小柯机器人

科学家绘制出成年人类心脏的细胞组成
2020-09-26 10:14

英国剑桥大学Sarah A. Teichmann等研究人员合作绘制出成年人类心脏的细胞组成。2020年9月24日,《自然》杂志在线发表了这一研究成果。

利用最先进的分析大规模单细胞和细胞核转录组,研究人员描述了六个成人心脏解剖区域。这些结果强调了心肌细胞、周细胞和成纤维细胞的细胞异质性,并揭示了不同的心房和心室亚群,其具有不同的发育起源和特殊特性。研究人员定义了心脏血管系统的复杂性及其沿动静脉轴的变化。在免疫区室中,研究人员发现心脏内的巨噬细胞具有炎症和保护性转录特征。此外,细胞-细胞相互作用的推断强调了心房和心室之间不同于骨骼肌的巨噬细胞-成纤维细胞-心肌细胞网络。这一人类心脏细胞图谱提高了人们对人类心脏的了解,并为今后的研究提供了参考。

据介绍,心血管疾病是全世界死亡的主要原因。深入了解疾病机制和治疗策略需要对健康心脏的分子过程有更深入的了解。了解心脏细胞的全部功能及其基因表达谱是这项工作的第一步。

附:英文原文
 
Title:Cells of the adult human heart
 
Author:Monika Litviňuková, Carlos Talavera-López, […]Sarah A. Teichmann 
 
Issue&Volume:24 September 2020
 
Abstract: Cardiovascular disease is the leading cause of death worldwide. Advanced insights into disease mechanisms and therapeutic strategies require deeper understanding of the healthy heart’s molecular processes. Knowledge of the full repertoire of cardiac cells and their gene expression profiles is a fundamental first step in this endeavor. Here, using state-of-the-art analyses of large-scale single-cell and nuclei transcriptomes, we characterise six anatomical adult heart regions. Our results highlight the cellular heterogeneity of cardiomyocytes, pericytes, and fibroblasts, revealing distinct atrial and ventricular subsets with diverse developmental origins and specialized properties. We define the complexity of the cardiac vasculature and its changes along the arterio-venous axis. In the immune compartment we identify cardiac resident macrophages with inflammatory and protective transcriptional signatures. Further, inference of cell-cell interactions highlight different macrophage-fibroblast-cardiomyocyte networks between atria and ventricles that are distinct from skeletal muscle. Our human cardiac cell atlas improves our understanding of the human heart and provides a healthy reference for future studies.
 
DOI:https://doi.org/10.1038/s41586-020-2797-4
 
Source: https://www.nature.com/articles/s41586-020-2797-4

Nature:《自然》,创刊于1869年。隶属于施普林格·自然出版集团,最新IF:43.07
官方网址:http://www.nature.com/
投稿链接:http://www.nature.com/authors/submit_manuscript.html


本期文章:《自然》:Online/在线发表

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