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科学家探讨HIV治疗实施的未来规划
2019-12-19 16:06

美国加州大学旧金山分校Steven G. Deeks等研究人员对HIV治疗的现状和未来规划进行了讨论。相关综述论文2019年12月18日在线发表在《自然》上。

研究人员回顾了为什么以及在哪里需要治疗,以及如何实现。研究人员主张将这些努力从资源丰富的地区扩展到撒哈拉以南非洲及其他地区:为了使干预措施产生效果,必须解决特定地区的生物、治疗和实施问题。

据介绍,尽管全球进行了大量投资,但目前只有60%的HIV感染者接受了抗逆转录病毒疗法。当前计划的可持续性仍然未知,关键发病率仅适度下降。考虑到终生用药的复杂性和费用,开发有效的治疗性干预措施现在已成为全球优先事项。

附:英文原文

Title: Why and where an HIV cure is needed and how it might be achieved

Author: Thumbi Ndungu, Joseph M. McCune, Steven G. Deeks

Issue&Volume: 2019-12-18

Abstract: Despite considerable global investment, only 60% of people who live with HIV currently receive antiretroviral therapy. The sustainability of current programmes remains unknown and key incidence rates are declining only modestly. Given the complexities and expenses associated with lifelong medication, developing an effective curative intervention is now a global priority. Here we review why and where a cure is needed, and how it might be achieved. We argue for expanding these efforts from resource-rich regions to sub-Saharan Africa and elsewhere: for any intervention to have an effect, region-specific biological, therapeutic and implementation issues must be addressed. Current barriers and limitations to HIV treatments are reviewed, and suggestions for future steps to achieve an effective curative intervention are discussed.

DOI: 10.1038/s41586-019-1841-8

Source:https://www.nature.com/articles/s41586-019-1841-8

Nature:《自然》,创刊于1869年。隶属于施普林格·自然出版集团,最新IF:43.07
官方网址:http://www.nature.com/
投稿链接:http://www.nature.com/authors/submit_manuscript.html


本期文章:《自然》:Online/在线发表

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