小柯机器人

2020年2月6日，《细胞》在线发表了美国杰克逊实验室Julia Oh研究组的最新成果，他们发现，宿主特异性的进化和传播动态塑造了人类皮肤中表皮葡萄球菌的功能多样化。

Title: Host-Specific Evolutionary and Transmission Dynamics Shape the Functional Diversification of Staphylococcus epidermidis in Human Skin

Author: Wei Zhou, Michelle Spoto, Rachel Hardy, Changhui Guan, Elizabeth Fleming, Peter J. Larson, Joseph S. Brown, Julia Oh

Issue&Volume: January 30, 2020

Abstract: Metagenomic inferences of bacterial strain diversity and infectious disease transmissionstudies largely assume a dominant, within-individual haplotype. We hypothesize thatwithin-individual bacterial population diversity is critical for homeostasis of ahealthy microbiome and infection risk. We characterized the evolutionary trajectoryand functional distribution of Staphylococcus epidermidis—a keystone skin microbe and opportunistic pathogen. Analyzing 1,482 S. epidermidis genomes from 5 healthy individuals, we found that skin S. epidermidis isolates coalesce into multiple founder lineages rather than a single colonizer.Transmission events, natural selection, and pervasive horizontal gene transfer resultin population admixture within skin sites and dissemination of antibiotic resistancegenes within-individual. We provide experimental evidence for how admixture can modulatevirulence and metabolism. Leveraging data on the contextual microbiome, we assesshow interspecies interactions can shape genetic diversity and mobile gene elements.Our study provides insights into how within-individual evolution of human skin microbesshapes their functional diversification.

DOI: 10.1016/j.cell.2020.01.006

Source: https://www.cell.com/cell/fulltext/S0092-8674(20)30053-2