小柯机器人

英国弗朗西斯·克里克研究所George Kassiotis团队发现，组织特异性和干扰素诱导表达的ACE2是无功能的。2020年10月19日，《自然—遗传学》在线发表了这项成果。

Title: Tissue-specific and interferon-inducible expression of nonfunctional ACE2 through endogenous retroelement co-option

Author: Kevin W. Ng, Jan Attig, William Bolland, George R. Young, Jack Major, Antoni G. Wrobel, Steve Gamblin, Andreas Wack, George Kassiotis

Issue&Volume: 2020-10-19

Abstract: Angiotensin-converting enzyme 2 (ACE2) is an entry receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and a regulator of several physiological processes. ACE2 has recently been proposed to be interferon (IFN) inducible, suggesting that SARS-CoV-2 may exploit this phenomenon to enhance viral spread and questioning the efficacy of IFN treatment in coronavirus disease 2019. Using a recent de novo transcript assembly that captured previously unannotated transcripts, we describe a new isoform of ACE2, generated by co-option of intronic retroelements as promoter and alternative exon. The new transcript, termed MIRb-ACE2, exhibits specific expression patterns across the aerodigestive and gastrointestinal tracts and is highly responsive to IFN stimulation. In contrast, canonical ACE2 expression is unresponsive to IFN stimulation. Moreover, the MIRb-ACE2 translation product is a truncated, unstable ACE2 form, lacking domains required for SARS-CoV-2 binding and is therefore unlikely to contribute to or enhance viral infection. 

DOI: 10.1038/s41588-020-00732-8

Source: https://www.nature.com/articles/s41588-020-00732-8

Nature Genetics：《自然—遗传学》，创刊于1992年。隶属于施普林格·自然出版集团，最新IF：41.307
官方网址：https://www.nature.com/ng/
投稿链接：https://mts-ng.nature.com/cgi-bin/main.plex