1 University of California--San Francisco 2 The University of North Carolina at Chapel Hill北卡罗来纳大学教堂山分校 3 University of Minnesota 4 The University of Texas at Austin德克萨斯大学奥斯汀分校 5 Ohio State University 5 University of Kentucky肯塔基大学 5 University of Michigan Ann Arbor密西根大学-安娜堡分校 5 University of Washington华盛顿大学 9 Purdue University 9 The University of Arizona亚利桑那大学 9 University of Florida佛罗里达大学 9 University of Illinois--Chicago 9 University of Maryland--Baltimore 9 University of Wisconsin Madison威斯康星大学麦迪逊分校 15 University of Southern California南加州大学 16 The University of Iowa爱荷华大学 16 The University of Tennessee田纳西大学 Health Science Center 16 The University of Utah犹他大学 19 The University of Kansas堪萨斯大学 19 University of Pittsburgh匹兹堡大学 21 University at Buffalo--SUNY 21 Virginia Commonwealth University 23 University of Colorado--Denver 24 Auburn University奥本大学 (Harrison) 24 Medical University of South Carolina Columbia南卡罗来纳大学哥伦比亚分校 24 Rutgers University New Brunswick罗格斯大学新伯朗士威校区 (Mario) 24 University of Georgia乔治亚大学 24 University of Mississippi密西西比大学 29 University of Connecticut康涅狄格大学 29 University of Nebraska Medical Center 31 Univ of the Sciences in Philadelphia-Philadelphia Col of Pharmacy Science 32 Mercer University 32 Oregon State University俄勒冈州立大学 32 Texas Tech University Health Sciences Center 32 University of California San Diego加利福尼亚大学圣地亚哥分校 32 University of Cincinnati辛辛那提大学 32 University of New Mexico新墨西哥大学 32 The University of Oklahoma俄克拉荷马大学 32 Washington State University华盛顿州立大学 32 Wayne State University韦恩州立大学 (Applebaum) 32 West Virginia University西弗吉尼亚大学 42 South Carolina College of Pharmacy 42 University of Arkansas阿肯色大学 for Medical Sciences 42 University of Missouri Columbia密苏里大学哥伦比亚分校--Kansas City 42 University of South Carolina Columbia南卡罗来纳大学哥伦比亚分校 46 Creighton University 46 Duquesne University迪尤肯大学 (Mylan) 46 Northeastern University美国东北大学 46 University of Montana 46 University of Rhode Island 51 Drake University 51 Samford University桑佛德大学 (McWhorter) 51 St. Louis College of Pharmacy 51 University of Houston休斯顿大学 51 University of the Pacific太平洋大学 (Long) 56 Albany College of Pharmacy and Health Sciences 56 Butler University 56 Campbell University 56 Idaho State University 56 University of Wyoming 61 Ferris State University 61 Massachusetts College of Pharmacy and Health Sciences--Boston 61 North Dakota State University 61 South Dakota State University 61 St.John's University圣约翰大学 61 Temple University天普大学
下面是从丹麦哥本哈根大学药学院药物化学系（ Department of Medicinal Chemistry ，Faculty of Pharmaceutical Sciences，University of Copenhagen ）的网页上复制来的。我们国内的药学院校的药物化学课程是否应该也做些相应的调整呢。供大家商榷。 Teaching "I am absolutely convinced that the synergy between research and education is one of the great aspects of modern science and one of the best investments a society can make in its future" E. J. Corey Laureate, Nobel Prize The mission of the Department of Medicinal Chemistry is to provide drug-related research-based courses taught at a high international level. The courses are available at undergraduate and graduate level of education as well as in Ph.D. programmes. The topics covered in the courses include organic chemistry, medicinal chemistry, molecular pharmacology, natural products, pharmacognosy and biostructural research. The Department of Medicinal Chemistry is conducting the following courses in English: Courses at graduate level Medicinal and Biostructural Chemistry （医药和生物结构化学） Structural and Computational Medicinal Chemistry （结构和计算药物化学） Advanced Synthetic Organic Chemistry （高等合成有机化学） Advanced Spectroscopy （高等波谱学） Advanced Pharmacognosy （高等生药学） Advances in medicinal Chemistry Research （药物化学研究进展） Master project in English It is possible to write the Master project in English at the Department of Medicinal Chemistry. PhD courses NMR Techniques in Drug research Biostructures and Molecular Modeling in Drug Research Drug Design and Discovery Receptor Structure and Function Chemical Biology and Combinatorial Methods
scienceChronic hydrogen-rich saline treatment attenuates vascular dysfunction in.pdf 来自东华大学和第二军医大学药学院的关于氢气对自发性高血压大鼠效应的研究，最近被 Biochemical Pharmacology （ 4.9 ）接受并在线发表。 这个研究虽然在研究套路上没有什么新意，但应该是关于高血压的第一篇研究，这里作为常规记录。（近闻美国 p 大的 Nakao 教授准备中断氢气的研究，他是临床医生，觉得氢气的研究涉及太多利益冲突，也就是说许多从事氢气商业的公司可能对氢气的研究有太多的影响。 Nakao 教授 在氢气和器官移植方面有许多开创性的研究，如果他退出这个领域，将是氢气生物学研究的巨大损失。由此想到，许多涉及到利益的研究对学术可能有正面促进作用，也有可能使学术被利益绑架，导致学者失去客观描述研究成果底线。） 高血压患者氧化应激是导致血管功能异常的重要因素。最近研究表明，氢气作为一种抗氧化物质可以选择性中和强毒性自由基（羟基自由基和亚硝酸阴离子）。本研究观察用氢气生理盐水慢性给药对高血压后血管功能异常的治疗作用及其机制。 8 周年龄自发高血压大鼠和对照 Wistar-Kyoto 鼠随机分为氢气盐水治疗组（ 6 mg/kg/d3 月腹腔注射）对照组。氢气盐水治疗组可显著改善异常的血管功能，包括血管增生和内皮细胞异常。 氢气治疗对血压无明显影响， 但可以显著提高压力感受反射功能。特别对高血压后氧化应激具有显著的改善作用，包括抗氧化酶（ SOD\CAT\Gpx\NADP 氧化酶等），对炎症反应如炎症因子和相关信号分子也有显著影响。对线粒体功能也有正面作用，虽然对一氧化氮的产物没有影响，但可以抑制 eNOS 的表达，促进 二 甲基精氨酸 二 甲胺水解酶 (DDAH) 表达，说明对内皮细胞功能有改善作用。 Chronic hydrogen-rich saline treatment attenuates vascular dysfunction in spontaneous hypertensive rats · Hao Zheng a , 1 , Yong-Sheng Yu b , 1 , , · a Department of Pharmaceutical Science and Technology, College of Chemistry and Biology, Donghua University, Shanghai, China · b Department of Pharmacology, Second Military Medical University, Shanghai, China · Received 13 November 2011. Revised 24 January 2012. Accepted 27 January 2012. Available online 8 February 2012. · http://dx.doi.org/10.1016/j.bcp.2012.01.031 , How to Cite or Link Using DOI Abstract 。 The 8-week-old spontaneously hypertensive rats (SHR) and age-matched Wist ar-Kyoto rats (WKY) were randomized into HRS-treated (6ml/k In hypertensive patients, increased oxidative stress is thought to be one important cause of vascular dysfunction. Recently, it has been suggested that hydrogen exerts a therapeutic antioxidant activity by selectively reducing hydroxyl radical and peroxynitrite, the most cytotoxic chemicals of reactive oxygen species (ROS). Herein, we investigated the protective effect of chronic treatment with hydrogen-rich saline (HRS) against vascular dysfunction in SHR and the underlying mechanism. g/d for 3 months, i.p.) and vehicle treated group. Treatment with HRS ameliorated vascular dysfunction including aortic hypertrophy and endothelial function in SHR. Treatment with HRS had no significant effect on blood pressure, but it signi ntly improved baroreflex function in SHR. Treatment with HRS abated oxidative stress, restored antioxidant enzymes including superoxide dismutase, glutathione peroxidase, and catalase, and suppressed NADPH oxidase. Furthermore, treatment with HRS depressed pro-inflammatory cytokines expression including IL-6 and IL-1β and suppressed NF-κB activation, restored mitochondrial function including ATP formation and membrane integrity. In addition, although treatment with HRS had no significant effect on nitric oxide amount in circulating or aorta, it suppressed endothelial nitric oxide synthase expression and upregulated dimethylarginine dimethylaminohydrolase 2 expression in SHR. In conclusion, treatment with HRS alleviates vascular dysfunction through abating oxidative stress, restoring baroreflex function, suppressing inflammation, preserving mitochondrial function, and enhancing nitric oxide bioavailability.
标签: 药学院
