http://blogs.sciencemag.org/scienceinsider/2009/11/a-plea-for-stud.html November 17, 2009 Should NIH Study Conflicts of Interest More? by Jocelyn Kaiser A new group is adding its voice to the furor over the influence of drug money on medical research and practice, saying there should be more money to study the problem. In a letter today to National Institutes of Health Director Francis Collins, 100 physicians, medical ethicists, and others call for funding: The recent disclosure of ghostwritten articles, physician payoffs, and the use of academic opinion leaders to increase markets for FDA-regulated products indicate that ethical lapses may permeate biomedical research. ... In your role as the director of the steward of medical and behavioral research for the Nation, we ask that you acknowledge the research gap on the effect of conflicts of interest and commercial influence on medical decisionmaking ... Between bench and bedside lies a path treacherous with ethical quandaries. NIH is the best place to launch and support a scientifically rigorous inquiry into the state of research ethics, industry-academic relationships, and the effect of these relationships on human health. There is currently no identifiable mechanism through which NIH would fund this research. The messagewe want more money for our researchseems self-serving, and it's not as though NIH doesn't fund anything in this area already. (For example, NIH grants have supported surveys of academics about their industry funding.) But Georgetown University physician Adriane Fugh-Berman, who heads a group called Pharmed Out that spearheaded the letter, says NIH tends to reject grant applications on topics such as ghostwriting and industry funding for medical education. I think that NIH has thought that it doesn't comes under their domain, and the trouble is that it doesn't come under anybody's domain, she says. The letter's signatories show that diverse voices have come together to speak out on the issue. The list includes psychiatrists, current and former journal editors, ethicists (including Lisa Bero of the University of California, San Francisco, who studies the influence of drug money on research), patient and consumer advocates, medical students, and Susan Wood, an FDA official who quit over meddling in science by the Bush Administration. Pharmed Out is funded from a 2004 legal settlement involving Pfizer's marketing of a drug. The letter ask for a face-to-face meeting with Collins. Stay tuned. 作者：梅进 来源：科学网 www.sciencenet.cn 发布时间：2009-11-19 13:13:03选择字号：小 中 大 NIH被要求加大科研伦理研究资助 11月17日，一个由100多名科学家、医师、医学伦理学者和期刊编辑组成的群体联名致信美国国立卫生研究院（NIH）院长Francis Collins，力促NIH资助更多针对类似代笔（ghostwriting）和产业资助等问题的研究， 信中说：近来曝光的代笔文章、医师不正当收入以及利用学术意见增加FDA管制产品的市场等现象，显示道德沦丧可能渗透进了生物医学研究我们要求你承认，在利益冲突和商业因素影响医学决策方面存在研究缺口NIH是发起和支持科学严格质询的最佳机构，来调查研究伦理和产研关系现状，以及这些关系对于人类健康的影响。因为当前不存在任何机制使NIH能够资助这类研究。（科学网 梅进/编译） 更多阅读 《科学》网站相关报道（英文）
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