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肠道微生物协助抵御耐药病原菌
2019-08-22 13:09

美国纪念斯隆凯特林癌症研究中心Eric G. Pamer研究组发现微生物菌群产生的羊毛硫细菌素能够重新恢复对耐万古霉素肠球菌的抗性。这一研究成果于2019年8月22日在线发表在《自然》上。

研究人员发现,BPSCSK通过分泌羊毛硫细菌素(类似于乳酸乳球菌产生的乳链菌肽-A)来减少VRE的生长。尽管体外BPSCSK和乳酸乳球菌抑制了VRE的生长,但只有BPSCSK在结肠中定殖才能降低体内VRE密度。与乳链菌肽-A相比,BPSCSK羊毛硫细菌素抑制肠道共生菌的活性更低。在VRE感染高风险的患者中,高丰度的羊毛硫细菌素基因与粪肠球菌密度降低有关。在移植患者来源的粪便的无菌小鼠中,对VRE定植的抗性与羊毛硫细菌素基因的丰度相关。因此,产生羊毛硫细菌素的共生胃肠道菌株能够减少VRE定植并作为潜在的益生菌剂以重建对VRE的抗性。

据悉,肠道共生细菌可以抑制耐万古霉素粪肠球菌(VRE)在肠道的致密定植,VRE是医院获得性感染的主要原因。含有Blautia producta BPSCSK的四联共生细菌可逆转抗生素引起VRE感染的易感性。

附:英文原文

Title: Microbiota-derived lantibiotic restores resistance against vancomycin-resistant Enterococcus

Author:ohn G. Kim, Simone Becattini, Thomas U. Moody, Pavel V. Shliaha, Eric R. Littmann, Ruth Seok, Mergim Gjonbalaj, Vincent Eaton, Emily Fontana, Luigi Amoretti, Roberta Wright, Silvia Caballero, Zhong-Min X. Wang, Hea-Jin Jung, Sejal M. Morjaria, Ingrid M. Leiner, Weige Qin, Ruben J. J. F. Ramos, Justin R. Cross, Seiko Narushima, Kenya Honda, Jonathan U. Peled, Ronald C. Hendrickson, Ying Taur, Marcel R. M. van den Brink, Eric G. Pamer

Issue&Volume: 2019-08-21

Abstract: Intestinal commensal bacteria can inhibit dense colonization of the gut by vancomycin-resistant Enterococcus faecium (VRE), a leading cause of hospital-acquired infections1,2. A four-strained consortium of commensal bacteria that contains Blautia producta BPSCSK can reverse antibiotic-induced susceptibility to VRE infection3. Here we show that BPSCSK reduces growth of VRE by secreting a lantibiotic that is similar to the nisin-A produced by Lactococcus lactis. Although the growth of VRE is inhibited by BPSCSK and L. lactis in vitro, only BPSCSK colonizes the colon and reduces VRE density in vivo. In comparison to nisin-A, the BPSCSK lantibiotic has reduced activity against intestinal commensal bacteria. In patients at high risk of VRE infection, high abundance of the lantibiotic gene is associated with reduced density of E. faecium. In germ-free mice transplanted with patient-derived faeces, resistance to VRE colonization correlates with abundance of the lantibiotic gene. Lantibiotic-producing commensal strains of the gastrointestinal tract reduce colonization by VRE and represent potential probiotic agents to re-establish resistance to VRE.

DOI: 10.1038/s41586-019-1501-z

Source:https://www.nature.com/articles/s41586-019-1501-z

Nature:《自然》,创刊于1869年。隶属于施普林格·自然出版集团,最新IF:43.07
官方网址:http://www.nature.com/
投稿链接:http://www.nature.com/authors/submit_manuscript.html


本期文章:《自然》:Online/在线发表

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