小柯机器人

德国科隆大学Matteo Bergami、马克斯普朗克衰老生物学研究所 Elisa Motori等研究人员合作发现，反应性星形胶质细胞中的线粒体-内质网接触促进血管重塑。这一研究成果于2020年3月26日在线发表在国际学术期刊《细胞—代谢》上。

Title: Mitochondria-Endoplasmic Reticulum Contacts in Reactive Astrocytes Promote Vascular Remodeling

Author: Jana Gbel, Esther Engelhardt, Patric Pelzer, Vignesh Sakthivelu, Hannah M. Jahn, Milica Jevtic, Kat Folz-Donahue, Christian Kukat, Astrid Schauss, Christian K. Frese, Patrick Giavalisco, Alexander Ghanem, Karl-Klaus Conzelmann, Elisa Motori, Matteo Bergami

Issue&Volume: 2020-03-26

Abstract: Astrocytes have emerged for playing important roles in brain tissue repair; however,the underlying mechanisms remain poorly understood. We show that acute injury andblood-brain barrier disruption trigger the formation of a prominent mitochondrial-enrichedcompartment in astrocytic endfeet, which enables vascular remodeling. Integrated imagingapproaches revealed that this mitochondrial clustering is part of an adaptive responseregulated by fusion dynamics. Astrocyte-specific conditional deletion of Mitofusin2 (Mfn2) suppressed perivascular mitochondrial clustering and disrupted mitochondria-endoplasmicreticulum (ER) contact sites. Functionally, two-photon imaging experiments showedthat these structural changes were mirrored by impaired mitochondrial Ca2+ uptake leading to abnormal cytosolic transients within endfeet in vivo. At the tissue level, a compromised vascular complexity in the lesioned area wasrestored by boosting mitochondrial-ER perivascular tethering in MFN2-deficient astrocytes.These data unmask a crucial role for mitochondrial dynamics in coordinating astrocyticlocal domains and have important implications for repairing the injured brain.

DOI: 10.1016/j.cmet.2020.03.005

Source: https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30120-0

Cell Metabolism：《细胞—代谢》，创刊于2005年。隶属于细胞出版社，最新IF：31.373
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