小柯机器人

近日，日本筑波大学Takeshi Sakurai、理化学研究所Genshiro A. Sunagawa等研究人员合作，发现一个能够在啮齿动物中诱导类似冬眠状态的神经回路。2020年6月11日，国际知名学术期刊《自然》在线发表了这一成果。

Title: A discrete neuronal circuit induces a hibernation-like state in rodents

Author: Tohru M. Takahashi, Genshiro A. Sunagawa, Shingo Soya, Manabu Abe, Katsuyasu Sakurai, Kiyomi Ishikawa, Masashi Yanagisawa, Hiroshi Hama, Emi Hasegawa, Atsushi Miyawaki, Kenji Sakimura, Masayo Takahashi, Takeshi Sakurai

Issue&Volume: 2020-06-11

Abstract: Hibernating mammals actively lower their body temperature to reduce energy expenditure when facing food scarcity1. This ability to induce a hypometabolic state has evoked great interest owing to its potential medical benefits2,3. Here we show that a hypothalamic neuronal circuit in rodents induces a long-lasting hypothermic and hypometabolic state similar to hibernation. In this state, although body temperature and levels of oxygen consumption are kept very low, the ability to regulate metabolism still remains functional, as in hibernation4. There was no obvious damage to tissues and organs or abnormalities in behaviour after recovery from this state. Our findings could enable the development of a method to induce a hibernation-like state, which would have potential applications in non-hibernating mammalian species including humans.

DOI: 10.1038/s41586-020-2163-6

Source: https://www.nature.com/articles/s41586-020-2163-6

Nature：《自然》，创刊于1869年。隶属于施普林格·自然出版集团，最新IF：69.504
官方网址：http://www.nature.com/
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