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视网膜神经可影响食物摄入信号
2020-04-23 14:26

美国国立卫生研究院Samer Hattar、Diego Carlos Fernandez等研究人员合作发现,视网膜神经可影响食物摄入信号。这一研究成果于2020年4月22日在线发表在《自然》上。

研究人员测试了视网膜输入是否调节了对非光信号的传输,例如限时喂养。通过固有的光敏性视网膜神经节细胞(ipRGCs),光信息传递到视交叉上核(SCN)–中央昼夜节律起搏器–以及脉间小叶(IGL)。

研究人员发现,从出生后早期阶段缺乏ipRGCs的成年小鼠对限时进食的传输能力受损,而在后期阶段ipRGCs的敲除则没有效果。产后早期的ipRGC神经分布会影响表达神经肽Y(NPY)的IGL神经元(以下简称IGLNPY神经元),并指导功能性IGLNPY-SCN回路的构建。

此外,在成年小鼠中使IGLNPY神经元沉默可模仿出生后早期ipRGC敲除产生的缺陷,而SCN中IGLNPY末端的急性抑制降低了食物预期活力。因此,在产后早期对ipRGCs的神经分布可以调节IGLNPY-SCN回路,从而可以影响限时进食。

据介绍,光照和食物供应量的每日变化是影响昼夜节律的主要时间线索。然而,对于将这些时间信息如何整合从而影响昼夜节律的回路知之甚少。

附:英文原文

Title: Retinal innervation tunes circuits that drive nonphotic entrainment to food

Author: Diego Carlos Fernandez, Ruchi Komal, Jennifer Langel, Jun Ma, Phan Q. Duy, Mario A. Penzo, Haiqing Zhao, Samer Hattar

Issue&Volume: 2020-04-22

Abstract: Daily changes in light and food availability are major time cues that influence circadian timing1. However, little is known about the circuits that integrate these time cues to drive a coherent circadian output1,2,3. Here we investigate whether retinal inputs modulate entrainment to nonphotic cues such as time-restricted feeding. Photic information is relayed to the suprachiasmatic nucleus (SCN)—the central circadian pacemaker—and the intergeniculate leaflet (IGL) through intrinsically photosensitive retinal ganglion cells (ipRGCs)4. We show that adult mice that lack ipRGCs from the early postnatal stages have impaired entrainment to time-restricted feeding, whereas ablation of ipRGCs at later stages had no effect. Innervation of ipRGCs at early postnatal stages influences IGL neurons that express neuropeptide Y (NPY) (hereafter, IGLNPY neurons), guiding the assembly of a functional IGLNPY–SCN circuit. Moreover, silencing IGLNPY neurons in adult mice mimicked the deficits that were induced by ablation of ipRGCs in the early postnatal stages, and acute inhibition of IGLNPY terminals in the SCN decreased food-anticipatory activity. Thus, innervation of ipRGCs in the early postnatal period tunes the IGLNPY–SCN circuit to allow entrainment to time-restricted feeding.

DOI: 10.1038/s41586-020-2204-1

Source: https://www.nature.com/articles/s41586-020-2204-1

Nature:《自然》,创刊于1869年。隶属于施普林格·自然出版集团,最新IF:69.504
官方网址:http://www.nature.com/
投稿链接:http://www.nature.com/authors/submit_manuscript.html


本期文章:《自然》:Online/在线发表

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