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基因转录的组织与调控研究综述
2019-08-29 15:37

德国马克斯·普朗克生物物理化学研究所Patrick Cramer就基因转录的组织与调控研究撰写了综述。相关综述2019年8月28日在线发表于《自然》。

作者表示,基因的转录调控决定细胞的身份和功能。最近的结构学研究已经阐明了在起始和延伸阶段期间RNA聚合酶介导的转录调节机制。显微镜观察到的结果表明,转录涉及细胞核内因子的浓缩。

作者称,一种编码蛋白基因的转录模型逐渐成型,在这个模型中不同的短暂浓缩物在基因启动子和基因体中形成,从而分别浓缩转录起始和延伸所需的因子。转录酶RNA聚合酶II可以以磷酸化依赖的方式在这些浓缩物之间穿梭。新的分子原则正在被定义,这将使转录组织和调节变得更合理,这也将指导未来的研究。

附:英文原文

Title: Organization and regulation of gene transcription

Author: Patrick Cramer

Issue&Volume: 2019-08-28

Abstract: The regulated transcription of genes determines cell identity and function. Recent structural studies have elucidated mechanisms that govern the regulation of transcription by RNA polymerases during the initiation and elongation phases. Microscopy studies have revealed that transcription involves the condensation of factors in the cell nucleus. A model is emerging for the transcription of protein-coding genes in which distinct transient condensates form at gene promoters and in gene bodies to concentrate the factors required for transcription initiation and elongation, respectively. The transcribing enzyme RNA polymerase II may shuttle between these condensates in a phosphorylation-dependent manner. Molecular principles are being defined that rationalize transcriptional organization and regulation, and that will guide future investigations.

DOI: 10.1038/s41586-019-1517-4

Source: https://www.nature.com/articles/s41586-019-1517-4

Nature:《自然》,创刊于1869年。隶属于施普林格·自然出版集团,最新IF:43.07
官方网址:http://www.nature.com/
投稿链接:http://www.nature.com/authors/submit_manuscript.html


本期文章:《自然》:Online/在线发表

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