小柯机器人

匹兹堡大学Alok V. Joglekar与中国医学科学院李贵登合作总结了T细胞抗原的发现之旅。2020年7月6日，《自然—方法学》在线发表了这一综述论文。

Title: T cell antigen discovery

Author: Alok V. Joglekar, Guideng Li

Issue&Volume: 2020-07-06

Abstract: T cells respond to threats in an antigen-specific manner using T cell receptors (TCRs) that recognize short peptide antigens presented on major histocompatibility complex (MHC) proteins. The TCR–peptide-MHC interaction mediated between a T cell and its target cell dictates its function and thereby influences its role in disease. A lack of approaches for antigen discovery has limited the fundamental understanding of the antigenic landscape of the overall T cell response. Recent advances in high-throughput sequencing, mass cytometry, microfluidics and computational biology have led to a surge in approaches to address the challenge of T cell antigen discovery. Here, we summarize the scope of this challenge, discuss in depth the recent exciting work and highlight the outstanding questions and remaining technical hurdles in this field.

DOI: 10.1038/s41592-020-0867-z

Source: https://www.nature.com/articles/s41592-020-0867-z

Nature Methods：《自然—方法学》，创刊于2004年。隶属于施普林格·自然出版集团，最新IF：47.99
官方网址：https://www.nature.com/nmeth/
投稿链接：https://mts-nmeth.nature.com/cgi-bin/main.plex