小柯机器人

近日，美国加州大学圣地亚哥分析Mark H. Tuszynski、Gunnar H. D. Poplawski等研究人员合作发现，损伤的成年神经元能够退化为胚胎转录生长状态。相关论文于2020年4月15日在线发表于国际学术期刊《自然》。

Title: Injured adult neurons regress to an embryonic transcriptional growth state

Author: Gunnar H. D. Poplawski, Riki Kawaguchi, Erna Van Niekerk, Paul Lu, Neil Mehta, Philip Canete, Richard Lie, Ioannis Dragatsis, Jessica M. Meves, Binhai Zheng, Giovanni Coppola, Mark H. Tuszynski

Issue&Volume: 2020-04-15

Abstract: Grafts of spinal-cord-derived neural progenitor cells (NPCs) enable the robust regeneration of corticospinal axons and restore forelimb function after spinal cord injury1; however, the molecular mechanisms that underlie this regeneration are unknown. Here we perform translational profiling specifically of corticospinal tract (CST) motor neurons in mice, to identify their ‘regenerative transcriptome’ after spinal cord injury and NPC grafting. Notably, both injury alone and injury combined with NPC grafts elicit virtually identical early transcriptomic responses in host CST neurons. However, in mice with injury alone this regenerative transcriptome is downregulated after two weeks, whereas in NPC-grafted mice this transcriptome is sustained. The regenerative transcriptome represents a reversion to an embryonic transcriptional state of the CST neuron. The huntingtin gene (Htt) is a central hub in the regeneration transcriptome; deletion of Htt significantly attenuates regeneration, which shows that Htt has a key role in neural plasticity after injury.

DOI: 10.1038/s41586-020-2200-5

Source: https://www.nature.com/articles/s41586-020-2200-5

Nature：《自然》，创刊于1869年。隶属于施普林格·自然出版集团，最新IF：69.504
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