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独特的同源盒编码指代秀丽隐杆线虫的所有神经元类别
2020-08-21 15:55

美国哥伦比亚大学Oliver Hobert研究组发现,独特的同源盒编码指代秀丽隐杆线虫的所有神经元类别。相关论文于2020年8月19日在线发表在《自然》杂志上。

通过检查秀丽隐杆线虫基因组编码的所有保守同源域蛋白的表达,研究人员发现,可以通过同源域蛋白表达的独特组合分别描述完整的118个秀丽隐杆线虫神经元类别。这提供了目前最简单的神经元多样性描述。计算和遗传功能丧失分析证实了同源域蛋白不仅提供神经元类型的独特描述,而且在指定神经元身份方面也起着关键作用。研究人员推测在定义独特神经元身份中同源盒基因的广泛使用反映了神经元细胞类型分化的进化历史。
 
据介绍,目前尚不清楚是否可以将神经元细胞类型多样性(由特定于细胞类型的解剖学、生物物理、功能和分子标记所定义)简化为神经元同一性的简单分子描述。
 
附:英文原文

Title: Unique homeobox codes delineate all the neuron classes of C. elegans

Author: Molly B. Reilly, Cyril Cros, Erdem Varol, Eviatar Yemini, Oliver Hobert

Issue&Volume: 2020-08-19

Abstract: It is not known at present whether neuronal cell-type diversity—defined by cell-type-specific anatomical, biophysical, functional and molecular signatures—can be reduced to relatively simple molecular descriptors of neuronal identity1. Here we show, through examination of the expression of all of the conserved homeodomain proteins encoded by the Caenorhabditis elegans genome2, that the complete set of 118 neuron classes of C. elegans can be described individually by unique combinations of the expression of homeodomain proteins, thereby providing—to our knowledge—the simplest currently known descriptor of neuronal diversity. Computational and genetic loss-of-function analyses corroborate the notion that homeodomain proteins not only provide unique descriptors of neuron type, but also have a critical role in specifying neuronal identity. We speculate that the pervasive use of homeobox genes in defining unique neuronal identities reflects the evolutionary history of neuronal cell-type specification. Each one of the complete set of 118 neuron classes in Caenorhabditis elegans can be specified individually by the expression of unique combinations of homeodomain proteins.

DOI: 10.1038/s41586-020-2618-9

Source: https://www.nature.com/articles/s41586-020-2618-9

Nature:《自然》,创刊于1869年。隶属于施普林格·自然出版集团,最新IF:43.07
官方网址:http://www.nature.com/
投稿链接:http://www.nature.com/authors/submit_manuscript.html


本期文章:《自然》:Online/在线发表

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