来自日本学者的研究发现，喂 20 ％的直链玉米淀粉可以促进肠道氢的产生，预防肝脏缺血引起的转氨酶增加。该论文最近发表在 Bioscience of Microbiota, Food and Health 。 全文： Bioscience of Microbiota, Food and Health Vol. 31 (4), 103_108, 2012 .pdf 本研究目的是观察喂高氢抗性淀粉对亚急性肝缺血再灌注损伤的保护作用。大鼠饲喂 20 ％的高直链玉米淀粉（ HAS ）或普通饮食对照 14 天。于第 12 天，制备肝脏 30 分钟缺血 45 分钟再灌注模型（这个研究显然有预防的目的和成分）。和对照组相比，喂高直链玉米淀粉的动物门静脉氢器浓度显著增加。缺血引起的血浆中丙氨酸转移酶和天门冬氨酸氨基转移酶增加受到明显抑制。结果表明，促进肠道细菌氢气产生的抗性淀粉对肝脏缺血有显著的预防效果。这一研究提示，高直链玉米淀粉可以作为一种诱导氢产生的健康食品成分。对各种氢气有效的疾病具有潜在的预防价值。 评价：该研究中和氧化应激相关的指标没有发现明显改变，特别是没有针对肝脏组织进行形态学观察是非常不够的。作为氢效应研究的模式，连续喂食对肝脏缺血的预防，从道理上并不是非常合理的设计。 采用灵敏的氢检测仪器，对各类可能影响氢产生的食品进行筛选，或许可以寻找到一类可以促进健康的保健食品。例如含甘露醇很高的冬虫夏草和海带，经过变性处理的淀粉，大豆中的寡聚糖等等。 We examined whether feeding high hydrogen generating resistant starch could suppress subacute hepatic ischemiareperfusion injury. Rats were fed a control diet with or without 20% high amylose cornstarch (HAS) supplementation for 14 days. On day 12, rats were subject to ischemia-reperfusion treatment. Portal hydrogen concentration was higher in the HAS group compared with the control group. Increased plasma alanine and aspartate aminotransferase activities due to ischemiareperfusion treatment tended to decrease, and a significant reduction was observed by HAS feeding when compared with the control group. In conclusion, HAS, which enhances hydrogen generation in the hindgut, alleviated subacute hepatic ischemia-reperfusion injury.
标签: 肝功能
