小柯机器人

美国博德研究所Galit Alter等研究人员合作揭示与SARS-CoV-2死亡率相关的体液反应改变轨迹。相关论文2020年11月3日在线发表在《细胞》杂志上。

Title: Compromised humoral functional evolution tracks with SARS-CoV-2 mortality

Author: Tomer Zohar, Carolin Loos, Stephanie Fischinger, Caroline Atyeo, Chuangqi Wang, Matthew D. Slein, John Burke, Jingyou Yu, Jared Feldman, Blake Marie Hauser, Tim Caradonna, Aaron Schmidt, Yongfei Cai, Hendrik Streeck, Edward T. Ryan, Dan H. Barouch, Richelle C. Charles, Douglas Lauffenburger, Galit Alter

Issue&Volume: 2020-11-03

Abstract: The urgent need for an effective SARS-CoV-2 vaccine has forced development to progress in the absence of well-defined correlates of immunity. While neutralization has been linked to protection against other pathogens, whether neutralization alone will be sufficient to drive protection against SARS-CoV-2 in the broader population remains unclear. Therefore, to fully define protective humoral immunity we dissected the early evolution of the humoral response in 193 hospitalized individuals ranging from moderate-to severe. Although robust IgM and IgA responses evolved in both survivors and non-survivors with severe disease, non-survivors showed attenuated IgG responses, accompanied by compromised Fc-receptor binding and Fc-effector activity, pointing to deficient humoral development rather than disease-enhancing humoral immunity. In contrast, individuals with moderate disease exhibited delayed responses that ultimately matured. These data highlight distinct humoral trajectories associated with resolution of SARS-CoV-2 infection and the need for early functional humoral immunity.

DOI: 10.1016/j.cell.2020.10.052

Source: https://www.cell.com/cell/fulltext/S0092-8674(20)31459-8