小柯机器人

信息素darcin引发固有和强化行为的神经回路
2020-02-10 09:54

美国哥伦比亚大学Richard Axel、冷泉港实验室Adam Kepecs等研究人员合作发现,信息素darcin引发固有和强化行为的神经回路。这一研究成果于2020年1月29日在线发表在国际学术期刊《自然》上。

研究人员发现,darcin引发了许多复杂且变化多端的行为,包括吸引力、超声波发声和尿液气味标记,并且还充当了学习范式的增强因素。研究人员确定了一个遗传鉴定的回路,即从嗅球延伸到杏仁核后内侧,这是对darcin的所有行为反应所必需的。此外,内侧杏仁核中darcin反应性神经元的光学活化可诱导信息素引起的先天性和条件性行为。这些神经元定义了一个区域分离的群体,其表达神经元的一氧化氮合成酶。研究人员认为,这一darcin激活的神经回路将信息素信息与内部状态整合在一起,从而引发变化的先天行为和强化行为,这可能会促进伴侣相遇与选择。
 
据悉,生物已经进化出多种行为策略,从而增加了遇到和评估伴侣的可能性。许多物种使用信息素传达有关潜在伴侣的位置、性别和社会地位的信息。在小鼠中,主要的尿蛋白darcin(存在于雄性的尿液中)提供了一种气味标记的成分,其可引起雌性接近并引起学习。
 
附:英文原文

Title: The pheromone darcin drives a circuit for innate and reinforced behaviours

Author: Ebru Demir, Kenneth Li, Natasha Bobrowski-Khoury, Joshua I. Sanders, Robert J. Beynon, Jane L. Hurst, Adam Kepecs, Richard Axel

Issue&Volume: 2020-01-29

Abstract: Organisms have evolved diverse behavioural strategies that enhance the likelihood of encountering and assessing mates1. Many species use pheromones to communicate information about the location, sexual and social status of potential partners2. In mice, the major urinary protein darcin—which is present in the urine of males—provides a component of a scent mark that elicits approach by females and drives learning3,4. Here we show that darcin elicits a complex and variable behavioural repertoire that consists of attraction, ultrasonic vocalization and urinary scent marking, and also serves as a reinforcer in learning paradigms. We identify a genetically determined circuit—extending from the accessory olfactory bulb to the posterior medial amygdala—that is necessary for all behavioural responses to darcin. Moreover, optical activation of darcin-responsive neurons in the medial amygdala induces both the innate and the conditioned behaviours elicited by the pheromone. These neurons define a topographically segregated population that expresses neuronal nitric oxide synthase. We suggest that this darcin-activated neural circuit integrates pheromonal information with internal state to elicit both variable innate behaviours and reinforced behaviours that may promote mate encounters and mate selection.

DOI: 10.1038/s41586-020-1967-8

Source: https://www.nature.com/articles/s41586-020-1967-8

Nature:《自然》,创刊于1869年。隶属于施普林格·自然出版集团,最新IF:43.07
官方网址:http://www.nature.com/
投稿链接:http://www.nature.com/authors/submit_manuscript.html


本期文章:《自然》:Online/在线发表

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