《自然》杂志预测2011年科研热点 http://news.sciencenet.cn//htmlnews/2011/1/242378.shtm 暗物质的关键时刻 一系列的地下试验将继续找寻暗物质粒子期待2011年能给我们个答案。 New year, new science http://www.nature.com/news/2010/101231/full/469012a.html Dark matter's moment of truth A number of underground experiments, such as XENON100 at Italy's Gran Sasso National Laboratory near L'Aquila, and the Cryogenic Dark Matter Search (CDMSII) in northern Minnesota's Soudan Mine, are hunting for dark matter particles and expect to release results in 2011. http://www.gopubmed.org/web/gopubmed/1?WEB01lys5moqoa0ueI2cI47I00h001000j100200010 998 documents semantically analyzed 1 2 3 Top Years Publications 2009 77 2007 72 2010 69 2008 64 2006 62 2000 60 2004 56 2003 55 2005 52 2001 44 2002 43 1993 43 1995 33 1994 26 1990 24 1996 22 1992 20 1989 16 1999 15 1991 15 1 2 3 1 2 3 Top Countries Publications USA 250 United Kingdom 61 Germany 53 Italy 39 France 34 Canada 33 Japan 29 China 27 Spain 23 Switzerland 18 Sweden 12 Israel 10 Australia 10 India 9 Poland 9 Russia 7 Brazil 7 Netherlands 7 Denmark 6 Mexico 5 1 2 3 1 2 3 ... 15 Top Cities Publications Oxford, United Kingdom 14 Pasadena, CA, USA 13 New York City 11 Chicago 11 London 10 Berkeley 10 Tokyo 9 Irvine 9 Batavia 9 Stockholm, Sweden 9 Princeton 9 Paris 8 Rome 8 Toronto 8 Beijing, China 8 Gainesville 8 Columbus 8 Seattle 7 Cambridge 7 Geneva 7 1 2 3 ... 15 1 2 3 ... 16 Top Journals Publications Phys Rev Lett 250 Science 83 Phys Rev D 67 Nature 56 Astrophys J 25 Plant Physiol 19 P Natl Acad Sci Usa 18 Philos T Roy Soc A 15 Environ Sci Technol 12 J Dairy Sci 7 Appl Environ Microb 7 Mikrobiologiia 6 Ann Ny Acad Sci 6 Ying Yong Sheng Tai Xue Bao 5 Sci Total Environ 5 Phys Rev E Stat Nonlin Soft Matter Phys 5 J Agr Food Chem 5 Water Res 5 J Neurosci 5 Rev Sci Instrum 4 1 2 3 ... 16 1 2 3 ... 192 Top Terms Publications Animals 161 Astronomy 157 Nature 124 Humans 108 European Continental Ancestry Group 92 Tocopherols 92 Gravitation 84 Temperature 79 Electrons 73 Cluster Analysis 66 Physics 64 Elementary Particles 64 Electronics 62 Radiation 55 Neurons 51 Adult 51 Optics 50 Rats 49 Evolution 49 Light 48 1 2 3 ... 192 1 2 3 ... 194 Top Authors Publications Waldrop M 7 Bergstrm L 6 Kamionkowski M 6 Collar J 6 Feng J 5 Amendola L 5 Nelson H 4 Paerl H 4 Mohapatra R 4 Kusenko A 4 Dodelson S 4 Matthews C 4 Gaitskell R 4 Frenk C 4 Lu A 4 Silk J 4 Wieczorek M 4 Romaniuk A 4 Schramm D 4 Griest K 4 1 2 3 ... 194
《自然》杂志预测2011年科研热点 http://news.sciencenet.cn//htmlnews/2011/1/242378.shtm 合成生物学：想想多细胞 科学家不用非得通过单个细胞弄清复杂的合成生物学了，我们可以期待有更多关于细胞群体行为的文章在今年发表。利用细菌来制药或许会成为现实。 New year, new science http://www.nature.com/news/2010/101231/full/469012a.html Synthetic biology: think multicellular No longer will scientists have to cram complicated synthetic biology into a single cell. Last year, researchers engineered an entire colony of bacteria to periodically fluoresce in unison, and we can expect many more papers exploring the behaviour of collections of cells. The goal is to exploit this teamwork to give bacteria useful functions such as producing medicinal drugs. http://www.gopubmed.org/web/gopubmed/1?WEB01lys5moqoa0ueI1tI37I00h001000j100200010 142 documents semantically analyzed 1 2 Top Years Publications 2007 17 2009 14 2004 12 2008 11 2005 9 2010 8 2006 8 1999 7 1988 7 2003 6 2001 6 2000 5 2002 5 1998 5 1997 3 1996 3 1995 2 1994 2 1992 2 1984 2 1 2 1 2 Top Countries Publications USA 55 Germany 11 Japan 9 Switzerland 7 Canada 6 China 5 Australia 5 United Kingdom 5 Spain 4 South Korea 4 Netherlands 3 Poland 2 Czech Republic 2 France 2 Hungary 2 Italy 2 Norway 2 Austria 1 Romania 1 Denmark 1 1 2 1 2 3 4 5 Top Cities Publications Mainz 4 San Diego 4 Princeton 4 Seoul, South Korea 4 Columbia, MO, USA 3 Basel 3 Bethesda 3 Austin 3 Chicago 3 Barcelona 2 Prague 2 Berkeley 2 Durham 2 Mnster 2 Madison 2 Budapest, Hungary 2 East Lansing 2 Pasadena, CA, USA 2 Salt Lake City 2 Guangzhou 2 1 2 3 4 5 1 2 3 ... 6 Top Journals Publications P Natl Acad Sci Usa 8 Nature 4 Biomaterials 4 J Bacteriol 3 Tissue Eng 3 J Biol Chem 3 J Cell Physiol 3 Curr Opin Biotechnol 2 J Am Chem Soc 2 Birth Defects Res C Embryo Today 2 Tissue Eng Part A 2 In Vitro Cell Dev-an 2 Cancer Res 2 J Cell Sci 2 J Appl Genet 1 Physiol Res 1 Bmc Syst Biol 1 Febs J 1 Arthritis Rheum 1 J Theor Biol 1 1 2 3 ... 6 1 2 3 ... 115 Top Terms Publications Animals 80 Humans 53 Proteins 42 Genes 42 extracellular region 31 Tissues 31 Peptides 27 Nature 25 Extracellular Matrix 24 Mice 24 Cells, Cultured 24 signal transduction 22 extracellular matrix 21 Models, Biological 20 Membranes 19 membrane 19 Amino Acid Sequence 19 Cell Adhesion 19 Biology 18 Gene Expression 18 1 2 3 ... 115 1 2 3 ... 28 Top Authors Publications Mller W 3 Cho C 3 Seo S 3 Akaike T 3 Quinn T 3 Glinsky V 3 Glinsky G 3 Weber W 2 Schroeder H 2 Wiens M 2 Hubbell J 2 Zhou T 2 Basu S 2 Choi Y 2 Mossine V 2 Deutscher S 2 Nie Q 2 Lee D 1 Kiener H 1 Watts G 1 1 2 3 ... 28
《自然》杂志预测2011年科研热点 http://news.sciencenet.cn//htmlnews/2011/1/242378.shtm 丙肝治疗 包括丙肝治疗药物Telaprevir在内的多种药物获批是人们在2011年的迫切愿望之一。全球有3%的人感染了丙肝病毒，Telaprevir或将为他们带来希望。 New year, new science http://www.nature.com/news/2010/101231/full/469012a.html Hepatitis C treatment Eagerly anticipated drug approvals in 2011 include a decision by the US Food and Drug Administration on telaprevir, which could provide relief for the 3% of the world's population infected with the hepatitisC virus. The drug was developed by Vertex Pharmaceuticals in Cambridge, Massachusetts. http://www.gopubmed.org/web/gopubmed/1?WEB01lys5moqoa0ueI17I1xI00h001000j100200010 28,964 documents semantically analyzed 1 2 Top Years Publications 2010 2,063 2009 2,063 2005 2,048 2008 2,017 2007 2,007 2006 1,980 2004 1,907 2003 1,732 2002 1,606 2001 1,492 2000 1,434 1999 1,279 1998 1,101 1997 1,060 1995 946 1996 918 1994 782 1993 608 1992 487 1991 374 1 2 1 2 3 ... 8 Top Countries Publications USA 6,179 Japan 2,913 Italy 2,244 France 1,871 Spain 1,319 Germany 1,293 United Kingdom 1,042 Canada 599 China 558 Australia 533 Taiwan 453 Brazil 380 Netherlands 293 Switzerland 264 Turkey 247 Belgium 225 Sweden 222 India 211 Poland 204 Austria 185 1 2 3 ... 8 1 2 3 ... 76 Top Cities Publications Tokyo 620 Paris 521 London 495 New York City 466 Madrid 441 Barcelona 319 Rome 316 Los Angeles 282 Boston 278 Milan 278 Taipei 267 Osaka 243 Bethesda 231 San Francisco 229 Baltimore 199 Sydney 185 Seattle 179 Philadelphia 174 Atlanta 174 Naples 170 1 2 3 ... 76 1 2 3 ... 136 Top Journals Publications Hepatology 974 J Hepatol 845 Transplant P 572 Am J Gastroenterol 448 J Viral Hepatitis 434 J Med Virol 415 Liver Transpl 380 Gastroenterology 354 Transplantation 306 J Gastroen Hepatol 298 Gastroen Clin Biol 295 World J Gastroentero 276 Lancet 274 Nippon Rinsho 273 Digest Dis Sci 269 Aids 253 Hepato-gastroenterol 249 Gut 214 Clin Infect Dis 213 Transfusion 209 1 2 3 ... 136 1 2 3 ... 866 Top Terms Publications Hepatitis C 27,207 Humans 27,108 Hepatitis 25,780 Patients 18,472 Viruses 18,316 Hepacivirus 16,451 Hepatitis Viruses 14,799 Adult 11,495 Hepatitis C, Chronic 11,300 Middle Aged 10,938 Hepatitis, Chronic 10,215 Antiviral Agents 9,988 Interferons 8,293 Hepatitis B 5,756 Ribavirin 5,683 Fibrosis 5,458 Aged 5,143 Evaluation Studies as Topic 4,999 Interferon-alpha 4,946 Serum 4,891 1 2 3 ... 866
《自然》杂志预测2011年科研热点 http://news.sciencenet.cn//htmlnews/2011/1/242378.shtm 基因组测序大爆发 在2011年里，人类基因组测序所需花费无疑将有所下降。下一代基因测序仪器已开始投放市场，这将使得进行全测序的人类基因组数量节节攀升。 New year, new science http://www.nature.com/news/2010/101231/full/469012a.html Genome-sequencing explosion This year should surely see the price of human-genome sequencing dropping to US$1,000 per genome. As next-generation sequencing machines reach the market, the number of fully sequenced human genomes will skyrocket. http://www.gopubmed.org/web/gopubmed/1?WEB01lys5moqoa0ueIvI1I00h001000j100200010 5,874 documents semantically analyzed 1 2 Top Years Publications 2010 801 2009 563 2008 434 2007 412 2005 381 2006 373 2002 328 2004 323 2003 315 2001 315 2000 259 1998 206 1999 176 1997 173 1996 139 1995 120 1994 92 1991 87 1992 84 1993 74 1 2 1 2 3 4 5 Top Countries Publications USA 2,460 United Kingdom 456 Japan 373 Germany 361 China 282 France 234 Canada 172 Italy 106 Australia 103 Sweden 101 Netherlands 76 Spain 71 India 62 South Korea 56 Brazil 56 Denmark 54 Switzerland 46 Singapore 40 Taiwan 37 Israel 33 1 2 3 4 5 1 2 3 ... 36 Top Cities Publications Bethesda 220 Houston 143 Tokyo 112 Cambridge 111 London 100 St. Louis 100 Seattle 94 Baltimore 91 Boston 87 Paris 78 Beijing, China 77 Rockville 77 New York City 75 Los Angeles 73 San Francisco 65 San Diego 61 Shanghai, China 59 Cambridge, USA 57 Berlin, Germany 57 Heidelberg 55 1 2 3 ... 36 1 2 3 ... 67 Top Journals Publications Genome Res 241 Nucleic Acids Res 144 Genomics 136 J Virol 127 Nature 127 P Natl Acad Sci Usa 113 Science 102 Bmc Genomics 92 Gene 81 Plos One 80 Virology 78 Hum Mol Genet 74 J Gen Virol 62 Genome Biol 60 Am J Hum Genet 59 Bioinformatics 57 J Biol Chem 57 Nat Genet 54 Hum Mutat 53 J Clin Microbiol 51 1 2 3 ... 67 1 2 3 ... 893 Top Terms Publications Genome 5,081 Genomics 5,060 Humans 4,640 Genes 3,668 Genome, Human 2,634 DNA 2,573 Base Sequence 2,456 Animals 2,011 Proteins 1,636 Sequence Analysis, DNA 1,500 Polymerase Chain Reaction 1,292 Mutation 1,265 Chromosomes 1,209 Nucleotides 1,032 chromosome 886 Patients 863 Chromosome Mapping 843 Technology 836 Amino Acid Sequence 811 Viruses 785 1 2 3 ... 893 1 2 3 ... 1527 Top Authors Publications Gibbs R 43 Green E 38 Weinstock G 25 Hillier L 24 Eichler E 22 Venter J 22 Waterston R 21 Scherer S 21 Marra M 20 McPherson J 18 Lander E 18 Wilson R 16 Mardis E 16 Adams M 16 Lehrach H 16 NISC Comparative Sequencing Program 15 Metzker M 14 Ohara O 14 Rosenthal A 14 Hayashizaki Y 13 1 2 3 ... 1527
《自然》杂志预测2011年科研热点 http://news.sciencenet.cn//htmlnews/2011/1/242378.shtm 干细胞研究：整装待发 科学家知道如何将人体细胞重编程为诱导多功能干细胞（iPS cell），并将iPS细胞转化成为其他细胞类型。接下来，从病人体内获取的iPS细胞将更多地应用到医学研究模型、潜在药物的筛选以及为何现存药物只对部分病人有用的研究上。 New year, new science http://www.nature.com/news/2010/101231/full/469012a.html Stem cells: ready for study Researchers have learned how to reprogram people's cells into induced pluripotent stem (iPS) cells, and on from that into other cell types: skin cells can be turned into nerve cells, for example. Patient-derived iPS cells will increasingly be used as models for studying medical conditions particularly those, such as psychiatric disorders, for which there are no good animal models, and little understanding of what is happening inside cells. They will also be used to screen potential drugs, and to probe why existing drugs help some patients but not others. http://www.gopubmed.org/web/gopubmed/1?WEB01lys5moqoa0ueIuI1lI0 2,051 documents semantically analyzed 1 2 Top Years Publications 2010 821 2009 428 2008 195 2007 73 2006 59 2005 51 2004 46 2003 36 2002 30 2000 26 2001 24 1998 23 1996 20 1999 19 1991 16 1995 15 1997 14 1994 14 1993 13 1987 12 1 2 1 2 3 Top Countries Publications USA 724 Japan 265 China 130 Germany 127 United Kingdom 120 Canada 54 Spain 45 France 44 Italy 42 South Korea 35 Israel 34 Singapore 31 Australia 24 Netherlands 20 Sweden 18 Switzerland 16 Belgium 14 Taiwan 13 India 12 Iran 12 1 2 3 1 2 3 ... 20 Top Cities Publications Boston 65 Los Angeles 59 Kyoto 59 Tokyo 55 Cambridge, USA 41 New York City 35 London 32 Singapore, Singapore 31 Baltimore 30 San Francisco 28 Shanghai, China 28 Beijing, China 28 Cambridge 27 Toronto 25 Philadelphia 23 Seoul, South Korea 22 Barcelona 20 Berlin, Germany 19 Guangzhou 19 Stanford 19 1 2 3 ... 20 1 2 3 ... 31 Top Journals Publications Stem Cells 99 Cell Stem Cell 63 Nature 48 Plos One 45 Stem Cells Dev 44 J Biol Chem 41 Blood 41 Proc Natl Acad Sci U S A 35 Regen Med 30 Nat Biotechnol 27 Stem Cell Rev 26 Cell 23 J Cell Physiol 22 Exp Hematol 22 Curr Stem Cell Res Ther 22 Development 20 J Cell Biochem 20 Biochem Biophys Res Commun 20 Differentiation 20 Cell Res 18 1 2 3 ... 31 1 2 3 ... 432 Top Terms Publications Stem Cells 1,939 stem cell differentiation 1,890 stem cell development 1,889 Pluripotent Stem Cells 1,576 Animals 1,269 Humans 1,067 Embryonic Stem Cells 1,032 Mice 1,005 Cell Differentiation 973 Genes 711 Cell Line 552 Cells, Cultured 456 Transcription Factors 455 Tissues 441 Proteins 425 Fibroblasts 415 Adult 401 Gene Expression 322 generative cell differentiation 320 POU domain, class 5, transcription factor 1 320 1 2 3 ... 432 1 2 3 ... 397 Top Authors Publications Hescheler J 12 Yamanaka S 8 Benvenisty N 8 Wobus A 7 Jaenisch R 6 Hochedlinger K 6 Andrews P 6 Seidel H 6 Tai A 5 Daley G 5 Sato C 5 Mizuno H 5 Sauer H 5 Wartenberg M 5 Young H 5 Black A 5 Turhan A 5 Visani G 5 McBurney M 5 Izpisa-Belmonte J 4 1 2 3 ... 397
《自然》杂志预测2011年科研热点 http://news.sciencenet.cn//htmlnews/2011/1/242378.shtm New year, new science http://www.nature.com/news/2010/101231/full/469012a.html GWAS prove their worth Genome-wide association studies (GWAS) have uncovered plenty of links between diseases and particular regions of the genome, but frustratingly haven't revealed much about the biochemistry behind these associations. In 2011, expect to see real mechanistic insights explaining how genes, and non-coding regions, affect the medical conditions they have been linked with. Metabolism, obesity and diabetes are among the hottest targets. 全基因组关联研究（GWAS）的价值证明 GWAS已为我们揭示了各种疾病与基因特定区域之间存在大量的关联。不过让人泄气的是，GWAS还未能显示出太多在这些关联背后的生物化学信息。在2011年，我们希望能真正了解到，基因及非编码区域对那些与代谢、肥胖和糖尿病相关的医学条件产生影响的内在机制。 http://www.gopubmed.org/web/gopubmed/1?WEB1mOWEB10O00d000j10020001000h00100090000 6,981 documents semantically analyzed Top Years Publications 2010 2,841 2009 2,094 2008 832 2007 387 2006 209 2005 204 2004 104 2003 77 2002 65 2001 44 2000 38 2011 26 1999 24 1998 13 1996 6 1997 4 1995 2 1994 1 1993 1 1 2 3 4 Top Countries Publications USA 2,784 United Kingdom 821 Germany 378 Japan 368 China 286 Canada 232 Netherlands 221 Australia 173 France 131 Spain 122 Italy 117 Sweden 109 South Korea 80 Finland 70 Taiwan 61 Denmark 56 Hong Kong 49 Belgium 49 Norway 48 Greece 40 1 2 3 4 1 2 3 ... 32 Top Cities Publications Boston 334 London 218 Bethesda 160 Oxford, United Kingdom 135 Cambridge 128 Tokyo 125 Los Angeles 119 Baltimore 116 Seattle 84 Houston 83 Chicago 83 New York City 82 Philadelphia 74 Toronto 73 Brisbane 64 Shanghai, China 63 Beijing, China 62 San Francisco 60 Rotterdam 59 Montreal 59 1 2 3 ... 32 1 2 3 ... 61 Top Journals Publications Nat Genet 340 Hum Mol Genet 201 Plos One 195 Genet Epidemiol 160 Plos Genet 151 Eur J Hum Genet 118 Am J Hum Genet 112 Bmc Genet 111 Bmc Proc 100 Bmc Med Genet 96 Hum Genet 90 Bioinformatics 89 Diabetes 86 Am J Med Genet B Neuropsychiatr Genet 74 J Hum Genet 70 Nature 69 Mol Psychiatry 68 Proc Natl Acad Sci U S A 67 Bmc Genomics 63 Genes Immun 56 1 2 3 ... 61 1 2 3 ... 797 Top Terms Publications Humans 5,191 Genes 4,566 Polymorphism, Single Nucleotide 3,623 Genotype 2,908 Genetic Predisposition to Disease 2,509 Genomics 2,220 Genome 2,220 Alleles 2,017 Phenotype 1,604 Chromosomes 1,555 Nucleotides 1,450 Patients 1,354 Adult 1,251 Genome, Human 1,217 Middle Aged 1,200 chromosome 1,194 Case-Control Studies 1,162 Variation (Genetics) 1,146 Risk Factors 1,029 Gene Frequency 985 1 2 3 ... 797 1 2 3 ... 2308 Top Authors Publications Daly M 25 Bouchard C 21 Cardon L 19 McCarthy M 18 Ioannidis J 17 Boerwinkle E 16 Rankinen T 15 Van Duijn C 14 Kraft P 14 Wijmenga C 14 Rao D 14 Prusse L 14 Hebebrand J 13 Cupples L 13 Stefansson K 12 Todd J 12 Morris A 12 Groop L 12 Schreiber S 12 Boomsma D 11 1 2 3 ... 2308
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