小柯机器人

靶向微生物群的母源抗体可保护新生儿免受肠道感染
2020-01-10 14:35

美国哈佛医学院Dennis L. Kasper研究团队发现,靶向微生物群的母源抗体可保护新生儿免受肠道感染。相关论文于2020年1月8日在线发表于国际学术期刊《自然》。

研究人员发现,当抗体通过胎盘或通过母乳传递时,针对母体微生物群的母体天然IgG抗体,可以保护缺乏产生IgG能力的新生小鼠免受肠道病原体肠毒素性大肠杆菌的感染。通过感染由母源抗体充足或抗体不足母体培育的幼崽,研究人员发现,母乳来源的IgG对于预防由产肠毒素的大肠杆菌诱导的粘膜疾病至关重要。IgG还提供针对大肠杆菌的全身感染的保护作用。幼崽使用新生儿Fc受体将IgG从牛奶转移到血清中。母鼠共生菌群可以诱导识别由产肠毒素的大肠杆菌和其他肠杆菌科细菌表达的抗原的抗体。抵抗共生泛菌属的母源抗体可保护幼崽抵抗肠毒素的大肠杆菌。微生物群能够引发针对特定新生儿病原体的保护性抗体,这种作用代表了新生儿中抵御感染的重要宿主防御机制。

据了解,尽管母源抗体可保护新生婴儿免受感染,但人们对如何在未事先接触病原体的情况下诱导保护性抗体知之甚少。

附:英文原文

Title: Microbiota-targeted maternal antibodies protect neonates from enteric infection

Author: Wen Zheng, Wenjing Zhao, Meng Wu, Xinyang Song, Florence Caro, Ximei Sun, Francesca Gazzaniga, Giuseppe Stefanetti, Sungwhan Oh, John J. Mekalanos, Dennis L. Kasper

Issue&Volume: 2020-01-08

Abstract: Although maternal antibodies protect newborn babies from infection1,2, little is known about how protective antibodies are induced without prior pathogen exposure. Here we show that neonatal mice that lack the capacity to produce IgG are protected from infection with the enteric pathogen enterotoxigenic Escherichia coli by maternal natural IgG antibodies against the maternal microbiota when antibodies are delivered either across the placenta or through breast milk. By challenging pups that were fostered by either maternal antibody-sufficient or antibody-deficient dams, we found that IgG derived from breast milk was crucial for protection against mucosal disease induced by enterotoxigenic E. coli. IgG also provides protection against systemic infection by E. coli. Pups used the neonatal Fc receptor to transfer IgG from milk into serum. The maternal commensal microbiota can induce antibodies that recognize antigens expressed by enterotoxigenic E. coli and other Enterobacteriaceae species. Induction of maternal antibodies against a commensal Pantoea species confers protection against enterotoxigenic E. coli in pups. This role of the microbiota in eliciting protective antibodies to a specific neonatal pathogen represents an important host defence mechanism against infection in neonates. Neonatal mice are protected against infection with the enteric pathogen enterotoxigenic Escherichia coli by maternally derived natural antibodies as well as by maternal commensal microbiota that induce antibodies that recognize antigens expressed by  Enterobacteriaceae.

DOI: 10.1038/s41586-019-1898-4

Source:https://www.nature.com/articles/s41586-019-1898-4

 

Nature:《自然》,创刊于1869年。隶属于施普林格·自然出版集团,最新IF:43.07
官方网址:http://www.nature.com/
投稿链接:http://www.nature.com/authors/submit_manuscript.html


本期文章:《自然》:Online/在线发表

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