小柯机器人

持久转录程序与远程记忆相关
2020-11-14 23:32

美国斯坦福大学Thomas C. Sdhof和Stephen R. Quake团队合作取得一项新成果。他们探明了持久的转录程序与远程记忆相关。这一研究成果发表在2020年11月11日出版的国际学术期刊《自然》杂志上。

他们使用长期环境恐惧记忆作为范式来杂交在前额内侧皮层中远程记忆存储基础的单细胞基因表达格局。他们发现在恐惧学习后持续数周的各种神经元中存在持续活动特异性转录改变。在广阔的可塑性编码空间中,他们鉴定了与膜融合相关的基因,这些基因可能在维持远程记忆中起重要作用。

出乎意料的是,星形胶质细胞和小胶质细胞也获得了与远程记忆相关的持久基因表达特征,表明它们积极地参与了记忆回路。与远程记忆印记相关的基因表达程序的发现为现有的脑分类法图谱增加了依赖于活动的细胞状态之重要意义,并阐明了远程记忆存储的微妙机制。

据悉,基因表达在学习和短期记忆中的作用已被广泛研究,但对远程记忆的了解却很少,这种记忆可以持续一生。

附:英文原文

Title: Persistent transcriptional programmes are associated with remote memory

Author: Michelle B. Chen, Xian Jiang, Stephen R. Quake, Thomas C. Sdhof

Issue&Volume: 2020-11-11

Abstract: The role of gene expression during learning and in short-term memories has been studied extensively1–3, but less is known about remote memories, which can persist for a lifetime4. Here we used long-term contextual fear memory as a paradigm to probe the single-cell gene expression landscape that underlies remote memory storage in the medial prefrontal cortex. We found persistent activity-specific transcriptional alterations in diverse populations of neurons that lasted for weeks after fear learning. Out of a vast plasticity-coding space, we identified genes associated with membrane fusion that could have important roles in the maintenance of remote memory. Unexpectedly, astrocytes and microglia also acquired persistent gene expression signatures that were associated with remote memory, suggesting that they actively contribute to memory circuits. The discovery of gene expression programmes associated with remote memory engrams adds an important dimension of activity-dependent cellular states to existing brain taxonomy atlases and sheds light on the elusive mechanisms of remote memory storage. The authors identify long-lasting transcriptional programmes in neurons and glia that are associated with the storage of a remote memory.

DOI: 10.1038/s41586-020-2905-5

Source: https://www.nature.com/articles/s41586-020-2905-5

Nature:《自然》,创刊于1869年。隶属于施普林格·自然出版集团,最新IF:43.07
官方网址:http://www.nature.com/
投稿链接:http://www.nature.com/authors/submit_manuscript.html


本期文章:《自然》:Online/在线发表

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