小柯机器人

美国费城儿童医院Mariko L. Bennett对环境和起源对驻留于大脑的巨噬细胞的影响及其治疗意义进行了综述。该文章12月2号在线发表在国际学术期刊《自然—神经科学》上。

小胶质细胞是大脑和脊髓的组织内巨噬细胞。它们对中枢神经系统发育、正常功能和退化都很重要。与传统单核细胞衍生的巨噬细胞不同，小胶质细胞来源于胚胎卵黄囊造血祖细胞，并在整个生命过程中自我更新。小胶质细胞在组织驻留巨噬细胞中也具有独特的遗传特征。 最近的研究确定了大脑内环境和发育史对小胶质细胞转录组的影响。在这篇综述中，研究人员介绍了这些文献，并讨论了起源对小胶质细胞功能的潜在影响，特别是使用骨髓或干细胞来源的细胞治疗神经系统疾病的现有和未来疗法。

附：英文原文

Title: The influence of environment and origin on brain resident macrophages and implications for therapy

Author: Mariko L. Bennett, F. Chris Bennett

Issue&Volume: 2019-12-02

Abstract: Microglia are the tissue-resident macrophages of the brain and spinal cord. They are critical players in the development, normal function, and decline of the CNS. Unlike traditional monocyte-derived macrophages, microglia originate from primitive hematopoiesis in the embryonic yolk sac and self-renew throughout life. Microglia also have a unique genetic signature among tissue resident macrophages. Recent studies identify the contributions of both brain environment and developmental history to the transcriptomic identity of microglia. Here we review this emerging literature and discuss the potential implications of origin on microglial function, with particular focus on existing and future therapies using bone-marrow- or stem-cell-derived cells for the treatment of neurological diseases.

DOI: 10.1038/s41593-019-0545-6

Source: https://www.nature.com/articles/s41593-019-0545-6

Nature Neuroscience：《自然—神经科学》，创刊于1998年。隶属于施普林格·自然出版集团，最新IF：28.771
官方网址：https://www.nature.com/neuro/
投稿链接：https://mts-nn.nature.com/cgi-bin/main.plex