小柯机器人

美国圣裘德儿童研究医院Thirumala-Devi Kanneganti研究组的一项最新工作表明，半胱氨酸蛋白酶6是先天免疫、炎症激活和宿主防御的关键调节因子。2020年4月15日，国际知名学术期刊《细胞》在线发表了这一成果。

Title: Caspase-6 Is a Key Regulator of Innate Immunity, Inflammasome Activation, and Host Defense

Author: Min Zheng, Rajendra Karki, Peter Vogel, Thirumala-Devi Kanneganti

Issue&Volume: 2020-04-15

Abstract: Caspases regulate cell death, immune responses, and homeostasis. Caspase-6 is categorizedas an executioner caspase but shows key differences from the other executioners. Overall,little is known about the functions of caspase-6 in biological processes apart fromapoptosis. Here, we show that caspase-6 mediates innate immunity and inflammasomeactivation. Furthermore, we demonstrate that caspase-6 promotes the activation ofprogrammed cell death pathways including pyroptosis, apoptosis, and necroptosis (PANoptosis)and plays an essential role in host defense against influenza A virus (IAV) infection.In addition, caspase-6 promoted the differentiation of alternatively activated macrophages(AAMs). Caspase-6 facilitated the RIP homotypic interaction motif (RHIM)-dependentbinding of RIPK3 to ZBP1 via its interaction with RIPK3. Altogether, our findingsreveal a vital role for caspase-6 in facilitating ZBP1-mediated inflammasome activation,cell death, and host defense during IAV infection, opening additional avenues fortreatment of infectious and autoinflammatory diseases and cancer.

DOI: 10.1016/j.cell.2020.03.040

Source: https://www.cell.com/cell/fulltext/S0092-8674(20)30333-0