 Robert G. Edwards “for the development of in vitro fertilization” The Nobel Prize in Physiology or Medicine 2009 Elizabeth H. Blackburn , Carol W. Greider and Jack W. Szostak “for the discovery of how chromosomes are protected by telomeres and the enzyme telomerase” The Nobel Prize in Physiology or Medicine 2008 Harald zur Hausen “for his discovery of human papilloma viruses causing cervical cancer” Françoise Barré-Sinoussi and Luc Montagnier “for their discovery of human immunodeficiency virus” The Nobel Prize in Physiology or Medicine 2007 Mario R. Capecchi , Sir Martin J. Evans and Oliver Smithies “for their discoveries of principles for introducing specific gene modifications in mice by the use of embryonic stem cells” The Nobel Prize in Physiology or Medicine 2006 Andrew Z. Fire and Craig C. Mello “for their discovery of RNA interference – gene silencing by double-stranded RNA” The Nobel Prize in Physiology or Medicine 2005 Barry J. Marshall and J. Robin Warren “for their discovery of the bacterium Helicobacter pylori and its role in gastritis and peptic ulcer disease” The Nobel Prize in Physiology or Medicine 2004 Richard Axel and Linda B. Buck “for their discoveries of odorant receptors and the organization of the olfactory system” The Nobel Prize in Physiology or Medicine 2003 Paul C. Lauterbur and Sir Peter Mansfield “for their discoveries concerning magnetic resonance imaging” The Nobel Prize in Physiology or Medicine 2002 Sydney Brenner , H. Robert Horvitz and John E. Sulston “for their discoveries concerning genetic regulation of organ development and programmed cell death'” The Nobel Prize in Physiology or Medicine 2001 Leland H. Hartwell , Tim Hunt and Sir Paul M. Nurse “for their discoveries of key regulators of the cell cycle” The Nobel Prize in Physiology or Medicine 2000 Arvid Carlsson , Paul Greengard and Eric R. Kandel “for their discoveries concerning signal transduction in the nervous system” The Nobel Prize in Physiology or Medicine 1999 Günter Blobel “for the discovery that proteins have intrinsic signals that govern their transport and localization in the cell” The Nobel Prize in Physiology or Medicine 1998 Robert F. Furchgott , Louis J. Ignarro and Ferid Murad “for their discoveries concerning nitric oxide as a signalling molecule in the cardiovascular system” The Nobel Prize in Physiology or Medicine 1997 Stanley B. Prusiner “for his discovery of Prions – a new biological principle of infection” The Nobel Prize in Physiology or Medicine 1996 Peter C. Doherty and Rolf M. Zinkernagel “for their discoveries concerning the specificity of the cell mediated immune defence” The Nobel Prize in Physiology or Medicine 1995 Edward B. Lewis , Christiane Nüsslein-Volhard and Eric F. Wieschaus “for their discoveries concerning the genetic control of early embryonic development” The Nobel Prize in Physiology or Medicine 1994 Alfred G. Gilman and Martin Rodbell “for their discovery of G-proteins and the role of these proteins in signal transduction in cells” The Nobel Prize in Physiology or Medicine 1993 Richard J. Roberts and Phillip A. Sharp “for their discoveries of split genes” The Nobel Prize in Physiology or Medicine 1992 Edmond H. Fischer and Edwin G. Krebs “for their discoveries concerning reversible protein phosphorylation as a biological regulatory mechanism” The Nobel Prize in Physiology or Medicine 1991 Erwin Neher and Bert Sakmann “for their discoveries concerning the function of single ion channels in cells” The Nobel Prize in Physiology or Medicine 1990 Joseph E. Murray and E. Donnall Thomas “for their discoveries concerning organ and cell transplantation in the treatment of human disease” The Nobel Prize in Physiology or Medicine 1989 J. Michael Bishop and Harold E. Varmus “for their discovery of the cellular origin of retroviral oncogenes” The Nobel Prize in Physiology or Medicine 1988 Sir James W. Black , Gertrude B. Elion and George H. Hitchings “for their discoveries of important principles for drug treatment” The Nobel Prize in Physiology or Medicine 1987 Susumu Tonegawa “for his discovery of the genetic principle for generation of antibody diversity” The Nobel Prize in Physiology or Medicine 1986 Stanley Cohen and Rita Levi-Montalcini “for their discoveries of growth factors” The Nobel Prize in Physiology or Medicine 1985 Michael S. Brown and Joseph L. Goldstein “for their discoveries concerning the regulation of cholesterol metabolism” The Nobel Prize in Physiology or Medicine 1984 Niels K. Jerne , Georges J.F. Köhler and César Milstein “for theories concerning the specificity in development and control of the immune system and the discovery of the principle for production of monoclonal antibodies” The Nobel Prize in Physiology or Medicine 1983 Barbara McClintock “for her discovery of mobile genetic elements” The Nobel Prize in Physiology or Medicine 1982 Sune K. Bergström , Bengt I. Samuelsson and John R. Vane “for their discoveries concerning prostaglandins and related biologically active substances” The Nobel Prize in Physiology or Medicine 1981 Roger W. Sperry “for his discoveries concerning the functional specialization of the cerebral hemispheres” David H. Hubel and Torsten N. Wiesel “for their discoveries concerning information processing in the visual system” The Nobel Prize in Physiology or Medicine 1980 Baruj Benacerraf , Jean Dausset and George D. Snell “for their discoveries concerning genetically determined structures on the cell surface that regulate immunological reactions” The Nobel Prize in Physiology or Medicine 1979 Allan M. Cormack and Godfrey N. Hounsfield “for the development of computer assisted tomography” The Nobel Prize in Physiology or Medicine 1978 Werner Arber , Daniel Nathans and Hamilton O. Smith “for the discovery of restriction enzymes and their application to problems of molecular genetics” The Nobel Prize in Physiology or Medicine 1977 Roger Guillemin and Andrew V. Schally “for their discoveries concerning the peptide hormone production of the brain” Rosalyn Yalow “for the development of radioimmunoassays of peptide hormones” The Nobel Prize in Physiology or Medicine 1976 Baruch S. Blumberg and D. Carleton Gajdusek “for their discoveries concerning new mechanisms for the origin and dissemination of infectious diseases” The Nobel Prize in Physiology or Medicine 1975 David Baltimore , Renato Dulbecco and Howard Martin Temin “for their discoveries concerning the interaction between tumour viruses and the genetic material of the cell” The Nobel Prize in Physiology or Medicine 1974 Albert Claude , Christian de Duve and George E. Palade “for their discoveries concerning the structural and functional organization of the cell” The Nobel Prize in Physiology or Medicine 1973 Karl von Frisch , Konrad Lorenz and Nikolaas Tinbergen “for their discoveries concerning organization and elicitation of individual and social behaviour patterns” The Nobel Prize in Physiology or Medicine 1972 Gerald M. Edelman and Rodney R. Porter “for their discoveries concerning the chemical structure of antibodies” The Nobel Prize in Physiology or Medicine 1971 Earl W. Sutherland, Jr. “for his discoveries concerning the mechanisms of the action of hormones” The Nobel Prize in Physiology or Medicine 1970 Sir Bernard Katz , Ulf von Euler and Julius Axelrod “for their discoveries concerning the humoral transmittors in the nerve terminals and the mechanism for their storage, release and inactivation” The Nobel Prize in Physiology or Medicine 1969 Max Delbrück , Alfred D. Hershey and Salvador E. Luria “for their discoveries concerning the replication mechanism and the genetic structure of viruses” The Nobel Prize in Physiology or Medicine 1968 Robert W. Holley , Har Gobind Khorana and Marshall W. Nirenberg “for their interpretation of the genetic code and its function in protein synthesis” The Nobel Prize in Physiology or Medicine 1967 Ragnar Granit , Haldan Keffer Hartline and George Wald “for their discoveries concerning the primary physiological and chemical visual processes in the eye” The Nobel Prize in Physiology or Medicine 1966 Peyton Rous “for his discovery of tumour-inducing viruses” Charles Brenton Huggins “for his discoveries concerning hormonal treatment of prostatic cancer” The Nobel Prize in Physiology or Medicine 1965 François Jacob , André Lwoff and Jacques Monod “for their discoveries concerning genetic control of enzyme and virus synthesis” The Nobel Prize in Physiology or Medicine 1964 Konrad Bloch and Feodor Lynen “for their discoveries concerning the mechanism and regulation of the cholesterol and fatty acid metabolism” The Nobel Prize in Physiology or Medicine 1963 Sir John Carew Eccles , Alan Lloyd Hodgkin and Andrew Fielding Huxley “for their discoveries concerning the ionic mechanisms involved in excitation and inhibition in the peripheral and central portions of the nerve cell membrane” The Nobel Prize in Physiology or Medicine 1962 Francis Harry Compton Crick , James Dewey Watson and Maurice Hugh Frederick Wilkins “for their discoveries concerning the molecular structure of nucleic acids and its significance for information transfer in living material” The Nobel Prize in Physiology or Medicine 1961 Georg von Békésy “for his discoveries of the physical mechanism of stimulation within the cochlea” The Nobel Prize in Physiology or Medicine 1960 Sir Frank Macfarlane Burnet and Peter Brian Medawar “for discovery of acquired immunological tolerance” The Nobel Prize in Physiology or Medicine 1959 Severo Ochoa and Arthur Kornberg “for their discovery of the mechanisms in the biological synthesis of ribonucleic acid and deoxyribonucleic acid” The Nobel Prize in Physiology or Medicine 1958 George Wells Beadle and Edward Lawrie Tatum “for their discovery that genes act by regulating definite chemical events” Joshua Lederberg “for his discoveries concerning genetic recombination and the organization of the genetic material of bacteria” The Nobel Prize in Physiology or Medicine 1957 Daniel Bovet “for his discoveries relating to synthetic compounds that inhibit the action of certain body substances, and especially their action on the vascular system and the skeletal muscles” The Nobel Prize in Physiology or Medicine 1956 André Frédéric Cournand , Werner Forssmann and Dickinson W. Richards “for their discoveries concerning heart catheterization and pathological changes in the circulatory system” The Nobel Prize in Physiology or Medicine 1955 Axel Hugo Theodor Theorell “for his discoveries concerning the nature and mode of action of oxidation enzymes” The Nobel Prize in Physiology or Medicine 1954 John Franklin Enders , Thomas Huckle Weller and Frederick Chapman Robbins “for their discovery of the ability of poliomyelitis viruses to grow in cultures of various types of tissue” The Nobel Prize in Physiology or Medicine 1953 Hans Adolf Krebs “for his discovery of the citric acid cycle” Fritz Albert Lipmann “for his discovery of co-enzyme A and its importance for intermediary metabolism” The Nobel Prize in Physiology or Medicine 1952 Selman Abraham Waksman “for his discovery of streptomycin, the first antibiotic effective against tuberculosis” The Nobel Prize in Physiology or Medicine 1951 Max Theiler “for his discoveries concerning yellow fever and how to combat it” The Nobel Prize in Physiology or Medicine 1950 Edward Calvin Kendall , Tadeus Reichstein and Philip Showalter Hench “for their discoveries relating to the hormones of the adrenal cortex, their structure and biological effects” The Nobel Prize in Physiology or Medicine 1949 Walter Rudolf Hess “for his discovery of the functional organization of the interbrain as a coordinator of the activities of the internal organs” Antonio Caetano de Abreu Freire Egas Moniz “for his discovery of the therapeutic value of leucotomy in certain psychoses” The Nobel Prize in Physiology or Medicine 1948 Paul Hermann Müller “for his discovery of the high efficiency of DDT as a contact poison against several arthropods” The Nobel Prize in Physiology or Medicine 1947 Carl Ferdinand Cori and Gerty Theresa Cori, née Radnitz “for their discovery of the course of the catalytic conversion of glycogen” Bernardo Alberto Houssay “for his discovery of the part played by the hormone of the anterior pituitary lobe in the metabolism of sugar” The Nobel Prize in Physiology or Medicine 1946 Hermann Joseph Muller “for the discovery of the production of mutations by means of X-ray irradiation” The Nobel Prize in Physiology or Medicine 1945 Sir Alexander Fleming , Ernst Boris Chain and Sir Howard Walter Florey “for the discovery of penicillin and its curative effect in various infectious diseases” The Nobel Prize in Physiology or Medicine 1944 Joseph Erlanger and Herbert Spencer Gasser “for their discoveries relating to the highly differentiated functions of single nerve fibres” The Nobel Prize in Physiology or Medicine 1943 Henrik Carl Peter Dam “for his discovery of vitamin K” Edward Adelbert Doisy “for his discovery of the chemical nature of vitamin K” The Nobel Prize in Physiology or Medicine 1942 No Nobel Prize was awarded this year. The prize money was with 1/3 allocated to the Main Fund and with 2/3 to the Special Fund of this prize section. The Nobel Prize in Physiology or Medicine 1941 No Nobel Prize was awarded this year. The prize money was with 1/3 allocated to the Main Fund and with 2/3 to the Special Fund of this prize section. The Nobel Prize in Physiology or Medicine 1940 No Nobel Prize was awarded this year. The prize money was with 1/3 allocated to the Main Fund and with 2/3 to the Special Fund of this prize section. The Nobel Prize in Physiology or Medicine 1939 Gerhard Domagk “for the discovery of the antibacterial effects of prontosil” The Nobel Prize in Physiology or Medicine 1938 Corneille Jean François Heymans “for the discovery of the role played by the sinus and aortic mechanisms in the regulation of respiration” The Nobel Prize in Physiology or Medicine 1937 Albert von Szent-Györgyi Nagyrápolt “for his discoveries in connection with the biological combustion processes, with special reference to vitamin C and the catalysis of fumaric acid” The Nobel Prize in Physiology or Medicine 1936 Sir Henry Hallett Dale and Otto Loewi “for their discoveries relating to chemical transmission of nerve impulses” The Nobel Prize in Physiology or Medicine 1935 Hans Spemann “for his discovery of the organizer effect in embryonic development” The Nobel Prize in Physiology or Medicine 1934 George Hoyt Whipple , George Richards Minot and William Parry Murphy “for their discoveries concerning liver therapy in cases of anaemia” The Nobel Prize in Physiology or Medicine 1933 Thomas Hunt Morgan “for his discoveries concerning the role played by the chromosome in heredity” The Nobel Prize in Physiology or Medicine 1932 Sir Charles Scott Sherrington and Edgar Douglas Adrian “for their discoveries regarding the functions of neurons” The Nobel Prize in Physiology or Medicine 1931 Otto Heinrich Warburg “for his discovery of the nature and mode of action of the respiratory enzyme” The Nobel Prize in Physiology or Medicine 1930 Karl Landsteiner “for his discovery of human blood groups” The Nobel Prize in Physiology or Medicine 1929 Christiaan Eijkman “for his discovery of the antineuritic vitamin” Sir Frederick Gowland Hopkins “for his discovery of the growth-stimulating vitamins” The Nobel Prize in Physiology or Medicine 1928 Charles Jules Henri Nicolle “for his work on typhus” The Nobel Prize in Physiology or Medicine 1927 Julius Wagner-Jauregg “for his discovery of the therapeutic value of malaria inoculation in the treatment of dementia paralytica” The Nobel Prize in Physiology or Medicine 1926 Johannes Andreas Grib Fibiger “for his discovery of the Spiroptera carcinoma” The Nobel Prize in Physiology or Medicine 1925 No Nobel Prize was awarded this year. The prize money was allocated to the Special Fund of this prize section. The Nobel Prize in Physiology or Medicine 1924 Willem Einthoven “for his discovery of the mechanism of the electrocardiogram” The Nobel Prize in Physiology or Medicine 1923 Frederick Grant Banting and John James Rickard Macleod “for the discovery of insulin” The Nobel Prize in Physiology or Medicine 1922 Archibald Vivian Hill “for his discovery relating to the production of heat in the muscle” Otto Fritz Meyerhof “for his discovery of the fixed relationship between the consumption of oxygen and the metabolism of lactic acid in the muscle” The Nobel Prize in Physiology or Medicine 1921 No Nobel Prize was awarded this year. The prize money was allocated to the Special Fund of this prize section. The Nobel Prize in Physiology or Medicine 1920 Schack August Steenberg Krogh “for his discovery of the capillary motor regulating mechanism” The Nobel Prize in Physiology or Medicine 1919 Jules Bordet “for his discoveries relating to immunity” The Nobel Prize in Physiology or Medicine 1918 No Nobel Prize was awarded this year. The prize money was allocated to the Special Fund of this prize section. The Nobel Prize in Physiology or Medicine 1917 No Nobel Prize was awarded this year. The prize money was allocated to the Special Fund of this prize section. The Nobel Prize in Physiology or Medicine 1916 No Nobel Prize was awarded this year. The prize money was allocated to the Special Fund of this prize section. The Nobel Prize in Physiology or Medicine 1915 No Nobel Prize was awarded this year. The prize money was allocated to the Special Fund of this prize section. The Nobel Prize in Physiology or Medicine 1914 Robert Bárány “for his work on the physiology and pathology of the vestibular apparatus” The Nobel Prize in Physiology or Medicine 1913 Charles Robert Richet “in recognition of his work on anaphylaxis” The Nobel Prize in Physiology or Medicine 1912 Alexis Carrel “in recognition of his work on vascular suture and the transplantation of blood vessels and organs” The Nobel Prize in Physiology or Medicine 1911 Allvar Gullstrand “for his work on the dioptrics of the eye” The Nobel Prize in Physiology or Medicine 1910 Albrecht Kossel “in recognition of the contributions to our knowledge of cell chemistry made through his work on proteins, including the nucleic substances” The Nobel Prize in Physiology or Medicine 1909 Emil Theodor Kocher “for his work on the physiology, pathology and surgery of the thyroid gland” The Nobel Prize in Physiology or Medicine 1908 Ilya Ilyich Mechnikov and Paul Ehrlich “in recognition of their work on immunity” The Nobel Prize in Physiology or Medicine 1907 Charles Louis Alphonse Laveran “in recognition of his work on the role played by protozoa in causing diseases” The Nobel Prize in Physiology or Medicine 1906 Camillo Golgi and Santiago Ramón y Cajal “in recognition of their work on the structure of the nervous system” The Nobel Prize in Physiology or Medicine 1905 Robert Koch “for his investigations and discoveries in relation to tuberculosis” The Nobel Prize in Physiology or Medicine 1904 Ivan Petrovich Pavlov “in recognition of his work on the physiology of digestion, through which knowledge on vital aspects of the subject has been transformed and enlarged” The Nobel Prize in Physiology or Medicine 1903 Niels Ryberg Finsen “in recognition of his contribution to the treatment of diseases, especially lupus vulgaris, with concentrated light radiation, whereby he has opened a new avenue for medical science” The Nobel Prize in Physiology or Medicine 1902 Ronald Ross “for his work on malaria, by which he has shown how it enters the organism and thereby has laid the foundation for successful research on this disease and methods of combating it” The Nobel Prize in Physiology or Medicine 1901 Emil Adolf von Behring “for his work on serum therapy, especially its application against diphtheria, by which he has opened a new road in the domain of medical science and thereby placed in the hands of the physician a victorious weapon against illness and deaths”
2019生理学或医学引文桂冠奖获得者 诸平 根据科睿唯安（ Clarivate Analytics ）2019年9月24日公布的2019年引文桂冠奖获奖者名单， 来自7个国家的19位科学家荣获“引文桂冠奖”， 生理学或医学领域的“引文桂冠奖”获奖科学家共6人， 其获奖者截图如下，仅供参考。 Hans Clevers，荷兰乌得勒支大学分子遗传学教授，胡布雷克特研究所(KNAW)和普林斯马克西玛儿科肿瘤中心首席研究员。 获奖原因：针对Wnt信号通路及其在干细胞和癌症中的作用研究，提供了一个新药物测试的环境，可以在不使用细胞系或实验动物的情况下进行药物试验。 高引论文（被引频次1200次） 标题 引用次数 年份 Wnt/β-catenin signaling in development and disease H Clevers Cell 127 (3), 469-480 5066 2006 Activation of β-catenin-Tcf signaling in colon cancer by mutations in β-catenin or APC PJ Morin, AB Sparks, V Korinek, N Barker, H Clevers, B Vogelstein, ... Science 275 (5307), 1787-1790 4309 1997 Identification of stem cells in small intestine and colon by marker gene Lgr5 N Barker, JH Van Es, J Kuipers, P Kujala, M Van Den Born, M Cozijnsen, ... Nature 449 (7165), 1003 3872 2007 Wnt signalling in stem cells and cancer T Reya, H Clevers Nature 434 (7035), 843 3821 2005 Constitutive transcriptional activation by a β-catenin-Tcf complex in APC−/− colon carcinoma V Korinek, N Barker, PJ Morin, D Van Wichen, R De Weger, KW Kinzler, ... Science 275 (5307), 1784-1787 3547 1997 Wnt/β-catenin signaling and disease H Clevers, R Nusse Cell 149 (6), 1192-1205 3490 2012 Single Lgr5 stem cells build crypt–villus structures in vitro without a mesenchymal niche T Sato, RG Vries, HJ Snippert, M Van De Wetering, N Barker, DE Stange, ... Nature 459 (7244), 262 2899 2009 The β-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells M Van De Wetering, E Sancho, C Verweij, W De Lau, I Oving, A Hurlstone, ... Cell 111 (2), 241-250 2122 2002 XTcf-3 transcription factor mediates β-catenin-induced axis formation in Xenopus embryos M Molenaar, M van de Wetering, M Oosterwegel, J Peterson-Maduro, ... Cell 86 (3), 391-399 1930 1996 Caught up in a Wnt storm: Wnt signaling in cancer RH Giles, JH Van Es, H Clevers Biochimica et Biophysica Acta (BBA)-Reviews on Cancer 1653 (1), 1-24 1757 2003 Crypt stem cells as the cells-of-origin of intestinal cancer N Barker, RA Ridgway, JH van Es, M van de Wetering, H Begthel, ... Nature 457 (7229), 608 1701 2009 Linking colorectal cancer to Wnt signaling M Bienz, H Clevers Cell 103 (2), 311-320 1698 2000 Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4 V Korinek, N Barker, P Moerer, E van Donselaar, G Huls, PJ Peters, ... Nature genetics 19 (4), 379 1676 1998 Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts T Sato, JH Van Es, HJ Snippert, DE Stange, RG Vries, M Van Den Born, ... Nature 469 (7330), 415 1519 2011 The cancer stem cell: premises, promises and challenges H Clevers Nature medicine 17 (3), 313 1498 2011 Notch/γ-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells JH van Es, ME van Gijn, O Riccio, M van den Born, M Vooijs, H Begthel, ... Nature 435 (7044), 959 1407 2005 Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation DA Glass II, P Bialek, JD Ahn, M Starbuck, MS Patel, H Clevers, ... Developmental cell 8 (5), 751-764 1307 2005 Armadillo coactivates transcription driven by the product of the Drosophila segment polarity gene dTCF M Van de Wetering, R Cavallo, D Dooijes, M van Beest, J van Es, ... Cell 88 (6), 789-799 1288 1997 Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells HJ Snippert, LG Van Der Flier, T Sato, JH Van Es, M Van Den Born, ... Cell 143 (1), 134-144 1232 2010 Stem cells, self-renewal, and differentiation in the intestinal epithelium LG Van Der Flier, H Clevers Annual review of physiology 71, 241-260 1227 2009 Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett's epithelium T Sato, DE Stange, M Ferrante, RGJ Vries, JH Van Es, S Van Den Brink, ... Gastroenterology 141 (5), 1762-1772 1214 2011 John W. Kappler，美国丹佛市国立犹太医学中心-生物医学研究系杰出教授，Philippa Marrack，美国丹佛市国立犹太医学中心-生物医学研究系杰出教授。 获奖原因：他们通过在胸腺中克隆消除操作发现了t细胞的耐受性，增进了对类风湿关节炎、狼疮和格林-巴利综合征等自身免疫性疾病的机制的了解。 高引论文（被引频次900次） T cell tolerance by clonal elimination in the thymus JW Kappler , N Roehm, P Marrack- Cell, 1987 - Elsevier The monoclonal antibody KJ23a reacts with T cell receptors utilizing the Vβ segment Vβ17a. T cells bearing Vβ17a+ receptors react with very high frequency with the MHC class II protein, IE. In this paper we show that T cells expressing Vβ17a are selectively eliminated… 被引用次数：2431 相关文章 所有 9 个版本 图书馆搜索 The Vβ-specific superantigen staphylococcal enterotoxin B: stimulation of mature T cells and clonal deletion in neonatal mice J White, A Herman, AM Pullen, R Kubo, JW Kappler …- Cell, 1989 - Elsevier Staphylococcal enterotoxin B is known to be a powerful T cell stimulant in mouse and man. In this paper we show that, for mice, this is because the protein in association with major histocompatibility complex class II molecules stimulates virtually all T cells bearing Vβ3 and… 被引用次数：1281 相关文章 所有 8 个版本 图书馆搜索 Antigen-inducible, H-2-restricted, interleukin-2-producing T cell hybridomas. Lack of independent antigen and H-2 recognition JW Kappler , B Skidmore, J White…- Journal of Experimental…, 1981 - jem.rupress.org We developed a method for production of antigen-specific, H-2-restricted T cell hybrids. The tumor cell partner in the fusions was itself a T cell hybrid, FS6-14.13. AG2 (or its derivatives), which could be induced to produce the growth factor, interleukin-2 (IL-2), in response to a… 被引用次数：1204 相关文章 所有 9 个版本 图书馆搜索 Self-tolerance eliminates T cells specific for Mls-modified products of the major histocompatibility complex JW Kappler , U Staerz, J White, PC Marrack- Nature, 1988 - nature.com In mice the product of the Mls a locus is an unusual antigen capable of interaction with certain products of the major histocompatibility locus (MHC) to form a ligand for a large portion of the T-cell α/β receptor repertoire, including nearly all receptors that use V β8. 1… 被引用次数：1209 相关文章 所有 7 个版本 图书馆搜索 Normal development of mice deficient in beta 2M, MHC class I proteins, and CD8+ T cells BH Koller, P Marrack, JW Kappler , O Smithies- Science, 1990 - science.sciencemag.org Major histocompatibility class I proteins display viral and self antigens to potentially responsive cells and are important for the maturation of T cells; beta 2-microglobulin (beta 2M) is required for their normal expression. Mouse chimeras derived from embryonic stem… 被引用次数：932 相关文章 所有 10 个版本 图书馆搜索 Superantigens: mechanism of T-cell stimulation and role in immune responses A Herman, JW Kappler , P Marrack…- Annual review of…, 1991 - annualreviews.org Superantigens combine with MHC class-II molecules to form the ligands that stimulate T cells via the Vβ element of the T-cell receptor. Two groups of superantigens have been described so far: first, endogenous murine products that include the MIs determinants, and… 被引用次数：997 相关文章 所有 7 个版本 图书馆搜索 高引论文（被引频次1100次） T cell tolerance by clonal elimination in the thymus JW Kappler, N Roehm, P Marrack - Cell, 1987 - Elsevier The monoclonal antibody KJ23a reacts with T cell receptors utilizing the Vβ segment Vβ17a. T cells bearing Vβ17a+ receptors react with very high frequency with the MHC class II protein, IE. In this paper we show that T cells expressing Vβ17a are selectively eliminated… 被引用次数：2431 相关文章 所有 9 个版本 图书馆搜索 The staphylococcal enterotoxins and their relatives P Marrack , J Kappler- Science, 1990 - science.sciencemag.org Staphylococcal enterotoxins and a group of related proteins made by Streptococci cause food poisoning and shock in man and animals. These proteins share an ability to bind to human and mouse major histocompatibility complex proteins. The complex ligand so formed… 被引用次数：2342 相关文章 所有 15 个版本 图书馆搜索 The Vβ-specific superantigen staphylococcal enterotoxin B: stimulation of mature T cells and clonal deletion in neonatal mice …, A Herman, AM Pullen, R Kubo, JW Kappler, P Marrack - Cell, 1989 - Elsevier Staphylococcal enterotoxin B is known to be a powerful T cell stimulant in mouse and man. In this paper we show that, for mice, this is because the protein in association with major histocompatibility complex class II molecules stimulates virtually all T cells bearing Vβ3 and… 被引用次数：1281 相关文章 所有 8 个版本 图书馆搜索 Self-tolerance eliminates T cells specific for Mls-modified products of the major histocompatibility complex JW Kappler, U Staerz, J White, PC Marrack - Nature, 1988 - nature.com In mice the product of the Mls a locus is an unusual antigen capable of interaction with certain products of the major histocompatibility locus (MHC) to form a ligand for a large portion of the T-cell α/β receptor repertoire, including nearly all receptors that use V β8. 1… 被引用次数：1209 相关文章 所有 7 个版本 图书馆搜索 Interaction of Staphylococcus aureus toxin superantigens with human T cells …, L Herron, J Callahan, P Marrack …- Proceedings of the…, 1989 - National Acad Sciences A modification of the polymerase chain reaction has been used to establish the fact that a collection of Staphylococcus aureus toxins are superantigens, each of which interacts with the T-cell alpha beta receptor of human T cells by means of a specific set of V beta elements. 被引用次数：1109 相关文章 所有 9 个版本 图书馆搜索 Ernst Bamberg，德国法兰克福马克斯普朗克生物物理研究所名誉所长，Karl Deisseroth，美国加利福尼亚州斯坦福大学霍华德休斯医学研究所研究员，生物工程和精神病学与行为科学D. H. Chen杰出教授。 Gero Miesenbock，英国牛津大学神经回路和行为中心主任兼生理学Waynflete教授。 获奖原因：在光遗传学领域做出的贡献。该技术构成了神经科学领域的一场革命，增强了人们对帕金森病、视力恢复、成瘾和情绪障碍的认识。 高引论文（被引频次910次） Millisecond-timescale, genetically targeted optical control of neural activity ES Boyden , F Zhang , E Bamberg , G Nagel…- Nature…, 2005 - nature.com Temporally precise, noninvasive control of activity in well-defined neuronal populations is a long-sought goal of systems neuroscience. We adapted for this purpose the naturally occurring algal protein Channelrhodopsin-2, a rapidly gated light-sensitive cation channel… 被引用次数：3551 相关文章 所有 20 个版本 图书馆搜索 Channelrhodopsin-2, a directly light-gated cation-selective membrane channel …, D Ollig, P Hegemann , E Bamberg - Proceedings of the…, 2003 - National Acad Sciences Microbial-type rhodopsins are found in archaea, prokaryotes, and eukaryotes. Some of them represent membrane ion transport proteins such as bacteriorhodopsin, a light-driven proton pump, or channelrhodopsin-1 (ChR1), a recently identified light-gated proton channel from… 被引用次数：2061 相关文章 所有 19 个版本 图书馆搜索 Multimodal fast optical interrogation of neural circuitry …, JF Liewald, K Kay , N Watzke, PG Wood, E Bamberg …- Nature, 2007 - nature.com Our understanding of the cellular implementation of systems-level neural processes like action, thought and emotion has been limited by the availability of tools to interrogate specific classes of neural cells within intact, living brain tissue. Here we identify and develop… 被引用次数：1567 相关文章 所有 25 个版本 图书馆搜索 Channelrhodopsin-1: a light-gated proton channel in green algae …, M Fuhrmann, S Kateriya , AM Musti, E Bamberg …- …, 2002 - science.sciencemag.org Phototaxis and photophobic responses of green algae are mediated by rhodopsins with microbial-type chromophores. We report a complementary DNA sequence in the green alga Chlamydomonas reinhardtiithat encodes a microbial opsin-related protein, which we term… 被引用次数：910 相关文章 所有 15 个版本 图书馆搜索 高引论文（被引频次1100次） 标题 引用次数 年份 Millisecond-timescale, genetically targeted optical control of neural activity ES Boyden, F Zhang, E Bamberg, G Nagel, K Deisseroth Nature neuroscience 8 (9), 1263 3551 2005 Parvalbumin neurons and gamma rhythms enhance cortical circuit performance VS Sohal, F Zhang, O Yizhar, K Deisseroth Nature 459 (7247), 698 1778 2009 Driving fast-spiking cells induces gamma rhythm and controls sensory responses JA Cardin, M Carlén, K Meletis, U Knoblich, F Zhang, K Deisseroth, ... Nature 459 (7247), 663 1773 2009 Multimodal fast optical interrogation of neural circuitry F Zhang, LP Wang, M Brauner, JF Liewald, K Kay, N Watzke, PG Wood, ... 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* 本文与微信公号 知识分子 （The-Intellectual） 和 民间科学家 （hfwang43） 同步推送 ** 加微信，请搜 民间科学家 或 hfwang43 添加，或扫下面二维码添加。 2015诺贝尔生理学或医学奖背后的另一推手 10.07.2015 尽管今年诺贝尔生理学或医学奖授给了三个人，国内媒体这两天关注的焦点基本上集中在屠呦呦一人身上。这也难怪，谁让她是中国本土的第一个诺贝尔科学奖获得者呢？不仅如此，大家也对屠呦呦获奖的国内国外推手很感兴趣。殊不知今年的诺贝尔生理学或医学奖背后，还真有另一 位应 该特别铭记的伟大推手。 在诺贝尔奖委员会提供的生理学或医学奖资料中，明确提到了第四个在人类战胜寄生虫病的战斗中作出了巨大贡献的人物，是他的科学素养、人道主义关怀、远见和胆识决定并推动了获奖者William C. Campbell在Merck公司研发和推广伊维菌素（Ivermectin）用于对付河盲症的创举。他就是咱们中国人民应该特别铭记和感谢的P. Roy Vagelos博士。 Vagelos先生对中国人民的伟大贡献，我2007年在科学网博文《院士总裁：科学家、企业家和一代完人P. Roy Vagelos博士》（链接： http://blog.sciencenet.cn/blog-176-2566.html ）中有所介绍，这里就不专门去讲了。 诺贝尔奖委员会在其发布的正式长资料中（链接: http://www.nobelprize.org/nobel_prizes/medicine/laureates/2015/advanced-medicineprize2015.pdf ），在谈及发现和发展出伊维菌素（Ivermectin）的两位获奖者William C. Campbell和Satoshi ōmura的成就时，专门提到Vagelos博士。 Today, Ivermectin is considered a highly effective treatment that only needs to be taken once or twice a year. In this way, citizens of even the most remote parts of the world can be reached. Credit should be given to Dr. Roy Vagelos, CEO at Merck, for influencing the company to make needed quantities of Ivermectin freely available to governments and patients for the treatment of River Blindness and Lymphatic Filariasis (Useem, 1998). The elimination of River Blindness and Elephantiasis are key targets for the WHO Regional Strategy to Eliminate Neglected Tropical Diseases. As of 2012, over 200 million people received Ivermectin for periods ranging from 1 to 25 years (WHO, 2013). For the elimination of Lymphatic Filariasis 118 million people have received Ivermectin and albendazole for periods ranging from 1 to 11 years. The global targets for the elimination of Lymphatic Filariasis(2020) and Onchocerciasis, (2025) are within reach. Together, the unique contributions by ōmura and Campbell have led to the identification of a new class of drugs with extraordinary efficiency against parasitic diseases. 试译：今天，伊维菌素（Ivermectin）被当作（河盲症和淋巴丝虫病）的有效治疗药物，一年只需要服用一到两次。这样，即使是世界上最偏远地区的居民都可以得到治疗。这应该归功于Roy Vagelos博士，当时美国Merck公司的CEO，是他影响了该公司免费提供所需数量的伊维菌素药物给世界上的政府和患者，以治疗河盲症和淋巴丝虫病（Useem, 1998）。根除河盲症和淋巴丝虫病是世界卫生组织（WHO）根除被忽略的热带病区域战略的主要目标。 截止到2012年，已经有超过两亿人接受了伊维菌素为期1到25年的治疗。为根除淋巴丝虫病，有1.18亿人接受了伊维菌素和阿苯达唑（albendazole）为期1到11年的治疗。全球根除淋巴丝虫病（时间2020年）和蟠尾丝虫病（时间2025年）的目标已经达成在望。ōmura和Campbell一起的独特贡献已经带来对一系列抗及寄生虫病具有卓越效率新药的确认。 在这段话中引用的一篇文献是宾夕法尼亚大学商学院管理系Michael Useem教授关于领导能力的著作The Leadership Moment（《领导力时刻》）中的第一章Roy Vagelos attacks river blindness（Useem, M. Roy Vagelos attacks river blindness. In: The Leadership Moment; Times Books, Random House Inc.: New York N.Y., pp.10-42, 1998.）。这个标题在Google上翻译成中文就是《罗伊瓦格洛斯攻击河盲症》。Vagelos在身为世界五百强的大企业Merck公司的研究部门主管、CEO和总裁的十几年间所创造的Merck在制药业商业上的辉煌，以及在帮助非洲抗击河盲症、在中国普及乙肝疫苗方面的壮举，在过去二十年中已经成为美国商学院领导能力课程中重要的案例和效仿的榜样。 Vagelos在当时面临的艰难决策，是支持William C. Campbell去开发毫无指望能为公司赚取利润，为世界上最穷的上亿穷人开发的免费新药，还是避免麻烦只专注于履行自己作为公司CEO为股东和投资人赚取利润的责任？公司是要赚钱的，但是赚钱的同时有时也还是能够做出一定的牺牲，为更多的人造福。这和我们中国人一直以来信奉的“君子爱财，取之有道”，“穷则独善其身，达则兼济天下”的做人准则是一致的。 历史证明，尽管为了免费开发和提供伊维菌素以对付河盲症，Merck公司直接的花费超过了2亿美元，但Vagelos当时作出的是有远见和负责任的决策，这不仅为根除危害世界上亿人的寄生虫病作出了不可磨灭的贡献，而且也很好地维护了Merck公司长远的利益。前面我提到2007年的那篇博文，就是为他的英雄故事深深感动后写的。 2015年诺贝尔生理学或医学奖奖励的伊维菌素的发现（Satoshi ōmura）和发展（William C. Campbell），以及青蒿素的发现（屠呦呦），都是实至名归。由此我们可以看到，只要条件合适，不同国家和不同社会制度下的真正的科学发现和成就都可能最后为整个人类造福。唯一不同的可能是，在中国大陆老是鼓励和宣传科学家们尽管自己清贫还要无私奉献；而在美国这样的地方，科学家们大概才是真正做到了中国古人所推崇的“穷则独善其身，达则兼济天下”。 我原来一直想说，以Vagelos先生对非洲和中国人民的健康作出的巨大贡献，诺贝尔委员会早就应该给他发一个诺贝尔和平奖。最近仔细想了想，其实Vagelos先生自己作为校友捐赠给宾夕法尼亚大学和哥伦比亚大学用于支持基础研究和教育的金钱数目，早就可以给他自己发不止二十个诺贝尔奖了。 所以还不如他自己去设立一个Vagelos奖算了。 王鸿飞与 P. Roy Vagelos博士在八达岭长城（2005年10月）。 * 本文与微信公号 知识分子 （The-Intellectual） 和 民间科学家 （hfwang43） 同步推送 ** 加微信，请搜 民间科学家 或 hfwang43 添加，或扫下面二维码添加。
我在四年前的一篇博文中介绍了Yamanaka的工作： 谈谈生物物理（7）--- 细胞的七十二变 http://blog.sciencenet.cn/blog-3468-49173.html 我们小组主要工作是做细胞分化和转化的研究，刚刚跟Sui谈到了今年的诺贝尔奖。Sui是目前细胞转化的领军人物，前年英国皇家学会邀请全球15位研究干细胞和细胞转化的顶尖的科学家（自然也包括Ynamanaka)做这一领域的十年前瞻，Sui名列其中。他告诉我不要把诺贝尔奖太当真，能给科学家真正的荣誉是“大自然”，而不是人类自身。诺贝尔奖就像奥斯卡，说他有价值不过是一年一度向大众科普一下科学家正在做的工作。（Sui Huang系统生物研究所的网页：） https://www.systemsbiology.org/sui-huang Sui讲了一段趣事，他在剑桥做细胞转化讲座的时候，Gurdon迟到但在会后向他道歉。原因不是他摆谱，真正的原因是他以78岁高龄还在亲手做实验！Sui还提到，可惜的是 Thomas Graf，他从80年代开始就开始做细胞人工转化的工作，那时的主流意见都不认可细胞转化，因此他破天荒的工作：使用GATA-1将Myeloblast转化为MEP 细胞，却默默不为人知。他向杂志投稿，得到的反馈是 “ It is the editorial policy of the journal not to publish articles that are based on overexpression experiments. ” 2004年他向 MIT的 Ruedi Jaenisch (细胞转化领域的另一位牛人, 2011年获得Wolf医学奖） 提议使用皮肤细胞转化为胚胎干细胞。 Ruedi Jaenisch断然拒绝，因为他认为 chromatin上的化学键改变会使这一转化不可能。Thomas Graf 在Cell:Stem Cell的Review 附于文后。 Sui还指出，Yamanaka的前瞻性工作固然重要，但是他的博士生Takahashi也因该得到承认。Yamanaka在NIH的讲座中提到，他在给博士生们提出这一工作的时候，他心里也没底。这一段Youtube录像最能体现他当时工作的艰辛。 http://www.youtube.com/watch?v=AD1sZU1yk-Y Sui今天给小组发的Email: “‘One of the rare non-surprising and I would say, well-deserved Nobel Prizes in medicine! At least this year it is on a cell that everyone has heard of! Don’t forget Sir John Gurdon ( 78 years old) for his famous textbook experiment (frog intestinal cell nuclear transfer) also got the Noble prize – so that is fair. I am very happy for him. And you are right: in 10 years iPS may be viewed more as an academically interesting research tool of little clinical utility. They are close to cancer attractors, and cases of cancer from stem cell therapy have been reported. Same fate as gene therapy perhaps. For you as a young scientist this is what I have to say: Don’t take it too seriously , view the NP’s like Oscar–equivalents in science. Focus on what nature tells you is good science, not what humans tell you is good science. NP’s are highly political, and capricious, not only those that go to Obama and Krugman and Carter and Kissinger…. Noble prizes reflect the collective mood and relative ignorance of mankind so one shall not overanalyze them in scientific terms. They are good for communicating once a year to the non-scientists on this planet what is going on in science. But on the science in this case: As you said, stunningly, both Gurdon and Yamanaka are not so much keen on understanding the underlying systems biology basis of reprogramming. Sir Gurdon, with whom I had the honor to discuss a few times when I gave talks in Cambridge, is at the very least politely, and perhaps even intrinsically, interested in networks and attractors, had sharp provocative qualitative questions but I not am sure if he “gets it”. (e.g.: he believes in trinary and n-ary branching processes which is of courses a mathematically very very unlikely singularity as opposed to binary branching, much as “trifurcation” is not a generic property of dynamical systems as opposed to bifurcation). John Gurdon works (still!) on the mechanisms of erasing epigenetic memory in the sense of chromatin modification. But very admirable, fascinating person. He apologized for joining late in the seminar I was giving because he was still pipetting! (at the age of 78!!). Yamanaka has been approached many times by Kuni Kaneko (strange attractor = cell type guy) and he told me that Yamanaka is neither interested nor has a clue about attractors. This is of course evident in his attempts to comment on the stochastic nature of reprogramming as we all know. Also I think the postdoc should be acknowledged, and also Thomas Graf who was lonely for many years in his struggle for recognition of the idea that cells can be reprogrammed across lineages by TF overexpression (following Weintraub’s tradition). Postdocs need to be recognized because: The idea is simple – many a PI has suggested the same experiment of overexpressing Oct4 , etc. to their postdocs (e.g. Ruedi Jaenisch has tried to convince his postdocs long before Yamanaka to do it but no one believed in it – they preferred the at that time less pedestrian looking, technically challenging nuclear transfer!). Thus, recognizing the importance of a project and doing it is actually the rate limiting factor in science – not having the idea!! Sadly, in biology, ideas, theory and deep understanding are on the backseat. So in summary, the lesson for you, is: unlike in physics and math, in biology the doers not the thinkers and those who understand rerum causas get the recognition. But the latter is much more fun! (felix qui potuit cognoscere rerum causas)， 知因求果者得其乐）。 Sui END 整个细胞转化的研究小史 典型的细胞转化 更多详细： Thomas Graf 在Cell:Stem Cell的Review ThomasGraf_HisorcalOrigiansCellReprog_201112.pdf
DL Coleman的论文被引用情况（2010年生理学或医学诺贝尔奖得主预测） http://www.sciencenet.cn/blog/user_content.aspx?id=365644 JM. Friedman的论文被引用情况（2010年生理学或医学诺贝尔奖得主预测） http://www.sciencenet.cn/blog/user_content.aspx?id=365652 2010年拉斯克奖揭晓 瘦素发现者获得基础医学奖 美国Lasker基金会9月22日公布了2010年拉斯克奖（Albert Lasker Award）的获奖者，今年共有4位科学家获奖。 2010年拉斯克基础医学奖授予美国杰克逊实验室的Douglas Coleman和洛克菲勒大学的Jeffrey Friedman。获奖理由是发现瘦素（leptin）。 Albert Lasker Basic Medical Research Award Award Description Douglas Coleman and Jeffrey M. Friedman For the discovery of leptin, a hormone that regulates appetite and body weighta breakthrough that opened obesity research to molecular exploration. http://www.laskerfoundation.org/awards/2010_b_description.htm
美国洛克菲勒大学 细胞生理学和免疫学实验室 教授兼高级医师 Ralph M. Steinman 获奖原因 因发现作为关键免疫应答调节物的树突状细胞而获奖 http://scholar.google.com.hk/scholar?hl=enq=+RM+Steinman++immunitybtnG=Searchas_sdt=2000as_ylo=as_vis=0 Dendritic cells and the control of immunity rockefeller.edu J Banchereau, RM Steinman - Nature, 1998 - rockefeller.edu Jacques Banchereau Ralph M. Steinman ........................................................................................ ......................................................................................................... ... ... Immunology has long been focused on antigens and lymphocytes, but the mere presence of these two parties does not ... Cited by 8831 - Related articles - View as HTML - BL Direct - All 16 versions Dendritic cells as adjuvants for immune -mediated resistance to tumors rupress.org G Schuler, RM Steinman - The Journal of experimental medicine, 1997 - jem.rupress.org Animal experiments as well as clinical experience, notably in melanoma, indicate that the immune system can recognize and kill tumor cells. In particular, CTLs recognize MHC class Ipeptide complexes on the tumor cell surface, and the peptides are derived from nonmutated or ... Cited by 375 - Related articles - BL Direct - All 9 versions Rapid generation of broad T-cell immunity in humans after a single injection of mature dendritic cells nih.gov Dhodapkar, RM Steinman , M Sapp, H - Journal of Clinical , 1999 - Am Soc Clin Investig Dendritic cells (DCs) are potent antigen-presenting cells that initiate protective T-cell immunity in mice. To study the immunogenicity of DCs in humans, we injected 9 healthy subjects subcutaneously with a control injection of autologous monocyte-derived, mature DCs, followed 46 weeks ... Cited by 354 - Related articles - BL Direct - All 13 versions Tolerogenic dendritic cells* rockefeller.edu RM Steinman , D Hawiger, MC Nussenzweig - 2003 - Annual Reviews ... both subsets can capture virus like particles (125) and soluble proteins (K. Liu, B. Bonifaz, K. Inaba RM Steinman , unpublished observations). ... mice prior to deletion and then stimulated in culture, they exhibited changes consistent with the development of immunity rather than ... Cited by 1521 - Related articles - BL Direct - All 9 versions Antigen-specific inhibition of effector T cell function in humans after injection of immature dendritic cells rupress.org Dhodapkar, RM Steinman , J Krasovsky, C - The Journal of , 2001 - jem.rupress.org ... Footnotes. Submitted: 13 September 2000; Revision requested 27 October 2000; Accepted: 7 November 2000. Previous Section. References. : Banchereau, J.,; RM Steinman . (1998) Dendritic cells and the control of immunity . Nature. 392:245252, pmid:9521319. ... Cited by 1028 - Related articles - BL Direct - All 7 versions rapidly induces the full maturation of dendritic cells in vivo and thereby acts as an adjuvant for combined CD4 and CD8 T cell immunity to a coadministered rupress.org Shimizu, C Smith, L Bonifaz, RM Steinman - The Journal of , 2003 - jem.rupress.org The maturation of dendritic cells (DCs) allows these antigen-presenting cells to initiate immunity . We pursued this concept in situ by studying the adjuvant action of -galactosylceramide (GalCer) in mice. A single iv injection of glycolipid induced the full maturation of splenic ... Cited by 320 - Related articles - BL Direct - All 7 versions The dendritic cell system and its role in immunogenicity rockefeller.edu RM Steinman - Annual review of immunology, 1991 - Annual Reviews ... 272 STEINMAN such as the acquisition of antigens in tissues, the migration to lymphoid organs, and the identification and activation of antigen ... share features of structure and function, the most notable being the ability to capture antigens and initiate T cell mediated immunity . ... Cited by 3645 - Related articles - All 7 versions Immune tolerance after delivery of dying cells to dendritic cells in situ rupress.org Saternus, Y Kimura, K Inaba, RM Steinman - The Journal of , 2002 - jem.rupress.org Peripheral immune tolerance is believed to be induced by the processing and presentation of self-tissues that die during physiologic tissue turnover. To examine the mechanism that mediates tolerance, we injected mice with dying syngeneic TAP / splenocytes loaded with small ... Cited by 284 - Related articles - BL Direct - All 9 versions The linkage of innate to adaptive immunity via maturing dendritic cells in vivo requires CD40 ligation in addition to antigen presentation and CD80/86 rupress.org K Liu, C Smith, AJ Bonito, RM Steinman - The Journal of , 2004 - jem.rupress.org Dendritic cell (DC) maturation is an innate response that leads to adaptive immunity to coadministered proteins. To begin to identify underlying mechanisms in intact lymphoid tissues, we studied -galactosylceramide. This glycolipid activates innate V14 + natural killer T cell (NKT) ... Cited by 281 - Related articles - BL Direct - All 13 versions Vaccinia virus inhibits the maturation of human dendritic cells: a novel mechanism of immune evasion jimmunol.org , A Chahroudi, WI Cox, RM Steinman , N - The Journal of , 1999 - Am Assoc Immnol Vaccinia virus employs multiple mechanisms to evade the immune system, yet is highly immunogenic. We studied the interaction between vaccinia and human dendritic cells (DCs), potent APCs. DCs develop from precursor cells in two stages: an immature stage in which ... Cited by 248 - Related articles - BL Direct - All 4 versions The use of dendritic cells in cancer immunotherapy G Schuler, B Schuler-Thurner, RM Steinman - Current opinion in , 2003 - Elsevier ... Author , * , Beatrice Schuler-Thurner E-mail The Corresponding Author , * and Ralph M Steinman E-mail ... immunogenicity trials (ie addressing a given variable in two ways and using immune monitoring to ... 1. RM Dallal and MT Lotze, The dendritic cell and human cancer vaccines ... Cited by 423 - Related articles - All 4 versions Vaccination with mage-3A1 peptidepulsed mature, monocyte-derived dendritic cells expands specific cytotoxic T cells and induces regression of some rupress.org Den Driesch, EB Brcker, RM Steinman , A - The Journal of , 1999 - jem.rupress.org ... Schuler, G.,; RM Steinman . (1997) Dendritic cells as adjuvants for immune -mediated resistance to tumors. J. Exp. ... Am. 4Suppl.1998S14pmid:9619263. : Banchereau, J.,; RM Steinman . (1998) Dendritic cells and the control of immunity . Nature. 393:245252, pmid:9521319. ... Cited by 1031 - Related articles - All 6 versions Avoiding horror autotoxicus: the importance of dendritic cells in peripheral T cell tolerance pnas.org RM Steinman , MC - Proceedings of the , 2002 - National Acad Sciences ... Contributed by Ralph Marvin Steinman . Next Section. Abstract. ... In the steady state, meaning in the absence of acute infection and inflammation, DCs are in an immature state and not fully differentiated to carry out their known roles as inducers of immunity . ... Cited by 781 - Related articles - BL Direct - All 10 versions Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo rupress.org , M Rivera, JV Ravetch, RM Steinman , MC - The Journal of , 2001 - jem.rupress.org ... Submitted: 26 June 2001; Revision requested 2 August 2001; Accepted: 10 August 2001. Previous Section. References. : Banchereau, J.,; RM Steinman . (1998) Dendritic cells and the control of immunity . Nature. 392:245252, pmid:9521319. ... Cited by 943 - Related articles - BL Direct - All 9 versions Dendritic cells in the immune response rockefeller.edu JG Tew, GJ Thorbecke, RM Steinman - J. Reticuloendothel. Soc, 1982 - rockefeller.edu 372 Tew, Thorbecke, and Steinman The names and abbreviations we recommend for the D-cells are listed in Table 1 The cardinal features of each category of D-cells are indicated in the column across from the name. As indicated in the footnotes, a number of names have ... Cited by 184 - Related articles - All 3 versions The induction of tolerance by dendritic cells that have captured apoptotic cells rupress.org RM Steinman , S Turley, I Mellman, K - The Journal of , 2000 - jem.rupress.org ... Resting respiratory tract dendritic cells preferentially stimulate T helper cell type 2 (Th2) responses and require obligatory cytokine signals for induction of Th1 immunity . J. Exp. Med. 188:20192031, pmid:9841916. Abstract/FREE Full Text. : O'Doherty, U.,; RM Steinman ,; M. ... Cited by 851 - Related articles - BL Direct - All 8 versions Differentiation of phagocytic monocytes into lymph node dendritic cells in vivo GJ Randolph, K Inaba, DF Robbiani, RM Steinman , WA - Immunity , 1999 - Elsevier We investigated the differentiation and trafficking of inflammatory monocytes that phagocytosed subcutaneously injected fluorescent microspheres. As expected, most of the monocytes became microsphere + macrophages, which remained in subcutaneous tissue. However, about ... Cited by 561 - Related articles - BL Direct - All 10 versions Direct expansion of functional CD25+ CD4+ regulatory T cells by antigen-processing dendritic cells rupress.org Olson, K Velinzon, K Inaba, RM Steinman - The Journal of , 2003 - jem.rupress.org ... K. Inaba and RM Steinman share senior authorship. ... 2001. Immunologic tolerance maintained by CD25 + CD4 + regulatory T cells: their common role in controlling autoimmunity, tumor immunity , and transplantation tolerance. Immunol. Rev. 182:1832. ... Cited by 594 - Related articles - BL Direct - All 8 versions Efficient targeting of protein antigen to the dendritic cell receptor DEC-205 in the steady state leads to antigen presentation on major histocompatibility rupress.org M Rivera, MC Nussenzweig, RM Steinman - The Journal of , 2002 - jem.rupress.org ... and RM Steinman . 1990. The distinct leukocyte integrins of mouse spleen dendritic cells as identified with new hamster monoclonal antibodies. J. Exp. Med. 171:17531771. Abstract/FREE Full Text. Heath, WR, and FR Carbone. 2001. Cross-presentation in viral immunity and ... Cited by 555 - Related articles - BL Direct - All 9 versions Interleukin 1 enhances T-dependent immune responses by amplifying the function of dendritic cells rupress.org SL Koide, K Inaba, RM Steinman - Journal of Experimental , 1987 - jem.rupress.org Evidence that soluble factors are important in T cell mitogenesis began with experiments in which leukocyte-conditioned media enhanced growth in the presence of lectin (1, 2). Two factors were identified in these media (3): IL-1, a macrophage product originally termed lymphocyte ... Cited by 156 - Related articles - All 4 versions Dendritic cell function in vivo during the steady state: a role in peripheral tolerance RM Steinman , D Hawiger, K Liu, L - Annals of the New , 2003 - interscience.wiley.com ... Med. 182: 261266. 9. DADAGLIO, G., CA NELSON, MB DECK, et al. 1997. Characterization and quantita- tion of peptide-MHC complexes produced from hen egg lysozyme using a mono- clonal antibody. Immunity 6: 727738. 10. STEINMAN , RM MC NUSSENZWEIG. 2002. ... Cited by 233 - Related articles - BL Direct - All 4 versions Human dendritic cells activate resting natural killer (NK) cells and are recognized via the NKp30 receptor by activated NK cells rupress.org Tsang, L Moretta, G Melioli, RM Steinman , - The Journal of , 2002 - jem.rupress.org ... Submitted: 2 July 2001; Accepted: 10 December 2001; Revision received 26 November 2001. Previous Section. References. Banchereau, J., and RM Steinman . 1998. Dendritic cells and the control of immunity . Nature. 392:245252. ... Cited by 547 - Related articles - BL Direct - All 7 versions Dendritic cells in the T-cell areas of lymphoid organs RM Steinman , M Pack, K Inaba - Immunological reviews, 1997 - interscience.wiley.com ... Abbot A. Tew JG. The rolllcular dendritic cell: long term antigen retention during immunity , Immunol Rev 1980;S3:29-S9, Liu YJ. Grouard G. de Bouteiller O, Bantliereau ), FoUicular dendritic cells and germinal centers, Im Rev Cytology 1996;166:139-179. Steinman RM . ... Cited by 455 - Related articles - BL Direct - All 3 versions TRANCE (tumor necrosis factor -related activation-induced cytokine), a new TNF family member predominantly expressed in T cells, is a dendritic cell rupress.org , SY Lee, B Sauter, HL Li, RM Steinman , Y - The Journal of , 1997 - jem.rupress.org ... Immunity . In press. : Inaba, K,; MInaba,; NRomani,; HAya,; MDeguchi,; SIkehara,; SMuramatsu,; RM Steinman . (1992) Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colonystimulating factor. ... Cited by 557 - Related articles - BL Direct - All 6 versions Selective blockade of inhibitory Fc receptor enables human dendritic cell maturation with IL-12p70 production and immunity to antibody-coated tumor cells nih.gov , E Bonvini, S Koenig, RM Steinman , - Proceedings of the , 2005 - National Acad Sciences The final differentiation or maturation of dendritic cells (DCs) in response to environmental stimuli influences their ability to both initiate immunity and determine the quality of the response to antigens. Circulating immune complexes and cell-bound immunoglobulins present in ... Cited by 124 - Related articles - All 12 versions Dendritic cells pulsed with protein antigens in vitro can prime antigen-specific, MHC-restricted T cells in situ nih.gov K Inaba, JP Metlay, MT Crowley, RM Steinman - ncbi.nlm.nih.gov ... By Kayo Inaba, Joshua P. Metlay, Mary T. Crowley, and Ralph M. Steinman ... generating MHC-peptide complexes and pre- senting these to primed T cells, it is evident that the den- dritic cell subset of APC greatly accelerates the early sensiti- zation phase of the immune response ... Cited by 487 - Related articles - All 5 versions Influenza virusinduced dendritic cell maturation is associated with the induction of strong T cell immunity to a coadministered, normally nonimmunogenic rupress.org MK Brimnes, L Bonifaz, RM Steinman , - The Journal of , 2003 - jem.rupress.org We evaluated the proposal that during microbial infection, dendritic cells (DCs) undergo maturation and present a mixture of peptides derived from the microbe as well as harmless environmental antigens. Mice were exposed to an aerosol of endotoxin free ovalbumin (OVA) in the ... Cited by 116 - Related articles - BL Direct - All 9 versions Control of the immune response at the level of antigen-presenting cells: a comparison of the function of dendritic cells and B lymphocytes JP Metlay, E Pure, RM Steinman - Adv Immunol, 1989 - books.google.com ADVANCES IN IMMUNOLOGY, VOL. 47 Control of the Immune Response at the Level of Antigen-Presenting Cells: A Comparison of the Function of Dendritic Cells and B Lymphocytes JOSHUA P. METLAY, ELLEN PURE, AND RALPH M. STEINMAN Rockefeller University ... Cited by 122 - Related articles - All 4 versions Taking dendritic cells into medicine RM Steinman , J Banchereau - Nature, 2007 - nature.com ... J. Exp. Med. 137, 11421162 (1973) | Article | PubMed | ISI | ChemPort |; Banchereau, J. Steinman , RM Dendritic cells and the control of immunity . Nature 392, 245252 (1998) | Article | PubMed | ISI | ChemPort |; Janeway, CA Medzhitov, R. Innate immune recognition. Annu. ... Cited by 405 - Related articles - BL Direct - All 6 versions In vivo targeting of antigens to maturing dendritic cells via the DEC-205 receptor improves T cell vaccination rupress.org , B Moltedo, TM Moran, RM Steinman - The Journal of , 2004 - jem.rupress.org ... Full Text. Fujii, S., K. Shimizu, C. Smith, L. Bonifaz, and RM Steinman . 2003. Activation of natural killer T cells by -galactosylceramide rapidly induces the full maturation of dendritic cells in vivo and thereby acts as an adjuvant for combined CD4 and CD8 T cell immunity to a co ... Cited by 276 - Related articles - BL Direct - All 10 versions
日本京都大学 再生医科学研究所干细胞生物学系教授、美国加州旧金山 心血管疾病研究所 高级调查员以及美国加州大学旧金山分校 解剖学教授 Shinya Yamanaka 获奖原因 因发现干细胞和开发诱导多能干细胞而获奖 http://scholar.google.com.hk/scholar?hl=enq=++S+Yamanaka+++stem+cells+btnG=Searchas_sdt=2000as_ylo=as_vis=0 Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors cell.com K Takahashi, S Yamanaka - Cell , 2006 - Elsevier Differentiated cells can be reprogrammed to an embryonic-like state by transfer of nuclear contents into oocytes or by fusion with embryonic stem (ES) cells . Little is known about factors that induce this reprogramming. Here, we demonstrate induction of pluripotent stem cells from mouse ... Cited by 2552 - Related articles - All 80 versions Induction of pluripotent stem cells from adult human fibroblasts by defined factors cell.com … Ohnuki, M Narita, T Ichisaka, K Tomoda, S Yamanaka - Cell , 2007 - Elsevier Successful reprogramming of differentiated human somatic cells into a pluripotent state would allow creation of patient- and disease-specific stem cells . We previously reported generation of induced pluripotent stem (iPS) cells , capable of germline transmission, from mouse ... Cited by 2016 - Related articles - BL Direct - All 89 versions Generation of germline-competent induced pluripotent stem cells ttu.edu K Okita, T Ichisaka, S Yamanaka - Nature, 2007 - nature.com We have previously shown that pluripotent stem cells can be induced from mouse fibroblasts by retroviral introduction of Oct3/4 (also called Pou5f1), Sox2, c-Myc and Klf4, and subsequent selection for Fbx15 (also called Fbxo15) expression. These induced pluripotent stem ... Cited by 1125 - Related articles - BL Direct - All 31 versions Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts uaslp.mx … , K Okita, Y Mochiduki, N Takizawa, S Yamanaka - Nature …, 2007 - nature.com Direct reprogramming of somatic cells provides an opportunity to generate patient- or disease-specific pluripotent stem cells . Such induced pluripotent stem (iPS) cells were generated from mouse fibroblasts by retroviral transduction of four transcription factors: Oct3/4, Sox2, ... Cited by 646 - Related articles - BL Direct - All 12 versions Generation of mouse induced pluripotent stem cells without viral vectors boar.or.kr … , M Nakagawa, H Hyenjong, T Ichisaka, S Yamanaka - Science, 2008 - sciencemag.org ... 5. N. Maherali et al., Cell Stem Cell 3, 340 (2008). 6. N. Maherali et al., Cell Stem Cell 1, 55 (2007). 7. WE Lowry et al., Proc. Natl. Acad. Sci. USA 105, 2883 (2008). 8. K. Okita, T. Ichisaka, S . Yamanaka , Nature 448, 313 (2007). ... 12. S . Yamanaka , Cell Stem Cell 1, 39 (2007). 13. ... Cited by 369 - Related articles - All 21 versions Generation of pluripotent stem cells from adult mouse liver and stomach cells ugr.es … T Ichisaka, K Okita, K Takahashi, T Chiba, S Yamanaka - Science, 2008 - AAAS Cited by 332 - Related articles - All 14 versions The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells cell.com … , K Takahashi, M Maruyama, M Maeda, S Yamanaka - Cell , 2003 - Elsevier ... 1 , Kazutoshi Takahashi 1 , Masayoshi Maruyama 1 , Mitsuyo Maeda 2 and Shinya Yamanaka Corresponding Author ... Embryonic stem (ES) cells derived from the inner cell mass (ICM) of blastocysts grow ... In search of a critical factor( s ) that underlies pluripotency in both ICM and ... Cited by 1207 - Related articles - All 25 versions Strategies and new developments in the generation of patient-specific pluripotent stem cells stanford.edu S Yamanaka - Cell Stem Cell , 2007 - Elsevier Generating pluripotent stem cells directly from cells obtained from patients is one of the ultimate goals in regenerative medicine. Two “reprogramming” strategies for the generation of pluripotent stem cells from somatic cells have been studied extensively: nuclear transfer to oocytes ... Cited by 200 - Related articles - All 19 versions Role of ERas in promoting tumour-like properties in mouse embryonic stem cells K Takahashi, K Mitsui, S Yamanaka - Nature, 2003 - nature.com Embryonic stem (ES) cells are pluripotent cells derived from early mammalian embryos 1, 2 . Their immortality and rapid growth make them attractive sources for stem cell therapies 3 ; however, they produce tumours (teratomas) when transplanted, which could preclude ... Cited by 154 - Related articles - BL Direct - All 9 versions Fbx15 is a novel target of Oct3/4 but is dispensable for embryonic stem cell self-renewal and mouse development nih.gov … , K Mitsui, M Maeda, H Niwa, S Yamanaka - … and cellular biology, 2003 - Am Soc Microbiol Embryonic stem (ES) cells are immortal and pluripotent cells derived from early mammalian embryos. Transcription factor Oct3/4 is essential for self-renewal of ES cells and early mouse development. However, only a few Oct3/4 target genes have been identified. In this study, ... Cited by 142 - Related articles - BL Direct - All 8 versions mTOR is essential for growth and proliferation in early mouse embryos and embryonic stem cells nih.gov … , H Kiyama, K Yonezawa, S Yamanaka - … and cellular biology, 2004 - Am Soc Microbiol TOR is a serine-threonine kinase that was originally identified as a target of rapamycin in Saccharomyces cerevisiae and then found to be highly conserved among eukaryotes. In Drosophila melanogaster, inactivation of TOR or its substrate, S6 kinase, results in reduced cell size ... Cited by 133 - Related articles - BL Direct - All 8 versions Induction of pluripotent stem cells from fibroblast cultures uci.edu K Takahashi, K Okita, M Nakagawa, S Yamanaka - Nature protocols, 2007 - nature.com Clinical application of embryonic stem (ES) cells faces difficulties regarding use of embryos, as well as tissue rejection after implantation. One way to circumvent these issues is to generate pluripotent stem cells directly from somatic cells . Somatic cells can be reprogrammed to ... Cited by 131 - Related articles - BL Direct - All 5 versions Induced pluripotent stem cell lines derived from human somatic cells fhcrc.org … -Otto, J Antosiewicz-Bourget, JL Frane, S Tian, J Nie, … - Science, 2007 - AAAS Cited by 1722 - Related articles - BL Direct - All 33 versions Directed and systematic differentiation of cardiovascular cells from mouse induced pluripotent stem cells ahajournals.org … Teranishi, K Okita, B Kim, S Matsuoka, S Yamanaka , … - Circulation, 2008 - Am Heart Assoc From the Laboratory of Stem Cell Differentiation, Stem Cell Research Center, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan (GN, HU, MT, JKY); Department of Stem Cell Biology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan (KO, SY); ... Cited by 106 - Related articles - All 5 versions Suppression of induced pluripotent stem cell generation by the p53
加拿大安大略癌症研究所 高级科学家 James E. Till 获奖原因 因在 DNA 因发现干细胞和开发诱导多能干细胞而获奖 http://scholar.google.com.hk/scholar?hl=enq=++JE+Till+++stem+cells+btnG=Searchas_sdt=2000as_ylo=as_vis=0 A stochastic model of stem cell proliferation, based on the growth of spleen colony-forming cells pnas.org JE Till , EA McCulloch, L Siminovitch - Proceedings of the National , 1964 - ncbi.nlm.nih.gov Normal mammalian hemopoietic tissue produces a continuous supply of dif- ferentiated blood cells whose functions are essential for life. These functional cells have limited life spans and are incapable of self-renewal. For example, erythro- cytes lack nuclei and thus, though ... Cited by 565 - Related articles - All 11 versions Physical separation of hemopoietic stem cells from cells forming colonies in culture Worton, EA McCulloch, JE Till - Journal of Cellular , 1969 - interscience.wiley.com ABSTRACT Mouse bone marrow cells in suspension were separated into a number of fractions on the basis of cell density by equilibrium density gradient centrifugation, or on the basis of cell size by velocity sedimentation. After each type of separation, the cells from the various ... Cited by 359 - Related articles - All 2 versions Hemopoietic stem cell differentiation. JE Till , EA McCulloch - Biochimica et biophysica acta, 1980 - ncbi.nlm.nih.gov 1: Biochim Biophys Acta. 1980 Nov 26;605(4):431-59. Hemopoietic stem cell differentiation. Till JE , McCulloch EA. Publication Types: Research Support, Non-US Gov't; Review. Mesh Terms: Animals; Antigens, Surface/immunology; Cell Differentiation*; Cell Division; ... Cited by 242 - Related articles - All 3 versions A stem cell model of human tumor growth: implications for tumor cell clonogenic assays. WJ Mackillop, A Ciampi, JE Till , RN - Journal of the National , 1983 - ncbi.nlm.nih.gov A simple stem cell model of human tumor growth is presented. Three tumor cell populations are predicted: stem , transitional, and end cells . The properties of these cells are discussed in terms of their behavior in currently available technologies for investigation of cell kinetics and ... Cited by 140 - Related articles - All 2 versions The distribution of colony-forming cells among spleen colonies utoronto.ca , EA McCulloch, JE Till - Journal of Cellular and , 1963 - tspace.library.utoronto.ca ... Gurney, CW, LG Lajtha and R. Oliver 1962 A method for investigation of stem - cell kinetics. Brit. J. Haemat., 8: 461-466. McCulloch, EA, and JE Till 1962 The sensitivity of cells from normal mouse bone marrow to gamrna radiation in vitro and in vivo. ... Cited by 511 - Related articles - View as HTML - All 5 versions The effect of differing demands for blood cell production on DNA synthesis by hemopoietic colony-forming cells of mice hematologylibrary.org , EA McCulloch, L Siminovitch, JE Till - , 1965 - bloodjournal.hematologylibrary.org ... By A. J. BECKER, EA MCCULLOCH, L. SIMIN0vITcH AND J. E. TILL ... These specialized cells are con- tinuously replaced by tile differentiation of descendants of progenitor or stem cells , which possess capacity for extensive proliferation and self-renewal.12-3'4 ... Cited by 483 - Related articles - All 8 versions Cytological evidence for a relationship between normal hematopoietic colony-forming cells and cells of the lymphoid system rupress.org AM Wu, JE Till , L Siminovitch, EA - The Journal of , 1968 - jem.rupress.org ... BY AM WU,$ BM, JE TILL , PH.D., L. SIMINOVITCH, ProD., Am) EA McCULLOCH, MD (From the Departments of Medicine and ... mouse hematopoietic colony- forming stem ceils can differentiate along both erythropoietic and granulocytic lines (1). This class of stem cells is present ... Cited by 308 - Related articles - All 11 versions Physical separation of hemopoietic stem cells differing in their capacity for self-renewal rupress.org RG Worton, EA McCulloch, JE Till - Journal of Experimental , 1969 - jem.rupress.org Two key properties of hemopoietic stem cells are their capacity for self- renewal and their capacity for differentiation. The stem ceils in mouse hemo- poietic tissues that may be detected by their ability to form macroscopic splenic colonies possess both these properties, but express ... Cited by 99 - Related articles - All 8 versions Evidence for a relationship between mouse hemopoietic stem cells and cells forming colonies in culture pnas.org AM Wu, L Siminovitch, JE Till , EA McCulloch - Proceedings of the National , 1968 - JSTOR The spleen colony technique' has proved to be a useful tool for the enumera- tion of hemopoietic stem cells in the mouse and for the study of their properties. However, since the method depends on colony formation in the spleens of heavily irradiated' or genetically anemic2 mice, it ... Cited by 84 - Related articles - All 8 versions A cytological study of the capacity for differentiation of normal hemopoietic colony-forming cells AM Wu, JE Till , L Siminovitch, EA - Journal of Cellular , 1967 - interscience.wiley.com ... teristics of the metaphase cells were not determined, it is possible that the marked cells in both tissues could have differenti- ated along the same pathway and if this were the case, they would have been de- rived from unipotent stem cells . Becker, McCulloch and Till ('63), Fow ... Cited by 224 - Related articles - All 2 versions Colony formation by normal and leukemic human marrow cells in culture: effect of conditioned medium from human leukocytes hematologylibrary.org NN Iscove, JS Senn, JE Till , EA - Blood, 1971 - bloodjournal.hematologylibrary.org ... Page 4. 4 ISCOVE ET AL. 7. Senn, JS, McCulloch, E. A., and Till , Table 3.-Marrow From Patients With Acute Myelogenous Leukemia in Relapse Patient0 Colonies/105 Nucleated Marrow Cells Tested Conditioned Medium No Conditioned Medium 1 18,24,21,31 0,0,0,0 ... Cited by 428 - Related articles - View as HTML - All 4 versions Stem cells in differentiation and neoplasia JE Till - Journal of Cellular Physiology, 1982 - interscience.wiley.com The stem cell concept continues to be very useful both for studies on cellular differentiation and for studies on neoplasia. At present the concept is being enlarged to include consideration of a new aspect: stem cell genetics, at the molecular level. Some questions are still to be ... Cited by 63 - Related articles - All 3 versions Introduction of a selectable gene into primitive stem cells capable of long-term reconstitution of the hemopoietic system of W/Wv mice JE Dick, MC Magli, D Huszar, RA Phillips, A Bernstein - Cell , 1985 - Elsevier ... B. Clarkson, PA Marks, and JE Till , eds. (Cold Spring Harbor, New York: Cold Spring Harbor Laboratory), pp. 109-120. Phillips, RA (1985). Comparison of different assays for multipotent hematopoietic stem cells . In Mediators in Cell Growth and Differentia- tion. ... Cited by 455 - Related articles - All 3 versions Spleen-colony formation in anemic mice of genotype WW utoronto.ca EA McCulloch, L Siminovitch, JE Till - Science, 1964 - sciencemag.org ... Our results sup- port the suggestion (18) that the stem cells responding to erythropoietin (19) are not identical with the stem cells that give rise to spleen colonies. EA MCCULLOCH L. SIMINOVITCH JE TILL Department of Medical Biophysics, University of Toronto, and ... Cited by 271 - Related articles - All 6 versions Purification and characterization of mouse hematopoietic stem cells uky.edu GJ Spangrude, S Heimfeld, IL Weissman - Science(Washington), 1988 - elegans.uky.edu ... Perhaps this model will prove sufficient for experiments designed to identify and isolate human hematopoietic stem cells . If so, the use of these cells in bone marrow transplantation, as targets for gene insertion therapy, and for the study of the ... 3. JE Till and EA McCulloch, Rad. ... Cited by 1692 - Related articles - View as HTML - All 8 versions The cellular basis of the genetically determined hemopoietic defect in anemic mice of genotype Sl/Sld hematologylibrary.org EA McCulloch, L Siminovitch, JE Till , ES - , 1965 - bloodjournal.hematologylibrary.org ... The spleen-colony method of assaying for the proliferative capacity of cells derived from hemopoietic tissue has been described elsewhere, ( Till and McCulloch7) and (McCulloch and Till8). ... be hemopoietic stem cells have been published elsewhere (Siminovitch et al.9). ... Cited by 261 - Related articles - All 6 versions Multilineage potential of adult human mesenchymal stem cells uniss.it MF Pittenger, AM Mackay, SC Beck, RK Jaiswal, R - Science, 1999 - sciencemag.org ... Natl. Acad. Sci. USA 95, 13726 (1998). 2. JE Till and EA McCulloch, Radiat. Res. 14, 213 (1961); BI Lord, in Stem Cells , CS Potten, Ed. (Academic Press, New York, 1996), pp. 401422; CI Civin et al., J. Immunol. 133, 157 (1984). 3. SA Kuznetsov et al., J. Bone Miner. Res. ... Cited by 8519 - Related articles - BL Direct - All 13 versions Proliferative state of blast cell progenitors in acute myeloblastic leukemia (AML) hematologylibrary.org MD Minden, JE Till , EA McCulloch - Blood, 1978 - bloodjournal.hematologylibrary.org ... By MD Minden, JE Till , and EA McCulloch Peripheral blood from patients with acute myeloblastic leukemia (AML) contains cells capable of giving rise to colonies in culture when stimulated by media conditioned by leukocytes (1CM) in the presence of phyto- hemagglutinin (PH ... Cited by 111 - Related articles - All 3 versions Regulatory mechanisms acting on hemopoietic stem cells . Some clinical implications. nih.gov EA McCulloch, JE Till - The American Journal of Pathology, 1971 - ncbi.nlm.nih.gov HEMOPOTETIC SrEM CELLS stand at the beginning of processes of exponential growth and cellular differentiation. They providethe origins from which marrow recovers after injury or grows after trans- plantation. When stem cells are damaged by injury or disease, the effects are ... Cited by 36 - Related articles - All 5 versions Regulation of hemopoietic stem cells JE Till - Stem Cells of Renewing Cell Populations. AB Cairnie, , 1976 Cited by 33 - Related articles
加拿大安大略癌症研究所 高级科学家 Ernest A. McCulloch 获奖原因 因在 DNA 因发现干细胞和开发诱导多能干细胞而获奖 http://scholar.google.com.hk/scholar?hl=enq=EA+McCulloch+++stem+cells+btnG=Searchas_sdt=2000as_ylo=as_vis=0 A stochastic model of stem cell proliferation, based on the growth of spleen colony-forming cells pnas.org JE Till, EA McCulloch , L Siminovitch - Proceedings of the National , 1964 - ncbi.nlm.nih.gov Normal mammalian hemopoietic tissue produces a continuous supply of dif- ferentiated blood cells whose functions are essential for life. These functional cells have limited life spans and are incapable of self-renewal. For example, erythro- cytes lack nuclei and thus, though ... Cited by 565 - Related articles - All 11 versions Physical separation of hemopoietic stem cells from cells forming colonies in culture RG Worton, EA McCulloch , JE - Journal of Cellular , 1969 - interscience.wiley.com ABSTRACT Mouse bone marrow cells in suspension were separated into a number of fractions on the basis of cell density by equilibrium density gradient centrifugation, or on the basis of cell size by velocity sedimentation. After each type of separation, the cells from the various ... Cited by 359 - Related articles - All 2 versions Hemopoietic stem cell differentiation. JE Till, EA McCulloch - Biochimica et biophysica acta, 1980 - ncbi.nlm.nih.gov 1: Biochim Biophys Acta. 1980 Nov 26;605(4):431-59. Hemopoietic stem cell differentiation. Till JE, McCulloch EA . Publication Types: Research Support, Non-US Gov't; Review. Mesh Terms: Animals; Antigens, Surface/immunology; Cell Differentiation*; Cell Division; ... Cited by 242 - Related articles - All 3 versions Mouse myeloma tumor stem cells : a primary cell culture assay. Park, DE Bergsagel, EA McCulloch - Journal of the National , 1971 - ncbi.nlm.nih.gov ... Park CH, Bergsagel DE, McCulloch EA . PMID: 5115909 MeSH Terms: Animals; Cell Count; Cells */radiation effects; Centrifugation; Culture Media; Culture Techniques*; Hematopoietic Stem Cells /radiation effects; Injections; ... Cited by 246 - Related articles The distribution of colony-forming cells among spleen colonies utoronto.ca L Siminovitch, EA McCulloch , - Journal of Cellular and , 1963 - tspace.library.utoronto.ca ... Gurney, CW, LG Lajtha and R. Oliver 1962 A method for investigation of stem - cell kinetics. Brit. J. Haemat., 8: 461-466. McCulloch , EA , and JE Till 1962 The sensitivity of cells from normal mouse bone marrow to gamrna radiation in vitro and in vivo. ... Cited by 511 - Related articles - View as HTML - All 5 versions The effect of differing demands for blood cell production on DNA synthesis by hemopoietic colony-forming cells of mice hematologylibrary.org Becker, EA McCulloch , L Siminovitch, JE - , 1965 - bloodjournal.hematologylibrary.org Page 1. The Effect of Differing Demands for Blood Cell Production on DNA Synthesis by Hemopoietic Colony-Forming Cells of Mice By A. J. BECKER, EA MCCULLOCH , L. SIMIN0vITcH AND J. E. TILL ... EA N'IcCUL- ... Page 3. 298 BECKER, MC CULLOCH , SIMINOVITCH AND TILL ... Cited by 483 - Related articles - All 8 versions Cytological evidence for a relationship between normal hematopoietic colony-forming cells and cells of the lymphoid system rupress.org , JE Till, L Siminovitch, EA McCulloch - The Journal of , 1968 - jem.rupress.org ... BY AM WU,$ BM, JE TILL, PH.D., L. SIMINOVITCH, ProD., Am) EA McCULLOCH , MD (From the Departments of Medicine and ... mouse hematopoietic colony- forming stem ceils can differentiate along both erythropoietic and granulocytic lines (1). This class of stem cells is present ... Cited by 308 - Related articles - All 11 versions Stem cells in normal and leukemic hemopoiesis (Henry Stratton Lecture, 1982) hematologylibrary.org EA McCulloch - Blood, 1983 - bloodjournal.hematologylibrary.org CELLULAR ORGANIZATION IN HEMATOPOIESIS Myelopoiesis The myeloid component of hemopoiesis is a typical cell renewal system.' It consists of three classes of cells that differ in their functional capacities (Fig. I). First, pluripotent stem cells are capable of self-renewal ... Cited by 122 - Related articles - All 5 versions Physical separation of hemopoietic stem cells differing in their capacity for self-renewal rupress.org RG Worton, EA McCulloch , JE Till - Journal of Experimental , 1969 - jem.rupress.org Two key properties of hemopoietic stem cells are their capacity for self- renewal and their capacity for differentiation. The stem ceils in mouse hemo- poietic tissues that may be detected by their ability to form macroscopic splenic colonies possess both these properties, but express ... Cited by 99 - Related articles - All 8 versions Stem cells in normal and leukemic hemopoiesis EA McCulloch - Blood, 1983 Cited by 122 - Related articles Evidence for a relationship between mouse hemopoietic stem cells and cells forming colonies in culture pnas.org AM Wu, L Siminovitch, JE Till, EA McCulloch - Proceedings of the National , 1968 - JSTOR The spleen colony technique' has proved to be a useful tool for the enumera- tion of hemopoietic stem cells in the mouse and for the study of their properties. However, since the method depends on colony formation in the spleens of heavily irradiated' or genetically anemic2 mice, it ... Cited by 84 - Related articles - All 8 versions A cytological study of the capacity for differentiation of normal hemopoietic colony-forming cells Till, L Siminovitch, EA McCulloch - Journal of Cellular , 1967 - interscience.wiley.com ... even with- out irradiation, support the growth of nor- mal hemopoietic colony-forming cells ( Mc - Culloch et d ... 182 A. M. WU, J. E. TILL, L. SIMINOVITCH AND EA McCULLOCH ... finding provides cyto- logicai proof that the original marrow sus- pension contained stem cells able to ... Cited by 224 - Related articles - All 2 versions Growth factors influence the sensitivity of leukemic stem cells to cytosine arabinoside in culture hematologylibrary.org , C Wang, S Minkin, EA McCulloch - , 1989 - bloodjournal.hematologylibrary.org ... Arabinoside in Culture By Jun Miyauchi. CoIm A. Kelleher, Chen Wang, Salomon Minkin, and Ernest A. McCulloch We have proposed that the blasts in acute myeloblastic leukemia (AML) are renewal populations maintained by a small subpopulation of stem cells . ... Cited by 77 - Related articles - All 5 versions Colony formation by normal and leukemic human marrow cells in culture: effect of conditioned medium from human leukocytes hematologylibrary.org Iscove, JS Senn, JE Till, EA McCulloch - Blood, 1971 - bloodjournal.hematologylibrary.org ... 1 Colony Formation by Normal and Leukemic Human Marrow Cells in Culture: Effect of Conditioned Medium From Human Leukocytes By NN IscovE, J. S. SENN, J. E. TILL AND EA MCCULLOCH Conditioned medium obtained from from the marrow of patients with acute ... Cited by 428 - Related articles - View as HTML - All 4 versions Self-renewal in culture of proliferative blast progenitor cells in acute myeloblastic leukemia hematologylibrary.org RN Buick, MD Minden, EA McCulloch - Blood, 1979 - bloodjournal.hematologylibrary.org ... to Dr. EA McCulloch . Ontario Cancer Institute, 500 Sherbourne Street. Toronto, Ontario M4X / K9, Canada. 1979 by Grune Stratton, Inc. 0006-4971/79/5402-00i2$0l.00/0 Page 2. 96 BUICK. MINDEN, AND McCULLOCH since this property provides individual stem cells with ... Cited by 175 - Related articles - All 4 versions The effect of erythropoietic stimulation on the hemopoietic colony-forming cells of mice hematologylibrary.org WR Bruce, EA McCulloch - Blood, 1964 - bloodjournal.hematologylibrary.org ... Hemopoietic Colony-forming Cells of Mice By WR BRUCE AND EA MCCULLOCH IT IS generally assumed (see for example, ref. ... the existence of a close relationship between colony-forming cells and the stem cells of the erythroid series. ... 218 BRUCE AND MC CULLOCH ... Cited by 163 - Related articles - All 4 versions The effects of three recombinant growth factors, IL-3, GM-CSF, and G-CSF, on the blast cells of acute myeloblastic leukemia maintained in short-term suspension hematologylibrary.org , MD Minden, S Minkin, EA McCulloch - , 1987 - bloodjournal.hematologylibrary.org ... Maintained in Short-Term Suspension Culture By Jun Miyauchi, CoIm A. Kelleher, Yu-Chung Yang, Gordon G. Wong, Steven C. Clark, Mark D. Minden, Salomon Minkin, and Ernest A. McCulloch The blast stem cells of acute myeloblastic leukemia (AML) ... Cited by 139 - Related articles - All 5 versions The cellular basis of the genetically determined hemopoietic defect in anemic mice of genotype Sl/Sld hematologylibrary.org EA McCulloch , L Siminovitch, JE Till, ES - , 1965 - bloodjournal.hematologylibrary.org ... 25, 1964. EA MCCULLOCH : Associate Professor, Department of Medical Biophysics, University ... extremely different. In a previous study ( McCulloch et al.5) the spleen-colony assay for hemo- poietic stem cells was used to investigate certain aspects of the effects of the ... Cited by 261 - Related articles - All 6 versions Direct evidence for the participation of bcl-2 in the regulation by retinoic acid of the Ara-C sensitivity of leukemic stem cells ZB Hu, MD Minden, EA McCulloch - Leukemia, 1995 - cat.inist.fr All-trans retinoic acid (ATRA) increases the sensitivity of AML blast cells to cytosine arabinoside (Ara-C) or daunorubicin (DNR) when ATRA is given after drug. We have proposed that down-regulation of bcl-2 is part of the mechanism by which ATRA regulates drug ... Cited by 53 - Related articles - BL Direct - All 3 versions Spleen-colony formation in anemic mice of genotype WW utoronto.ca EA McCulloch , L Siminovitch, JE Till - Science, 1964 - sciencemag.org ... Our results sup- port the suggestion (18) that the stem cells responding to erythropoietin (19) are not identical with the stem cells that give rise to spleen colonies. EA MCCULLOCH L. SIMINOVITCH JE TILL Department of Medical Biophysics, University of Toronto, and ... Cited by 271 - Related articles - All 6 versions
2010年诺贝尔奖得主预测 位于美国缅因州巴港的杰克逊实验室 名誉高级科研人员 Douglas L. Coleman 获奖原因 因发现调节食欲和新陈代谢的激素致轻素而获奖 http://scholar.google.com.hk/scholar?hl=enq=DL+Coleman++obesity+btnG=Searchas_sdt=2000as_ylo=as_vis=0 Obese and diabetes: two mutant genes causing diabetes- obesity syndromes in mice DL Coleman - Diabetologia, 1978 - Springer Summary. The diabetes syndromes produced by the two single gene mutations, obese (ob), and diabetes (db) are identical when both genes are expressed on the same inbred background, whereas on different backgrounds the syndrome changes from a severe- ... Cited by 770 - Related articles - All 2 versions Effect of genetic background on the therapeutic effects of dehydroepiandrosterone (DHEA) in diabetes- obesity mutants and in aged normal mice. DL Coleman , RW Schwizer, EH Leiter - Diabetes, 1984 - Am Diabetes Assoc Dehydroepiandrosterone (DHEA) was fed at 0.1-0.4% in the diet to genetically diabetic (db/db) or obese (ob/ob) C57BL/KsJ (BL/Ks) or C57BL/6J (BL/6) mice. Treatment of BL/Ks-db/db or ob/ob mice with 0.4% DHEA prevented hyperglycemia, islet atrophy, and ... Cited by 296 - Related articles - All 5 versions Laboratory animals exhibiting obesity and diabetes syndromes L Herberg, DL Coleman - Metabolism, 1977 - Elsevier Spontaneous hyperglycemia, hyperinsulinemia and obesity are common features for at least one period of the life-time in some strains of mice. Both genetic and environmental factors are involved in the pathogenesis of the diabetes-like syndrome, making these strains ... Cited by 286 - Related articles - All 2 versions Diabetes- obesity syndromes in mice. DL Coleman - Diabetes, 1982 - ncbi.nlm.nih.gov 1. Diabetes. 1982;31(Suppl 1 Pt 2):1-6. Diabetes- obesity syndromes in mice. Coleman DL . Several different rodent models are available for metabolic studies on the development of diabetes. Although the abnormalities associated ... Cited by 251 - Related articles Fat (fat) and tubby (tub): two autosomal recessive mutations causing obesity syndromes in the mouse oxfordjournals.org DL Coleman , EM Eicher - Journal of Heredity, 1990 - Am Genetic Assoc From The Jackson Laboratory, Bar Harbor, Maine 04609. This research was funded in part by NIH research grants DK14461 (DLC), GM20919 and RR01183 (EME). We thank Christina Gott for originally noting the pro- genitor tubby male, Janice Southern for establishing the ... Cited by 159 - Related articles - All 7 versions Obesity genes: beneficial effects in heterozygous mice DL Coleman - Science, 1979 - sciencemag.org The mouse mutant genes obese (ob) and diabetes (db) cause similar obesity -diabetes states in homozygotes. These obesity syndromes are characterized by a more efficient conversion of food to lipid and, once stored, a slower rate of catabolism on fasting. Heterozygous mice, ... Cited by 94 - Related articles - All 3 versions Thermogenesis in diabetes- obesity syndromes in mutant mice DL Coleman - Diabetologia, 1982 - Springer Summary. The two mouse mutants, obese (ob) and diabetes (db), cause similar diabetes- obesity syn- dromes that are characterized by a marked increase in apparent metabolic efficiency with regard to utilizati- on of energy. A failure to thermoregulate in a normal fashion would ... Cited by 40 - Related articles - All 3 versions The influence of genetic background on the expression of the obese (Ob) gene in the mouse DL Coleman , KP Hummel - Diabetologia, 1973 - Springer ... 1. Bleisch, VR, :M;ayer, J., Dickie, MM,: Familial diabetes mellitus in mice associated with insulin re- sistance, obesity , and hyperplasia of the islets of Langerhans. Amer. J. Path. 28, 369--385 (1952). 2. Coleman , DL , ]~ ?.: The influence of genetic background on the expression of the obese (o5) gene in the mouse. Diabetologia, 9, 287-- 293 (1973). 5. Haessler, HA, Crawford, J. ]). : Alterations in the fatty acid composition of depot fat associated with obesity . Ann. RT. ... Cited by 437 - Related articles - All 2 versions Plasma corticosterone concentrations in diabetic (db) mice DL Coleman , DL Burkart - Diabetologia, 1977 - Springer ... 51, 598-646 (1971) 2. Marshall, NB, Andrus, SW, Mayer, J.: Organ weights in three forms of obesity . Amer. ... Endocrinology 93, 510-513 (1973) Hummel, KP, Coleman , DL , Lane, PW: The influence of genetic background on the expression of mutations at the dia- betes locus in the ... Cited by 43 - Related articles - All 2 versions Hyperinsulinemia in pre-weaning diabetes (db) mice DL Coleman , KP Hummel - Diabetologia, 1974 - Springer ... 610 DL Coleman and KP Hummel: Hyperinsulinemia in Pre-Weaning Diabetes (db) Mice Insulin resistance is a pronounced feature of diabetes mice which is recognizable as sooll as obesity becomes apparent and which increases with age, be- coming almost total in the later ... Cited by 77 - Related articles - All 2 versions Diabetes and Obesity : Thrifty Mutants? DL Coleman - Nutrition reviews, 1978 - interscience.wiley.com A limited number of reprints of this article may be obtained from he author THERE ARE NO REPRINTS OF UNSIGNED REVIEWS ... NUTRITION REVIEWS I VOL. 36, NO. 5 MAY 1978 128 ... 150 NUTR/T/ON REWEWS I VOL. 36, NO. 5 YAY 1078 Cited by 23 - Related articles - All 2 versions Acetone metabolism in mice: increased activity in mice heterozygous for obesity genes pnas.org DL Coleman - Proceedings of the National Academy of , 1980 - National Acad Sciences ABSTRACT Mice were found to convert acetone to lactate at appreciable rates. The conversion of acetone to gluconeogenic precursors could provide additional glycolytic intermediates that would allow the more complete utilization of lipid stores and increase survival time during ... Cited by 21 - Related articles - All 8 versions Antiobesity effects of etiocholanolones in diabetes (db), viable yellow (Avy), and normal mice DL COLEMAN - Endocrinology, 1985 - Endocrine Soc ... DOUGLAS L. COLEMAN ... Two metabolites of the adrenal steroid dehy-droepiandrosterone (DHEA), 3 -hydroxyetiocholanolone and 3-hydroxyetiocholanolone, were found to have antiobesity properties with respect to both prevention of the development of obesity as well as ... Cited by 31 - Related articles - All 3 versions Studies with the mutation, diabetes, in the mouse DL Coleman , KP Hummel - Diabetologia, 1967 - Springer ... 6 and 7). Degranulation of fi-cells is a consistent finding and apparently occurs as early as the onset of obesity as it is evident in the islets of 25-day old dia- betics. ... Page 4. Vol. 3, No. 2, 1967 DL COLEMAN and KP HUmMeL. Studies with the Mutation, Diabetes 241 ... Cited by 207 - Related articles - All 2 versions The influence of genetic background on expression of mutations at the diabetes locus in the mouse. I. C57BL/KsJ and C57BL/6J strains KP Hummel, DL Coleman , PW Lane - Biochemical genetics, 1972 - Springer ... Our studies emphasize the importance of genetic control in attempts to determine causes and courses of diseases such as diabetes or obesity . ... Diabetologia 6:252. Coleman , DL , and Hummel, KP (1967). Studies with the mutation, diabetes, in the mouse. Diabetologia 3:238. ... Cited by 133 - Related articles - All 2 versions Influence of genetic background on the expression of mutations at the diabetes locus in the mouse. II. Studies on background modifiers DL Coleman , KP Hummel - Contemporary topics in the study of , 1975 - Academic Press Cited by 34 - Related articles Insulin secretion in experimental obesity WJ Malaisse, F Malaisse-Lagae, DL Coleman - Metabolism, 1968 - Elsevier In mice rendered obese by adminitration of goldthioglucose, the pancreas increases both its store of insulin and its capacity to secrete insulin in vitro in response to glucose and theophylline in direct proportion to the actual body weight. In hereditarily obese mice ( ), the insulin ... Cited by 16 - Related articles - All 2 versions Lessons from studies with genetic forms of diabetes in the mouse* DL Coleman - Metabolism, 1983 - Elsevier ... References. DL Coleman , Diabetes- obesity syndromes in mice, Diabetes 31 (1982) (suppl 1), pp. 16. View Record in Scopus | Cited By in Scopus (167). ... DL Coleman , Obesity genes: Beneficial effects in heterozygous mice, Science 203 (1979), pp. 663664. ... Cited by 14 - Related articles - All 2 versions The effects of hypothalamics lesions in genetically diabetic mice DL Coleman , KP Hummel - Diabetologia, 1970 - Springer ... Amer. J. Physiol. 211, 229--231 (1966). 8. l?Ialaisse, WJ, Malaisse-Lagae, F., Coleman , DL : Insulin secretion in e:cperimental obesity . Metabolism 17, 802--807 (1968). 9. Mayer, J., French, RG, Zighera, CF, Barrnett, RJ : Hypothalamic obesity in the mouse. ... Cited by 27 - Related articles - All 2 versions
标签: 生理学或医学
