小柯机器人

英国威康桑格研究所David J. Adams、美国加州大学旧金山分校Allan Balmain等研究人员合作绘制出已知和潜在人类致癌物在小鼠中的突变特征图谱。该研究于2020年9月28日在线发表于国际一流学术期刊《自然—遗传学》。

Title: The mutational signature profile of known and suspected human carcinogens in mice

Author: Laura Riva, Arun R. Pandiri, Yun Rose Li, Alastair Droop, James Hewinson, Michael A. Quail, Vivek Iyer, Rebecca Shepherd, Ronald A. Herbert, Peter J. Campbell, Robert C. Sills, Ludmil B. Alexandrov, Allan Balmain, David J. Adams

Issue&Volume: 2020-09-28

Abstract: Epidemiological studies have identified many environmental agents that appear to significantly increase cancer risk in human populations. By analyzing tumor genomes from mice chronically exposed to 1 of 20 known or suspected human carcinogens, we reveal that most agents do not generate distinct mutational signatures or increase mutation burden, with most mutations, including driver mutations, resulting from tissue-specific endogenous processes. We identify signatures resulting from exposure to cobalt and vinylidene chloride and link distinct human signatures (SBS19 and SBS42) with 1,2,3-trichloropropane, a haloalkane and pollutant of drinking water, and find these and other signatures in human tumor genomes. We define the cross-species genomic landscape of tumors induced by an important compendium of agents with relevance to human health. A genomic analysis of tumors in mice caused by known or suspected carcinogens shows that most carcinogens do not generate distinct mutational signatures.

DOI: 10.1038/s41588-020-0692-4

Source: https://www.nature.com/articles/s41588-020-0692-4

Nature Genetics：《自然—遗传学》，创刊于1992年。隶属于施普林格·自然出版集团，最新IF：41.307
官方网址：https://www.nature.com/ng/
投稿链接：https://mts-ng.nature.com/cgi-bin/main.plex