小柯机器人

荷兰癌症研究所Christian U. Blank等研究人员对新辅助检查点阻断的临床试验进行了展望性讨论。这一论文于2020年4月9日在线发表于《自然—医学》。

Title: Learning from clinical trials of neoadjuvant checkpoint blockade

Author: Judith M. Versluis, Georgina V. Long, Christian U. Blank

Issue&Volume: 2020-04-09

Abstract: Neoadjuvant checkpoint inhibition, in which the therapy is administered before surgery, is a promising new approach to managing bulky but resectable melanoma, and is also being explored in other cancers. This strategy has a high pathologic response rate, which correlates with survival outcomes. The fact that biopsies are routinely available provides a unique opportunity for understanding the responses to therapy and carrying out reverse translation in which these data are used to select therapies in the clinic or in trials that are more likely to improve patient outcomes. In this Perspective, we discuss the rationale for neoadjuvant immunotherapy in resectable solid tumors based on preclinical and human translational data, summarize the results of recent clinical trials and ongoing research, and focus on future directions for enhancing reverse translation.

DOI: 10.1038/s41591-020-0829-0

Source: https://www.nature.com/articles/s41591-020-0829-0

Nature Medicine：《自然—医学》，创刊于1995年。隶属于施普林格·自然出版集团，最新IF：87.241
官方网址：https://www.nature.com/nm/
投稿链接：https://mts-nmed.nature.com/cgi-bin/main.plex