小柯机器人

美国科罗拉多大学博尔德分校Roy Parker团队的一项最新研究发现，DEAD-Box蛋白eIF4A调节RNA凝集。相关论文2020年1月9日在线发表在《细胞》上。

据了解，应激颗粒是参与应激反应和神经退行性疾病的非翻译mRNA和蛋白质的凝集物。

附：英文原文

Title: Modulation of RNA Condensation by the DEAD-Box Protein eIF4A

Author: Devin Tauber, Gabriel Tauber, Anthony Khong, Briana Van Treeck, Jerry Pelletier, Roy Parker

Issue&Volume: January 9, 2020

Abstract: Stress granules are condensates of non-translating mRNAs and proteins involved inthe stress response and neurodegenerative diseases. Stress granules form in part throughintermolecular RNA-RNA interactions, and to better understand how RNA-based condensationoccurs, we demonstrate that RNA is effectively recruited to the surfaces of RNA orRNP condensates in vitro. We demonstrate that, through ATP-dependent RNA binding, the DEAD-box protein eIF4Areduces RNA condensation in vitro and limits stress granule formation in cells. This defines a function for eIF4A tolimit intermolecular RNA-RNA interactions in cells. These results establish an importantrole for eIF4A, and potentially other DEAD-box proteins, as ATP-dependent RNA chaperonesthat limit the condensation of RNA, analogous to the function of proteins like HSP70in combatting protein aggregates.

DOI: 10.1016/j.cell.2019.12.031

Source: https://www.cell.com/cell/fulltext/S0092-8674(19)31393-5