小柯机器人

炎性2型cDC可获得cDC1和巨噬细胞的特征
2020-05-12 13:44
来源：小柯机器人

比利时根特大学Bart N. Lambrecht、Martin Guilliams等研究人员合作发现，炎性2型cDC获得cDC1和巨噬细胞的特征来协调免疫呼吸道病毒感染的能力。 该项研究成果于2020年5月8日在线发表在《免疫》杂志上。

研究人员表示，IRF8+1型和IRF4+2型常规树突状细胞（分别为cDC1和cDC2）之间表型和功能的区分已广为接受。但尚不清楚当另外单核细胞来源的细胞（MC）变成合格的抗原呈递细胞（APC）时，这种区分在炎症条件下的功能如何。
 
在呼吸道病毒感染的模型中使用单细胞技术，研究人员发现肺cDC2获得了与MC共享的Fc受体CD64以及与cDC1共享的IRF8的表达。这些炎性cDC2（inf-cDC2）在诱导CD4+T辅助（Th）细胞极化以及同时呈递抗原给CD8+T细胞方面表现优异。当与inf-cDC2分离后，MC缺少APC功能。Inf-cDC2响应于细胞内Toll样受体和1型干扰素受体信号转导而成熟，上调IRF8依赖性成熟模块，并通过恢复期血清和Fc受体获得抗原。因为杂交inf-cDC2很容易与单核细胞来源的细胞混淆，所以它们的存在可以解释为什么APC功能被看做MC。
 
附：英文原文

Title: Inflammatory Type 2 cDCs Acquire Features of cDC1s and Macrophages to Orchestrate Immunity to Respiratory Virus Infection

Author: Cedric Bosteels, Katrijn Neyt, Manon Vanheerswynghels, Mary J. van Helden, Dorine Sichien, Nincy Debeuf, Sofie De Prijck, Victor Bosteels, Niels Vandamme, Liesbet Martens, Yvan Saeys, Els Louagie, Manon Lesage, David L. Williams, Shiau-Choot Tang, Johannes U. Mayer, Franca Ronchese, Charlotte L. Scott, Hamida Hammad, Martin Guilliams, Bart N. Lambrecht

Issue&Volume: 2020-05-08

Abstract: The phenotypic and functional dichotomy between IRF8+ type 1 and IRF4+ type 2 conventional dendritic cells (cDC1s and cDC2s, respectively) is well accepted; it is unknown how robust this dichotomy is under inflammatory conditions, when additionally monocyte-derived cells (MCs) become competent antigen-presenting cells (APCs). Using single-cell technologies in models of respiratory viral infection, we found that lung cDC2s acquired expression of the Fc receptor CD64 shared with MCs and of IRF8 shared with cDC1s. These inflammatory cDC2s (inf-cDC2s) were superior in inducing CD4+ T helper (Th) cell polarization while simultaneously presenting antigen to CD8+ T cells. When carefully separated from inf-cDC2s, MCs lacked APC function. Inf-cDC2s matured in response to cell-intrinsic Toll-like receptor and type 1 interferon receptor signaling, upregulated an IRF8-dependent maturation module, and acquired antigens via convalescent serum and Fc receptors. Because hybrid inf-cDC2s are easily confused with monocyte-derived cells, their existence could explain why APC functions have been attributed to MCs.

DOI: 10.1016/j.immuni.2020.04.005

Source: https://www.cell.com/immunity/fulltext/S1074-7613(20)30163-1

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